Polyphenols in the prevention and treatment of sepsis syndromes: Rationale and pre-clinical evidence

Nutrition

Volumn 25, Issue 10, 2009, Pages 981-997

  Shapiro, Haim ^a   Lev, Shaul ^a   Cohen, Jonathan ^a   Singer, Pierre ^a  

^a RABIN MEDICAL CENTER   (Israel)

Author keywords

Critical illness; Inflammation; Nuclear factor kappa B; Nutritional support; Phytochemicals

Indexed keywords

3 INDOLEMETHANOL; ANTHOCYANIN; BACTERIUM LIPOPOLYSACCHARIDE; BAICALEIN; CAFFEIC ACID PHENETHYL ESTER; CURCUMIN; EPIGALLOCATECHIN GALLATE; GENISTEIN; GLABRIDIN; GREEN TEA EXTRACT; HESPERIDIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUTEOLIN; NARINGENIN; OLEUROPEIN; PLACEBO; POLYPHENOL DERIVATIVE; POLYPHENON E; QUERCETIN; RESVERATROL; SILYMARIN; SULFORAPHANE; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR NRF2; TURMERIC; WOGONIN; XANTHOPHYLL;

ACUTE PANCREATITIS; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; CANCER PREVENTION; CELL PROTECTION; CLINICAL TRIAL; COLITIS; CRITICAL ILLNESS; DIGESTIVE SYSTEM INFLAMMATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG ELIMINATION; DRUG MECHANISM; DRUG MEGADOSE; DRUG METABOLISM; DRUG TOLERABILITY; DRUG WITHDRAWAL; ENDOTOXEMIA; GASTROINTESTINAL TUMOR; HEPATITIS; HUMAN; INFLAMMATORY DISEASE; INSULIN RESISTANCE; INTENSIVE CARE; JAUNDICE; KIDNEY INJURY; LIVER FAILURE; LIVER TOXICITY; LUNG INJURY; MAXIMUM PLASMA CONCENTRATION; MUSCULOSKELETAL PAIN; NEOPLASM; NONHUMAN; NUTRITIONAL SUPPORT; OBESITY; PRIORITY JOURNAL; REVIEW; SEPSIS; SEPTIC SHOCK; SINGLE DRUG DOSE; SKIN INFECTION; ULCERATIVE COLITIS; WOUND;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CRITICAL ILLNESS; DRUG EVALUATION, PRECLINICAL; ENDOTOXEMIA; FLAVONOIDS; HUMANS; PHENOLS; PLANTS, EDIBLE; SEPSIS; SHOCK, SEPTIC;

CURCUMA LONGA; RODENTIA; THEOBROMA CACAO;

EID: 69249217897     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nut.2009.02.010     Document Type: Review

References (106)

1. Lever A., and Mackenzie I. Sepsis: definition, epidemiology, and diagnosis. BMJ 335 (2007) 879-883
2. Annane D., Bellissant E., and Cavaillon J.M. Septic shock. Lancet 365 (2005) 63-78
3. Opara E.C., and Rockway S.W. Antioxidants and micronutrients. Dis Mon 52 (2006) 151-163
4. Stapleton R.D., Jones N., and Heyland D.K. Feeding critically ill patients: what is the optimal amount of energy?. Crit Care Med 35 (2007) S535-S540
5. Berger M.M., and Chioléro R.L. Antioxidant supplementation in sepsis and systemic inflammatory response syndrome. Crit Care Med 35 (2007) S584-S590
6. Iason G. The role of plant secondary metabolites in mammalian herbivory: ecological perspectives. Proc Nutr Soc 64 (2005) 123-131
7. Higdon J. In: Higdon J. (Ed). An evidence-based approach to dietary phytochemicals. Preface (2007), Thieme, New York
8. Kris-Etherton P.M., Hecker K.D., Bonanome A., Coval S.M., Binkoski A.E., Hilpert K.F., et al. Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Am J Med 113 (2002) 71S-88S
9. Bravo L. Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev 56 (1998) 317-333
10. Scalbert A., Manach C., Morand C., Remesy C., and Jimenez L. Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr 45 (2005) 287-306
11. Carlson J.R., Bauer B.A., Vincent A., Limburg P.J., and Wilson T. Reading the tea leaves: anticarcinogenic properties of (-)-epigallocatechin-3-gallate. Mayo Clin Proc 82 (2007) 725-732
12. Joe B., Vijaykumar M., and Lokesh B.R. Biological properties of curcumin-cellular and molecular mechanisms of action. Crit Rev Food Sci Nutr 44 (2004) 97-111
13. Park D., Huang T., and Frishman W.H. Phytoestrogens as cardioprotective agents. Cardiol Rev 13 (2005) 13-17
14. Baur J.A., and Sinclair D.A. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 5 (2006) 493-506
15. Proceedings of the 1st International Conference on Polyphenols and Health. Vichy, France, November 18-21, 2004. Am J Clin Nutr 2005;81:215S-335S.
16. Manach C., Mazur A., and Scalbert A. Polyphenols and prevention of cardiovascular diseases. Curr Opin Lipidol 16 (2005) 77-84
17. Higdon J., and Flavonoids. In: Higdon J. (Ed). An evidence-based approach to dietary phytochemicals (2007), Thieme, New York 114-126
18. Shapiro H., Singer P., Halpern Z., and Bruck R. Polyphenols in the treatment of inflammatory bowel disease and acute pancreatitis. Gut 56 (2007) 426-435
19. Das S., and Das D.K. Resveratrol: a therapeutic promise for cardiovascular diseases. Recent Patents Cardiovasc Drug Discov 2 (2007) 133-138
20. Singer P., Shapiro H., and Cohen J. Brain death and organ damage: the modulating effects of nutrition. Transplantation 80 (2005) 1363-1368
21. Gescher A. Polyphenolic phytochemicals versus non-steroidal anti-inflammatory drugs: which are better cancer chemopreventive agents?. J Chemother Suppl 4 (2004) 3-6
22. Rahman I. Antioxidant therapies in COPD. Int J Chron Obstruct Pulmon Dis 1 (2006) 15-29
23. Hu M. Commentary: bioavailability of flavonoids and polyphenols: call to arms. Mol Pharm 4 (2007) 803-806
24. Manach C., Williamson G., Morand C., Scalbert A., and Rémésy C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81 (2005) 230S-242S
25. Stevenson D.E., and Hurst R.D. Polyphenolic phytochemicals-just antioxidants or much more?. Cell Mol Life Sci 64 (2007) 2900-2916
26. Biesalski H.K. Polyphenols and inflammation: basic interactions. Curr Opin Clin Nutr Metab Care 10 (2007) 724-728
27. Rahman I., Biswas S.K., and Kirkham P.A. Regulation of inflammation and redox signaling by dietary polyphenols. Biochem Pharmacol 72 (2006) 1439-1452
28. Surh Y.J., Kundu J.K., Na H.K., and Lee J.S. Redox-sensitive transcription factors as prime targets for chemoprevention with anti-inflammatory and antioxidative phytochemicals. J Nutr 135 (2005) 2993S-3001S
29. Liu S.F., and Malik A.B. NF-kappa B activation as a pathological mechanism of septic shock and inflammation. Am J Physiol Lung Cell Mol Physiol 290 (2006) L622-L645
30. Singleton K.D., Serkova N., Beckey V.E., and Wischmeyer P.E. Glutamine attenuates lung injury and improves survival after sepsis: role of enhanced heat shock protein expression. Crit Care Med 33 (2005) 1206-1213
31. Kaur G., Tirkey N., Bharrhan S., Chanana V., Rishi P., and Chopra K. Inhibition of oxidative stress and cytokine activity by curcumin in amelioration of endotoxin-induced experimental hepatoxicity in rodents. Clin Exp Immunol 145 (2006) 313-321
32. Motohashi H., and Yamamoto M. Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med 10 (2004) 549-557
33. Shen S.C., Lee W.R., Lin H.Y., Huang H.C., Ko C.H., Yang L.L., et al. In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production. Eur J Pharmacol 446 (2002) 187-194
34. Dunsmore K.E., Chen P.G., and Wong H.R. Curcumin, a medicinal herbal compound capable of inducing the heat shock response. Crit Care Med 29 (2001) 2199-2204
35. Prior R.L. Fruits and vegetables in the prevention of cellular oxidative damage. Am J Clin Nutr 78 (2003) 570S-578S
36. Morikawa T., Matsuda H., Ninomiya K., and Yoshikawa M. Medicinal foodstuffs. XXIX. Potent protective effects of sesquiterpenes and curcumin from Zedoariae Rhizoma on liver injury induced by D-galactosamine/lipopolysaccharide or tumor necrosis factor-alpha. Biol Pharm Bull 25 (2002) 627-631
37. Lukita-Atmadja W., Ito Y., Baker G.L., and McCuskey R.S. Effect of curcuminoids as anti-inflammatory agents on the hepatic microvascular response to endotoxin. Shock 17 (2002) 399-403
38. Kaur G., Tirkey N., and Chopra K. Beneficial effect of hesperidin on lipopolysaccharide-induced hepatotoxicity. Toxicology 226 (2006) 152-160
39. Yuan G.J., Gong Z.J., Sun X.M., Zheng S.H., and Li X. Tea polyphenols inhibit expressions of iNOS and TNF-α and prevent lipopolysaccharide-induced liver injury in rats. Hepatobiliary Pancreat Dis Int 5 (2006) 262-267
40. Yokozawa T., Rhyu D.Y., Cho E.J., and Aoyagi K. Protective activity of (-)-epicatechin 3-O-gallate against peroxynitrite-mediated renal damage. Free Radic Res 37 (2003) 561-571
41. Yang F., de Villiers W.J., McClain C.J., and Varilek G.W. Green tea polyphenols block endotoxin-induced tumor necrosis factor-production and lethality in a murine model. J Nutr 128 (1998) 2334-2340
42. Li W., Ashok M., Li J., Yang H., Sama A.E., and Wang H. A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1. PLoS ONE 2 (2007) e1153, 2007
43. Di Paola R., Mazzon E., Muia C., Crisafulli C., Genovese T., Di Bella P., et al. Green tea polyphenol extract attenuates zymosan-induced non-septic shock in mice. Shock 26 (2006) 402-409
44. Kanno S., Shouji A., Tomizawa A., Hiura T., Osanai Y., Ujibe M., et al. Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophages. Life Sci 78 (2006) 673-681
45. Madan B., and Ghosh B. Diferuloylmethane inhibits neutrophil infiltration and improves survival of mice in high-dose endotoxin shock. Shock 19 (2003) 91-96
46. Chen H.W., Kuo H.T., Chai C.Y., Ou J.L., and Yang R.C. Pretreatment of curcumin attenuates coagulopathy and renal injury in LPS-induced endotoxemia. J Endotoxin Res 13 (2007) 15-23
47. Kotanidou A., Xagorari A., Bagli E., Kitsanta P., Fotsis T., Papapetropoulos A., et al. Luteolin reduces lipopolysaccharide-induced lethal toxicity and expression of proinflammatory molecules in mice. Am J Respir Crit Care Med 165 (2002) 818-823
48. Takahashi K., Morikawa A., Kato Y., Sugiyama T., Koide N., Mu M.M., et al. Flavonoids protect mice from two types of lethal shock induced by endotoxin. FEMS Immunol Med Microbiol 31 (2001) 29-33
49. Cheng P.Y., Lee Y.M., Wu Y.S., Chang T.W., Jin J.S., and Yen M.H. Protective effect of baicalein against endotoxic shock in rats in vivo and in vitro. Biochem Pharmacol 73 (2007) 793-804
50. Kang J.S., Jeon Y.J., Park S.K., Yang K.H., and Kim H.M. Protection against lipopolysaccharide-induced sepsis and inhibition of interleukin-1beta and prostaglandin E2 synthesis by silymarin. Biochem Pharmacol 67 (2004) 175-181
51. Van Dien M., Takahashi K., Mu M.M., Koide N., Sugiyama T., Mori I., et al. Protective effect of wogonin on endotoxin-induced lethal shock in D-galactosamine-sensitized mice. Microbiol Immunol 45 (2001) 751-756
52. Kang J.S., Yoon Y.D., Cho I.J., Han M.H., Lee C.W., Park S.K., et al. Glabridin, an isoflavan from licorice root, inhibits inducible nitric-oxide synthase expression and improves survival of mice in experimental model of septic shock. J Pharmacol Exp Ther 312 (2005) 1187-1194
53. Jung W.K., Choi I., Lee D.Y., Yea S.S., Choi Y.H., Kim M.M., et al. Caffeic acid phenethyl ester protects mice from lethal endotoxin shock and inhibits lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW 264.7 macrophages via the p38/ERK and NF-kappaB pathways. Int J Biochem Cell Biol 40 (2008) 2572-2582
54. Fatehi M., Anvari K., and Fatehi-Hassanabad Z. The beneficial effects of protein tyrosine kinase inhibition on the circulatory failure induced by endotoxin in the rat. Shock 18 (2002) 450-455
55. Ruetten H., and Thiemermann C. Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: a possible role for protein tyrosine kinase. Br J Pharmacol 122 (1997) 59-70
56. Bermejo A., Zarzuelo A., and Duarte J. In vivo vascular effects of genistein on a rat model of septic shock induced by lipopolysaccharide. J Cardiovasc Pharmacol 42 (2003) 329-338
57. Pergola C., Rossi A., Dugo P., Cuzzocrea S., and Sautebin L. Inhibition of nitric oxide biosynthesis by anthocyanin fraction of blackberry extract. Nitric Oxide 15 (2006) 30-39
58. Siddiqui A.M., Cui X., Wu R., Dong W., Zhou M., Hu M., et al. The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-gamma. Crit Care Med 34 (2006) 1874-1882
59. Wheeler D.S., Lahni P.M., Hake P.W., Denenberg A.G., Wong H.R., Snead C., et al. The green tea polyphenol epigallocatechin-3-gallate improves systemic hemodynamics and survival in rodent models of polymicrobial sepsis. Shock 28 (2007) 353-359
60. Giamarellos-Bourboulis E.J., Geladopoulos T., Chrisofos M., Koutoukas P., Vassiliadis J., Alexandrou I., et al. Oleuropein: a novel immunomodulator conferring prolonged survival in experimental sepsis by Pseudomonas aeruginosa. Shock 26 (2006) 410-416
61. Kawaguchi K., Kikuchi S., Hasunuma R., Maruyama H., Yoshikawa T., and Kumazawa Y. A citrus flavonoid hesperidin suppresses infection-induced endotoxin shock in mice. Biol Pharm Bull 27 (2004) 679-683
62. Walle T., Hsieh F., DeLegge M.H., Oatis Jr. J.E., and Walle U.K. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos 32) (2004) 1377-1382
63. Landry D.W., and Oliver J.A. The pathogenesis of vasodilatory shock. N Engl J Med 345 (2001) 588-595
64. Chen L.Y., Zuraw B.L., Zhao M., Liu F.T., Huang S., and Pan Z.K. Involvement of protein tyrosine kinase in Toll-like receptor 4-mediated NF-kappa B activation in human peripheral blood monocytes. Am J Physiol Lung Cell Mol Physiol 284 (2003) L607-L613
65. Mahn K., Borras C., Knock G.A., Taylor P., Khan I.Y., Sugden D., et al. Dietary soy isoflavone induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced blood pressure in vivo. FASEB J 19 (2005) 1755-1757
66. Li H.F., Zhang P., Tian Z.F., Qiu X.Q., Zhang Y.F., Wu J.X., et al. Differential mechanisms involved in effects of genistein and 17-beta-estradiol on porcine coronary arteries. Pharmazie 61 (2006) 461-465
67. Sautebin L., Rossi A., Serraino I., Dugo P., Di Paola R., Mondello L., et al. Effect of anthocyanins contained in a blackberry extract on the circulatory failure and multiple organ dysfunction caused by endotoxin in the rat. Planta Med 70 (2004) 745-752
68. Zhu S., Li W., Li J., Sama A.E., and Wang H. Caging a beast in the inflammation arena: use of Chinese medicinal herbs to inhibit a late mediator of lethal sepsis, HMGB1. Int J Clin Exp Med 1 (2008) 64-75
69. Buras J.A., Holzmann B., and Sitkovsky M. Animal models of sepsis: setting the stage. Nat Rev Drug Discov 4 (2005) 854-865
70. Hatcher H., Planalp R., Cho J., Torti F.M., and Torti S.V. Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci 65 (2008) 1631-1652
71. Chan M.M. Inhibition of tumor necrosis factor by curcumin, a phytochemical. Biochem Pharmacol 49 (1995) 1551-1556
72. Singh S., and Aggarwal B.B. Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]. J Biol Chem 270 (1995) 24995-25000
73. The molecular targets and therapeutic uses of curcumin in health and disease. Adv Exp Med Biol (2007) 595
74. Anand P., Kunnumakkara A.B., Newman R.A., and Aggarwal B.B. Bioavailability of curcumin: problems and promises. Mol Pharm 4 (2007) 807-818
75. Lao C.D., Ruffin M.T.I.V., Normolle D., Heath D.D., Murray S.I., Bailey J.M., et al. Dose escalation of a curcuminoid formulation. BMC Complement Altern Med 6 (2006) 10
76. Cheng A.L., Hsu C.H., Lin J.K., Hsu M.M., Ho Y.F., Shen T.S., et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 21 (2001) 2895-2900
77. Strimpakos A.S., and Sharma R.A. Curcumin: preventive and therapeutic properties in laboratory studies and clinical trials. Antioxid Redox Signal 10 (2008) 511-545
78. Hanai H., Iida T., Takeuchi K., Watanabe F., Maruyama Y., Andoh A., et al. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol 4 (2006) 1502-1506
79. Shoskes D., Lapierre C., Cruz-Correa M., Muruve N., Rosario R., Fromkin B., et al. Beneficial effects of the bioflavonoids curcumin and quercetin on early function in cadaveric renal transplantation: a randomized placebo controlled trial. Transplantation 80 (2005) 1556-1559
80. National Institutes of Health. Search of: curcumin. Available at: http://www.clinicaltrials.gov/ct2/results?term=curcumin. Accessed April 20, 2009.
81. Lee J.J., Huang W.T., Shao D.Z., Liao J.F., and Lin M.T. Blocking NF-kappaB activation may be an effective strategy in the fever therapy. Jpn J Physiol 53 (2003) 367-375
82. Zhang M., Deng C., Zheng J., Xia J., and Sheng D. Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats by activation of peroxisome proliferator-activated receptor gamma. Int Immunopharmacol 6 (2006) 1233-1242
83. Gradisar H., Keber M.M., Pristovsek P., and Jerala R. MD-2 as the target of curcumin in the inhibition of response to LPS. J Leukoc Biol 82 (2007) 968-974
84. Youn H.S., Saitoh S.I., Miyake K., and Hwang D.H. Inhibition of homodimerization of toll-like receptor 4 by curcumin. Biochem Pharmacol 72 (2006) 62-69
85. Shen S.Q., Zhang Y., Xiang J.J., and Xiong C.L. Protective effect of curcumin against liver warm ischemia/reperfusion injury in rat model is associated with regulation of heat shock protein and antioxidant enzymes. World J Gastroenterol 13 (2007) 1953-1961
86. Hu M., Du Q., Vancurova I., Lin X., Miller E.J., Simms H.H., and Wang P. Proapoptotic effect of curcumin on human neutrophils: activation of the p38 mitogen-activated protein kinase pathway. Crit Care Med 33 (2005) 2571-2578
87. Protti A., and Singer M. Bench-to-bedside review: potential strategies to protect or reverse mitochondrial dysfunction in sepsis-induced organ failure. Crit Care 10 (2006) 228
88. Weiss Y.G., Maloyan A., Tazelaar J., Raj N., and Deutschman C.S. Adenoviral transfer of HSP-70 into pulmonary epithelium ameliorates experimental acute respiratory distress syndrome. J Clin Invest 110 (2002) 801-806
89. Kolls J.K. Oxidative stress in sepsis: a redox redux. J Clin Invest 116 (2006) 860-863
90. Sumpio B.E., Cordova A.C., Berke-Schlessel D.W., Qin F., and Chen Q.H. Green tea, the "Asian paradox," and cardiovascular disease. J Am Coll Surg 202 (2006) 813-825
91. Iso H., Date C., Wakai K., Fukui M., and Tamakoshi A. JACC Study Group. The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults. Ann Intern Med 144 (2006) 554-562
92. Kuriyama S., Shimazu T., Ohmori K., Kikuchi N., Nakaya N., Nishino Y., et al. Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: the Ohsaki study. JAMA 296 (2006) 1255-1265
93. Luo H., Tang L., Tang M., Billam M., Huang T., Yu J., et al. Phase IIa chemoprevention trial of green tea polyphenols in high-risk individuals of liver cancer: modulation of urinary excretion of green tea polyphenols and 8-hydroxydeoxyguanosine. Carcinogenesis 27 (2006) 262-268
94. National Institutes of Health. Search of: green tea. Available at: http://clinicaltrials.gov/ct2/results?term=green+tea. Accessed April 20, 2009.
95. Lambert J.D., Sang S., and Yang C.S. Biotransformation of green tea polyphenols and the biological activities of those metabolites. Mol Pharm 4 (2007) 819-825
96. Chow H.H., Cai Y., Hakim I.A., Crowell J.A., Shahi F., Brooks C.A., et al. Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals. Clin Cancer Res 9 (2003) 3312-3319
97. Chow H.H., Hakim I.A., Vining D.R., Crowell J.A., Tome M.E., Ranger-Moore J., et al. Modulation of human glutathione s-transferases by polyphenone intervention. Cancer Epidemiol Biomarkers Prev 16 (2007) 1662-1666
98. Chow H.H., Hakim I.A., Vining D.R., Crowell J.A., Cordova C.A., Chew W.M., et al. Effects of repeated green tea catechin administration on human cytochrome P450 activity. Cancer Epidemiol Biomarkers Prev 15 (2006) 2473-2476
99. Hill A.M., Coates A.M., Buckley J.D., Ross R., Thielecke F., and Howe P.R. Can EGCG reduce abdominal fat in obese subjects?. J Am Coll Nutr 26 (2007) 396S-402S
100. Fidan H., Sahin O., Yavuz Y., Kilbas A., Cetinkaya Z., Ela Y., et al. Caffeic acid phenethyl ester reduces mortality and sepsis-induced lung injury in rats. Crit Care Med 35 (2007) 2822-2829
101. Bonkovsky H.L. Hepatotoxicity associated with supplements containing Chinese green tea (Camellia sinensis). Ann Intern Med 144 (2006) 68-71
102. Molinari M., Watt K.D., Kruszyna T., Nelson R., Walsh M., Huang W.Y., et al. Acute liver failure induced by green tea extracts: case report and review of the literature. Liver Transplant 12 (2006) 1892-1895
103. Kolgazi M., Sener G., Cetinel S., Gedik N., and Alican I. Resveratrol reduces renal and lung injury caused by sepsis in rats. J Surg Res 134 (2006) 315-321
104. Meng Y., Zhang M., Xu J., Liu X.M., and Ma Q.Y. Effect of resveratrol on microcirculation disorder and lung injury following severe acute pancreatitis in rats. World J Gastroenterol 11 (2005) 433-435
105. Baur J.A., Pearson K.J., Price N.L., Jamieson H.A., Lerin C., Kalra A., et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444 (2006) 337-342
106. Tekin A., Küçükkartallar T., Türkyilmaz S., Dinckan A., Esen H., Ateş B., et al. Effects of caffeic acid phenethyl ester (CAPE) on sepsis in rats. Inflammation 31 (2008) 273-280