Base excision repair and design of small molecule inhibitors of human DNA polymerase β

Cellular and Molecular Life Sciences

Volumn 67, Issue 21, 2010, Pages 3633-3647

  Wilson, Samuel H ^a   Beard, William A ^a   Shock, David D ^a   Batra, Vinod K ^a   Cavanaugh, Nisha A ^a   Prasad, Rajendra ^a   Hou, Esther W ^a   Liu, Yuan ^a   Asagoshi, Kenjiro ^a   Horton, Julie K ^a   Stefanick, Donna F ^a   Kedar, Padmini S ^a   Carrozza, Michael J ^a   Masaoka, Aya ^a   Heacock, Michelle L ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Base excision repair; DNA polymerase ; DNA repair deficiency; Mouse models; PARP inhibitors; PARP 1; Small molecule inhibitors; Structural biology

Indexed keywords

ATM PROTEIN; ATR PROTEIN; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DNA DIRECTED DNA POLYMERASE BETA; DNA GLYCOSYLTRANSFERASE; EMBONIC ACID; HIGH MOBILITY GROUP B1 PROTEIN; MESYLIC ACID METHYL ESTER; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; TEMOZOLOMIDE; XRCC1 PROTEIN;

CELL CYCLE ARREST; CELL KILLING; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DNA ALKYLATION; DNA CROSS LINKING; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; DRUG CYTOTOXICITY; ENZYME INHIBITION; EXCISION REPAIR; GENOTOXICITY; HUMAN; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; DNA POLYMERASE BETA; DNA REPAIR; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MODELS, MOLECULAR;

MAMMALIA;

EID: 78149469632     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-010-0489-1     Document Type: Review

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