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Volumn 75, Issue 2, 2013, Pages 323-333

Cannabidiol for neurodegenerative disorders: Important new clinical applications for this phytocannabinoid?

Author keywords

Cannabidiol; Cannabinoid signalling system; Huntington's disease; Neonatal ischaemia; Neuroprotection; Parkinson's disease

Indexed keywords

6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; ADENOSINE; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CALCIUM; CANNABIDIOL; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CYCLOOXYGENASE 2; DRONABINOL; ENDOCANNABINOID; GLUTAMIC ACID; HUNTINGTIN; INDUCIBLE NITRIC OXIDE SYNTHASE; ION CHANNEL; METABOTROPIC RECEPTOR; NABIXIMOLS; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SEROTONIN; SEROTONIN 1A RECEPTOR;

EID: 84872256489     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2012.04341.x     Document Type: Article
Times cited : (266)

References (109)
  • 1
    • 0842347092 scopus 로고
    • A comparative study on some chemical and biological characteristics of various samples of cannabis resin
    • Grlic L. A comparative study on some chemical and biological characteristics of various samples of cannabis resin. Bull Narc 1976; 14: 37-46.
    • (1976) Bull Narc , vol.14 , pp. 37-46
    • Grlic, L.1
  • 2
    • 0036838389 scopus 로고    scopus 로고
    • Cannabidiol: an overview of some pharmacological aspects
    • Mechoulam R, Parker LA, Gallily R. Cannabidiol: an overview of some pharmacological aspects. J Clin Pharmacol 2002; 42: 11S-9S.
    • (2002) J Clin Pharmacol , vol.42
    • Mechoulam, R.1    Parker, L.A.2    Gallily, R.3
  • 4
    • 28844489930 scopus 로고    scopus 로고
    • A tale of two cannabinoids: the therapeutic rationale for combining tetrahydrocannabinol and cannabidiol
    • Russo E, Guy GW. A tale of two cannabinoids: the therapeutic rationale for combining tetrahydrocannabinol and cannabidiol. Med Hypotheses 2006; 66: 234-46.
    • (2006) Med Hypotheses , vol.66 , pp. 234-246
    • Russo, E.1    Guy, G.W.2
  • 5
    • 1642268380 scopus 로고    scopus 로고
    • Oral anti-inflammatory activity of cannabidiol, a non-psychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw
    • Costa B, Colleoni M, Conti S, Parolaro D, Franke C, Trovato AE, Giagnoni G. Oral anti-inflammatory activity of cannabidiol, a non-psychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw. Naunyn Schmiedebergs Arch Pharmacol 2004; 369: 294-9.
    • (2004) Naunyn Schmiedebergs Arch Pharmacol , vol.369 , pp. 294-299
    • Costa, B.1    Colleoni, M.2    Conti, S.3    Parolaro, D.4    Franke, C.5    Trovato, A.E.6    Giagnoni, G.7
  • 6
    • 79955663620 scopus 로고    scopus 로고
    • THC and CBD oromucosal spray (Sativex®) in the management of spasticity associated with multiple sclerosis
    • Sastre-Garriga J, Vila C, Clissold S, Montalban X. THC and CBD oromucosal spray (Sativex®) in the management of spasticity associated with multiple sclerosis. Expert Rev Neurother 2011; 11: 627-37.
    • (2011) Expert Rev Neurother , vol.11 , pp. 627-637
    • Sastre-Garriga, J.1    Vila, C.2    Clissold, S.3    Montalban, X.4
  • 8
    • 33846529870 scopus 로고    scopus 로고
    • Potential therapeutical effects of cannabidiol in children with pharmacoresistant epilepsy
    • Cortesi M, Fusar-Poli P. Potential therapeutical effects of cannabidiol in children with pharmacoresistant epilepsy. Med Hypotheses 2007; 68: 920-1.
    • (2007) Med Hypotheses , vol.68 , pp. 920-921
    • Cortesi, M.1    Fusar-Poli, P.2
  • 11
    • 79960304851 scopus 로고    scopus 로고
    • Regulation of nausea and vomiting by cannabinoids
    • Parker LA, Rock EM, Limebeer CL. Regulation of nausea and vomiting by cannabinoids. Br J Pharmacol 2011; 163: 1411-22.
    • (2011) Br J Pharmacol , vol.163 , pp. 1411-1422
    • Parker, L.A.1    Rock, E.M.2    Limebeer, C.L.3
  • 13
    • 33748492117 scopus 로고    scopus 로고
    • The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells
    • Massi P, Vaccani A, Bianchessi S, Costa B, Macchi P, Parolaro D. The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells. Cell Mol Life Sci 2006; 63: 2057-66.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 2057-2066
    • Massi, P.1    Vaccani, A.2    Bianchessi, S.3    Costa, B.4    Macchi, P.5    Parolaro, D.6
  • 18
    • 79952486586 scopus 로고    scopus 로고
    • The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1A receptors
    • Gomes FV, Resstel LBM, Guimarães FS. The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1A receptors. Psychopharmacology 2011; 213: 465-73.
    • (2011) Psychopharmacology , vol.213 , pp. 465-473
    • Gomes, F.V.1    Resstel, L.B.M.2    Guimarães, F.S.3
  • 20
    • 72749107868 scopus 로고    scopus 로고
    • The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB2 and adenosine receptors
    • Castillo A, Tolón MR, Fernández-Ruiz J, Romero J, Martinez-Orgado J. The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB2 and adenosine receptors. Neurobiol Dis 2010; 37: 434-40.
    • (2010) Neurobiol Dis , vol.37 , pp. 434-440
    • Castillo, A.1    Tolón, M.R.2    Fernández-Ruiz, J.3    Romero, J.4    Martinez-Orgado, J.5
  • 21
    • 34547984234 scopus 로고    scopus 로고
    • Cannabidiol reduced the striatal atrophy caused 3-nitropropionic acid in vivo by mechanisms independent of the activation of cannabinoid, vanilloid TRPV1 and adenosine A2A receptors
    • Sagredo O, Ramos JA, Decio A, Mechoulam R, Fernández-Ruiz J. Cannabidiol reduced the striatal atrophy caused 3-nitropropionic acid in vivo by mechanisms independent of the activation of cannabinoid, vanilloid TRPV1 and adenosine A2A receptors. Eur J Neurosci 2007; 26: 843-51.
    • (2007) Eur J Neurosci , vol.26 , pp. 843-851
    • Sagredo, O.1    Ramos, J.A.2    Decio, A.3    Mechoulam, R.4    Fernández-Ruiz, J.5
  • 22
    • 79960062773 scopus 로고    scopus 로고
    • Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington's disease
    • Sagredo O, Pazos MR, Satta V, Ramos JA, Pertwee RG, Fernández-Ruiz J. Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington's disease. J Neurosci Res 2011; 89: 1509-18.
    • (2011) J Neurosci Res , vol.89 , pp. 1509-1518
    • Sagredo, O.1    Pazos, M.R.2    Satta, V.3    Ramos, J.A.4    Pertwee, R.G.5    Fernández-Ruiz, J.6
  • 23
    • 84862077856 scopus 로고    scopus 로고
    • Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington's disease: role of CB1 and CB2 receptors
    • Valdeolivas S, Satta V, Pertwee RG, Fernández-Ruiz J, Sagredo O. Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington's disease: role of CB1 and CB2 receptors. ACS Chem Neurosci 2012; 3: 400-6.
    • (2012) ACS Chem Neurosci , vol.3 , pp. 400-406
    • Valdeolivas, S.1    Satta, V.2    Pertwee, R.G.3    Fernández-Ruiz, J.4    Sagredo, O.5
  • 24
    • 17444370570 scopus 로고    scopus 로고
    • Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's disease
    • Lastres-Becker I, Molina-Holgado F, Ramos JA, Mechoulam R, Fernández-Ruiz J. Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's disease. Neurobiol Dis 2005; 19: 96-107.
    • (2005) Neurobiol Dis , vol.19 , pp. 96-107
    • Lastres-Becker, I.1    Molina-Holgado, F.2    Ramos, J.A.3    Mechoulam, R.4    Fernández-Ruiz, J.5
  • 25
    • 79960300079 scopus 로고    scopus 로고
    • Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ9-THCV in animal models of Parkinson's disease
    • García C, Palomo-Garo C, García-Arencibia M, Ramos J, Pertwee RG, Fernández-Ruiz J. Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ9-THCV in animal models of Parkinson's disease. Br J Pharmacol 2011; 163: 1495-506.
    • (2011) Br J Pharmacol , vol.163 , pp. 1495-1506
    • García, C.1    Palomo-Garo, C.2    García-Arencibia, M.3    Ramos, J.4    Pertwee, R.G.5    Fernández-Ruiz, J.6
  • 26
    • 84872241762 scopus 로고    scopus 로고
    • Phase II-clinical trial on neuroprotection with cannabinoids in Huntington's disease (SAT-HD). EudraCT 2010-024227-24.
    • García de Yébenes J. Phase II-clinical trial on neuroprotection with cannabinoids in Huntington's disease (SAT-HD). EudraCT 2010-024227-24.
    • García de Yébenes, J.1
  • 29
    • 0037707636 scopus 로고    scopus 로고
    • Post-ischemic treatment with cannabidiol prevents electroencephalographic flattening, hyperlocomotion and neuronal injury in gerbils
    • Braida D, Pegorini S, Arcidiacono MV, Consalez GG, Croci L, Sala M. Post-ischemic treatment with cannabidiol prevents electroencephalographic flattening, hyperlocomotion and neuronal injury in gerbils. Neurosci Lett 2003; 346: 61-4.
    • (2003) Neurosci Lett , vol.346 , pp. 61-64
    • Braida, D.1    Pegorini, S.2    Arcidiacono, M.V.3    Consalez, G.G.4    Croci, L.5    Sala, M.6
  • 30
    • 77955696255 scopus 로고    scopus 로고
    • Therapeutic potential of non-psychotropic cannabidiol in ischemic stroke
    • Hayakawa K, Mishima K, Fujiwara M. Therapeutic potential of non-psychotropic cannabidiol in ischemic stroke. Pharmaceuticals 2010; 3: 2197-212.
    • (2010) Pharmaceuticals , vol.3 , pp. 2197-2212
    • Hayakawa, K.1    Mishima, K.2    Fujiwara, M.3
  • 31
    • 33646078800 scopus 로고    scopus 로고
    • Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement
    • Esposito G, De Filippis D, Maiuri MC, De Stefano D, Carnuccio R, Iuvone T. Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement. Neurosci Lett 2006; 99: 91-5.
    • (2006) Neurosci Lett , vol.99 , pp. 91-95
    • Esposito, G.1    De Filippis, D.2    Maiuri, M.C.3    De Stefano, D.4    Carnuccio, R.5    Iuvone, T.6
  • 32
    • 1842510018 scopus 로고    scopus 로고
    • Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells
    • Iuvone T, Esposito G, Esposito R, Santamaria R, Di Rosa M, Izzo AA. Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells. J Neurochem 2004; 89: 134-41.
    • (2004) J Neurochem , vol.89 , pp. 134-141
    • Iuvone, T.1    Esposito, G.2    Esposito, R.3    Santamaria, R.4    Di Rosa, M.5    Izzo, A.A.6
  • 33
    • 79960293903 scopus 로고    scopus 로고
    • Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis-like disease in C57BL/6 mice
    • Kozela E, Lev N, Kaushansky N, Eilam R, Rimmerman N, Levy R, Ben-Nun A, Juknat A, Vogel Z. Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis-like disease in C57BL/6 mice. Br J Pharmacol 2011; 163: 1507-19.
    • (2011) Br J Pharmacol , vol.163 , pp. 1507-1519
    • Kozela, E.1    Lev, N.2    Kaushansky, N.3    Eilam, R.4    Rimmerman, N.5    Levy, R.6    Ben-Nun, A.7    Juknat, A.8    Vogel, Z.9
  • 37
    • 33646734889 scopus 로고    scopus 로고
    • Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression
    • Carrier EJ, Auchampach JA, Hillard CJ. Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression. Proc Natl Acad Sci USA 2006; 103: 7895-900.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 7895-7900
    • Carrier, E.J.1    Auchampach, J.A.2    Hillard, C.J.3
  • 38
    • 77954175115 scopus 로고    scopus 로고
    • Cannabinoid activation of peroxisome proliferator-activated receptors: potential for modulation of inflammatory disease
    • O'Sullivan SE, Kendall DA. Cannabinoid activation of peroxisome proliferator-activated receptors: potential for modulation of inflammatory disease. Immunobiology 2010; 215: 611-6.
    • (2010) Immunobiology , vol.215 , pp. 611-616
    • O'Sullivan, S.E.1    Kendall, D.A.2
  • 44
    • 38349158960 scopus 로고    scopus 로고
    • 9-tetrahydrocannabivarin
    • 9-tetrahydrocannabivarin. Br J Pharmacol 2008; 153: 199-215.
    • (2008) Br J Pharmacol , vol.153 , pp. 199-215
    • Pertwee, R.G.1
  • 45
    • 59549106886 scopus 로고    scopus 로고
    • The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-beta glycine receptor function
    • Ahrens J, Demir R, Leuwer M, de la Roche J, Krampfl K, Foadi N, Karst M, Haeseler G. The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-beta glycine receptor function. Pharmacology 2009; 83: 217-22.
    • (2009) Pharmacology , vol.83 , pp. 217-222
    • Ahrens, J.1    Demir, R.2    Leuwer, M.3    de la Roche, J.4    Krampfl, K.5    Foadi, N.6    Karst, M.7    Haeseler, G.8
  • 46
    • 77950094856 scopus 로고    scopus 로고
    • Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes
    • Yamaori S, Kushihara M, Yamamoto I, Watanabe K. Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes. Biochem Pharmacol 2010; 79: 1691-8.
    • (2010) Biochem Pharmacol , vol.79 , pp. 1691-1698
    • Yamaori, S.1    Kushihara, M.2    Yamamoto, I.3    Watanabe, K.4
  • 47
    • 79960583719 scopus 로고    scopus 로고
    • Differential inhibition of human cytochrome P450 2A6 and 2B6 by major phytocannabinoids
    • Yamaori S, Maeda C, Yamamoto I, Watanabe K. Differential inhibition of human cytochrome P450 2A6 and 2B6 by major phytocannabinoids. Forensic Toxicol 2011; 29: 117-24.
    • (2011) Forensic Toxicol , vol.29 , pp. 117-124
    • Yamaori, S.1    Maeda, C.2    Yamamoto, I.3    Watanabe, K.4
  • 48
    • 80054732392 scopus 로고    scopus 로고
    • Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6
    • Yamaori S, Okamoto Y, Yamamoto I, Watanabe K. Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Drug Metab Dispos 2011; 39: 2049-56.
    • (2011) Drug Metab Dispos , vol.39 , pp. 2049-2056
    • Yamaori, S.1    Okamoto, Y.2    Yamamoto, I.3    Watanabe, K.4
  • 49
    • 79953287136 scopus 로고    scopus 로고
    • Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety
    • Yamaori S, Ebisawa J, Okushima Y, Yamamoto I, Watanabe K. Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. Life Sci 2011; 88: 730-6.
    • (2011) Life Sci , vol.88 , pp. 730-736
    • Yamaori, S.1    Ebisawa, J.2    Okushima, Y.3    Yamamoto, I.4    Watanabe, K.5
  • 50
    • 33745086856 scopus 로고    scopus 로고
    • Cannabinoids attenuate norepinephrine-induced melatonin biosynthesis in the rat pineal gland by reducing arylalkylamine N-acetyltransferase activity without involvement of cannabinoid receptors
    • Koch M, Dehghani F, Habazettl I, Schomerus C, Korf H-W. Cannabinoids attenuate norepinephrine-induced melatonin biosynthesis in the rat pineal gland by reducing arylalkylamine N-acetyltransferase activity without involvement of cannabinoid receptors. J Neurochem 2006; 98: 267-78.
    • (2006) J Neurochem , vol.98 , pp. 267-278
    • Koch, M.1    Dehghani, F.2    Habazettl, I.3    Schomerus, C.4    Korf, H.-W.5
  • 51
    • 60149102476 scopus 로고    scopus 로고
    • Δ9-tetrahydrocannabinol and cannabidiol modulate mitogen-induced tryptophan degradation and neopterin formation in peripheral blood mononuclear cells in vitro
    • Jenny M, Santer E, Pirich E, Schennach H, Fuchs D. Δ9-tetrahydrocannabinol and cannabidiol modulate mitogen-induced tryptophan degradation and neopterin formation in peripheral blood mononuclear cells in vitro. J Neuroimmunol 2009; 207: 75-82.
    • (2009) J Neuroimmunol , vol.207 , pp. 75-82
    • Jenny, M.1    Santer, E.2    Pirich, E.3    Schennach, H.4    Fuchs, D.5
  • 52
    • 67650824999 scopus 로고    scopus 로고
    • Cannabidiol-2′,6′-dimethyl ether, a cannabidiol derivative, is a highly potent and selective 15-lipoxygenase inhibitor
    • Takeda S, Usami N, Yamamoto I, Watanabe K. Cannabidiol-2′, 6′-dimethyl ether, a cannabidiol derivative, is a highly potent and selective 15-lipoxygenase inhibitor. Drug Metab Dispos 2009; 37: 1733-7.
    • (2009) Drug Metab Dispos , vol.37 , pp. 1733-1737
    • Takeda, S.1    Usami, N.2    Yamamoto, I.3    Watanabe, K.4
  • 53
    • 55049102688 scopus 로고    scopus 로고
    • Generation of reactive oxygen species during mouse hepatic microsomal metabolism of cannabidiol and cannabidiol hydroxy-quinone
    • Usami N, Yamamoto I, Watanabe K. Generation of reactive oxygen species during mouse hepatic microsomal metabolism of cannabidiol and cannabidiol hydroxy-quinone. Life Sci 2008; 83: 717-24.
    • (2008) Life Sci , vol.83 , pp. 717-724
    • Usami, N.1    Yamamoto, I.2    Watanabe, K.3
  • 55
    • 21144454795 scopus 로고    scopus 로고
    • In vitro inhibitory effects of cannabinoids on progesterone 17α-hydroxylase activity in rat testis microsomes
    • Funahashi T, Ikeuchi H, Yamaori S, Kimura T, Yamamoto I, Watanabe K. In vitro inhibitory effects of cannabinoids on progesterone 17α-hydroxylase activity in rat testis microsomes. J Health Sci 2005; 51: 369-75.
    • (2005) J Health Sci , vol.51 , pp. 369-375
    • Funahashi, T.1    Ikeuchi, H.2    Yamaori, S.3    Kimura, T.4    Yamamoto, I.5    Watanabe, K.6
  • 57
    • 83055161839 scopus 로고    scopus 로고
    • Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent
    • Sreevalsan S, Joseph S, Jutooru I, Chadalapaka G, Safe SH. Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent. Anticancer Res 2011; 31: 3799-807.
    • (2011) Anticancer Res , vol.31 , pp. 3799-3807
    • Sreevalsan, S.1    Joseph, S.2    Jutooru, I.3    Chadalapaka, G.4    Safe, S.H.5
  • 59
    • 56249141071 scopus 로고    scopus 로고
    • 1A receptor stimulation reduces D1 receptor-induced dyskinesia and improves movement in the hemiparkinsonian rat
    • 1A receptor stimulation reduces D1 receptor-induced dyskinesia and improves movement in the hemiparkinsonian rat. Neuropharmacology 2008; 55: 1321-8.
    • (2008) Neuropharmacology , vol.55 , pp. 1321-1328
    • Dupre, K.B.1    Eskow, K.L.2    Barnum, C.J.3    Bishop, C.4
  • 60
    • 78751653077 scopus 로고    scopus 로고
    • 1A receptors in the treatment of schizophrenia and Parkinson's disease
    • 1A receptors in the treatment of schizophrenia and Parkinson's disease. CNS Neurosci Ther 2011; 17: 58-65.
    • (2011) CNS Neurosci Ther , vol.17 , pp. 58-65
    • Ohno, Y.1
  • 62
    • 46649094780 scopus 로고    scopus 로고
    • Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats
    • Campos AC, Guimarães FS. Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats. Psychopharmacology 2008; 199: 223-30.
    • (2008) Psychopharmacology , vol.199 , pp. 223-230
    • Campos, A.C.1    Guimarães, F.S.2
  • 64
    • 77953917373 scopus 로고    scopus 로고
    • Intra-dorsal periaqueductal gray administration of cannabidiol blocks panic-like response by activating 5-HT1A receptors
    • Soares VdeP, Campos AC, de Bortoli VC, Zangrossi H, Guimarães FS, Zuardi AW. Intra-dorsal periaqueductal gray administration of cannabidiol blocks panic-like response by activating 5-HT1A receptors. Behav Brain Res 2010; 213: 225-9.
    • (2010) Behav Brain Res , vol.213 , pp. 225-229
    • Soares, V.1    Campos, A.C.2    de Bortoli, V.C.3    Zangrossi, H.4    Guimarães, F.S.5    Zuardi, A.W.6
  • 65
    • 78651436142 scopus 로고    scopus 로고
    • Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action
    • Maione S, Piscitelli F, Gatta L, Vita D, De Petrocellis L, Palazzo E, de Novellis V, Di Marzo V. Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action. Br J Pharmacol 2011; 162: 584-96.
    • (2011) Br J Pharmacol , vol.162 , pp. 584-596
    • Maione, S.1    Piscitelli, F.2    Gatta, L.3    Vita, D.4    De Petrocellis, L.5    Palazzo, E.6    de Novellis, V.7    Di Marzo, V.8
  • 66
    • 80052341043 scopus 로고    scopus 로고
    • Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews
    • Rock EM, Goodwin JM, Limebeer CL, Breuer A, Pertwee RG, Mechoulam R, Parker LA. Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews. Psychopharmacology 2011; 215: 505-12.
    • (2011) Psychopharmacology , vol.215 , pp. 505-512
    • Rock, E.M.1    Goodwin, J.M.2    Limebeer, C.L.3    Breuer, A.4    Pertwee, R.G.5    Mechoulam, R.6    Parker, L.A.7
  • 67
    • 3142697890 scopus 로고    scopus 로고
    • A comparative analysis of the potential of cannabinoids and ondansetron to suppress cisplatin-induced emesis in the Suncus murinus (house musk shrew)
    • Kwiatkowska M, Parker LA, Burton P, Mechoulam R. A comparative analysis of the potential of cannabinoids and ondansetron to suppress cisplatin-induced emesis in the Suncus murinus (house musk shrew). Psychopharmacology 2004; 174: 254-9.
    • (2004) Psychopharmacology , vol.174 , pp. 254-259
    • Kwiatkowska, M.1    Parker, L.A.2    Burton, P.3    Mechoulam, R.4
  • 68
    • 1642578318 scopus 로고    scopus 로고
    • Effect of cannabinoids on lithium-induced vomiting in the Suncus murinus (house musk shrew)
    • Parker LA, Kwiatkowska M, Burton P, Mechoulam R. Effect of cannabinoids on lithium-induced vomiting in the Suncus murinus (house musk shrew). Psychopharmacology 2004; 171: 156-61.
    • (2004) Psychopharmacology , vol.171 , pp. 156-161
    • Parker, L.A.1    Kwiatkowska, M.2    Burton, P.3    Mechoulam, R.4
  • 73
    • 0032493197 scopus 로고    scopus 로고
    • Cannabidiol and (-)Δ9-tetrahydrocannabinol are neuroprotective antioxidants
    • Hampson AJ, Grimaldi M, Axelrod J, Wink D. Cannabidiol and (-)Δ9-tetrahydrocannabinol are neuroprotective antioxidants. Proc Natl Acad Sci USA 1998; 95: 8268-73.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8268-8273
    • Hampson, A.J.1    Grimaldi, M.2    Axelrod, J.3    Wink, D.4
  • 74
    • 78651456305 scopus 로고    scopus 로고
    • Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study
    • Ruiz-Valdepeñas L, Martínez-Orgado JA, Benito C, Millán A, Tolón RM, Romero J. Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study. J Neuroinflammation 2011; 8: 5.
    • (2011) J Neuroinflammation , vol.8 , pp. 5
    • Ruiz-Valdepeñas, L.1    Martínez-Orgado, J.A.2    Benito, C.3    Millán, A.4    Tolón, R.M.5    Romero, J.6
  • 75
    • 84861460855 scopus 로고    scopus 로고
    • Cannabidiol-treated rats exhibited higher motor score after cryogenic spinal cord injury
    • Kwiatkoski M, Guimarães FS, Del-Bel E. Cannabidiol-treated rats exhibited higher motor score after cryogenic spinal cord injury. Neurotox Res 2012; 21: 271-80.
    • (2012) Neurotox Res , vol.21 , pp. 271-280
    • Kwiatkoski, M.1    Guimarães, F.S.2    Del-Bel, E.3
  • 77
    • 0036488182 scopus 로고    scopus 로고
    • Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1
    • Marsicano G, Moosmann B, Hermann H, Lutz B, Behl C. Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1. J Neurochem 2002; 80: 448-56.
    • (2002) J Neurochem , vol.80 , pp. 448-456
    • Marsicano, G.1    Moosmann, B.2    Hermann, H.3    Lutz, B.4    Behl, C.5
  • 79
    • 84856513007 scopus 로고    scopus 로고
    • Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ(9)-tetrahydrocannabinol in BV-2 microglial cells
    • Juknat A, Pietr M, Kozela E, Rimmerman N, Levy R, Coppola G, Geschwind D, Vogel Z. Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ(9)-tetrahydrocannabinol in BV-2 microglial cells. Br J Pharmacol in press, 2012).
    • (2012) Br J Pharmacol
    • Juknat, A.1    Pietr, M.2    Kozela, E.3    Rimmerman, N.4    Levy, R.5    Coppola, G.6    Geschwind, D.7    Vogel, Z.8
  • 82
    • 33344456093 scopus 로고    scopus 로고
    • The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells
    • Esposito G, De Filippis D, Carnuccio R, Izzo AA, Iuvone T. The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells. J Mol Med (Berl) 2006; 84: 253-8.
    • (2006) J Mol Med (Berl) , vol.84 , pp. 253-258
    • Esposito, G.1    De Filippis, D.2    Carnuccio, R.3    Izzo, A.A.4    Iuvone, T.5
  • 86
    • 77955643169 scopus 로고    scopus 로고
    • Molecular mechanisms and potential therapeutical targets in Huntington's disease
    • Zuccato C, Valenza M, Cattaneo E. Molecular mechanisms and potential therapeutical targets in Huntington's disease. Physiol Rev 2010; 90: 905-81.
    • (2010) Physiol Rev , vol.90 , pp. 905-981
    • Zuccato, C.1    Valenza, M.2    Cattaneo, E.3
  • 88
    • 77953894712 scopus 로고    scopus 로고
    • Huntington's disease: progress toward effective disease-modifying treatments and a cure
    • Johnson CD, Davidson BL. Huntington's disease: progress toward effective disease-modifying treatments and a cure. Hum Mol Genet 2010; 19: R98-R102.
    • (2010) Hum Mol Genet , vol.19
    • Johnson, C.D.1    Davidson, B.L.2
  • 90
    • 0038201773 scopus 로고    scopus 로고
    • Effects of cannabinoids in the rat model of Huntington's disease generated by an intrastriatal injection of malonate
    • Lastres-Becker I, Bizat N, Boyer F, Hantraye P, Brouillet E, Fernández-Ruiz J. Effects of cannabinoids in the rat model of Huntington's disease generated by an intrastriatal injection of malonate. Neuroreport 2003; 14: 813-6.
    • (2003) Neuroreport , vol.14 , pp. 813-816
    • Lastres-Becker, I.1    Bizat, N.2    Boyer, F.3    Hantraye, P.4    Brouillet, E.5    Fernández-Ruiz, J.6
  • 96
    • 38449091547 scopus 로고    scopus 로고
    • Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects
    • Nagatsu T, Sawada M. Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects. J Neural Transm Suppl 2007; 72: 113-20.
    • (2007) J Neural Transm Suppl , vol.72 , pp. 113-120
    • Nagatsu, T.1    Sawada, M.2
  • 97
    • 33846401540 scopus 로고    scopus 로고
    • Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties
    • García-Arencibia M, González S, de Lago E, Ramos JA, Mechoulam R, Fernández-Ruiz J. Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties. Brain Res 2007; 1134: 162-70.
    • (2007) Brain Res , vol.1134 , pp. 162-170
    • García-Arencibia, M.1    González, S.2    de Lago, E.3    Ramos, J.A.4    Mechoulam, R.5    Fernández-Ruiz, J.6
  • 98
    • 67649843735 scopus 로고    scopus 로고
    • The endocannabinoid system as a target for the treatment of motor dysfunction
    • Fernández-Ruiz J. The endocannabinoid system as a target for the treatment of motor dysfunction. Br J Pharmacol 2009; 156: 1029-40.
    • (2009) Br J Pharmacol , vol.156 , pp. 1029-1040
    • Fernández-Ruiz, J.1
  • 100
    • 0022818369 scopus 로고
    • Open label evaluation of cannabidiol in dystonic movement disorders
    • Consroe P, Sandyk R, Snider SR. Open label evaluation of cannabidiol in dystonic movement disorders. Int J Neurosci 1986; 30: 277-82.
    • (1986) Int J Neurosci , vol.30 , pp. 277-282
    • Consroe, P.1    Sandyk, R.2    Snider, S.R.3
  • 106
    • 79952378224 scopus 로고    scopus 로고
    • Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice
    • Avraham Y, Grigoriadis N, Poutahidis T, Vorobiev L, Magen I, Ilan Y, Mechoulam R, Berry E. Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice. Br J Pharmacol 2011; 162: 1650-8.
    • (2011) Br J Pharmacol , vol.162 , pp. 1650-1658
    • Avraham, Y.1    Grigoriadis, N.2    Poutahidis, T.3    Vorobiev, L.4    Magen, I.5    Ilan, Y.6    Mechoulam, R.7    Berry, E.8
  • 108
    • 77957687873 scopus 로고    scopus 로고
    • Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study
    • Morgan CJ, Schafer G, Freeman TP, Curran HV. Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study. Br J Psychiatry 2010; 197: 285-90.
    • (2010) Br J Psychiatry , vol.197 , pp. 285-290
    • Morgan, C.J.1    Schafer, G.2    Freeman, T.P.3    Curran, H.V.4
  • 109
    • 1542283741 scopus 로고    scopus 로고
    • A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis
    • Sumariwalla PF, Gallily R, Tchilibon S, Fride E, Mechoulam R, Feldmann M. A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis. Arthritis Rheum 2004; 50: 985-98.
    • (2004) Arthritis Rheum , vol.50 , pp. 985-998
    • Sumariwalla, P.F.1    Gallily, R.2    Tchilibon, S.3    Fride, E.4    Mechoulam, R.5    Feldmann, M.6


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