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Volumn 59, Issue 3, 2014, Pages 870-885

Interferon regulatory factor 3 constrains IKKβ/NF-κB signaling to alleviate hepatic steatosis and insulin resistance

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; LIPID;

EID: 84896696454     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.26751     Document Type: Article
Times cited : (134)

References (42)
  • 1
    • 84871090162 scopus 로고    scopus 로고
    • Global obesity: trends, risk factors and policy implications
    • Malik VS, Willett WC, Hu FB. Global obesity: trends, risk factors and policy implications. Nat Rev Endocrinol 2012;9:13-27.
    • (2012) Nat Rev Endocrinol , vol.9 , pp. 13-27
    • Malik, V.S.1    Willett, W.C.2    Hu, F.B.3
  • 2
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006;444:860-867.
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 4
    • 77955806634 scopus 로고    scopus 로고
    • JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction
    • Solinas G, Karin M. JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction. FASEB J 2010;24:2596-2611.
    • (2010) FASEB J , vol.24 , pp. 2596-2611
    • Solinas, G.1    Karin, M.2
  • 5
    • 77950343252 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    • Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010;140:900-917.
    • (2010) Cell , vol.140 , pp. 900-917
    • Hotamisligil, G.S.1
  • 7
    • 34247636362 scopus 로고    scopus 로고
    • PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism
    • Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, et al. PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. PLoS Genet 2007;3:e64.
    • (2007) PLoS Genet , vol.3
    • Medina-Gomez, G.1    Gray, S.L.2    Yetukuri, L.3    Shimomura, K.4    Virtue, S.5    Campbell, M.6
  • 8
    • 78650878363 scopus 로고    scopus 로고
    • NF-κB, inflammation, and metabolic disease
    • Baker RG, Hayden MS, Ghosh S. NF-κB, inflammation, and metabolic disease. Cell Metab 2011;13:11-22.
    • (2011) Cell Metab , vol.13 , pp. 11-22
    • Baker, R.G.1    Hayden, M.S.2    Ghosh, S.3
  • 10
    • 84857861919 scopus 로고    scopus 로고
    • Mechanisms for insulin resistance: common threads and missing links
    • Samuel VT, Shulman GI. Mechanisms for insulin resistance: common threads and missing links. Cell 2012;148:852-871.
    • (2012) Cell , vol.148 , pp. 852-871
    • Samuel, V.T.1    Shulman, G.I.2
  • 11
    • 42649114059 scopus 로고    scopus 로고
    • The IRF family transcription factors in immunity and oncogenesis
    • Tamura T, Yanai H, Savitsky D, Taniguchi T. The IRF family transcription factors in immunity and oncogenesis. Annu Rev Immunol 2008;26:535-584.
    • (2008) Annu Rev Immunol , vol.26 , pp. 535-584
    • Tamura, T.1    Yanai, H.2    Savitsky, D.3    Taniguchi, T.4
  • 12
    • 84872013157 scopus 로고    scopus 로고
    • Interferon regulatory factor 3 is a negative regulator of pathological cardiac hypertrophy
    • Lu J, Bian ZY, Zhang R, Zhang Y, Liu C, Yan L, et al. Interferon regulatory factor 3 is a negative regulator of pathological cardiac hypertrophy. Basic Res Cardiol 2013;108:326.
    • (2013) Basic Res Cardiol , vol.108 , pp. 326
    • Lu, J.1    Bian, Z.Y.2    Zhang, R.3    Zhang, Y.4    Liu, C.5    Yan, L.6
  • 13
    • 84878913857 scopus 로고    scopus 로고
    • Role of interferon regulatory factor 4 in the regulation of pathological cardiac hypertrophy
    • Jiang DS, Bian ZY, Zhang Y, Zhang SM, Liu Y, Zhang R, et al. Role of interferon regulatory factor 4 in the regulation of pathological cardiac hypertrophy. Hypertension 2013;61:1193-1202.
    • (2013) Hypertension , vol.61 , pp. 1193-1202
    • Jiang, D.S.1    Bian, Z.Y.2    Zhang, Y.3    Zhang, S.M.4    Liu, Y.5    Zhang, R.6
  • 14
    • 84881030779 scopus 로고    scopus 로고
    • Interferon regulatory factor 9 protects against hepatic insulin resistance and steatosis in male mice
    • Wang XA, Zhang R, Jiang D, Deng W, Zhang S, Deng S, et al. Interferon regulatory factor 9 protects against hepatic insulin resistance and steatosis in male mice. Hepatology 2013;58:603-616.
    • (2013) Hepatology , vol.58 , pp. 603-616
    • Wang, X.A.1    Zhang, R.2    Jiang, D.3    Deng, W.4    Zhang, S.5    Deng, S.6
  • 15
    • 84881642190 scopus 로고    scopus 로고
    • Interferon regulatory factor 7 deficiency prevents diet-induced obesity and insulin resistance
    • Wang XA, Zhang R, Zhang S, Deng S, Jiang D, Zhong J, et al. Interferon regulatory factor 7 deficiency prevents diet-induced obesity and insulin resistance. Am J Physiol Endocrinol Metab 2013;305:E485-495.
    • (2013) Am J Physiol Endocrinol Metab , vol.305
    • Wang, X.A.1    Zhang, R.2    Zhang, S.3    Deng, S.4    Jiang, D.5    Zhong, J.6
  • 16
    • 37449021303 scopus 로고    scopus 로고
    • Interferon regulatory factors are transcriptional regulators of adipogenesis
    • Eguchi J, Yan QW, Schones DE, Kamal M, Hsu CH, Zhang MQ, et al. Interferon regulatory factors are transcriptional regulators of adipogenesis. Cell Metab 2008;7:86-94.
    • (2008) Cell Metab , vol.7 , pp. 86-94
    • Eguchi, J.1    Yan, Q.W.2    Schones, D.E.3    Kamal, M.4    Hsu, C.H.5    Zhang, M.Q.6
  • 18
    • 38949212626 scopus 로고    scopus 로고
    • Interferon regulatory factor family of transcription factors and regulation of oncogenesis
    • Takaoka A, Tamura T, Taniguchi T. Interferon regulatory factor family of transcription factors and regulation of oncogenesis. Cancer Sci 2008;99:467-478.
    • (2008) Cancer Sci , vol.99 , pp. 467-478
    • Takaoka, A.1    Tamura, T.2    Taniguchi, T.3
  • 19
    • 33748051738 scopus 로고    scopus 로고
    • IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors
    • Honda K, Taniguchi T. IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat Rev Immunol 2006;6:644-658.
    • (2006) Nat Rev Immunol , vol.6 , pp. 644-658
    • Honda, K.1    Taniguchi, T.2
  • 20
    • 0018864840 scopus 로고
    • Regulation of hepatic fatty acid oxidation and ketone body production
    • McGarry JD, Foster DW. Regulation of hepatic fatty acid oxidation and ketone body production. Annu Rev Biochem 1980;49:395-420.
    • (1980) Annu Rev Biochem , vol.49 , pp. 395-420
    • McGarry, J.D.1    Foster, D.W.2
  • 21
    • 0028085078 scopus 로고
    • The insulin signaling system
    • White MF, Kahn CR. The insulin signaling system. J Biol Chem 1994;269:1-4.
    • (1994) J Biol Chem , vol.269 , pp. 1-4
    • White, M.F.1    Kahn, C.R.2
  • 22
    • 79955661493 scopus 로고    scopus 로고
    • Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver
    • Li Y, Xu S, Giles A, Nakamura K, Lee JW, Hou X, et al. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB J 2011;25:1664-1679.
    • (2011) FASEB J , vol.25 , pp. 1664-1679
    • Li, Y.1    Xu, S.2    Giles, A.3    Nakamura, K.4    Lee, J.W.5    Hou, X.6
  • 24
    • 33845768987 scopus 로고    scopus 로고
    • Integrating cell-signalling pathways with NF-kappaB and IKK function
    • Perkins ND. Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 2007;8:49-62.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 49-62
    • Perkins, N.D.1
  • 25
    • 79151478555 scopus 로고    scopus 로고
    • Type 2 diabetes as an inflammatory disease
    • Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 2011;11:98-107.
    • (2011) Nat Rev Immunol , vol.11 , pp. 98-107
    • Donath, M.Y.1    Shoelson, S.E.2
  • 26
    • 52949096557 scopus 로고    scopus 로고
    • Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
    • Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 2008;135:61-73.
    • (2008) Cell , vol.135 , pp. 61-73
    • Zhang, X.1    Zhang, G.2    Zhang, H.3    Karin, M.4    Bai, H.5    Cai, D.6
  • 27
    • 84867051812 scopus 로고    scopus 로고
    • IKKbeta/NF-kappaB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes
    • Li J, Tang Y, Cai D. IKKbeta/NF-kappaB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes. Nat Cell Biol 2012;14:999-1012.
    • (2012) Nat Cell Biol , vol.14 , pp. 999-1012
    • Li, J.1    Tang, Y.2    Cai, D.3
  • 28
    • 38949119419 scopus 로고    scopus 로고
    • Salsalate improves glycemia and inflammatory parameters in obese young adults
    • Fleischman A, Shoelson SE, Bernier R, Goldfine AB. Salsalate improves glycemia and inflammatory parameters in obese young adults. Diabetes Care 2008;31:289-294.
    • (2008) Diabetes Care , vol.31 , pp. 289-294
    • Fleischman, A.1    Shoelson, S.E.2    Bernier, R.3    Goldfine, A.B.4
  • 30
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
    • Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, et al. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 2001;293:1673-1677.
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3    Hansen, L.4    Li, Z.W.5    Karin, M.6
  • 31
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
    • Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 2005;11:183-190.
    • (2005) Nat Med , vol.11 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3    Melendez, P.A.4    Hansen, L.5    Lee, J.6
  • 33
    • 84875221877 scopus 로고    scopus 로고
    • Blockade of receptor activator of nuclear factor-kappaB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus
    • Kiechl S, Wittmann J, Giaccari A, Knoflach M, Willeit P, Bozec A, et al. Blockade of receptor activator of nuclear factor-kappaB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus. Nat Med 2013;19:358-363.
    • (2013) Nat Med , vol.19 , pp. 358-363
    • Kiechl, S.1    Wittmann, J.2    Giaccari, A.3    Knoflach, M.4    Willeit, P.5    Bozec, A.6
  • 34
    • 33845490856 scopus 로고    scopus 로고
    • Review: the role of insulin resistance in nonalcoholic fatty liver disease
    • Utzschneider KM, Kahn SE. Review: the role of insulin resistance in nonalcoholic fatty liver disease. J Clin Endocrinol Metab 2006;91:4753-4761.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 4753-4761
    • Utzschneider, K.M.1    Kahn, S.E.2
  • 35
    • 55649103668 scopus 로고    scopus 로고
    • Insulin resistance, inflammation, and non-alcoholic fatty liver disease
    • Tilg H, Moschen AR. Insulin resistance, inflammation, and non-alcoholic fatty liver disease. Trends Endocrinol Metab 2008;19:371-379.
    • (2008) Trends Endocrinol Metab , vol.19 , pp. 371-379
    • Tilg, H.1    Moschen, A.R.2
  • 36
    • 39049183044 scopus 로고    scopus 로고
    • Regulation and function of IKK and IKK-related kinases
    • Hacker H, Karin M. Regulation and function of IKK and IKK-related kinases. Sci STKE 2006;2006:re13.
    • (2006) Sci STKE , vol.2006
    • Hacker, H.1    Karin, M.2
  • 37
    • 0031893220 scopus 로고    scopus 로고
    • Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation
    • Lin R, Heylbroeck C, Pitha PM, Hiscott J. Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. Mol Cell Biol 1998;18:2986-2996.
    • (1998) Mol Cell Biol , vol.18 , pp. 2986-2996
    • Lin, R.1    Heylbroeck, C.2    Pitha, P.M.3    Hiscott, J.4
  • 38
    • 0347065364 scopus 로고    scopus 로고
    • Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa
    • Wietek C, Miggin SM, Jefferies CA, O'Neill LA. Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa. J Biol Chem 2003;278:50923-50931.
    • (2003) J Biol Chem , vol.278 , pp. 50923-50931
    • Wietek, C.1    Miggin, S.M.2    Jefferies, C.A.3    O'Neill, L.A.4
  • 39
    • 4644252538 scopus 로고    scopus 로고
    • One nucleotide in a κB site can determine cofactor specificity for NF-κB dimers
    • Leung TH, Hoffmann A, Baltimore D. One nucleotide in a κB site can determine cofactor specificity for NF-κB dimers. Cell 2004;118:453-464.
    • (2004) Cell , vol.118 , pp. 453-464
    • Leung, T.H.1    Hoffmann, A.2    Baltimore, D.3
  • 40
    • 24144465889 scopus 로고    scopus 로고
    • Molecular determinants of crosstalk between nuclear receptors and Toll-like receptors
    • Ogawa S, Lozach J, Benner C, Pascual G, Tangirala RK, Westin S, et al. Molecular determinants of crosstalk between nuclear receptors and Toll-like receptors. Cell 2005;122:707-721.
    • (2005) Cell , vol.122 , pp. 707-721
    • Ogawa, S.1    Lozach, J.2    Benner, C.3    Pascual, G.4    Tangirala, R.K.5    Westin, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.