-
1
-
-
0031882260
-
Reactive oxygen species as mediators of signal transduction in cardiovascular disease
-
J. Abe, and B.C. Berk Reactive oxygen species as mediators of signal transduction in cardiovascular disease Trends Cardiovasc. Med. 8 1998 59 64
-
(1998)
Trends Cardiovasc. Med.
, vol.8
, pp. 59-64
-
-
Abe, J.1
Berk, B.C.2
-
2
-
-
10644282295
-
The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans
-
J. Apfeld, G. O'Connor, T. McDonagh, P.S. DiStefano, and R. Curtis The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans Genes Dev. 18 2004 3004 3009
-
(2004)
Genes Dev.
, vol.18
, pp. 3004-3009
-
-
Apfeld, J.1
O'Connor, G.2
McDonagh, T.3
Distefano, P.S.4
Curtis, R.5
-
3
-
-
84871717211
-
Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan
-
D.J. Baker, M.M. Dawlaty, T. Wijshake, K.B. Jeganathan, L. Malureanu, J.H. van Ree, R. Crespo-Diaz, S. Reyes, L. Seaburg, V. Shapiro, and et al. Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan Nat. Cell Biol. 15 2013 96 102
-
(2013)
Nat. Cell Biol.
, vol.15
, pp. 96-102
-
-
Baker, D.J.1
Dawlaty, M.M.2
Wijshake, T.3
Jeganathan, K.B.4
Malureanu, L.5
Van Ree, J.H.6
Crespo-Diaz, R.7
Reyes, S.8
Seaburg, L.9
Shapiro, V.10
-
4
-
-
13944278132
-
Mitochondria, oxidants, and aging
-
R.S. Balaban, S. Nemoto, and T. Finkel Mitochondria, oxidants, and aging Cell 120 2005 483 495
-
(2005)
Cell
, vol.120
, pp. 483-495
-
-
Balaban, R.S.1
Nemoto, S.2
Finkel, T.3
-
5
-
-
84907659600
-
Aging. Aging-induced type I interferon response at the choroid plexus negatively affects brain function
-
K. Baruch, A. Deczkowska, E. David, J.M. Castellano, O. Miller, A. Kertser, T. Berkutzki, Z. Barnett-Itzhaki, D. Bezalel, T. Wyss-Coray, and et al. Aging. Aging-induced type I interferon response at the choroid plexus negatively affects brain function Science 346 2014 89 93
-
(2014)
Science
, vol.346
, pp. 89-93
-
-
Baruch, K.1
Deczkowska, A.2
David, E.3
Castellano, J.M.4
Miller, O.5
Kertser, A.6
Berkutzki, T.7
Barnett-Itzhaki, Z.8
Bezalel, D.9
Wyss-Coray, T.10
-
6
-
-
5444262078
-
IKKbeta/NF-kappaB activation causes severe muscle wasting in mice
-
D. Cai, J.D. Frantz, N.E. Tawa Jr., P.A. Melendez, B.C. Oh, H.G. Lidov, P.O. Hasselgren, W.R. Frontera, J. Lee, D.J. Glass, and S.E. Shoelson IKKbeta/NF-kappaB activation causes severe muscle wasting in mice Cell 119 2004 285 298
-
(2004)
Cell
, vol.119
, pp. 285-298
-
-
Cai, D.1
Frantz, J.D.2
Tawa, N.E.3
Melendez, P.A.4
Oh, B.C.5
Lidov, H.G.6
Hasselgren, P.O.7
Frontera, W.R.8
Lee, J.9
Glass, D.J.10
Shoelson, S.E.11
-
7
-
-
14644427890
-
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
-
D. Cai, M. Yuan, D.F. Frantz, P.A. Melendez, L. Hansen, J. Lee, and S.E. Shoelson Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB Nat. Med. 11 2005 183 190
-
(2005)
Nat. Med.
, vol.11
, pp. 183-190
-
-
Cai, D.1
Yuan, M.2
Frantz, D.F.3
Melendez, P.A.4
Hansen, L.5
Lee, J.6
Shoelson, S.E.7
-
8
-
-
84873638532
-
Aging, cellular senescence, and cancer
-
J. Campisi Aging, cellular senescence, and cancer Annu. Rev. Physiol. 75 2013 685 705
-
(2013)
Annu. Rev. Physiol.
, vol.75
, pp. 685-705
-
-
Campisi, J.1
-
9
-
-
84910052931
-
Age-associated loss of lamin-B leads to systemic inflammation and gut hyperplasia
-
H. Chen, X. Zheng, and Y. Zheng Age-associated loss of lamin-B leads to systemic inflammation and gut hyperplasia Cell 159 2014 829 843
-
(2014)
Cell
, vol.159
, pp. 829-843
-
-
Chen, H.1
Zheng, X.2
Zheng, Y.3
-
10
-
-
84937412433
-
20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans
-
N. Chondrogianni, K. Georgila, N. Kourtis, N. Tavernarakis, and E.S. Gonos 20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans FASEB J. 29 2015 611 622
-
(2015)
FASEB J.
, vol.29
, pp. 611-622
-
-
Chondrogianni, N.1
Georgila, K.2
Kourtis, N.3
Tavernarakis, N.4
Gonos, E.S.5
-
11
-
-
84874967142
-
Identification of seven loci affecting mean telomere length and their association with disease
-
e1-e2
-
V. Codd, C.P. Nelson, E. Albrecht, M. Mangino, J. Deelen, J.L. Buxton, J.J. Hottenga, K. Fischer, T. Esko, I. Surakka, and et al. Identification of seven loci affecting mean telomere length and their association with disease Nat. Genet. 45 2013 422 427.e1-e2
-
(2013)
Nat. Genet.
, vol.45
, pp. 422-427
-
-
Codd, V.1
Nelson, C.P.2
Albrecht, E.3
Mangino, M.4
Deelen, J.5
Buxton, J.L.6
Hottenga, J.J.7
Fischer, K.8
Esko, T.9
Surakka, I.10
-
12
-
-
84891713034
-
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
-
J.P. Coppé, C.K. Patil, F. Rodier, Y. Sun, D.P. Muñoz, J. Goldstein, P.S. Nelson, P.Y. Desprez, and J. Campisi Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor PLoS Biol. 6 2008 2853 2868
-
(2008)
PLoS Biol.
, vol.6
, pp. 2853-2868
-
-
Coppé, J.P.1
Patil, C.K.2
Rodier, F.3
Sun, Y.4
Muñoz, D.P.5
Goldstein, J.6
Nelson, P.S.7
Desprez, P.Y.8
Campisi, J.9
-
13
-
-
84878954836
-
Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements
-
M. De Cecco, S.W. Criscione, E.J. Peckham, S. Hillenmeyer, E.A. Hamm, J. Manivannan, A.L. Peterson, J.A. Kreiling, N. Neretti, and J.M. Sedivy Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements Aging Cell 12 2013 247 256
-
(2013)
Aging Cell
, vol.12
, pp. 247-256
-
-
De Cecco, M.1
Criscione, S.W.2
Peckham, E.J.3
Hillenmeyer, S.4
Hamm, E.A.5
Manivannan, J.6
Peterson, A.L.7
Kreiling, J.A.8
Neretti, N.9
Sedivy, J.M.10
-
14
-
-
84891506556
-
Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues
-
M. De Cecco, S.W. Criscione, A.L. Peterson, N. Neretti, J.M. Sedivy, and J.A. Kreiling Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues Aging (Albany, N.Y.) 5 2013 867 883
-
(2013)
Aging (Albany, N.Y.)
, vol.5
, pp. 867-883
-
-
De Cecco, M.1
Criscione, S.W.2
Peterson, A.L.3
Neretti, N.4
Sedivy, J.M.5
Kreiling, J.A.6
-
15
-
-
84902345421
-
Intertissue control of the nucleolus via a myokine-dependent longevity pathway
-
F. Demontis, V.K. Patel, W.R. Swindell, and N. Perrimon Intertissue control of the nucleolus via a myokine-dependent longevity pathway Cell Rep. 7 2014 1481 1494
-
(2014)
Cell Rep.
, vol.7
, pp. 1481-1494
-
-
Demontis, F.1
Patel, V.K.2
Swindell, W.R.3
Perrimon, N.4
-
16
-
-
84896351253
-
Hexosamine pathway metabolites enhance protein quality control and prolong life
-
M.S. Denzel, N.J. Storm, A. Gutschmidt, R. Baddi, Y. Hinze, E. Jarosch, T. Sommer, T. Hoppe, and A. Antebi Hexosamine pathway metabolites enhance protein quality control and prolong life Cell 156 2014 1167 1178
-
(2014)
Cell
, vol.156
, pp. 1167-1178
-
-
Denzel, M.S.1
Storm, N.J.2
Gutschmidt, A.3
Baddi, R.4
Hinze, Y.5
Jarosch, E.6
Sommer, T.7
Hoppe, T.8
Antebi, A.9
-
17
-
-
0037174629
-
Timing requirements for insulin/IGF-1 signaling in C. elegans
-
A. Dillin, D.K. Crawford, and C. Kenyon Timing requirements for insulin/IGF-1 signaling in C. elegans Science 298 2002 830 834
-
(2002)
Science
, vol.298
, pp. 830-834
-
-
Dillin, A.1
Crawford, D.K.2
Kenyon, C.3
-
18
-
-
28244466940
-
Caloric restriction in humans: potential pitfalls and health concerns
-
A.J. Dirks, and C. Leeuwenburgh Caloric restriction in humans: potential pitfalls and health concerns Mech. Ageing Dev. 127 2006 1 7
-
(2006)
Mech. Ageing Dev.
, vol.127
, pp. 1-7
-
-
Dirks, A.J.1
Leeuwenburgh, C.2
-
19
-
-
84937516271
-
GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration
-
M.A. Egerman, S.M. Cadena, J.A. Gilbert, A. Meyer, H.N. Nelson, S.E. Swalley, C. Mallozzi, C. Jacobi, L.L. Jennings, I. Clay, and et al. GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration Cell Metab. 22 2015 164 174
-
(2015)
Cell Metab.
, vol.22
, pp. 164-174
-
-
Egerman, M.A.1
Cadena, S.M.2
Gilbert, J.A.3
Meyer, A.4
Nelson, H.N.5
Swalley, S.E.6
Mallozzi, C.7
Jacobi, C.8
Jennings, L.L.9
Clay, I.10
-
20
-
-
84902317419
-
Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration
-
C. Elabd, W. Cousin, P. Upadhyayula, R.Y. Chen, M.S. Chooljian, J. Li, S. Kung, K.P. Jiang, and I.M. Conboy Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration Nat. Commun. 5 2014 4082
-
(2014)
Nat. Commun.
, vol.5
, pp. 4082
-
-
Elabd, C.1
Cousin, W.2
Upadhyayula, P.3
Chen, R.Y.4
Chooljian, M.S.5
Li, J.6
Kung, S.7
Jiang, K.P.8
Conboy, I.M.9
-
21
-
-
33846111415
-
Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans
-
C. Franceschi, M. Capri, D. Monti, S. Giunta, F. Olivieri, F. Sevini, M.P. Panourgia, L. Invidia, L. Celani, M. Scurti, and et al. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans Mech. Ageing Dev. 128 2007 92 105
-
(2007)
Mech. Ageing Dev.
, vol.128
, pp. 92-105
-
-
Franceschi, C.1
Capri, M.2
Monti, D.3
Giunta, S.4
Olivieri, F.5
Sevini, F.6
Panourgia, M.P.7
Invidia, L.8
Celani, L.9
Scurti, M.10
-
22
-
-
84872142459
-
JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation
-
M.S. Han, D.Y. Jung, C. Morel, S.A. Lakhani, J.K. Kim, R.A. Flavell, and R.J. Davis JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation Science 339 2013 218 222
-
(2013)
Science
, vol.339
, pp. 218-222
-
-
Han, M.S.1
Jung, D.Y.2
Morel, C.3
Lakhani, S.A.4
Kim, J.K.5
Flavell, R.A.6
Davis, R.J.7
-
23
-
-
84872806231
-
Genome-wide methylation profiles reveal quantitative views of human aging rates
-
G. Hannum, J. Guinney, L. Zhao, L. Zhang, G. Hughes, S. Sadda, B. Klotzle, M. Bibikova, J.B. Fan, Y. Gao, and et al. Genome-wide methylation profiles reveal quantitative views of human aging rates Mol. Cell 49 2013 359 367
-
(2013)
Mol. Cell
, vol.49
, pp. 359-367
-
-
Hannum, G.1
Guinney, J.2
Zhao, L.3
Zhang, L.4
Hughes, G.5
Sadda, S.6
Klotzle, B.7
Bibikova, M.8
Fan, J.B.9
Gao, Y.10
-
24
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
D.E. Harrison, R. Strong, Z.D. Sharp, J.F. Nelson, C.M. Astle, K. Flurkey, N.L. Nadon, J.E. Wilkinson, K. Frenkel, C.S. Carter, and et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice Nature 460 2009 392 395
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
Strong, R.2
Sharp, Z.D.3
Nelson, J.F.4
Astle, C.M.5
Flurkey, K.6
Nadon, N.L.7
Wilkinson, J.E.8
Frenkel, K.9
Carter, C.S.10
-
25
-
-
84886111619
-
DNA methylation age of human tissues and cell types
-
S. Horvath DNA methylation age of human tissues and cell types Genome Biol. 14 2013 R115
-
(2013)
Genome Biol.
, vol.14
, pp. R115
-
-
Horvath, S.1
-
26
-
-
84878138385
-
Mitonuclear protein imbalance as a conserved longevity mechanism
-
R.H. Houtkooper, L. Mouchiroud, D. Ryu, N. Moullan, E. Katsyuba, G. Knott, R.W. Williams, and J. Auwerx Mitonuclear protein imbalance as a conserved longevity mechanism Nature 497 2013 451 457
-
(2013)
Nature
, vol.497
, pp. 451-457
-
-
Houtkooper, R.H.1
Mouchiroud, L.2
Ryu, D.3
Moullan, N.4
Katsyuba, E.5
Knott, G.6
Williams, R.W.7
Auwerx, J.8
-
27
-
-
84858000209
-
The sirtuin SIRT6 regulates lifespan in male mice
-
Y. Kanfi, S. Naiman, G. Amir, V. Peshti, G. Zinman, L. Nahum, Z. Bar-Joseph, and H.Y. Cohen The sirtuin SIRT6 regulates lifespan in male mice Nature 483 2012 218 221
-
(2012)
Nature
, vol.483
, pp. 218-221
-
-
Kanfi, Y.1
Naiman, S.2
Amir, G.3
Peshti, V.4
Zinman, G.5
Nahum, L.6
Bar-Joseph, Z.7
Cohen, H.Y.8
-
28
-
-
84900338737
-
Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors
-
L. Katsimpardi, N.K. Litterman, P.A. Schein, C.M. Miller, F.S. Loffredo, G.R. Wojtkiewicz, J.W. Chen, R.T. Lee, A.J. Wagers, and L.L. Rubin Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors Science 344 2014 630 634
-
(2014)
Science
, vol.344
, pp. 630-634
-
-
Katsimpardi, L.1
Litterman, N.K.2
Schein, P.A.3
Miller, C.M.4
Loffredo, F.S.5
Wojtkiewicz, G.R.6
Chen, J.W.7
Lee, R.T.8
Wagers, A.J.9
Rubin, L.L.10
-
29
-
-
0027771804
-
A C. elegans mutant that lives twice as long as wild type
-
C. Kenyon, J. Chang, E. Gensch, A. Rudner, and R. Tabtiang A C. elegans mutant that lives twice as long as wild type Nature 366 1993 461 464
-
(1993)
Nature
, vol.366
, pp. 461-464
-
-
Kenyon, C.1
Chang, J.2
Gensch, E.3
Rudner, A.4
Tabtiang, R.5
-
30
-
-
80053445278
-
Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae
-
U. Kruegel, B. Robison, T. Dange, G. Kahlert, J.R. Delaney, S. Kotireddy, M. Tsuchiya, S. Tsuchiyama, C.J. Murakami, J. Schleit, and et al. Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae PLoS Genet. 7 2011 e1002253
-
(2011)
PLoS Genet.
, vol.7
-
-
Kruegel, U.1
Robison, B.2
Dange, T.3
Kahlert, G.4
Delaney, J.R.5
Kotireddy, S.6
Tsuchiya, M.7
Tsuchiyama, S.8
Murakami, C.J.9
Schleit, J.10
-
31
-
-
84896726774
-
Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response
-
V.M. Labunskyy, M.V. Gerashchenko, J.R. Delaney, A. Kaya, B.K. Kennedy, M. Kaeberlein, and V.N. Gladyshev Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response PLoS Genet. 10 2014 e1004019
-
(2014)
PLoS Genet.
, vol.10
-
-
Labunskyy, V.M.1
Gerashchenko, M.V.2
Delaney, J.R.3
Kaya, A.4
Kennedy, B.K.5
Kaeberlein, M.6
Gladyshev, V.N.7
-
32
-
-
84867051812
-
IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes
-
J. Li, Y. Tang, and D. Cai IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes Nat. Cell Biol. 14 2012 999 1012
-
(2012)
Nat. Cell Biol.
, vol.14
, pp. 999-1012
-
-
Li, J.1
Tang, Y.2
Cai, D.3
-
33
-
-
36049049392
-
IRE1 signaling affects cell fate during the unfolded protein response
-
J.H. Lin, H. Li, D. Yasumura, H.R. Cohen, C. Zhang, B. Panning, K.M. Shokat, M.M. Lavail, and P. Walter IRE1 signaling affects cell fate during the unfolded protein response Science 318 2007 944 949
-
(2007)
Science
, vol.318
, pp. 944-949
-
-
Lin, J.H.1
Li, H.2
Yasumura, D.3
Cohen, H.R.4
Zhang, C.5
Panning, B.6
Shokat, K.M.7
Lavail, M.M.8
Walter, P.9
-
34
-
-
77956274584
-
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
-
M.M. Lipinski, B. Zheng, T. Lu, Z. Yan, B.F. Py, A. Ng, R.J. Xavier, C. Li, B.A. Yankner, C.R. Scherzer, and J. Yuan Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease Proc. Natl. Acad. Sci. USA 107 2010 14164 14169
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 14164-14169
-
-
Lipinski, M.M.1
Zheng, B.2
Lu, T.3
Yan, Z.4
Py, B.F.5
Ng, A.6
Xavier, R.J.7
Li, C.8
Yankner, B.A.9
Scherzer, C.R.10
Yuan, J.11
-
35
-
-
79961023008
-
EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan
-
G. Liu, J. Rogers, C.T. Murphy, and C. Rongo EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan EMBO J. 30 2011 2990 3003
-
(2011)
EMBO J.
, vol.30
, pp. 2990-3003
-
-
Liu, G.1
Rogers, J.2
Murphy, C.T.3
Rongo, C.4
-
36
-
-
84877687210
-
Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy
-
F.S. Loffredo, M.L. Steinhauser, S.M. Jay, J. Gannon, J.R. Pancoast, P. Yalamanchi, M. Sinha, C. Dall'Osso, D. Khong, J.L. Shadrach, and et al. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy Cell 153 2013 828 839
-
(2013)
Cell
, vol.153
, pp. 828-839
-
-
Loffredo, F.S.1
Steinhauser, M.L.2
Jay, S.M.3
Gannon, J.4
Pancoast, J.R.5
Yalamanchi, P.6
Sinha, M.7
Dall'Osso, C.8
Khong, D.9
Shadrach, J.L.10
-
37
-
-
84877814611
-
DNA damage in normally and prematurely aged mice
-
A.Y. Maslov, S. Ganapathi, M. Westerhof, W. Quispe-Tintaya, R.R. White, B. Van Houten, E. Reiling, M.E. Dollé, H. van Steeg, P. Hasty, and et al. DNA damage in normally and prematurely aged mice Aging Cell 12 2013 467 477
-
(2013)
Aging Cell
, vol.12
, pp. 467-477
-
-
Maslov, A.Y.1
Ganapathi, S.2
Westerhof, M.3
Quispe-Tintaya, W.4
White, R.R.5
Van Houten, B.6
Reiling, E.7
Dollé, M.E.8
Van Steeg, H.9
Hasty, P.10
-
38
-
-
84889600900
-
Programmed cell senescence during mammalian embryonic development
-
D. Muñoz-Espín, M. Cañamero, A. Maraver, G. Gómez-López, J. Contreras, S. Murillo-Cuesta, A. Rodríguez-Baeza, I. Varela-Nieto, J. Ruberte, M. Collado, and M. Serrano Programmed cell senescence during mammalian embryonic development Cell 155 2013 1104 1118
-
(2013)
Cell
, vol.155
, pp. 1104-1118
-
-
Muñoz-Espín, D.1
Cañamero, M.2
Maraver, A.3
Gómez-López, G.4
Contreras, J.5
Murillo-Cuesta, S.6
Rodríguez-Baeza, A.7
Varela-Nieto, I.8
Ruberte, J.9
Collado, M.10
Serrano, M.11
-
39
-
-
77957814604
-
Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres
-
R.J. O'Sullivan, S. Kubicek, S.L. Schreiber, and J. Karlseder Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres Nat. Struct. Mol. Biol. 17 2010 1218 1225
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 1218-1225
-
-
O'Sullivan, R.J.1
Kubicek, S.2
Schreiber, S.L.3
Karlseder, J.4
-
40
-
-
84883114523
-
Overexpression of Atg5 in mice activates autophagy and extends lifespan
-
J.O. Pyo, S.M. Yoo, H.H. Ahn, J. Nah, S.H. Hong, T.I. Kam, S. Jung, and Y.K. Jung Overexpression of Atg5 in mice activates autophagy and extends lifespan Nat. Commun. 4 2013 2300
-
(2013)
Nat. Commun.
, vol.4
, pp. 2300
-
-
Pyo, J.O.1
Yoo, S.M.2
Ahn, H.H.3
Nah, J.4
Hong, S.H.5
Kam, T.I.6
Jung, S.7
Jung, Y.K.8
-
41
-
-
68249096784
-
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
-
F. Rodier, J.P. Coppé, C.K. Patil, W.A. Hoeijmakers, D.P. Muñoz, S.R. Raza, A. Freund, E. Campeau, A.R. Davalos, and J. Campisi Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion Nat. Cell Biol. 11 2009 973 979
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 973-979
-
-
Rodier, F.1
Coppé, J.P.2
Patil, C.K.3
Hoeijmakers, W.A.4
Muñoz, D.P.5
Raza, S.R.6
Freund, A.7
Campeau, E.8
Davalos, A.R.9
Campisi, J.10
-
42
-
-
0027401203
-
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
-
D.R. Rosen, T. Siddique, D. Patterson, D.A. Figlewicz, P. Sapp, A. Hentati, D. Donaldson, J. Goto, J.P. O'Regan, H.X. Deng, and et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis Nature 362 1993 59 62
-
(1993)
Nature
, vol.362
, pp. 59-62
-
-
Rosen, D.R.1
Siddique, T.2
Patterson, D.3
Figlewicz, D.A.4
Sapp, P.5
Hentati, A.6
Donaldson, D.7
Goto, J.8
O'Regan, J.P.9
Deng, H.X.10
-
43
-
-
84883476818
-
Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH
-
A. Satoh, C.S. Brace, N. Rensing, P. Cliften, D.F. Wozniak, E.D. Herzog, K.A. Yamada, and S. Imai Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH Cell Metab. 18 2013 416 430
-
(2013)
Cell Metab.
, vol.18
, pp. 416-430
-
-
Satoh, A.1
Brace, C.S.2
Rensing, N.3
Cliften, P.4
Wozniak, D.F.5
Herzog, E.D.6
Yamada, K.A.7
Imai, S.8
-
44
-
-
84893857285
-
Antioxidants accelerate lung cancer progression in mice
-
V.I. Sayin, M.X. Ibrahim, E. Larsson, J.A. Nilsson, P. Lindahl, and M.O. Bergo Antioxidants accelerate lung cancer progression in mice Sci. Transl. Med. 6 2014 221ra15
-
(2014)
Sci. Transl. Med.
, vol.6
, pp. 221ra15
-
-
Sayin, V.I.1
Ibrahim, M.X.2
Larsson, E.3
Nilsson, J.A.4
Lindahl, P.5
Bergo, M.O.6
-
45
-
-
33750584214
-
TLR4 links innate immunity and fatty acid-induced insulin resistance
-
H. Shi, M.V. Kokoeva, K. Inouye, I. Tzameli, H. Yin, and J.S. Flier TLR4 links innate immunity and fatty acid-induced insulin resistance J. Clin. Invest. 116 2006 3015 3025
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 3015-3025
-
-
Shi, H.1
Kokoeva, M.V.2
Inouye, K.3
Tzameli, I.4
Yin, H.5
Flier, J.S.6
-
46
-
-
38949099761
-
Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
-
A. Simonsen, R.C. Cumming, A. Brech, P. Isakson, D.R. Schubert, and K.D. Finley Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila Autophagy 4 2008 176 184
-
(2008)
Autophagy
, vol.4
, pp. 176-184
-
-
Simonsen, A.1
Cumming, R.C.2
Brech, A.3
Isakson, P.4
Schubert, D.R.5
Finley, K.D.6
-
47
-
-
84900323323
-
Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle
-
M. Sinha, Y.C. Jang, J. Oh, D. Khong, E.Y. Wu, R. Manohar, C. Miller, S.G. Regalado, F.S. Loffredo, J.R. Pancoast, and et al. Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle Science 344 2014 649 652
-
(2014)
Science
, vol.344
, pp. 649-652
-
-
Sinha, M.1
Jang, Y.C.2
Oh, J.3
Khong, D.4
Wu, E.Y.5
Manohar, R.6
Miller, C.7
Regalado, S.G.8
Loffredo, F.S.9
Pancoast, J.R.10
-
48
-
-
84872137308
-
Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies
-
D. Stenesen, J.M. Suh, J. Seo, K. Yu, K.S. Lee, J.S. Kim, K.J. Min, and J.M. Graff Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies Cell Metab. 17 2013 101 112
-
(2013)
Cell Metab.
, vol.17
, pp. 101-112
-
-
Stenesen, D.1
Suh, J.M.2
Seo, J.3
Yu, K.4
Lee, K.S.5
Kim, J.S.6
Min, K.J.7
Graff, J.M.8
-
49
-
-
84889565689
-
Senescence is a developmental mechanism that contributes to embryonic growth and patterning
-
M. Storer, A. Mas, A. Robert-Moreno, M. Pecoraro, M.C. Ortells, V. Di Giacomo, R. Yosef, N. Pilpel, V. Krizhanovsky, J. Sharpe, and W.M. Keyes Senescence is a developmental mechanism that contributes to embryonic growth and patterning Cell 155 2013 1119 1130
-
(2013)
Cell
, vol.155
, pp. 1119-1130
-
-
Storer, M.1
Mas, A.2
Robert-Moreno, A.3
Pecoraro, M.4
Ortells, M.C.5
Di Giacomo, V.6
Yosef, R.7
Pilpel, N.8
Krizhanovsky, V.9
Sharpe, J.10
Keyes, W.M.11
-
50
-
-
84879343155
-
XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity
-
R.C. Taylor, and A. Dillin XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity Cell 153 2013 1435 1447
-
(2013)
Cell
, vol.153
, pp. 1435-1447
-
-
Taylor, R.C.1
Dillin, A.2
-
51
-
-
84863181604
-
Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities
-
U. Tomaru, S. Takahashi, A. Ishizu, Y. Miyatake, A. Gohda, S. Suzuki, A. Ono, J. Ohara, T. Baba, S. Murata, and et al. Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities Am. J. Pathol. 180 2012 963 972
-
(2012)
Am. J. Pathol.
, vol.180
, pp. 963-972
-
-
Tomaru, U.1
Takahashi, S.2
Ishizu, A.3
Miyatake, Y.4
Gohda, A.5
Suzuki, S.6
Ono, A.7
Ohara, J.8
Baba, T.9
Murata, S.10
-
52
-
-
84907393377
-
AMPK modulates tissue and organismal aging in a non-cell-autonomous manner
-
M. Ulgherait, A. Rana, M. Rera, J. Graniel, and D.W. Walker AMPK modulates tissue and organismal aging in a non-cell-autonomous manner Cell Rep. 8 2014 1767 1780
-
(2014)
Cell Rep.
, vol.8
, pp. 1767-1780
-
-
Ulgherait, M.1
Rana, A.2
Rera, M.3
Graniel, J.4
Walker, D.W.5
-
53
-
-
84918592495
-
SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age
-
M. Van Meter, M. Kashyap, S. Rezazadeh, A.J. Geneva, T.D. Morello, A. Seluanov, and V. Gorbunova SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age Nat. Commun. 5 2014 5011
-
(2014)
Nat. Commun.
, vol.5
, pp. 5011
-
-
Van Meter, M.1
Kashyap, M.2
Rezazadeh, S.3
Geneva, A.J.4
Morello, T.D.5
Seluanov, A.6
Gorbunova, V.7
-
54
-
-
84873635293
-
Genome instability and aging
-
J. Vijg, and Y. Suh Genome instability and aging Annu. Rev. Physiol. 75 2013 645 668
-
(2013)
Annu. Rev. Physiol.
, vol.75
, pp. 645-668
-
-
Vijg, J.1
Suh, Y.2
-
55
-
-
84902075251
-
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
-
S.A. Villeda, K.E. Plambeck, J. Middeldorp, J.M. Castellano, K.I. Mosher, J. Luo, L.K. Smith, G. Bieri, K. Lin, D. Berdnik, and et al. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice Nat. Med. 20 2014 659 663
-
(2014)
Nat. Med.
, vol.20
, pp. 659-663
-
-
Villeda, S.A.1
Plambeck, K.E.2
Middeldorp, J.3
Castellano, J.M.4
Mosher, K.I.5
Luo, J.6
Smith, L.K.7
Bieri, G.8
Lin, K.9
Berdnik, D.10
-
56
-
-
84928963751
-
Widespread Proteome Remodeling and Aggregation in Aging C. elegans
-
D.M. Walther, P. Kasturi, M. Zheng, S. Pinkert, G. Vecchi, P. Ciryam, R.I. Morimoto, C.M. Dobson, M. Vendruscolo, M. Mann, and F.U. Hartl Widespread Proteome Remodeling and Aggregation in Aging C. elegans Cell 161 2015 919 932
-
(2015)
Cell
, vol.161
, pp. 919-932
-
-
Walther, D.M.1
Kasturi, P.2
Zheng, M.3
Pinkert, S.4
Vecchi, G.5
Ciryam, P.6
Morimoto, R.I.7
Dobson, C.M.8
Vendruscolo, M.9
Mann, M.10
Hartl, F.U.11
-
57
-
-
66149167336
-
DNA damage response and cellular senescence in tissues of aging mice
-
C. Wang, D. Jurk, M. Maddick, G. Nelson, C. Martin-Ruiz, and T. von Zglinicki DNA damage response and cellular senescence in tissues of aging mice Aging Cell 8 2009 311 323
-
(2009)
Aging Cell
, vol.8
, pp. 311-323
-
-
Wang, C.1
Jurk, D.2
Maddick, M.3
Nelson, G.4
Martin-Ruiz, C.5
Von Zglinicki, T.6
-
58
-
-
84896696454
-
Interferon regulatory factor 3 constrains IKKβ/NF-κB signaling to alleviate hepatic steatosis and insulin resistance
-
X.A. Wang, R. Zhang, Z.G. She, X.F. Zhang, D.S. Jiang, T. Wang, L. Gao, W. Deng, S.M. Zhang, L.H. Zhu, and et al. Interferon regulatory factor 3 constrains IKKβ/NF-κB signaling to alleviate hepatic steatosis and insulin resistance Hepatology 59 2014 870 885
-
(2014)
Hepatology
, vol.59
, pp. 870-885
-
-
Wang, X.A.1
Zhang, R.2
She, Z.G.3
Zhang, X.F.4
Jiang, D.S.5
Wang, T.6
Gao, L.7
Deng, W.8
Zhang, S.M.9
Zhu, L.H.10
-
59
-
-
84896822092
-
Type 2 diabetes as a redox disease
-
J.D. Watson Type 2 diabetes as a redox disease Lancet 383 2014 841 843
-
(2014)
Lancet
, vol.383
, pp. 841-843
-
-
Watson, J.D.1
-
60
-
-
84923325979
-
D-Glucosamine supplementation extends life span of nematodes and of ageing mice
-
S. Weimer, J. Priebs, D. Kuhlow, M. Groth, S. Priebe, J. Mansfeld, T.L. Merry, S. Dubuis, B. Laube, A.F. Pfeiffer, and et al. D-Glucosamine supplementation extends life span of nematodes and of ageing mice Nat. Commun. 5 2014 3563
-
(2014)
Nat. Commun.
, vol.5
, pp. 3563
-
-
Weimer, S.1
Priebs, J.2
Kuhlow, D.3
Groth, M.4
Priebe, S.5
Mansfeld, J.6
Merry, T.L.7
Dubuis, S.8
Laube, B.9
Pfeiffer, A.F.10
-
61
-
-
84900299463
-
The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans
-
C. Yee, W. Yang, and S. Hekimi The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans Cell 157 2014 897 909
-
(2014)
Cell
, vol.157
, pp. 897-909
-
-
Yee, C.1
Yang, W.2
Hekimi, S.3
-
62
-
-
84879888338
-
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
-
S. Yoshimoto, T.M. Loo, K. Atarashi, H. Kanda, S. Sato, S. Oyadomari, Y. Iwakura, K. Oshima, H. Morita, M. Hattori, and et al. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome Nature 499 2013 97 101
-
(2013)
Nature
, vol.499
, pp. 97-101
-
-
Yoshimoto, S.1
Loo, T.M.2
Atarashi, K.3
Kanda, H.4
Sato, S.5
Oyadomari, S.6
Iwakura, Y.7
Oshima, K.8
Morita, H.9
Hattori, M.10
-
63
-
-
84885167222
-
Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging
-
Y.H. Youm, R.W. Grant, L.R. McCabe, D.C. Albarado, K.Y. Nguyen, A. Ravussin, P. Pistell, S. Newman, R. Carter, A. Laque, and et al. Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging Cell Metab. 18 2013 519 532
-
(2013)
Cell Metab.
, vol.18
, pp. 519-532
-
-
Youm, Y.H.1
Grant, R.W.2
McCabe, L.R.3
Albarado, D.C.4
Nguyen, K.Y.5
Ravussin, A.6
Pistell, P.7
Newman, S.8
Carter, R.9
Laque, A.10
-
64
-
-
51349095898
-
Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function
-
C. Zhang, and A.M. Cuervo Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function Nat. Med. 14 2008 959 965
-
(2008)
Nat. Med.
, vol.14
, pp. 959-965
-
-
Zhang, C.1
Cuervo, A.M.2
-
65
-
-
32044453080
-
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
-
K. Zhang, X. Shen, J. Wu, K. Sakaki, T. Saunders, D.T. Rutkowski, S.H. Back, and R.J. Kaufman Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response Cell 124 2006 587 599
-
(2006)
Cell
, vol.124
, pp. 587-599
-
-
Zhang, K.1
Shen, X.2
Wu, J.3
Sakaki, K.4
Saunders, T.5
Rutkowski, D.T.6
Back, S.H.7
Kaufman, R.J.8
-
66
-
-
84877734347
-
Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH
-
G. Zhang, J. Li, S. Purkayastha, Y. Tang, H. Zhang, Y. Yin, B. Li, G. Liu, and D. Cai Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH Nature 497 2013 211 216
-
(2013)
Nature
, vol.497
, pp. 211-216
-
-
Zhang, G.1
Li, J.2
Purkayastha, S.3
Tang, Y.4
Zhang, H.5
Yin, Y.6
Li, B.7
Liu, G.8
Cai, D.9
-
67
-
-
84929435164
-
Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging
-
W. Zhang, J. Li, K. Suzuki, J. Qu, P. Wang, J. Zhou, X. Liu, R. Ren, X. Xu, A. Ocampo, and et al. Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging Science 348 2015 1160 1163
-
(2015)
Science
, vol.348
, pp. 1160-1163
-
-
Zhang, W.1
Li, J.2
Suzuki, K.3
Qu, J.4
Wang, P.5
Zhou, J.6
Liu, X.7
Ren, R.8
Xu, X.9
Ocampo, A.10
|