A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

Science

Volumn 348, Issue 6239, 2015, Pages 1160-1163

  Zhang, Weiqi ^a   Li, Jingyi ^b   Suzuki, Keiichiro ^c   Qu, Jing ^d   Wang, Ping ^a   Zhou, Junzhi ^a   Liu, Xiaomeng ^b   Ren, Ruotong ^a   Xu, Xiuling ^a   Ocampo, Alejandro ^c   Yuan, Tingting ^a   Yang, Jiping ^a   Li, Ying ^a   Shi, Liang ^e   Guan, Dee ^a   Pan, Huize ^a   Duan, Shunlei ^a   Ding, Zhichao ^a   Li, Mo ^c   Yi, Fei ^f   Bai, Ruijun ^d   Wang, Yayu ^e   Chen, Chang ^a   Yang, Fuquan ^a   Li, Xiaoyu ^b   Wang, Zimei ^g   Aizawa, Emi ^c   Goebl, April ^c,h   Soligalla, Rupa Devi ^c   Reddy, Pradeep ^c   Esteban, Concepcion Rodriguez ^c   Tang, Fuchou ^b,i,j   Liu, Guang Hui ^a,g,j,k   Belmonte, Juan Carlos Izpisua ^c   more..

^a INSTITUTE OF BIOPHYSICS   (China)

^b PEKING UNIVERSITY   (China)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^d INSTITUTE OF ZOOLOGY   (China)

^e 306 HOSPITAL OF PLA   (China)

^f STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g SHENZHEN UNIVERSITY   (China)

^h CATHOLIC UNIVERSITY OF MURCIA   (Spain)

ⁱ BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^j Center for Molecular and Translational Medicine (CMTM)   (China)

^k BEIJING INSTITUTE FOR BRAIN DISORDERS   (China)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H3; WERNER SYNDROME PROTEIN; DNA BINDING PROTEIN; EXODEOXYRIBONUCLEASE; HETEROCHROMATIN; HETEROCHROMATIN-SPECIFIC NONHISTONE CHROMOSOMAL PROTEIN HP-1; LAMINA-ASSOCIATED POLYPEPTIDE 2; MEMBRANE PROTEIN; METHYLTRANSFERASE; NONHISTONE PROTEIN; RECQ HELICASE; REPRESSOR PROTEIN; SUV39H1 PROTEIN, HUMAN; WRN PROTEIN, HUMAN;

AGING; CHROMOSOME; EMBRYO; GENETIC ENGINEERING; GERM CELL; PROTEIN; SENESCENCE;

ARTICLE; CELL AGING; CELL DIFFERENTIATION; CELL NUCLEUS MEMBRANE; CHROMATIN IMMUNOPRECIPITATION; CHROMATIN STRUCTURE; CONTROLLED STUDY; COPY NUMBER VARIATION; EMBRYONIC STEM CELL; GENE MUTATION; GENETIC MODEL; HETEROCHROMATIN; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; NUCLEAR LAMINA; PHENOTYPE; PREMATURE AGING; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WERNER SYNDROME; WILD TYPE; AGING; ANIMAL; BIOLOGICAL MODEL; CENTROMERE; CHEMISTRY; GENE INACTIVATION; GENETIC EPIGENESIS; GENETICS; HEK293 CELL LINE; MESENCHYMAL STROMA CELL; METABOLISM; MOUSE;

AGING; ANIMALS; CELL AGING; CELL DIFFERENTIATION; CENTROMERE; CHROMOSOMAL PROTEINS, NON-HISTONE; DNA-BINDING PROTEINS; EPIGENESIS, GENETIC; EXODEOXYRIBONUCLEASES; GENE KNOCKOUT TECHNIQUES; HEK293 CELLS; HETEROCHROMATIN; HUMANS; MEMBRANE PROTEINS; MESENCHYMAL STROMAL CELLS; METHYLTRANSFERASES; MICE; MODELS, BIOLOGICAL; RECQ HELICASES; REPRESSOR PROTEINS; WERNER SYNDROME;

EID: 84929435164     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaa1356     Document Type: Article

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