-
1
-
-
0042743766
-
Dynamics of DNA replication in mammalian somatic cells, nucleotide pool modulates origin choice and interorigin spacing
-
Anglana M, Apiou F, Bensimon A, Debatisse M. 2003. Dynamics of DNA replication in mammalian somatic cells: nucleotide pool modulates origin choice and interorigin spacing. Cell 114:385-394.
-
(2003)
Cell
, vol.114
, pp. 385-394
-
-
Anglana, M.1
Apiou, F.2
Bensimon, A.3
Debatisse, M.4
-
2
-
-
17244367849
-
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
-
Bartkova J, et al. 2005. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434:864-870.
-
(2005)
Nature
, vol.434
, pp. 864-870
-
-
Bartkova, J.1
-
3
-
-
33845235459
-
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
-
Bartkova J, et al. 2006. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 444: 633-637.
-
(2006)
Nature
, vol.444
, pp. 633-637
-
-
Bartkova, J.1
-
4
-
-
77949410508
-
Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase
-
Beck H, et al. 2010. Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase. J. Cell Biol. 188:629-638.
-
(2010)
J. Cell Biol.
, vol.188
, pp. 629-638
-
-
Beck, H.1
-
5
-
-
79955525482
-
Nucleotide deficiency promotes genomic instability in early stages of cancer development
-
Bester AC, et al. 2011. Nucleotide deficiency promotes genomic instability in early stages of cancer development. Cell 145:435-446.
-
(2011)
Cell
, vol.145
, pp. 435-446
-
-
Bester, A.C.1
-
6
-
-
77649165394
-
Maintaining genome stability at the replication fork
-
Branzei D, Foiani M. 2010. Maintaining genome stability at the replication fork. Nat. Rev. Mol. Cell Biol. 11:208-219.
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 208-219
-
-
Branzei, D.1
Foiani, M.2
-
7
-
-
33845792555
-
CellProfiler, image analysis software for identifying and quantifying cell phenotypes
-
Carpenter AE, et al. 2006. CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol. 7:R100.
-
(2006)
Genome Biol
, vol.7
-
-
Carpenter, A.E.1
-
8
-
-
47749141560
-
ATR, an essential regulator of genome integrity
-
Cimprich KA, Cortez D. 2008. ATR: an essential regulator of genome integrity. Nat. Rev. Mol. Cell Biol. 9:616-627.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 616-627
-
-
Cimprich, K.A.1
Cortez, D.2
-
9
-
-
52949092763
-
Replication fork movement sets chromatin loop size and origin choice in mammalian cells
-
Courbet S, et al. 2008. Replication fork movement sets chromatin loop size and origin choice in mammalian cells. Nature 455:557-560.
-
(2008)
Nature
, vol.455
, pp. 557-560
-
-
Courbet, S.1
-
10
-
-
33845269825
-
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
-
Di Micco R, et al. 2006. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 444:638-642.
-
(2006)
Nature
, vol.444
, pp. 638-642
-
-
Di Micco, R.1
-
11
-
-
0034306184
-
Temporally coordinated assembly and disassembly of replication factories in the absence of DNA synthesis
-
Dimitrova DS, Gilbert DM. 2000. Temporally coordinated assembly and disassembly of replication factories in the absence of DNA synthesis. Nat. Cell Biol. 2:686-694.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 686-694
-
-
Dimitrova, D.S.1
Gilbert, D.M.2
-
12
-
-
80052632895
-
Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease
-
Dominguez-Kelly R, et al. 2011. Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease. J. Cell Biol. 194: 567-579.
-
(2011)
J. Cell Biol.
, vol.194
, pp. 567-579
-
-
Dominguez-Kelly, R.1
-
13
-
-
67649655402
-
Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases
-
Fekairi S, et al. 2009. Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases. Cell 138:78-89.
-
(2009)
Cell
, vol.138
, pp. 78-89
-
-
Fekairi, S.1
-
14
-
-
80051758435
-
Structure-specific DNA endonuclease Mus81/Eme1 generates DNA damage caused by Chk1 inactivation
-
doi, 10. 1371/journal. pone.0023517
-
Forment JV, Blasius M, Guerini I, Jackson SP. 2011. Structure-specific DNA endonuclease Mus81/Eme1 generates DNA damage caused by Chk1 inactivation. PLoS One 6:e23517. doi:10.1371/journal.pone.0023517.
-
(2011)
PLoS One
, vol.6
-
-
Forment, J.V.1
Blasius, M.2
Guerini, I.3
Jackson, S.P.4
-
15
-
-
35848930133
-
The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks
-
Hanada K, et al. 2007. The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks. Nat. Struct. Mol. Biol. 14:1096-1104.
-
(2007)
Nat. Struct. Mol. Biol.
, vol.14
, pp. 1096-1104
-
-
Hanada, K.1
-
16
-
-
79955490586
-
Replication stress induces 53BP1-containing OPT domains in G1 cells
-
Harrigan JA, et al. 2011. Replication stress induces 53BP1-containing OPT domains in G1 cells. J. Cell Biol. 193:97-108.
-
(2011)
J. Cell Biol.
, vol.193
, pp. 97-108
-
-
Harrigan, J.A.1
-
17
-
-
70949083026
-
Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
-
Hirai H, et al. 2009. Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents. Mol. Cancer Ther. 8:2992-3000.
-
(2009)
Mol. Cancer Ther.
, vol.8
, pp. 2992-3000
-
-
Hirai, H.1
-
18
-
-
38049075810
-
The histone methyltransferase SET8 is required for S-phase progression
-
Jørgensen S, et al. 2007. The histone methyltransferase SET8 is required for S-phase progression. J. Cell Biol. 179:1337-1345.
-
(2007)
J. Cell Biol.
, vol.179
, pp. 1337-1345
-
-
Jørgensen, S.1
-
19
-
-
62549132126
-
Cyclin A-Cdk1 regulates the origin firing program in mammalian cells
-
Katsuno Y, et al. 2009. Cyclin A-Cdk1 regulates the origin firing program in mammalian cells. Proc. Natl. Acad. Sci. U. S. A. 106:3184-3189.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 3184-3189
-
-
Katsuno, Y.1
-
20
-
-
34249859996
-
Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement
-
Kiviharju-af Hallstrom TM, et al. 2007. Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement. Proc. Natl. Acad. Sci. U. S. A. 104:7211-7216.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 7211-7216
-
-
Kiviharju-af Hallstrom, T.M.1
-
21
-
-
33646029128
-
Fluorescent cell barcoding in flow cytometry allows high-throughput drug screening and signaling profiling
-
Krutzik PO, Nolan GP. 2006. Fluorescent cell barcoding in flow cytometry allows high-throughput drug screening and signaling profiling. Nature Methods 3:361-368.
-
(2006)
Nature Methods
, vol.3
, pp. 361-368
-
-
Krutzik, P.O.1
Nolan, G.P.2
-
22
-
-
81055138203
-
Surviving chromosome replication, the many roles of the S-phase checkpoint pathway
-
Labib K, De Piccoli G. 2011. Surviving chromosome replication: the many roles of the S-phase checkpoint pathway. Philos. Trans. R. Soc. Lond. B Biol. Sci. 366:3554-3561.
-
(2011)
Philos. Trans. R. Soc. Lond. B Biol. Sci.
, vol.366
, pp. 3554-3561
-
-
Labib, K.1
De Piccoli, G.2
-
23
-
-
3142552523
-
Chk1 is haploinsufficient for multiple functions critical to tumor suppression
-
Lam MH, Liu Q, Elledge SJ, Rosen JM. 2004. Chk1 is haploinsufficient for multiple functions critical to tumor suppression. Cancer Cell 6:45-59.
-
(2004)
Cancer Cell
, vol.6
, pp. 45-59
-
-
Lam, M.H.1
Liu, Q.2
Elledge, S.J.3
Rosen, J.M.4
-
24
-
-
34249944668
-
Arrested replication fork processing, interplay between checkpoints and recombination
-
Lambert S, Froget B, Carr AM. 2007. Arrested replication fork processing: interplay between checkpoints and recombination. DNA Repair 6:1042-1061.
-
(2007)
DNA Repair
, vol.6
, pp. 1042-1061
-
-
Lambert, S.1
Froget, B.2
Carr, A.M.3
-
25
-
-
0030950537
-
Cooperating oncogenes converge to regulate cyclin/ cdk complexes
-
Lloyd AC, et al. 1997. Cooperating oncogenes converge to regulate cyclin/ cdk complexes. Genes Dev. 11:663-677.
-
(1997)
Genes Dev
, vol.11
, pp. 663-677
-
-
Lloyd, A.C.1
-
27
-
-
84860353697
-
An extra allele of Chk1 limits oncogeneinduced replicative stress and promotes transformation
-
Lopez-Contreras AJ, Gutierrez-Martinez P, Specks J, Rodrigo-Perez S, Fernandez-Capetillo O. 2012. An extra allele of Chk1 limits oncogeneinduced replicative stress and promotes transformation. J. Exp. Med. 209: 455-461.
-
(2012)
J. Exp. Med.
, vol.209
, pp. 455-461
-
-
Lopez-Contreras, A.J.1
Gutierrez-Martinez, P.2
Specks, J.3
Rodrigo-Perez, S.4
Fernandez-Capetillo, O.5
-
28
-
-
79952281751
-
53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress
-
Lukas C, et al. 2011. 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress. Nat. Cell Biol. 13:243-253.
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 243-253
-
-
Lukas, C.1
-
29
-
-
82455164158
-
Limiting replication initiation factors execute the temporal programme of origin firing in budding yeast
-
Mantiero D, Mackenzie A, Donaldson A, Zegerman P. 2011. Limiting replication initiation factors execute the temporal programme of origin firing in budding yeast. EMBO J. 30:4805-4814.
-
(2011)
EMBO J
, vol.30
, pp. 4805-4814
-
-
Mantiero, D.1
Mackenzie, A.2
Donaldson, A.3
Zegerman, P.4
-
30
-
-
80053544629
-
Regulatory control of the resolution of DNA recombination intermediates during meiosis and mitosis
-
Matos J, Blanco MG, Maslen S, Skehel JM, West SC. 2011. Regulatory control of the resolution of DNA recombination intermediates during meiosis and mitosis. Cell 147:158-172.
-
(2011)
Cell
, vol.147
, pp. 158-172
-
-
Matos, J.1
Blanco, M.G.2
Maslen, S.3
Skehel, J.M.4
West, S.C.5
-
31
-
-
67649641641
-
Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair
-
Munoz IM, et al. 2009. Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. Mol. Cell 35:116-127.
-
(2009)
Mol. Cell
, vol.35
, pp. 116-127
-
-
Munoz, I.M.1
-
33
-
-
0026616796
-
Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase
-
Parker LL, Piwnica-Worms H. 1992. Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase. Science 257:1955-1957.
-
(1992)
Science
, vol.257
, pp. 1955-1957
-
-
Parker, L.L.1
Piwnica-Worms, H.2
-
34
-
-
77957982422
-
Chk1 promotes replication fork progression by controlling replication initiation
-
Petermann E, Woodcock M, Helleday T. 2010. Chk1 promotes replication fork progression by controlling replication initiation. Proc. Natl. Acad. Sci. U. S. A. 107:16090-16095.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 16090-16095
-
-
Petermann, E.1
Woodcock, M.2
Helleday, T.3
-
35
-
-
84857060479
-
dNTP pools determine fork progression and origin usage under replication stress
-
Poli J, et al. 2012. dNTP pools determine fork progression and origin usage under replication stress. EMBO J. 31:883-894.
-
(2012)
EMBO J
, vol.31
, pp. 883-894
-
-
Poli, J.1
-
36
-
-
70549085855
-
Eukaryotic DNA replication control, lock and load, then fire
-
Remus D, Diffley JF. 2009. Eukaryotic DNA replication control: lock and load, then fire. Curr. Opin. Cell Biol. 21:771-777.
-
(2009)
Curr. Opin. Cell Biol.
, vol.21
, pp. 771-777
-
-
Remus, D.1
Diffley, J.F.2
-
37
-
-
0345552249
-
Simultaneous determination of pyrimidine or purine deoxyribonucleoside triphosphates using a polymerase assay
-
Roy B, et al. 1999. Simultaneous determination of pyrimidine or purine deoxyribonucleoside triphosphates using a polymerase assay. Anal. Biochem. 269:403-409.
-
(1999)
Anal. Biochem.
, vol.269
, pp. 403-409
-
-
Roy, B.1
-
38
-
-
79959629469
-
Analysis of protein dynamics at active, stalled, and collapsed replication forks
-
Sirbu BM, et al. 2011. Analysis of protein dynamics at active, stalled, and collapsed replication forks. Genes Dev. 25:1320-1327.
-
(2011)
Genes Dev
, vol.25
, pp. 1320-1327
-
-
Sirbu, B.M.1
-
39
-
-
13944266820
-
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
-
Sørensen CS, et al. 2005. The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nat. Cell Biol. 7:195-201.
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 195-201
-
-
Sørensen, C.S.1
-
40
-
-
84855908936
-
Safeguarding genome integrity, the checkpoint kinases ATR CHK1 and WEE1 restrain CDK activity during normal DNA replication
-
Sørensen CS, Syljuåsen RG. 2012. Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication. Nucleic Acids Res. 40:477-486.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 477-486
-
-
Sørensen, C.S.1
Syljuåsen, R.G.2
-
41
-
-
67649662604
-
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair
-
Svendsen JM, et al. 2009. Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Cell 138:63-77.
-
(2009)
Cell
, vol.138
, pp. 63-77
-
-
Svendsen, J.M.1
-
42
-
-
20244388673
-
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage
-
Syljuåsen RG, et al. 2005. Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Mol. Cell. Biol. 25:3553-3562.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 3553-3562
-
-
Syljuåsen, R.G.1
-
43
-
-
34249935010
-
Maintenance of fork integrity at damaged DNA and natural pause sites
-
Tourriere H, Pasero P. 2007. Maintenance of fork integrity at damaged DNA and natural pause sites. DNA Repair (Amst.) 6:900-913.
-
(2007)
DNA Repair (Amst.)
, vol.6
, pp. 900-913
-
-
Tourriere, H.1
Pasero, P.2
-
44
-
-
70449522304
-
Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription
-
Tuduri S, et al. 2009. Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription. Nature Cell Biol. 11:1315-1324.
-
(2009)
Nature Cell Biol
, vol.11
, pp. 1315-1324
-
-
Tuduri, S.1
-
45
-
-
33746094659
-
Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1
-
Vassilev LT, et al. 2006. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proc. Natl. Acad. Sci. U. S. A. 103: 10660-10665.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 10660-10665
-
-
Vassilev, L.T.1
-
46
-
-
0035476889
-
Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers
-
Wu CL, et al. 2001. Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers. Cancer Res. 61:7325-7332.
-
(2001)
Cancer Res
, vol.61
, pp. 7325-7332
-
-
Wu, C.L.1
|