-
1
-
-
0642307264
-
Karnofsky award lecture. Imatinib as a paradigm of targeted therapies
-
Druker B. J., David A. Karnofsky Award lecture. Imatinib as a paradigm of targeted therapies. J. Clin. Oncol. 21, 239s-245s (2003).
-
(2003)
J. Clin. Oncol.
, vol.21
-
-
Druker, B.J.1
David, A.2
-
2
-
-
10744233716
-
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
-
DOI 10.1056/NEJMoa022457
-
O'Brien, S. G. et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N. Engl. J. Med. 348, 994-1004 (2003). (Pubitemid 36302244)
-
(2003)
New England Journal of Medicine
, vol.348
, Issue.11
, pp. 994-1004
-
-
O'Brien, S.G.1
Guilhot, F.2
Larson, R.A.3
Gathmann, I.4
Baccarani, M.5
Cervantes, F.6
Cornelissen, J.J.7
Fischer, T.8
Hochhaus, A.9
Hughes, T.10
Lechner, K.11
Nielsen, J.L.12
Rousselot, P.13
Reiffers, J.14
Saglio, G.15
Shepherd, J.16
Simonsson, B.17
Gratwohl, A.18
Goldman, J.M.19
Kantarjian, H.20
Taylor, K.21
Verhoef, G.22
Bolton, A.E.23
Capdeville, R.24
Druker, B.J.25
more..
-
3
-
-
79953271634
-
The evolving war on cancer
-
Haber, D. A., Gray, N. S. & Baselga, J. The evolving war on cancer. Cell 145, 19-24 (2011).
-
(2011)
Cell
, vol.145
, pp. 19-24
-
-
Haber, D.A.1
Gray, N.S.2
Baselga, J.3
-
4
-
-
84255197842
-
Cancer immunotherapy comes of age
-
Mellman, I., Coukos, G. & Dranoff, G. Cancer immunotherapy comes of age. Nature 480, 480-489 (2011).
-
(2011)
Nature
, vol.480
, pp. 480-489
-
-
Mellman, I.1
Coukos, G.2
Dranoff, G.3
-
5
-
-
77955066199
-
Sipuleucel-T immunotherapy for castration-resistant prostate cancer
-
Kantoff, P. W. et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N. Engl. J. Med. 363, 411-422 (2010).
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 411-422
-
-
Kantoff, P.W.1
-
6
-
-
33646794392
-
Checkpoint blockade in cancer immunotherapy
-
Korman, A., Peggs, K. & Allison, J. P. Checkpoint blockade in cancer immunotherapy. Adv. Immunol. 90, 293-335 (2006).
-
(2006)
Adv. Immunol.
, vol.90
, pp. 293-335
-
-
Korman, A.1
Peggs, K.2
Allison, J.P.3
-
7
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi, F. S. et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363, 711-723 (2010).
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
-
8
-
-
79959772576
-
Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
-
Robert, C. et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N. Engl. J. Med. 364, 2517-2526 (2011).
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 2517-2526
-
-
Robert, C.1
-
9
-
-
73149092567
-
Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
-
Wolchok, J. D. et al. Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin. Cancer Res. 15, 7412-7420 (2009).
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 7412-7420
-
-
Wolchok, J.D.1
-
10
-
-
78249257291
-
CD4+ T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation.
-
Rakhra, K. et al. CD4+ T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. Cancer Cell 18, 485-498 (2010).
-
(2010)
Cancer Cell
, vol.18
, pp. 485-498
-
-
Rakhra, K.1
-
11
-
-
44949166624
-
The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination
-
DOI 10.1038/nm1769, PII NM1769
-
Chiarle, R. et al. The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination. Nature Med. 14, 676-680 (2008). (Pubitemid 351809545)
-
(2008)
Nature Medicine
, vol.14
, Issue.6
, pp. 676-680
-
-
Chiarle, R.1
Martinengo, C.2
Mastini, C.3
Ambrogio, C.4
D'Escamard, V.5
Forni, G.6
Inghirami, G.7
-
12
-
-
84857506147
-
Consequence of dose scheduling of sunitinib on host immune response elements and vaccine combination therapy
-
8 Aug doi:10.1002/ijc.26219
-
Farsaci, B., Higgins, J. P. & Hodge, J. W. Consequence of dose scheduling of sunitinib on host immune response elements and vaccine combination therapy. Int. J. Cancer 8 Aug 2011 (doi:10.1002/ijc.26219).
-
(2011)
Int. J. Cancer
-
-
Farsaci, B.1
Higgins, J.P.2
Hodge, J.W.3
-
13
-
-
84858762252
-
-
This paper details how alterations in the scheduling of the targeted therapy sunitinib significantly alter TReg cell populations, and that pretreating with sunitinib improves vaccine efficacy in animal models; whereas, co-administration had no effect on vaccine efficacy
-
This paper details how alterations in the scheduling of the targeted therapy sunitinib significantly alter TReg cell populations, and that pretreating with sunitinib improves vaccine efficacy in animal models; whereas, co-administration had no effect on vaccine efficacy.
-
-
-
-
14
-
-
63549105681
-
Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients
-
Ko, J. S. et al. Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients. Clin. Cancer Res. 15, 2148-2157 (2009).
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 2148-2157
-
-
Ko, J.S.1
-
15
-
-
25444444988
-
Activation of dendritic cells via inhibition of Jak2/STAT3 signaling
-
Nefedova, Y. et al. Activation of dendritic cells via inhibition of Jak2/STAT3 signaling. J. Immunol. 175, 4338-4346 (2005). (Pubitemid 41361968)
-
(2005)
Journal of Immunology
, vol.175
, Issue.7
, pp. 4338-4346
-
-
Nefedova, Y.1
Cheng, P.2
Gilkes, D.3
Blaskovich, M.4
Beg, A.A.5
Sebti, S.M.6
Gabrilovich, D.I.7
-
16
-
-
27144538568
-
Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the Janus-activated kinase 2/signal transducers and activators of transcription 3 pathway
-
DOI 10.1158/0008-5472.CAN-05-0529
-
Nefedova, Y. et al. Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway. Cancer Res. 65, 9525-9535 (2005). (Pubitemid 41508023)
-
(2005)
Cancer Research
, vol.65
, Issue.20
, pp. 9525-9535
-
-
Nefedova, Y.1
Nagaraj, S.2
Rosenbauer, A.3
Muro-Cacho, C.4
Sebti, S.M.5
Gabrilovich, D.I.6
-
17
-
-
84858774518
-
-
This paper discusses the use of a JAK2 inhibitor to improve the maturation of DCs, showing that animals treated with JAK2 inhibitors have increased numbers of mature DCs, increased T cell priming by DCs and have increased surival when the inhibitor was combined with a DC vaccine
-
This paper discusses the use of a JAK2 inhibitor to improve the maturation of DCs, showing that animals treated with JAK2 inhibitors have increased numbers of mature DCs, increased T cell priming by DCs and have increased surival when the inhibitor was combined with a DC vaccine.
-
-
-
-
18
-
-
77950205394
-
The proteasome inhibitor bortezomib sensitizes melanoma cells toward adoptive CTL attack
-
Seeger, J. M. et al. The proteasome inhibitor bortezomib sensitizes melanoma cells toward adoptive CTL attack. Cancer Res. 70, 1825-1834 (2010).
-
(2010)
Cancer Res.
, vol.70
, pp. 1825-1834
-
-
Seeger, J.M.1
-
19
-
-
45549086241
-
Targeting AKT signaling sensitizes cancer to cellular immunotherapy
-
Hahnel, P. S. et al. Targeting AKT signaling sensitizes cancer to cellular immunotherapy. Cancer Res. 68, 3899-3906 (2008).
-
(2008)
Cancer Res.
, vol.68
, pp. 3899-3906
-
-
Hahnel, P.S.1
-
20
-
-
3042722266
-
Immunotherapy: Bewitched, bothered, and bewildered no more
-
DOI 10.1126/science.1099688
-
Steinman, R. M. & Mellman, I. Immunotherapy: bewitched, bothered, and bewildered no more. Science 305, 197-200 (2004). (Pubitemid 38886724)
-
(2004)
Science
, vol.305
, Issue.5681
, pp. 197-200
-
-
Steinman, R.M.1
Mellman, I.2
-
21
-
-
17644425689
-
The B7 family revisited
-
DOI 10.1146/annurev.immunol.23.021704.115611
-
Greenwald, R. J., Freeman, G. J. & Sharpe, A. H. The B7 family revisited. Annu. Rev. Immunol. 23, 515-548 (2005). (Pubitemid 40563179)
-
(2005)
Annual Review of Immunology
, vol.23
, pp. 515-548
-
-
Greenwald, R.J.1
Freeman, G.J.2
Sharpe, A.H.3
-
22
-
-
0037096878
-
+ T cells
-
May, K. F. Jr, Chen, L., Zheng, P. & Liu, Y. Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells. Cancer Res. 62, 3459-3465 (2002). (Pubitemid 34651393)
-
(2002)
Cancer Research
, vol.62
, Issue.12
, pp. 3459-3465
-
-
May Jr., K.F.1
Chen, L.2
Zheng, P.3
Liu, Y.4
-
23
-
-
0031007143
-
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
-
DOI 10.1038/nm0697-682
-
Melero, I. et al. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nature Med. 3, 682-685 (1997). (Pubitemid 27264981)
-
(1997)
Nature Medicine
, vol.3
, Issue.6
, pp. 682-685
-
-
Melero, I.1
Shuford, W.W.2
Newby, S.A.3
Aruffo, A.4
Ledbetter, J.A.5
Hellstrom, K.E.6
Mittler, R.S.7
Chen, L.8
-
24
-
-
0037103147
-
4-1BB-specific monoclonal antibody promotes the generation of tumor-specific immune responses by direct activation of CD8 T cells in a CD40-dependent manner
-
Miller, R. E. et al. 4-1BB-specific monoclonal antibody promotes the generation of tumor-specific immune responses by direct activation of CD8 T cells in a CD40-dependent manner. J. Immunol. 169, 1792-1800 (2002). (Pubitemid 34857639)
-
(2002)
Journal of Immunology
, vol.169
, Issue.4
, pp. 1792-1800
-
-
Miller, R.E.1
Jones, J.2
Le, T.3
Whitmore, J.4
Boiani, N.5
Gliniak, B.6
Lynch, D.H.7
-
25
-
-
77952325212
-
Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals
-
Mitsui, J. et al. Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals. Clin. Cancer Res. 16, 2781-2791 (2010).
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 2781-2791
-
-
Mitsui, J.1
-
26
-
-
42649125225
-
PD-1 and its ligands in tolerance and immunity
-
DOI 10.1146/annurev.immunol.26.021607.090331
-
Keir, M. E., Butte, M. J., Freeman, G. J. & Sharpe, A. H. PD-1 and its ligands in tolerance and immunity. Annu. Rev. Immunol. 26, 677-704 (2008). (Pubitemid 351600389)
-
(2008)
Annual Review of Immunology
, vol.26
, pp. 677-704
-
-
Keir, M.E.1
Butte, M.J.2
Freeman, G.J.3
Sharpe, A.H.4
-
27
-
-
63449124514
-
Anti-programmed death-1 synergizes with granulocyte macrophage colony-stimulating factor-secreting tumor cell immunotherapy providing therapeutic benefit to mice with established tumors
-
Li, B. et al. Anti-programmed death-1 synergizes with granulocyte macrophage colony-stimulating factor-secreting tumor cell immunotherapy providing therapeutic benefit to mice with established tumors. Clin. Cancer Res. 15, 1623-1634 (2009).
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 1623-1634
-
-
Li, B.1
-
28
-
-
42949105127
-
Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients
-
DOI 10.1073/pnas.0712237105
-
Hodi, F. S. et al. Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients. Proc. Natl Acad. Sci. USA 105, 3005-3010 (2008). (Pubitemid 351723658)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.8
, pp. 3005-3010
-
-
Hodi, F.S.1
Butler, M.2
Oble, D.A.3
Seiden, M.V.4
Haluska, F.G.5
Kruse, A.6
MacRae, S.7
Nelson, M.8
Canning, C.9
Lowy, I.10
Korman, A.11
Lautz, D.12
Russell, S.13
Jaklitsch, M.T.14
Ramaiya, N.15
Chen, T.C.16
Neuberg, D.17
Allison, J.P.18
Mihm, M.C.19
Dranoff, G.20
more..
-
29
-
-
26444577543
-
Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions
-
DOI 10.1172/JCI24772
-
Boruchov, A. M. et al. Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions. J. Clin. Invest. 115, 2914-2923 (2005). (Pubitemid 41434419)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.10
, pp. 2914-2923
-
-
Boruchov, A.M.1
Heller, G.2
Veri, M.-C.3
Bonvini, E.4
Ravetch, J.V.5
Young, J.W.6
-
31
-
-
84856332921
-
Cetuximab chemotherapy enhances dendritic cell-mediated phagocytosis of colon cancer cells and ignites a highly efficient colon cancer antigen-specific cytotoxic T-cell response in vitro
-
Correale, P. et al. Cetuximab chemotherapy enhances dendritic cell-mediated phagocytosis of colon cancer cells and ignites a highly efficient colon cancer antigen-specific cytotoxic T-cell response in vitro. Int. J. Cancer 130, 1577-1589 (2012).
-
(2012)
Int. J. Cancer
, vol.130
, pp. 1577-1589
-
-
Correale, P.1
-
32
-
-
0043136619
-
+ T cell effector function and tumor-free survival in Her-2/neu-transgenic mice
-
Wolpoe, M. E. et al. HER-2/neu-specific monoclonal antibodies collaborate with HER-2/neu-targeted granulocyte macrophage colony-stimulating factor secreting whole cell vaccination to augment CD8+ T cell effector function and tumor-free survival in Her-2/neu-transgenic mice. J. Immunol. 171, 2161-2169 (2003). (Pubitemid 36966500)
-
(2003)
Journal of Immunology
, vol.171
, Issue.4
, pp. 2161-2169
-
-
Wolpoe, M.E.1
Lutz, E.R.2
Ercolini, A.M.3
Murata, S.4
Ivie, S.E.5
Garrett, E.S.6
Emens, L.A.7
Jaffee, E.M.8
Reilly, R.T.9
-
33
-
-
79960842306
-
T-bet expression in intratumoral lymphoid structures after neoadjuvant trastuzumab plus docetaxel for HER2-overexpressing breast carcinoma predicts survival
-
Ladoire, S. et al. T-bet expression in intratumoral lymphoid structures after neoadjuvant trastuzumab plus docetaxel for HER2-overexpressing breast carcinoma predicts survival. Br. J. Cancer 105, 366-371 (2011).
-
(2011)
Br. J. Cancer
, vol.105
, pp. 366-371
-
-
Ladoire, S.1
-
34
-
-
77955534002
-
The therapeutic effect of anti-HER2/neu antibody depends on both innate and adaptive immunity
-
Park, S. et al. The therapeutic effect of anti-HER2/neu antibody depends on both innate and adaptive immunity. Cancer Cell 18, 160-170 (2010).
-
(2010)
Cancer Cell
, vol.18
, pp. 160-170
-
-
Park, S.1
-
35
-
-
43049144967
-
+ T cell responses in mice through Fc-mediated activation of DCs
-
DOI 10.1172/JCI34333
-
Kim, P. S. et al. Antibody association with HER-2/neu-targeted vaccine enhances CD8 T cell responses in mice through Fc-mediated activation of DCs. J. Clin. Invest. 118, 1700-1711 (2008). (Pubitemid 351632374)
-
(2008)
Journal of Clinical Investigation
, vol.118
, Issue.5
, pp. 1700-1711
-
-
Kim, P.S.1
Armstrong, T.D.2
Song, H.3
Wolpoe, M.E.4
Weiss, V.5
Manning, E.A.6
Huang, L.Q.7
Murata, S.8
Sgouros, G.9
Emens, L.A.10
Reilly, R.T.11
Jaffee, E.M.12
-
36
-
-
70350435441
-
Concurrent trastuzumab and HER2/neu-specific vaccination in patients with metastatic breast cancer
-
Disis, M. L. et al. Concurrent trastuzumab and HER2/neu-specific vaccination in patients with metastatic breast cancer. J. Clin. Oncol. 27, 4685-4692 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 4685-4692
-
-
Disis, M.L.1
-
37
-
-
79955570584
-
Anti-ErbB-2 mAb therapy requires type i and II interferons and synergizes with anti-PD-1 or anti-CD137 mAb therapy
-
Stagg, J. et al. Anti-ErbB-2 mAb therapy requires type I and II interferons and synergizes with anti-PD-1 or anti-CD137 mAb therapy. Proc. Natl Acad. Sci. USA 108, 7142-7147 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 7142-7147
-
-
Stagg, J.1
-
38
-
-
84858774520
-
-
This paper demonstrates how targeted monoclonal antibody therapies, such as HER2 antibodies, require immune-mediated tumour destruction for clinical responses and synergize with both co-stimulatory 4-1BB agonistic antibodies, as well as blockade of an inhibitory signal through a PD1 antibody
-
This paper demonstrates how targeted monoclonal antibody therapies, such as HER2 antibodies, require immune-mediated tumour destruction for clinical responses and synergize with both co-stimulatory 4-1BB agonistic antibodies, as well as blockade of an inhibitory signal through a PD1 antibody.
-
-
-
-
39
-
-
79953190024
-
IL-12 enhances the antitumor actions of trastuzumab via NK cell IFN-γ production
-
Jaime-Ramirez, A. C. et al. IL-12 enhances the antitumor actions of trastuzumab via NK cell IFN-γ production. J. Immunol. 186, 3401-3409 (2011).
-
(2011)
J. Immunol.
, vol.186
, pp. 3401-3409
-
-
Jaime-Ramirez, A.C.1
-
40
-
-
70949093473
-
A phase i trial of paclitaxel and trastuzumab in combination with interleukin-12 in patients with HER2/neu-expressing malignancies
-
Bekaii-Saab, T. S. et al. A phase I trial of paclitaxel and trastuzumab in combination with interleukin-12 in patients with HER2/neu-expressing malignancies. Mol. Cancer Ther. 8, 2983-2991 (2009).
-
(2009)
Mol. Cancer Ther.
, vol.8
, pp. 2983-2991
-
-
Bekaii-Saab, T.S.1
-
41
-
-
77954054889
-
Putative contribution of CD56 positive cells in cetuximab treatment efficacy in first-line metastatic colorectal cancer patients
-
Marechal, R. et al. Putative contribution of CD56 positive cells in cetuximab treatment efficacy in first-line metastatic colorectal cancer patients. BMC Cancer 10, 340 (2010).
-
(2010)
BMC Cancer
, vol.10
, pp. 340
-
-
Marechal, R.1
-
42
-
-
48549098958
-
Complement-dependent tumor cell lysis triggered by combinations of epidermal growth factor receptor antibodies
-
Dechant, M. et al. Complement-dependent tumor cell lysis triggered by combinations of epidermal growth factor receptor antibodies. Cancer Res. 68, 4998-5003 (2008).
-
(2008)
Cancer Res.
, vol.68
, pp. 4998-5003
-
-
Dechant, M.1
-
43
-
-
77953046198
-
Complement activation mediates cetuximab inhibition of non-small cell lung cancer tumor growth in vivo
-
Hsu, Y. F. et al. Complement activation mediates cetuximab inhibition of non-small cell lung cancer tumor growth in vivo. Mol. Cancer 9, 139 (2010).
-
(2010)
Mol. Cancer
, vol.9
, pp. 139
-
-
Hsu, Y.F.1
-
44
-
-
78149365345
-
STAT3: A target to enhance antitumor immune response
-
Lee, H., Pal, S. K., Reckamp, K., Figlin, R. A. & Yu, H. STAT3: a target to enhance antitumor immune response. Curr. Top. Microbiol. Immunol. 344, 41-59 (2011).
-
(2011)
Curr. Top. Microbiol. Immunol.
, vol.344
, pp. 41-59
-
-
Lee, H.1
Pal, S.K.2
Reckamp, K.3
Figlin, R.A.4
Yu, H.5
-
45
-
-
64249096161
-
Central role of tumor-associated CD8+ T effector/memory cells in restoring systemic antitumor immunity
-
Kilinc, M. O., Gu, T., Harden, J. L., Virtuoso, L. P. & Egilmez, N. K. Central role of tumor-associated CD8+ T effector/memory cells in restoring systemic antitumor immunity. J. Immunol. 182, 4217-4225 (2009).
-
(2009)
J. Immunol.
, vol.182
, pp. 4217-4225
-
-
Kilinc, M.O.1
Gu, T.2
Harden, J.L.3
Virtuoso, L.P.4
Egilmez, N.K.5
-
46
-
-
29144514645
-
Effector memory T cells, early metastasis, and survival in colorectal cancer
-
DOI 10.1056/NEJMoa051424
-
Pages, F. et al. Effector memory T cells, early metastasis, and survival in colorectal cancer. N. Engl. J. Med. 353, 2654-2666 (2005). (Pubitemid 41817714)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.25
, pp. 2654-2666
-
-
Pages, F.1
Berger, A.2
Camus, M.3
Sanchez-Cabo, F.4
Costes, A.5
Molidor, R.6
Mlecnik, B.7
Kirilovsky, A.8
Nilsson, M.9
Damotte, D.10
Meatchi, T.11
Bruneval, P.12
Cugnenc, P.-H.13
Trajanoski, Z.14
Fridman, W.-H.15
Galon, J.16
-
47
-
-
58149303099
-
Prognostic significance of tumor-infiltrating T-lymphocytes in primary and metastatic lesions of advanced stage ovarian cancer
-
Leffers, N. et al. Prognostic significance of tumor-infiltrating T-lymphocytes in primary and metastatic lesions of advanced stage ovarian cancer. Cancer Immunol. Immunother. 58, 449-459 (2009).
-
(2009)
Cancer Immunol. Immunother.
, vol.58
, pp. 449-459
-
-
Leffers, N.1
-
48
-
-
82555164917
-
TOR in the immune system
-
Araki, K., Ellebedy, A. H. & Ahmed, R. TOR in the immune system. Curr. Opin. Cell Biol. 23, 707-715 (2011).
-
(2011)
Curr. Opin. Cell Biol.
, vol.23
, pp. 707-715
-
-
Araki, K.1
Ellebedy, A.H.2
Ahmed, R.3
-
49
-
-
67650074206
-
MTOR regulates memory CD8 T-cell differentiation
-
Araki, K. et al. mTOR regulates memory CD8 T-cell differentiation. Nature 460, 108-112 (2009).
-
(2009)
Nature
, vol.460
, pp. 108-112
-
-
Araki, K.1
-
50
-
-
84858756686
-
-
This paper illustrates how inhibitors of the mTOR pathway, such as rapamycin, enhance memory T cell differentiation and augment their function in multiple different animal models of viral infection
-
This paper illustrates how inhibitors of the mTOR pathway, such as rapamycin, enhance memory T cell differentiation and augment their function in multiple different animal models of viral infection.
-
-
-
-
51
-
-
79951670258
-
Temsirolimus an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines
-
Wang, Y., Wang, X. Y., Subjeck, J. R., Shrikant, P. A. & Kim, H. L. Temsirolimus, an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines. Br. J. Cancer 104, 643-652 (2011).
-
(2011)
Br. J. Cancer
, vol.104
, pp. 643-652
-
-
Wang, Y.1
Wang, X.Y.2
Subjeck, J.R.3
Shrikant, P.A.4
Kim, H.L.5
-
52
-
-
79958806173
-
MTOR kinase inhibitor AZD8055 enhances the immunotherapeutic activity of an agonist CD40 antibody in cancer treatment
-
Jiang, Q. et al. mTOR kinase inhibitor AZD8055 enhances the immunotherapeutic activity of an agonist CD40 antibody in cancer treatment. Cancer Res. 71, 4074-4084 (2011).
-
(2011)
Cancer Res.
, vol.71
, pp. 4074-4084
-
-
Jiang, Q.1
-
53
-
-
78650188983
-
An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness
-
Procaccini, C. et al. An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness. Immunity 33, 929-941 (2010).
-
(2010)
Immunity
, vol.33
, pp. 929-941
-
-
Procaccini, C.1
-
54
-
-
79952750887
-
Regulatory T cells require mammalian target of rapamycin signaling to maintain both homeostasis and alloantigen-driven proliferation in lymphocyte-replete mice
-
Wang, Y. et al. Regulatory T cells require mammalian target of rapamycin signaling to maintain both homeostasis and alloantigen-driven proliferation in lymphocyte-replete mice. J. Immunol. 186, 2809-2818 (2011).
-
(2011)
J. Immunol.
, vol.186
, pp. 2809-2818
-
-
Wang, Y.1
-
55
-
-
72549086625
-
Deregulated GSK3β sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase
-
Mai, W. et al. Deregulated GSK3β sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase. Clin. Cancer Res. 15, 6810-6819 (2009).
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 6810-6819
-
-
Mai, W.1
-
56
-
-
34547782316
-
Inhibition of GSK-3β activity attenuates proliferation of human colon cancer cells in rodents
-
DOI 10.1111/j.1349-7006.2007.00545.x
-
Shakoori, A. et al. Inhibition of GSK-3 β activity attenuates proliferation of human colon cancer cells in rodents. Cancer Sci. 98, 1388-1393 (2007). (Pubitemid 47241761)
-
(2007)
Cancer Science
, vol.98
, Issue.9
, pp. 1388-1393
-
-
Shakoori, A.1
Mai, W.2
Miyashita, K.3
Yasumoto, K.4
Takahashi, Y.5
Ooi, A.6
Kawakami, K.7
Minamoto, T.8
-
57
-
-
80053997259
-
A human memory T cell subset with stem cell-like properties
-
Gattinoni, L. et al. A human memory T cell subset with stem cell-like properties. Nature Med. 17, 1290-1297 (2011).
-
(2011)
Nature Med.
, vol.17
, pp. 1290-1297
-
-
Gattinoni, L.1
-
58
-
-
84858774529
-
-
This paper demonstrates how targeted therapies, such as GSK3β inhibitors, are able to drive T cell differentiation to retain long-lasting, self-renewing, Tscm cells that provide potent tumour protection in adoptive T cell transfer models
-
This paper demonstrates how targeted therapies, such as GSK3β inhibitors, are able to drive T cell differentiation to retain long-lasting, self-renewing, Tscm cells that provide potent tumour protection in adoptive T cell transfer models.
-
-
-
-
59
-
-
28544443984
-
Promoting apoptosis as a strategy for cancer drug discovery
-
DOI 10.1038/nrc1736
-
Fesik, S. W. Promoting apoptosis as a strategy for cancer drug discovery. Nature Rev. Cancer 5, 876-885 (2005). (Pubitemid 41746032)
-
(2005)
Nature Reviews Cancer
, vol.5
, Issue.11
, pp. 876-885
-
-
Fesik, S.W.1
-
60
-
-
77957729423
-
IAP inhibitors enhance co-stimulation to promote tumor immunity
-
Dougan, M. et al. IAP inhibitors enhance co-stimulation to promote tumor immunity. J. Exp. Med. 207, 2195-2206 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 2195-2206
-
-
Dougan, M.1
-
61
-
-
84858774522
-
-
This paper shows that IAP inhibitors increase T cell responses to multiple different immune stimuli in vitro and that combining IAP inhibitors with tumour vaccination decreases tumour growth kinetics
-
This paper shows that IAP inhibitors increase T cell responses to multiple different immune stimuli in vitro and that combining IAP inhibitors with tumour vaccination decreases tumour growth kinetics.
-
-
-
-
62
-
-
45849120966
-
(Un)expected roles of c-IAPs in apoptotic and NFκB signaling pathways
-
Varfolomeev, E. & Vucic, D. (Un)expected roles of c-IAPs in apoptotic and NFκB signaling pathways. Cell Cycle 7, 1511-1521 (2008). (Pubitemid 351881313)
-
(2008)
Cell Cycle
, vol.7
, Issue.11
, pp. 1511-1521
-
-
Varfolomeev, E.1
Vucic, D.2
-
63
-
-
0033991158
-
Escape of human solid tumors from T-cell recognition: Molecular mechanisms and functional significance
-
Marincola, F. M., Jaffee, E. M., Hicklin, D. J. & Ferrone, S. Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance. Adv. Immunol. 74, 181-273 (2000).
-
(2000)
Adv. Immunol.
, vol.74
, pp. 181-273
-
-
Marincola, F.M.1
Jaffee, E.M.2
Hicklin, D.J.3
Ferrone, S.4
-
64
-
-
32944469894
-
Bortezomib: Proteasome inhibition as an effective anticancer therapy
-
DOI 10.1146/annurev.med.57.042905.122625
-
Richardson, P. G., Mitsiades, C., Hideshima, T. & Anderson, K. C. Bortezomib: proteasome inhibition as an effective anticancer therapy. Annu. Rev. Med. 57, 33-47 (2006). (Pubitemid 43261977)
-
(2006)
Annual Review of Medicine
, vol.57
, pp. 33-47
-
-
Richardson, P.G.1
Mitsiades, C.2
Hideshima, T.3
Anderson, K.C.4
-
65
-
-
38949113714
-
Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma
-
DOI 10.1182/blood-2007-03-078535
-
Shi, J. et al. Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma. Blood 111, 1309-1317 (2008). (Pubitemid 351213417)
-
(2008)
Blood
, vol.111
, Issue.3
, pp. 1309-1317
-
-
Shi, J.1
Tricot, G.J.2
Garg, T.K.3
Malaviarachchi, P.A.4
Szmania, S.M.5
Kellum, R.E.6
Storrie, B.7
Mulder, A.8
Shaughnessy Jr., J.D.9
Barlogie, B.10
Van Rhee, F.11
-
66
-
-
40449100492
-
Sensitization of tumor cells to NK cell-mediated killing by proteasome inhibition
-
Hallett, W. H. et al. Sensitization of tumor cells to NK cell-mediated killing by proteasome inhibition. J. Immunol. 180, 163-170 (2008).
-
(2008)
J. Immunol.
, vol.180
, pp. 163-170
-
-
Hallett, W.H.1
-
67
-
-
19944432123
-
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
-
DOI 10.1016/j.molcel.2004.12.030, PII S1097276505010403
-
Chen, L. et al. Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol. Cell 17, 393-403 (2005). (Pubitemid 40193310)
-
(2005)
Molecular Cell
, vol.17
, Issue.3
, pp. 393-403
-
-
Chen, L.1
Willis, S.N.2
Wei, A.3
Smith, B.J.4
Fletcher, J.I.5
Hinds, M.G.6
Colman, P.M.7
Day, C.L.8
Adams, J.M.9
Huang, D.C.S.10
-
68
-
-
48149087775
-
Treatment with proteasome inhibitor bortezomib enhances antigen-specific CD8+ T-cell-mediated antitumor immunity induced by DNA vaccination
-
Tseng, C. W. et al. Treatment with proteasome inhibitor bortezomib enhances antigen-specific CD8+ T-cell-mediated antitumor immunity induced by DNA vaccination. J. Mol. Med. 86, 899-908 (2008).
-
(2008)
J. Mol. Med.
, vol.86
, pp. 899-908
-
-
Tseng, C.W.1
-
69
-
-
61649110680
-
Activation of Akt as a mechanism for tumor immune evasion
-
Noh, K. H. et al. Activation of Akt as a mechanism for tumor immune evasion. Mol. Ther. 17, 439-447 (2009).
-
(2009)
Mol. Ther.
, vol.17
, pp. 439-447
-
-
Noh, K.H.1
-
70
-
-
77954373338
-
Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function
-
Boni, A. et al. Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function. Cancer Res. 70, 5213-5219 (2010).
-
(2010)
Cancer Res.
, vol.70
, pp. 5213-5219
-
-
Boni, A.1
-
71
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman, P. B. et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N. Engl. J. Med. 364, 2507-2516 (2011).
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
-
72
-
-
77953916528
-
HSP90 at the hub of protein homeostasis: Emerging mechanistic insights
-
Taipale, M., Jarosz, D. F. & Lindquist, S. HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nature Rev. Mol. Cell Biol. 11, 515-528 (2010).
-
(2010)
Nature Rev. Mol. Cell Biol.
, vol.11
, pp. 515-528
-
-
Taipale, M.1
Jarosz, D.F.2
Lindquist, S.3
-
73
-
-
33846328749
-
Inhibitor of heat-shock protein 90 enhances the antitumor effect of DNA vaccine targeting clients of heat-shock protein
-
Lin, C. C. et al. Inhibitor of heat-shock protein 90 enhances the antitumor effect of DNA vaccine targeting clients of heat-shock protein. Mol. Ther. 15, 404-410 (2007).
-
(2007)
Mol. Ther.
, vol.15
, pp. 404-410
-
-
Lin, C.C.1
-
74
-
-
70149088170
-
Heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17- demethoxygeldanamycin enhances EphA2+ tumor cell recognition by specific CD8+ T cells
-
Kawabe, M. et al. Heat shock protein 90 inhibitor 17- dimethylaminoethylamino-17-demethoxygeldanamycin enhances EphA2+ tumor cell recognition by specific CD8+ T cells. Cancer Res. 69, 6995-7003 (2009).
-
(2009)
Cancer Res.
, vol.69
, pp. 6995-7003
-
-
Kawabe, M.1
-
75
-
-
69349093499
-
Heat shock protein 90 inhibitor BIIB021 (CNF2024) depletes NF-κB and sensitizes Hodgkin's lymphoma cells for natural killer cell-mediated cytotoxicity
-
Boll, B. et al. Heat shock protein 90 inhibitor BIIB021 (CNF2024) depletes NF-κB and sensitizes Hodgkin's lymphoma cells for natural killer cell-mediated cytotoxicity. Clin. Cancer Res. 15, 5108-5116 (2009).
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 5108-5116
-
-
Boll, B.1
-
76
-
-
70449717531
-
Heat shock protein-90 inhibitors increase MHC class I-related chain A and B ligand expression on multiple myeloma cells and their ability to trigger NK cell degranulation
-
Fionda, C. et al. Heat shock protein-90 inhibitors increase MHC class I-related chain A and B ligand expression on multiple myeloma cells and their ability to trigger NK cell degranulation. J. Immunol. 183, 4385-4394 (2009).
-
(2009)
J. Immunol.
, vol.183
, pp. 4385-4394
-
-
Fionda, C.1
-
77
-
-
33646239388
-
The DNA damage response arouses the immune system
-
Gasser, S. & Raulet, D. H. The DNA damage response arouses the immune system. Cancer Res. 66, 3959-3962 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 3959-3962
-
-
Gasser, S.1
Raulet, D.H.2
-
78
-
-
64849109372
-
Effective in vivo induction of NKG2D ligands in acute myeloid leukaemias by all-trans-retinoic acid or sodium valproate
-
Poggi, A. et al. Effective in vivo induction of NKG2D ligands in acute myeloid leukaemias by all-trans-retinoic acid or sodium valproate. Leukemia 23, 641-648 (2009).
-
(2009)
Leukemia
, vol.23
, pp. 641-648
-
-
Poggi, A.1
-
79
-
-
28244502269
-
Cancer cells become susceptible to natural killer cell killing after exposure to histone deacetylase inhibitors due to glycogen synthase kinase-3-dependent expression of MHC class I-related chain A and B
-
DOI 10.1158/0008-5472.CAN-05-0599
-
Skov, S. et al. Cancer cells become susceptible to natural killer cell killing after exposure to histone deacetylase inhibitors due to glycogen synthase kinase-3-dependent expression of MHC class I-related chain A and B. Cancer Res. 65, 11136-11145 (2005). (Pubitemid 41713385)
-
(2005)
Cancer Research
, vol.65
, Issue.23
, pp. 11136-11145
-
-
Skov, S.1
Pedersen, M.T.2
Andresen, L.3
Straten, P.T.4
Woetmann, A.5
Odum, N.6
-
80
-
-
33947259319
-
Immunosuppressive strategies that are mediated by tumor cells
-
DOI 10.1146/annurev.immunol.25.022106.141609
-
Rabinovich, G. A., Gabrilovich, D. & Sotomayor, E. M. Immunosuppressive strategies that are mediated by tumor cells. Annu. Rev. Immunol. 25, 267-296 (2007). (Pubitemid 46697910)
-
(2007)
Annual Review of Immunology
, vol.25
, pp. 267-296
-
-
Rabinovich, G.A.1
Gabrilovich, D.2
Sotomayor, E.M.3
-
81
-
-
30744449235
-
Angiogenesis as a therapeutic target
-
DOI 10.1038/nature04483, PII NATURE04483
-
Ferrara, N. & Kerbel, R. S. Angiogenesis as a therapeutic target. Nature 438, 967-974 (2005). (Pubitemid 43093963)
-
(2005)
Nature
, vol.438
, Issue.7070
, pp. 967-974
-
-
Ferrara, N.1
Kerbel, R.S.2
-
82
-
-
63949087054
-
Influence of bevacizumab, sunitinib and sorafenib as single agents or in combination on the inhibitory effects of VEGF on human dendritic cell differentiation from monocytes
-
Alfaro, C. et al. Influence of bevacizumab, sunitinib and sorafenib as single agents or in combination on the inhibitory effects of VEGF on human dendritic cell differentiation from monocytes. Br. J. Cancer 100, 1111-1119 (2009).
-
(2009)
Br. J. Cancer
, vol.100
, pp. 1111-1119
-
-
Alfaro, C.1
-
83
-
-
61649125595
-
The dysfunction and abnormal signaling pathway of dendritic cells loaded by tumor antigen can be overcome by neutralizing VEGF in multiple myeloma
-
Yang, D. H. et al. The dysfunction and abnormal signaling pathway of dendritic cells loaded by tumor antigen can be overcome by neutralizing VEGF in multiple myeloma. Leuk. Res. 33, 665-670 (2009).
-
(2009)
Leuk. Res.
, vol.33
, pp. 665-670
-
-
Yang, D.H.1
-
84
-
-
77955406159
-
Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer
-
Shrimali, R. K. et al. Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer. Cancer Res. 70, 6171-6180 (2010).
-
(2010)
Cancer Res.
, vol.70
, pp. 6171-6180
-
-
Shrimali, R.K.1
-
85
-
-
65549141834
-
The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies
-
Ozao-Choy, J. et al. The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies. Cancer Res. 69, 2514-2522 (2009).
-
(2009)
Cancer Res.
, vol.69
, pp. 2514-2522
-
-
Ozao-Choy, J.1
-
86
-
-
84858774525
-
-
This paper demonstrates how a targeted therapy, sunitinib, is able to decrease both the number and function of suppressive cells (TReg cells and MDSCs) in tumour-infiltrating lymphocytes in an in vivo mouse model of colon cancer, and that combining sunitinib with agonistic 4-1BB antibodies and IL-12 improved responses to therapy
-
This paper demonstrates how a targeted therapy, sunitinib, is able to decrease both the number and function of suppressive cells (TReg cells and MDSCs) in tumour-infiltrating lymphocytes in an in vivo mouse model of colon cancer, and that combining sunitinib with agonistic 4-1BB antibodies and IL-12 improved responses to therapy.
-
-
-
-
87
-
-
80054098093
-
Sunitinib facilitates the activation and recruitment of therapeutic anti-tumor immunity in concert with specific vaccination
-
Bose, A. et al. Sunitinib facilitates the activation and recruitment of therapeutic anti-tumor immunity in concert with specific vaccination. Int. J. Cancer 129, 2158-2170 (2011).
-
(2011)
Int. J. Cancer
, vol.129
, pp. 2158-2170
-
-
Bose, A.1
-
88
-
-
47049127786
-
Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses
-
Hipp, M. M. et al. Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses. Blood 111, 5610-5620 (2008).
-
(2008)
Blood
, vol.111
, pp. 5610-5620
-
-
Hipp, M.M.1
-
89
-
-
78649916060
-
Targeting STAT3 in adoptively transferred T cells promotes their in vivo expansion and antitumor effects
-
Kujawski, M. et al. Targeting STAT3 in adoptively transferred T cells promotes their in vivo expansion and antitumor effects. Cancer Res. 70, 9599-9610 (2010).
-
(2010)
Cancer Res.
, vol.70
, pp. 9599-9610
-
-
Kujawski, M.1
-
90
-
-
84155185190
-
Regression of established hepatocellular carcinoma is induced by chemo-immunotherapy in an orthotopic murine model
-
Avella, D. M. et al. Regression of established hepatocellular carcinoma is induced by chemo-immunotherapy in an orthotopic murine model. Hepatology 55, 141-152 (2011).
-
(2011)
Hepatology
, vol.55
, pp. 141-152
-
-
Avella, D.M.1
-
91
-
-
78049370405
-
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma
-
Green, M. R. et al. Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Blood 116, 3268-3277 (2010).
-
(2010)
Blood
, vol.116
, pp. 3268-3277
-
-
Green, M.R.1
-
92
-
-
0034176031
-
Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation
-
Hwu, P. et al. Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation. J. Immunol. 164, 3596-3599 (2000). (Pubitemid 30169812)
-
(2000)
Journal of Immunology
, vol.164
, Issue.7
, pp. 3596-3599
-
-
Hwu, P.1
Du, M.X.2
Lapointe, R.3
Do, M.4
Taylor, M.W.5
Young, H.A.6
-
93
-
-
80052493233
-
Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido
-
Balachandran, V. P. et al. Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido. Nature Med. 17, 1094-1100 (2011).
-
(2011)
Nature Med.
, vol.17
, pp. 1094-1100
-
-
Balachandran, V.P.1
-
94
-
-
84858766728
-
-
This paper shows how imatinib blocks the supressor function of MDSCs through the inhibition of IDO, and that combining imatinib with CTLA4 antibodies improves clinical responses
-
This paper shows how imatinib blocks the supressor function of MDSCs through the inhibition of IDO, and that combining imatinib with CTLA4 antibodies improves clinical responses.
-
-
-
-
95
-
-
58149187113
-
Imatinib mesylate inhibits CD4+ CD25+ regulatory T cell activity and enhances active immunotherapy against BCR-ABL-tumors
-
Larmonier, N. et al. Imatinib mesylate inhibits CD4+ CD25+ regulatory T cell activity and enhances active immunotherapy against BCR-ABL-tumors. J. Immunol. 181, 6955-6963 (2008).
-
(2008)
J. Immunol.
, vol.181
, pp. 6955-6963
-
-
Larmonier, N.1
-
96
-
-
77950346282
-
Immunity inflammation, and cancer
-
Grivennikov, S. I., Greten, F. R. & Karin, M. Immunity, inflammation, and cancer. Cell 140, 883-899 (2010).
-
(2010)
Cell
, vol.140
, pp. 883-899
-
-
Grivennikov, S.I.1
Greten, F.R.2
Karin, M.3
-
97
-
-
79958696667
-
Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression
-
Schmid, M. C. et al. Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression. Cancer Cell 19, 715-727 (2011).
-
(2011)
Cancer Cell
, vol.19
, pp. 715-727
-
-
Schmid, M.C.1
-
98
-
-
84858774524
-
-
This paper demonstrates how pharmacological and genetic inhibition of the PI3K pathway impedes immune-mediated tumour-promoting inflammation, which slowed tumour growth
-
This paper demonstrates how pharmacological and genetic inhibition of the PI3K pathway impedes immune-mediated tumour-promoting inflammation, which slowed tumour growth.
-
-
-
-
99
-
-
33745859743
-
The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells
-
DOI 10.1084/jem.20051848
-
Sumimoto, H., Imabayashi, F., Iwata, T. & Kawakami, Y. The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells. J. Exp. Med. 203, 1651-1656 (2006). (Pubitemid 44036269)
-
(2006)
Journal of Experimental Medicine
, vol.203
, Issue.7
, pp. 1651-1656
-
-
Sumimoto, H.1
Imabayashi, F.2
Iwata, T.3
Kawakami, Y.4
-
100
-
-
45749134564
-
The anticancer immune response: Indispensable for therapeutic success?
-
DOI 10.1172/JCI35180
-
Zitvogel, L. et al. The anticancer immune response: indispensable for therapeutic success? J. Clin. Invest. 118, 1991-2001 (2008). (Pubitemid 351872317)
-
(2008)
Journal of Clinical Investigation
, vol.118
, Issue.6
, pp. 1991-2001
-
-
Zitvogel, L.1
Apetoh, L.2
Ghiringhelli, F.3
Andre, F.4
Tesniere, A.5
Kroemer, G.6
-
101
-
-
79952390627
-
Immune parameters affecting the efficacy of chemotherapeutic regimens
-
Zitvogel, L., Kepp, O. & Kroemer, G. Immune parameters affecting the efficacy of chemotherapeutic regimens. Nature Rev. Clin. Oncol. 8, 151-160 (2011).
-
(2011)
Nature Rev. Clin. Oncol.
, vol.8
, pp. 151-160
-
-
Zitvogel, L.1
Kepp, O.2
Kroemer, G.3
-
102
-
-
25144466458
-
+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity
-
DOI 10.1158/1078-0432.CCR-05-0883
-
Suzuki, E., Kapoor, V., Jassar, A. S., Kaiser, L. R. & Albelda, S. M. Gemcitabine selectively eliminates splenic Gr-1 +CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity. Clin. Cancer Res. 11, 6713-6721 (2005). (Pubitemid 41339014)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.18
, pp. 6713-6721
-
-
Suzuki, E.1
Kapoor, V.2
Jassar, A.S.3
Kaiser, L.R.4
Albelda, S.M.5
-
103
-
-
77951086882
-
5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity
-
Vincent, J. et al. 5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity. Cancer Res. 70, 3052-3061 (2010).
-
(2010)
Cancer Res.
, vol.70
, pp. 3052-3061
-
-
Vincent, J.1
-
104
-
-
70349976708
-
Combining radiation, immunotherapy, and antiangiogenesis agents in the management of cancer: The Three Musketeers or just another quixotic combination?
-
Kamrava, M., Bernstein, M. B., Camphausen, K. & Hodge, J. W. Combining radiation, immunotherapy, and antiangiogenesis agents in the management of cancer: the Three Musketeers or just another quixotic combination? Mol. Biosyst. 5, 1262-1270 (2009).
-
(2009)
Mol. Biosyst.
, vol.5
, pp. 1262-1270
-
-
Kamrava, M.1
Bernstein, M.B.2
Camphausen, K.3
Hodge, J.W.4
-
105
-
-
34250204076
-
Phenotypic and functional effects of heat shock protein 90 inhibition on dendritic cell
-
Bae, J. et al. Phenotypic and functional effects of heat shock protein 90 inhibition on dendritic cell. J. Immunol. 178, 7730-7737 (2007). (Pubitemid 46898044)
-
(2007)
Journal of Immunology
, vol.178
, Issue.12
, pp. 7730-7737
-
-
Bae, J.1
Mitsiades, C.2
Tai, Y.-T.3
Bertheau, R.4
Shammas, M.5
Batchu, R.B.6
Li, C.7
Catley, L.8
Prabhala, R.9
Anderson, K.C.10
Munshi, N.C.11
-
106
-
-
79251588744
-
EC144, a synthetic inhibitor of heat shock protein 90, blocks innate and adaptive immune responses in models of inflammation and autoimmunity
-
Yun, T. J. et al. EC144, a synthetic inhibitor of heat shock protein 90, blocks innate and adaptive immune responses in models of inflammation and autoimmunity. J. Immunol. 186, 563-575 (2011).
-
(2011)
J. Immunol.
, vol.186
, pp. 563-575
-
-
Yun, T.J.1
-
107
-
-
77955415749
-
The proteasome inhibitor bortezomib disrupts tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression and natural killer (NK) cell killing of TRAIL receptor-positive multiple myeloma cells
-
Feng, X. et al. The proteasome inhibitor bortezomib disrupts tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression and natural killer (NK) cell killing of TRAIL receptor-positive multiple myeloma cells. Mol. Immunol. 47, 2388-2396 (2010).
-
(2010)
Mol. Immunol.
, vol.47
, pp. 2388-2396
-
-
Feng, X.1
-
108
-
-
66349096076
-
Proteasome inhibition induces apoptosis in primary human natural killer cells and suppresses NKp46-mediated cytotoxicity
-
Wang, X. et al. Proteasome inhibition induces apoptosis in primary human natural killer cells and suppresses NKp46-mediated cytotoxicity. Haematologica 94, 470-478 (2009).
-
(2009)
Haematologica
, vol.94
, pp. 470-478
-
-
Wang, X.1
-
109
-
-
84856490854
-
Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression
-
Rossi, L. E. et al. Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression. J. Leukoc. Biol. 91, 321-331 (2011).
-
(2011)
J. Leukoc. Biol.
, vol.91
, pp. 321-331
-
-
Rossi, L.E.1
-
110
-
-
84655164923
-
Experimental mouse tumour models: What can be learnt about human cancer immunology?
-
Dranoff, G. Experimental mouse tumour models: what can be learnt about human cancer immunology? Nature Rev. Immunol. 12, 61-66 (2011).
-
(2011)
Nature Rev. Immunol.
, vol.12
, pp. 61-66
-
-
Dranoff, G.1
-
111
-
-
33746924449
-
Combination therapy with anti-CTL antigen-4 and anti-4-1BB antibodies enhances cancer immunity and reduces autoimmunity
-
DOI 10.1158/0008-5472.CAN-05-2128
-
Kocak, E. et al. Combination therapy with anti-CTL antigen-4 and anti-4-1BB antibodies enhances cancer immunity and reduces autoimmunity. Cancer Res. 66, 7276-7284 (2006). (Pubitemid 44197709)
-
(2006)
Cancer Research
, vol.66
, Issue.14
, pp. 7276-7284
-
-
Kocak, E.1
Lute, K.2
Chang, X.3
May Jr., K.F.4
Exten, K.R.5
Zhang, H.6
Abdessalam, S.F.7
Lehman, A.M.8
Jarjoura, D.9
Zheng, P.10
Liu, Y.11
-
112
-
-
77749279776
-
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
-
Curran, M. A., Montalvo, W., Yagita, H. & Allison, J. P. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc. Natl Acad. Sci. USA 107, 4275-4280 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 4275-4280
-
-
Curran, M.A.1
Montalvo, W.2
Yagita, H.3
Allison, J.P.4
-
113
-
-
79959312575
-
Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival
-
Topp, M. S. et al. Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival. J. Clin. Oncol. 29, 2493-2498 (2011).
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 2493-2498
-
-
Topp, M.S.1
-
114
-
-
79952092706
-
Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy
-
Burris, H. A. et al. Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy. J. Clin. Oncol. 29, 398-405 (2011).
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 398-405
-
-
Burris, H.A.1
-
115
-
-
85101896436
-
Immune surveillance and therapy of lymphomas driven by ebstein-barr-virus Protein LMP1 in a mouse model
-
in the press
-
Zhang, B. et al. Immune surveillance and therapy of lymphomas driven by ebstein-barr-virus Protein LMP1 in a mouse model. Cell (in the press).
-
Cell
-
-
Zhang, B.1
-
116
-
-
80052227854
-
Localization and density of immune cells in the invasive margin of human colorectal cancer liver metastases are prognostic for response to chemotherapy
-
Halama, N. et al. Localization and density of immune cells in the invasive margin of human colorectal cancer liver metastases are prognostic for response to chemotherapy. Cancer Res. 71, 5670-5677 (2011).
-
(2011)
Cancer Res.
, vol.71
, pp. 5670-5677
-
-
Halama, N.1
-
117
-
-
73949092850
-
Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer
-
Denkert, C. et al. Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer. J. Clin. Oncol. 28, 105-113 (2010).
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 105-113
-
-
Denkert, C.1
-
118
-
-
1642378018
-
+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative
-
DOI 10.1002/eji.200324181
-
Ghiringhelli, F. et al. CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative. Eur. J. Immunol. 34, 336-344 (2004). (Pubitemid 39255944)
-
(2004)
European Journal of Immunology
, vol.34
, Issue.2
, pp. 336-344
-
-
Ghiringhelli, F.1
Larmonier, N.2
Schmitt, E.3
Parcellier, A.4
Cathelin, D.5
Garrido, C.6
Chauffert, B.7
Solary, E.8
Bonnotte, B.9
Martin, F.10
-
119
-
-
1542720380
-
Surgical Removal of Primary Tumor Reverses Tumor-Induced Immunosuppression Despite the Presence of Metastatic Disease
-
DOI 10.1158/0008-5472.CAN-03-2646
-
Danna, E. A. et al. Surgical removal of primary tumor reverses tumor-induced immunosuppression despite the presence of metastatic disease. Cancer Res. 64, 2205-2211 (2004). (Pubitemid 38339474)
-
(2004)
Cancer Research
, vol.64
, Issue.6
, pp. 2205-2211
-
-
Danna, E.A.1
Sinha, P.2
Gilbert, M.3
Clements, V.K.4
Pulaski, B.A.5
Ostrand-Rosenberg, S.6
-
120
-
-
84857910542
-
Clinical and immunologic evaluation of dendritic cell-based immunotherapy in combination with gemcitabine and/or S-1 in patients with advanced pancreatic carcinoma
-
Kimura, Y. et al. Clinical and immunologic evaluation of dendritic cell-based immunotherapy in combination with gemcitabine and/or S-1 in patients with advanced pancreatic carcinoma. Pancreas (2011).
-
(2011)
Pancreas
-
-
Kimura, Y.1
-
121
-
-
81255127285
-
Therapeutic vaccination with TG4010 and first-line chemotherapy in advanced non-small-cell lung cancer: A controlled phase 2B trial
-
Quoix, E. et al. Therapeutic vaccination with TG4010 and first-line chemotherapy in advanced non-small-cell lung cancer: a controlled phase 2B trial. Lancet Oncol. 12, 1125-1133 (2011).
-
(2011)
Lancet Oncol.
, vol.12
, pp. 1125-1133
-
-
Quoix, E.1
-
122
-
-
79955140403
-
Imatinib treatment induces CD5+ B lymphocytes and IgM natural antibodies with anti-leukemic reactivity in patients with chronic myelogenous leukemia
-
Catellani, S., Pierri, I., Gobbi, M., Poggi, A. & Zocchi, M. R. Imatinib treatment induces CD5+ B lymphocytes and IgM natural antibodies with anti-leukemic reactivity in patients with chronic myelogenous leukemia. PLoS ONE 6, e18925 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Catellani, S.1
Pierri, I.2
Gobbi, M.3
Poggi, A.4
Zocchi, M.R.5
-
123
-
-
78650625238
-
Imatinib plus peginterferon alfa-2a in chronic myeloid leukemia
-
Preudhomme, C. et al. Imatinib plus peginterferon alfa-2a in chronic myeloid leukemia. N. Engl. J. Med. 363, 2511-2521 (2010).
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 2511-2521
-
-
Preudhomme, C.1
-
124
-
-
69249097885
-
Synthetic tumor-specific breakpoint peptide vaccine in patients with chronic myeloid leukemia and minimal residual disease: A phase 2 trial
-
Jain, N. et al. Synthetic tumor-specific breakpoint peptide vaccine in patients with chronic myeloid leukemia and minimal residual disease: a phase 2 trial. Cancer 115, 3924-3934 (2009).
-
(2009)
Cancer
, vol.115
, pp. 3924-3934
-
-
Jain, N.1
-
125
-
-
65949085379
-
Natural killer cell IFN-γ levels predict long-term survival with imatinib mesylate therapy in gastrointestinal stromal tumor-bearing patients
-
Menard, C. et al. Natural killer cell IFN-γ levels predict long-term survival with imatinib mesylate therapy in gastrointestinal stromal tumor-bearing patients. Cancer Res. 69, 3563-3569 (2009).
-
(2009)
Cancer Res.
, vol.69
, pp. 3563-3569
-
-
Menard, C.1
-
126
-
-
84858766731
-
-
This paper demonstrates that the presence of NK cells in patients with gastrointestinal stromal tumour treated with imatinib serves as an independent prognostic factor of clinical response, suggesting that off-target effects of imatinib that stimulate NK cells may partially account for its therapeutic success
-
This paper demonstrates that the presence of NK cells in patients with gastrointestinal stromal tumour treated with imatinib serves as an independent prognostic factor of clinical response, suggesting that off-target effects of imatinib that stimulate NK cells may partially account for its therapeutic success.
-
-
-
-
127
-
-
37349080670
-
Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial
-
DOI 10.1016/S0140-6736(07)61904-7, PII S0140673607619047
-
Escudier, B. et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet 370, 2103-2111 (2007). (Pubitemid 350296300)
-
(2007)
Lancet
, vol.370
, Issue.9605
, pp. 2103-2111
-
-
Escudier, B.1
Pluzanska, A.2
Koralewski, P.3
Ravaud, A.4
Bracarda, S.5
Szczylik, C.6
Chevreau, C.7
Filipek, M.8
Melichar, B.9
Bajetta, E.10
Gorbunova, V.11
Bay, J.-O.12
Bodrogi, I.13
Jagiello-Gruszfeld, A.14
Moore, N.15
-
128
-
-
79952055852
-
Immunological effects of bevacizumab-based treatment in metastatic colorectal cancer
-
Manzoni, M. et al. Immunological effects of bevacizumab-based treatment in metastatic colorectal cancer. Oncology 79, 187-196 (2010).
-
(2010)
Oncology
, vol.79
, pp. 187-196
-
-
Manzoni, M.1
-
129
-
-
79961166712
-
Natural killer (NK): Dendritic cell (DC) cross talk induced by therapeutic monoclonal antibody triggers tumor antigen-specific T cell immunity
-
Lee, S. C., Srivastava, R. M., Lopez-Albaitero, A., Ferrone, S. & Ferris, R. L. Natural killer (NK): dendritic cell (DC) cross talk induced by therapeutic monoclonal antibody triggers tumor antigen-specific T cell immunity. Immunol. Res. 50, 248-254 (2011).
-
(2011)
Immunol. Res.
, vol.50
, pp. 248-254
-
-
Lee, S.C.1
Srivastava, R.M.2
Lopez-Albaitero, A.3
Ferrone, S.4
Ferris, R.L.5
-
130
-
-
80052490775
-
Activation of tumor-promoting type 2 macrophages by EGFR-targeting antibody cetuximab
-
Pander, J. et al. Activation of tumor-promoting type 2 macrophages by EGFR-targeting antibody cetuximab. Clin. Cancer Res. 17, 5668-5673 (2011).
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 5668-5673
-
-
Pander, J.1
-
131
-
-
69949180337
-
Enhancement of TRAIL cytotoxicity by AG-490 in human ALL cells is characterized by downregulation of cIAP-1 and cIAP-2 through inhibition of Jak2/Stat3
-
Lanuti, P. et al. Enhancement of TRAIL cytotoxicity by AG-490 in human ALL cells is characterized by downregulation of cIAP-1 and cIAP-2 through inhibition of Jak2/Stat3. Cell Res. 19, 1079-1089 (2009).
-
(2009)
Cell Res.
, vol.19
, pp. 1079-1089
-
-
Lanuti, P.1
-
132
-
-
77957701558
-
The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: A therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody
-
Benson, D. M. Jr, et al. The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody. Blood 116, 2286-2294 (2010).
-
(2010)
Blood
, vol.116
, pp. 2286-2294
-
-
Benson Jr. D., M.1
-
133
-
-
80055021878
-
Biological effects and clinical significance of lenalidomide-induced tumour flare reaction in patients with chronic lymphocytic leukaemia: In vivo evidence of immune activation and antitumour response
-
Chanan-Khan, A. A. et al. Biological effects and clinical significance of lenalidomide-induced tumour flare reaction in patients with chronic lymphocytic leukaemia: in vivo evidence of immune activation and antitumour response. Br. J. Haematol. 155, 457-467 (2011).
-
(2011)
Br. J. Haematol.
, vol.155
, pp. 457-467
-
-
Chanan-Khan, A.A.1
-
134
-
-
78049386125
-
Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma
-
Gorgun, G. et al. Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma. Blood 116, 3227-3237 (2010).
-
(2010)
Blood
, vol.116
, pp. 3227-3237
-
-
Gorgun, G.1
-
135
-
-
79955977369
-
The role of phosphatidylinositol 3-kinase-δ in the immunomodulatory effects of lenalidomide in chronic lymphocytic leukemia
-
Herman, S. E. et al. The role of phosphatidylinositol 3-kinase-δ in the immunomodulatory effects of lenalidomide in chronic lymphocytic leukemia. Blood 117, 4323-4327 (2011).
-
(2011)
Blood
, vol.117
, pp. 4323-4327
-
-
Herman, S.E.1
-
136
-
-
83455220035
-
IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect
-
Benson, D. M. Jr, et al. IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect. Blood 118, 6387-6391 (2011).
-
(2011)
Blood
, vol.118
, pp. 6387-6391
-
-
Benson Jr. D., M.1
-
137
-
-
58149198796
-
IFN-β production by TLR4-stimulated innate immune cells is negatively regulated by GSK3-β
-
Wang, H. et al. IFN-β production by TLR4-stimulated innate immune cells is negatively regulated by GSK3-β. J. Immunol. 181, 6797-6802 (2008).
-
(2008)
J. Immunol.
, vol.181
, pp. 6797-6802
-
-
Wang, H.1
-
138
-
-
84858766182
-
Blockade of immune checkpoints in cancer immunotherapy
-
Pardoll, D. M. Blockade of immune checkpoints in cancer immunotherapy. Nature Rev. Cancer 12, 252-264 (2012).
-
(2012)
Nature Rev. Cancer
, vol.12
, pp. 252-264
-
-
Pardoll, D.M.1
|