메뉴 건너뛰기




Volumn 16, Issue 9, 2015, Pages 707-714

Clinical trial success rates of anti-obesity agents: The importance of combination therapies

Author keywords

Anti obesity agents; Clinical trials; Combination therapies

Indexed keywords

AMFEBUTAMONE; ANTIOBESITY AGENT; CANNABINOID RECEPTOR; LIRAGLUTIDE; LORCASERIN; PHENTERMINE PLUS TOPIRAMATE;

EID: 84938683124     PISSN: 14677881     EISSN: 1467789X     Source Type: Journal    
DOI: 10.1111/obr.12299     Document Type: Article
Times cited : (10)

References (32)
  • 1
    • 31544478378 scopus 로고    scopus 로고
    • Defining overweight and obesity
    • www document. (accessed May 22, 2014).
    • Centers for Disease Control and Prevention (2012) Defining overweight and obesity. [www document] URL: http://www.cdc.gov/obesity/adult/defining.html (accessed May 22, 2014).
    • (2012)
  • 2
    • 84938683304 scopus 로고    scopus 로고
    • Health risk classification according to body mass index (BMI)
    • www document. (accessed May 22, 2014).
    • Health Canada (2003) Health risk classification according to body mass index (BMI). [www document] URL: http://www.hc-sc.gc.ca/fn-an/nutrition/weights-poids/guide-ld-adult/cg_quick_ref-ldc_rapide_ref-table4-eng.php (accessed May 22, 2014).
    • (2003)
  • 3
    • 82955227225 scopus 로고    scopus 로고
    • Adult obesity prevalence in Canada and the United States
    • www document. (accessed May 22, 2014).
    • Shields M, Carroll MD, Ogden CL. (2011) Adult obesity prevalence in Canada and the United States. [www document] URL: http://www.cdc.gov/nchs/data/databriefs/db56.pdf (accessed May 22, 2014).
    • (2011)
    • Shields, M.1    Carroll, M.D.2    Ogden, C.L.3
  • 4
    • 64649083354 scopus 로고    scopus 로고
    • The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis
    • Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health 2009; 9: 88.
    • (2009) BMC Public Health , vol.9 , pp. 88
    • Guh, D.P.1    Zhang, W.2    Bansback, N.3    Amarsi, Z.4    Birmingham, C.L.5    Anis, A.H.6
  • 5
    • 84866110751 scopus 로고    scopus 로고
    • The pharmaceutical market for obesity therapies
    • Wong D, Sullivan K, Heap G. The pharmaceutical market for obesity therapies. Nat Rev Drug Discov 2012; 11: 669-670.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 669-670
    • Wong, D.1    Sullivan, K.2    Heap, G.3
  • 6
    • 84858077267 scopus 로고    scopus 로고
    • The medical care costs of obesity: an instrumental variables approach
    • John C, Chad M. The medical care costs of obesity: an instrumental variables approach. J Health Econ 2012; 31: 219-230.
    • (2012) J Health Econ , vol.31 , pp. 219-230
    • John, C.1    Chad, M.2
  • 7
    • 34248180472 scopus 로고    scopus 로고
    • 2006 Canadian Clinical Practice Guidelines on the management and prevention of obesity in adults and children [summary]
    • Lau DC, Douketis JD, Morrison KM, Hramiak IM, Sharma AM, Ur E. 2006 Canadian Clinical Practice Guidelines on the management and prevention of obesity in adults and children [summary]. CMAJ 2007; 176: S1-S13.
    • (2007) CMAJ , vol.176 , pp. S1-S13
    • Lau, D.C.1    Douketis, J.D.2    Morrison, K.M.3    Hramiak, I.M.4    Sharma, A.M.5    Ur, E.6
  • 8
    • 79961165599 scopus 로고    scopus 로고
    • Current and future drug targets in weight management
    • Witkamp RF. Current and future drug targets in weight management. Pharm Res 2011; 28: 1792-1818.
    • (2011) Pharm Res , vol.28 , pp. 1792-1818
    • Witkamp, R.F.1
  • 10
    • 0344234865 scopus 로고    scopus 로고
    • FDA announces withdrawal fenfluramine and dexfenfluramine (fen-phen)
    • www document. (accessed May 23, 2014).
    • FDA.(1997) FDA announces withdrawal fenfluramine and dexfenfluramine (fen-phen). [www document] URL http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm179871.htm (accessed May 23, 2014).
    • (1997)
  • 11
    • 84868371299 scopus 로고    scopus 로고
    • Risk of a clinical drug trial in patients with moderate to severe rheumatoid arthritis
    • Jayasundara KS, Keystone EC, Parker JL. Risk of a clinical drug trial in patients with moderate to severe rheumatoid arthritis. J Rheumatology 2012; 39: 2066-2070.
    • (2012) J Rheumatology , vol.39 , pp. 2066-2070
    • Jayasundara, K.S.1    Keystone, E.C.2    Parker, J.L.3
  • 12
    • 84859860067 scopus 로고    scopus 로고
    • Drug development risk in HIV-1 clinical trials: the effect of drug class
    • Osborne BJW, Kaul R, Parker JL. Drug development risk in HIV-1 clinical trials: the effect of drug class. J Pharm Health Serv Res 2011; 2: 211-216.
    • (2011) J Pharm Health Serv Res , vol.2 , pp. 211-216
    • Osborne, B.J.W.1    Kaul, R.2    Parker, J.L.3
  • 13
    • 78650407137 scopus 로고    scopus 로고
    • The success rate of new drug development in clinical trials: Crohn's disease
    • Parker JL, Clare Kohler J. The success rate of new drug development in clinical trials: Crohn's disease. J Pharm Pharm Sci 2010; 13: 191-197.
    • (2010) J Pharm Pharm Sci , vol.13 , pp. 191-197
    • Parker, J.L.1    Clare Kohler, J.2
  • 14
    • 79959315593 scopus 로고    scopus 로고
    • Clinical trial risk in non-Hodgkin's lymphoma: endpoint and target selection
    • Parker JL, Zhang ZY, Buckstein R. Clinical trial risk in non-Hodgkin's lymphoma: endpoint and target selection. J Pharm Pharm Sci 2011; 14: 227-235.
    • (2011) J Pharm Pharm Sci , vol.14 , pp. 227-235
    • Parker, J.L.1    Zhang, Z.Y.2    Buckstein, R.3
  • 16
    • 84902352095 scopus 로고    scopus 로고
    • Clinical trial risk in castration resistant prostate cancer: immunotherapies show promise
    • Tenuta J, Klotz L, Parker JL. Clinical trial risk in castration resistant prostate cancer: immunotherapies show promise. BJU Int 2013; 113(5b): E82-E89.
    • (2013) BJU Int , vol.113 , Issue.5 , pp. E82-E89
    • Tenuta, J.1    Klotz, L.2    Parker, J.L.3
  • 18
    • 84876161582 scopus 로고    scopus 로고
    • FDA approves Belviq to treat some overweight or obese adults
    • [www document] URL(accessed May 26, 2014).
    • FDA. (2012) FDA approves Belviq to treat some overweight or obese adults. [www document] URL http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm309993.htm (accessed May 26, 2014).
    • (2012)
  • 19
    • 84886674345 scopus 로고    scopus 로고
    • FDA approves weight-management drug Qsymia
    • [WWW document] URL:(accessed May 26, 2014).
    • FDA. (2012) FDA approves weight-management drug Qsymia. [WWW document] URL: http://www.fda.gov/newsevents/newsroom/pressannouncements/ucm312468.htm (accessed May 26, 2014).
    • (2012)
  • 20
    • 84929963055 scopus 로고    scopus 로고
    • FDA approves weight management drug Contrave
    • [WWW document] URL:(accessed December 16, 2014).
    • FDA. (2014) FDA approves weight management drug Contrave. [WWW document] URL: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm413896.htm (accessed December 16, 2014).
    • (2014)
  • 21
    • 84929963055 scopus 로고    scopus 로고
    • FDA approves weight management drug Saxenda
    • URL: [www document](accessed December 24, 2014).
    • FDA. (2014) FDA approves weight management drug Saxenda. URL: [www document] http://www.fda.gov/NewsEvents/Newsroom/PressAnnoucements/ucm427913.htm (accessed December 24, 2014).
    • (2014)
  • 22
    • 34848929006 scopus 로고    scopus 로고
    • The physiology of body weight regulation: are we too efficient for our own good?
    • Dokken BB, Tsao TS. The physiology of body weight regulation: are we too efficient for our own good? Diabetes Spectrum 2007; 20: 166-170.
    • (2007) Diabetes Spectrum , vol.20 , pp. 166-170
    • Dokken, B.B.1    Tsao, T.S.2
  • 23
  • 24
    • 67649631173 scopus 로고    scopus 로고
    • Combination pharmaceutical therapies for obesity
    • Gadde KM, Allison DB. Combination pharmaceutical therapies for obesity. Expert Opin Pharmacother 2009; 10: 921-925.
    • (2009) Expert Opin Pharmacother , vol.10 , pp. 921-925
    • Gadde, K.M.1    Allison, D.B.2
  • 25
    • 84914153872 scopus 로고    scopus 로고
    • The role of combination therapy in managing pulmonary arterial hypertension
    • Ghofrani HA, Humbert M The role of combination therapy in managing pulmonary arterial hypertension. Eur Reposit Rev 2014; 23: 469-475.
    • (2014) Eur Reposit Rev , vol.23 , pp. 469-475
    • Ghofrani, H.A.1    Humbert, M.2
  • 26
    • 67650677868 scopus 로고    scopus 로고
    • Guidance for industry diabetes mellitus: developing drugs and therapeutic biologics for treatment and prevention
    • [www document] URL:(accessed May 30, 2014).
    • FDA. (2008) Guidance for industry diabetes mellitus: developing drugs and therapeutic biologics for treatment and prevention. [www document] URL: http://www.fda.gov/downloads/Drugs/Guidances/ucm071624.pdf (accessed May 30, 2014).
    • (2008)
  • 27
    • 84875230354 scopus 로고    scopus 로고
    • Obesity and the endocannabinoid system: is there still a future for CB1 antagonists in obesity?
    • Serrano A, Pavon FJ, Suarez J etal. Obesity and the endocannabinoid system: is there still a future for CB1 antagonists in obesity? Curr Obes Rep 2012; 1: 216-228.
    • (2012) Curr Obes Rep , vol.1 , pp. 216-228
    • Serrano, A.1    Pavon, F.J.2    Suarez, J.3
  • 28
    • 84938680662 scopus 로고    scopus 로고
    • The rise and fall of CB1 receptor antagonists: possible future perspectives
    • Badgy G. The rise and fall of CB1 receptor antagonists: possible future perspectives. BMC Pharmacol 2011; 11(Suppl. 2): A55.
    • (2011) BMC Pharmacol , vol.11 , pp. A55
    • Badgy, G.1
  • 29
    • 84873156296 scopus 로고    scopus 로고
    • Mechanisms underlying current and future anti-obesity drugs
    • Adan RA. Mechanisms underlying current and future anti-obesity drugs. Trends Neurosci 2013; 36: 133-140.
    • (2013) Trends Neurosci , vol.36 , pp. 133-140
    • Adan, R.A.1
  • 30
    • 84938733214 scopus 로고    scopus 로고
    • [WWW document](accessed March 30, 2015).
    • ClinicalTrial.gov.Cardiovascular outcomes study of naltrexone SR/bupropion SR in overweight and obese subjects with cardiovascular risk factors (The Light Study) (2015) [WWW document] https://clinicaltrials.gov/ct2/show/NCT01601704 (accessed March 30, 2015).
    • (2015)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.