메뉴 건너뛰기




Volumn 484, Issue 2-3, 2004, Pages 249-257

In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake

Author keywords

Anandamide; Cannabinoid; Cannabinoid receptor; Multiple sclerosis; Transporter; Uptake

Indexed keywords

AMINE; ANANDAMIDE; ANANDAMIDE REUPTAKE INHIBITOR; BLOCKING AGENT; ETHANOLAMINE DERIVATIVE; N ARACHIDONOYL(2 METHYL 4 HYDROXYPHENYL)AMINE; N OLEOYL(1' HYDROXYBENZYL) 2' ETHANOLAMINE; UNCLASSIFIED DRUG;

EID: 1642505613     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2003.11.027     Document Type: Article
Times cited : (94)

References (51)
  • 1
    • 0037314324 scopus 로고    scopus 로고
    • Activation of capsaicin-sensitive primary sensory neurones induces anandamide production and release
    • Ahluwalia J., Yaqoob M., Urban L., Bevan S., Nagy I. Activation of capsaicin-sensitive primary sensory neurones induces anandamide production and release. J. Neurochem. 84:2003;585-591.
    • (2003) J. Neurochem. , vol.84 , pp. 585-591
    • Ahluwalia, J.1    Yaqoob, M.2    Urban, L.3    Bevan, S.4    Nagy, I.5
  • 5
    • 12244313878 scopus 로고    scopus 로고
    • Chronic ethanol inhibits the anandamide transport and increases extracellular anandamide levels in cerebellar granule neurons
    • Basavarajappa B.S., Saito M., Cooper T.B., Hungund B.L. Chronic ethanol inhibits the anandamide transport and increases extracellular anandamide levels in cerebellar granule neurons. Eur. J. Pharmacol. 466:2003;73-83.
    • (2003) Eur. J. Pharmacol. , vol.466 , pp. 73-83
    • Basavarajappa, B.S.1    Saito, M.2    Cooper, T.B.3    Hungund, B.L.4
  • 6
    • 0034720298 scopus 로고    scopus 로고
    • Carrier-mediated transport and enzymatic hydrolysis of the endogenous cannabinoid 2-arachidonylglycerol
    • Beltramo M., Piomelli D. Carrier-mediated transport and enzymatic hydrolysis of the endogenous cannabinoid 2-arachidonylglycerol. Neuroreport. 11:2000;1231-1235.
    • (2000) Neuroreport , vol.11 , pp. 1231-1235
    • Beltramo, M.1    Piomelli, D.2
  • 7
    • 0030865871 scopus 로고    scopus 로고
    • Functional role of high-affinity anandamide transport, as revealed by selective inhibition
    • Beltramo M., Stella N., Calignano A., Lin S.Y., Makriyannis A., Piomelli D. Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science. 277:1997;1094-1097.
    • (1997) Science , vol.277 , pp. 1094-1097
    • Beltramo, M.1    Stella, N.2    Calignano, A.3    Lin, S.Y.4    Makriyannis, A.5    Piomelli, D.6
  • 8
    • 0034332637 scopus 로고    scopus 로고
    • N-acyl-dopamines: Novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo
    • Bisogno T., Melck D., Bobrov Myu. , Gretskaya N.M., Bezuglov V.V., De Petrocellis L., Di Marzo V. N-acyl-dopamines: novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo. Biochem. J. 351:2000;3817-3824.
    • (2000) Biochem. J. , vol.351 , pp. 3817-3824
    • Bisogno, T.1    Melck, D.2    Bobrov, M.Y.U.3    Gretskaya, N.M.4    Bezuglov, V.V.5    De Petrocellis, L.6    Di Marzo, V.7
  • 10
    • 0037192605 scopus 로고    scopus 로고
    • Arvanil-induced inhibition of spasticity and persistent pain: Evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB(1)/CB(2) receptors
    • Brooks J.W., Pryce G., Bisogno T., Jaggar S.I., Hankey D.J., Brown P., Bridges D., Ledent C., Bifulco M., Rice A.S., Di Marzo V., Baker D. Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB(1)/CB(2) receptors. Eur. J. Pharmacol. 439:2002;83-92.
    • (2002) Eur. J. Pharmacol. , vol.439 , pp. 83-92
    • Brooks, J.W.1    Pryce, G.2    Bisogno, T.3    Jaggar, S.I.4    Hankey, D.J.5    Brown, P.6    Bridges, D.7    Ledent, C.8    Bifulco, M.9    Rice, A.S.10    Di Marzo, V.11    Baker, D.12
  • 11
    • 0037126618 scopus 로고    scopus 로고
    • Direct inhibition of T-type calcium channels by the endogenous cannabinoid anandamide
    • Chemin J., Monteil A., Perez-Reyes E., Nargeot J., Lory P. Direct inhibition of T-type calcium channels by the endogenous cannabinoid anandamide. EMBO J. 20:2001;7033-7040.
    • (2001) EMBO J. , vol.20 , pp. 7033-7040
    • Chemin, J.1    Monteil, A.2    Perez-Reyes, E.3    Nargeot, J.4    Lory, P.5
  • 13
    • 0037008258 scopus 로고    scopus 로고
    • UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of anandamide
    • De Lago E., Fernandez-Ruiz J., Ortega-Gutierrez S., Viso A., Lopez-Rodriguez M.L., Ramos J.A. UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of anandamide. Eur. J. Pharmacol. 449:2002;99-103.
    • (2002) Eur. J. Pharmacol. , vol.449 , pp. 99-103
    • De Lago, E.1    Fernandez-Ruiz, J.2    Ortega-Gutierrez, S.3    Viso, A.4    Lopez-Rodriguez, M.L.5    Ramos, J.A.6
  • 14
    • 0034644842 scopus 로고    scopus 로고
    • Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: Inhibitors of anandamide uptake with negligible capsaicin-like activity
    • De Petrocellis L., Bisogno T., Davis J.B., Pertwee R.G., Di Marzo V. Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity. FEBS Lett. 483:2000;52-56.
    • (2000) FEBS Lett. , vol.483 , pp. 52-56
    • De Petrocellis, L.1    Bisogno, T.2    Davis, J.B.3    Pertwee, R.G.4    Di Marzo, V.5
  • 15
    • 0035918311 scopus 로고    scopus 로고
    • The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism
    • De Petrocellis L., Bisogno T., Maccarrone M., Davis J.B., Finazzi-Agro A., Di Marzo V. The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism. J. Biol. Chem. 276:2001;12856-12863.
    • (2001) J. Biol. Chem. , vol.276 , pp. 12856-12863
    • De Petrocellis, L.1    Bisogno, T.2    MacCarrone, M.3    Davis, J.B.4    Finazzi-Agro, A.5    Di Marzo, V.6
  • 18
    • 0029031421 scopus 로고
    • Anandamide, an endogenous cannabinomimetic eicosanoid: Killing two birds with one stone
    • Di Marzo V., Fontana A. Anandamide, an endogenous cannabinomimetic eicosanoid: killing two birds with one stone. Prostaglandins Leukot. Essent. Fat. Acids. 53:1995;1-11.
    • (1995) Prostaglandins Leukot. Essent. Fat. Acids , vol.53 , pp. 1-11
    • Di Marzo, V.1    Fontana, A.2
  • 20
    • 0032401036 scopus 로고    scopus 로고
    • Endocannabinoids: Endogenous cannabinoid receptor ligands with neuromodulatory action
    • Di Marzo V., Melck D., Bisogno T., De Petrocellis L. Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action. Trends Neurosci. 21:1998;521-528.
    • (1998) Trends Neurosci. , vol.21 , pp. 521-528
    • Di Marzo, V.1    Melck, D.2    Bisogno, T.3    De Petrocellis, L.4
  • 21
    • 0033567190 scopus 로고    scopus 로고
    • Biosynthesis and inactivation of the endocannabinoid 2- arachidonoylglycerol in circulating and tumoral macrophages
    • Di Marzo V., Bisogno T., De Petrocellis L., Melck D., Orlando P., Wagner J.A., Kunos G. Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages. Eur. J. Biochem. 264:1999;258-267.
    • (1999) Eur. J. Biochem. , vol.264 , pp. 258-267
    • Di Marzo, V.1    Bisogno, T.2    De Petrocellis, L.3    Melck, D.4    Orlando, P.5    Wagner, J.A.6    Kunos, G.7
  • 25
    • 0037181180 scopus 로고    scopus 로고
    • Noladin ether, a putative novel endocannabinoid: Inactivation mechanisms and a sensitive method for its quantification in rat tissues
    • Fezza F., Bisogno T., Minassi A., Appendino G., Mechoulam R., Di Marzo V. Noladin ether, a putative novel endocannabinoid: inactivation mechanisms and a sensitive method for its quantification in rat tissues. FEBS Lett. 513:2002;294-298.
    • (2002) FEBS Lett. , vol.513 , pp. 294-298
    • Fezza, F.1    Bisogno, T.2    Minassi, A.3    Appendino, G.4    Mechoulam, R.5    Di Marzo, V.6
  • 26
    • 0035659279 scopus 로고    scopus 로고
    • Nefopam reduces thermal hypersensitivity in acute and postoperative pain models in the rat
    • Girard P., Pansart Y., Coppe M.-C., Gillardin J.-M. Nefopam reduces thermal hypersensitivity in acute and postoperative pain models in the rat. Pharmacol. Res. 44:2001;541-545.
    • (2001) Pharmacol. Res. , vol.44 , pp. 541-545
    • Girard, P.1    Pansart, Y.2    Coppe, M.-C.3    Gillardin, J.-M.4
  • 31
    • 0033666960 scopus 로고    scopus 로고
    • The movement of N-arachidonoylethanolamine (anandamide) across cellular membranes
    • Hillard C.J., Jarrahian A. The movement of N-arachidonoylethanolamine (anandamide) across cellular membranes. Chem. Phys. Lipids. 108:2000;123-134.
    • (2000) Chem. Phys. Lipids , vol.108 , pp. 123-134
    • Hillard, C.J.1    Jarrahian, A.2
  • 32
    • 0030852614 scopus 로고    scopus 로고
    • Accumulation of N-arachidonoylethanolamine (anandamide) into cerebellar granule cells occurs via facilitated diffusion
    • Hillard C.J., Edgemond W.S., Jarrahian A., Campbell W.B. Accumulation of N-arachidonoylethanolamine (anandamide) into cerebellar granule cells occurs via facilitated diffusion. J. Neurochem. 69:1997;631-638.
    • (1997) J. Neurochem. , vol.69 , pp. 631-638
    • Hillard, C.J.1    Edgemond, W.S.2    Jarrahian, A.3    Campbell, W.B.4
  • 35
    • 0034070409 scopus 로고    scopus 로고
    • Structure-activity relationships among N-arachidonylethanolamine (Anandamide) head group analogues for the anandamide transporter
    • Jarrahian A., Manna S., Edgemond W.S., Campbell W.B., Hillard C.J. Structure-activity relationships among N-arachidonylethanolamine (Anandamide) head group analogues for the anandamide transporter. J. Neurochem. 74:2000;2597-2606.
    • (2000) J. Neurochem. , vol.74 , pp. 2597-2606
    • Jarrahian, A.1    Manna, S.2    Edgemond, W.S.3    Campbell, W.B.4    Hillard, C.J.5
  • 37
    • 0037341020 scopus 로고    scopus 로고
    • Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease
    • Lastres-Becker I., de Miguel R., De Petrocellis L., Makriyannis A., Di Marzo V., Fernandez-Ruiz J. Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease. J. Neurochem. 84:2003;1097-1109.
    • (2003) J. Neurochem. , vol.84 , pp. 1097-1109
    • Lastres-Becker, I.1    De Miguel, R.2    De Petrocellis, L.3    Makriyannis, A.4    Di Marzo, V.5    Fernandez-Ruiz, J.6
  • 38
    • 0035924218 scopus 로고    scopus 로고
    • Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors
    • Lopez-Rodriguez M.L., Viso A., Ortega-Gutierrez S., Lastres-Becker I., Gonzalez S., Fernandez-Ruiz J., Ramos J.A. Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors. J. Med. Chem. 44:2001;4505-4508.
    • (2001) J. Med. Chem. , vol.44 , pp. 4505-4508
    • Lopez-Rodriguez, M.L.1    Viso, A.2    Ortega-Gutierrez, S.3    Lastres-Becker, I.4    Gonzalez, S.5    Fernandez-Ruiz, J.6    Ramos, J.A.7
  • 39
    • 0242585423 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: Comparison with effects on fatty acid amidohydrolase
    • Lopez-Rodriguez M.L., Viso A., Ortega-Gutierrez S., Fowler C.J., Tiger G., de Lago E., Fernandez-Ruiz J., Ramos J.A. Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase. J. Med. Chem. 46:2003;1512-1522.
    • (2003) J. Med. Chem. , vol.46 , pp. 1512-1522
    • Lopez-Rodriguez, M.L.1    Viso, A.2    Ortega-Gutierrez, S.3    Fowler, C.J.4    Tiger, G.5    De Lago, E.6    Fernandez-Ruiz, J.7    Ramos, J.A.8
  • 42
    • 0035883892 scopus 로고    scopus 로고
    • Lipopolysaccharide downregulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes
    • Maccarrone M., De Petrocellis L., Bari M., Fezza F., Salvati S., Di Marzo V., Finazzi-Agro A. Lipopolysaccharide downregulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes. Arch. Biochem. Biophys. 393:2001;321-328.
    • (2001) Arch. Biochem. Biophys. , vol.393 , pp. 321-328
    • MacCarrone, M.1    De Petrocellis, L.2    Bari, M.3    Fezza, F.4    Salvati, S.5    Di Marzo, V.6    Finazzi-Agro, A.7
  • 47
    • 0030611978 scopus 로고    scopus 로고
    • Pharmacology of cannabinoid CB1 and CB2 receptors
    • Pertwee R.G. Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacol. Ther. 74:1997;129-180.
    • (1997) Pharmacol. Ther. , vol.74 , pp. 129-180
    • Pertwee, R.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.