-
1
-
-
56549089781
-
Mitochondrial DNA damage is a hallmark of chemically induced and the R6/2 transgenic model of Huntington's disease
-
Acevedo-Torres K, Berrios L, Rosario N, Dufault V, Skatchkov S, Eaton MJ, Torres-Ramos CA, Ayala-Torres S (2009) Mitochondrial DNA damage is a hallmark of chemically induced and the R6/2 transgenic model of Huntington's disease. DNA Repair (Amst.) 8, 126-136.
-
(2009)
DNA Repair (Amst.)
, vol.8
, pp. 126-136
-
-
Acevedo-Torres, K.1
Berrios, L.2
Rosario, N.3
Dufault, V.4
Skatchkov, S.5
Eaton, M.J.6
Torres-Ramos, C.A.7
Ayala-Torres, S.8
-
2
-
-
0344172784
-
Measurement of oxidatively induced base lesions in liver from Wistar rats of different ages
-
Anson RM, Senturker S, Dizdaroglu M, Bohr VA (1999) Measurement of oxidatively induced base lesions in liver from Wistar rats of different ages. Free Radic. Biol. Med. 27, 456-462.
-
(1999)
Free Radic. Biol. Med.
, vol.27
, pp. 456-462
-
-
Anson, R.M.1
Senturker, S.2
Dizdaroglu, M.3
Bohr, V.A.4
-
3
-
-
0031916984
-
The free radical theory of aging matures
-
Beckman KB, Ames BN (1998) The free radical theory of aging matures. Physiol. Rev. 78, 547-581.
-
(1998)
Physiol. Rev.
, vol.78
, pp. 547-581
-
-
Beckman, K.B.1
Ames, B.N.2
-
4
-
-
0021905437
-
DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall
-
Bohr VA, Smith CA, Okumoto DS, Hanawalt PC (1985) DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall. Cell 40, 359-369.
-
(1985)
Cell
, vol.40
, pp. 359-369
-
-
Bohr, V.A.1
Smith, C.A.2
Okumoto, D.S.3
Hanawalt, P.C.4
-
5
-
-
80052359532
-
Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair
-
Borgesius NZ, de Waard MC, van der Pluijm I, Omrani A, Zondag GC, van der Horst GT, Melton DW, Hoeijmakers JH, Jaarsma D, Elgersma Y (2011) Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair. J. Neurosci. 31, 12543-12553.
-
(2011)
J. Neurosci.
, vol.31
, pp. 12543-12553
-
-
Borgesius, N.Z.1
de Waard, M.C.2
van der Pluijm, I.3
Omrani, A.4
Zondag, G.C.5
van der Horst, G.T.6
Melton, D.W.7
Hoeijmakers, J.H.8
Jaarsma, D.9
Elgersma, Y.10
-
6
-
-
38049044432
-
Intra-organ variation in age-related mutation accumulation in the mouse
-
Busuttil RA, Garcia AM, Reddick RL, Dolle ME, Calder RB, Nelson JF, Vijg J (2007) Intra-organ variation in age-related mutation accumulation in the mouse. PLoS ONE 2, e876.
-
(2007)
PLoS ONE
, vol.2
-
-
Busuttil, R.A.1
Garcia, A.M.2
Reddick, R.L.3
Dolle, M.E.4
Calder, R.B.5
Nelson, J.F.6
Vijg, J.7
-
7
-
-
55149105227
-
Effect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cells
-
Busuttil RA, Munoz DP, Garcia AM, Rodier F, Kim WH, Suh Y, Hasty P, Campisi J, Vijg J (2008) Effect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cells. PLoS ONE 3, e3458.
-
(2008)
PLoS ONE
, vol.3
-
-
Busuttil, R.A.1
Munoz, D.P.2
Garcia, A.M.3
Rodier, F.4
Kim, W.H.5
Suh, Y.6
Hasty, P.7
Campisi, J.8
Vijg, J.9
-
8
-
-
0031431666
-
Problems in the measurement of 8-oxoguanine in human DNA. Report of a workshop, DNA oxidation, held in Aberdeen, UK, 19-21 January, 1997
-
Collins A, Cadet J, Epe B, Gedik C (1997) Problems in the measurement of 8-oxoguanine in human DNA. Report of a workshop, DNA oxidation, held in Aberdeen, UK, 19-21 January, 1997. Carcinogenesis 18, 1833-1836.
-
(1997)
Carcinogenesis
, vol.18
, pp. 1833-1836
-
-
Collins, A.1
Cadet, J.2
Epe, B.3
Gedik, C.4
-
9
-
-
1042278890
-
Are we sure we know how to measure 8-oxo-7,8-dihydroguanine in DNA from human cells?
-
Collins AR, Cadet J, Moller L, Poulsen HE, Vina J (2004) Are we sure we know how to measure 8-oxo-7, 8-dihydroguanine in DNA from human cells? Arch. Biochem. Biophys. 423, 57-65.
-
(2004)
Arch. Biochem. Biophys.
, vol.423
, pp. 57-65
-
-
Collins, A.R.1
Cadet, J.2
Moller, L.3
Poulsen, H.E.4
Vina, J.5
-
10
-
-
0038799736
-
Oxidative DNA damage: mechanisms, mutation, and disease
-
Cooke MS, Evans MD, Dizdaroglu M, Lunec J (2003) Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J. 17, 1195-1214.
-
(2003)
FASEB J.
, vol.17
, pp. 1195-1214
-
-
Cooke, M.S.1
Evans, M.D.2
Dizdaroglu, M.3
Lunec, J.4
-
11
-
-
2942523593
-
Endogenous DNA damage in humans: a review of quantitative data
-
De Bont R, van Larebeke N (2004) Endogenous DNA damage in humans: a review of quantitative data. Mutagenesis 19, 169-185.
-
(2004)
Mutagenesis
, vol.19
, pp. 169-185
-
-
De Bont, R.1
van Larebeke, N.2
-
12
-
-
0030699271
-
Rapid accumulation of genome rearrangements in liver but not in brain of old mice
-
Dollé ME, Giese H, Hopkins CL, Martus HJ, Hausdorff JM, Vijg J (1997) Rapid accumulation of genome rearrangements in liver but not in brain of old mice. Nat. Genet. 17, 431-434.
-
(1997)
Nat. Genet.
, vol.17
, pp. 431-434
-
-
Dollé, M.E.1
Giese, H.2
Hopkins, C.L.3
Martus, H.J.4
Hausdorff, J.M.5
Vijg, J.6
-
13
-
-
33645980992
-
Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice
-
Dollé ME, Busuttil RA, Garcia AM, Wijnhoven S, van Drunen E, Niedernhofer LJ, van der Horst G, Hoeijmakers JH, van Steeg H, Vijg J (2006) Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice. Mutat. Res. 596, 22-35.
-
(2006)
Mutat. Res.
, vol.596
, pp. 22-35
-
-
Dollé, M.E.1
Busuttil, R.A.2
Garcia, A.M.3
Wijnhoven, S.4
van Drunen, E.5
Niedernhofer, L.J.6
van der Horst, G.7
Hoeijmakers, J.H.8
van Steeg, H.9
Vijg, J.10
-
14
-
-
84868570176
-
Analysis of DNA damage and repair in nuclear and mitochondrial DNA of animal cells using quantitative PCR
-
Furda AM, Bess AS, Meyer JN, Van Houten B (2012a) Analysis of DNA damage and repair in nuclear and mitochondrial DNA of animal cells using quantitative PCR. Methods Mol. Biol. 920, 111-132.
-
(2012)
Methods Mol. Biol.
, vol.920
, pp. 111-132
-
-
Furda, A.M.1
Bess, A.S.2
Meyer, J.N.3
Van Houten, B.4
-
15
-
-
84864293513
-
Oxidants and not alkylating agents induce rapid mtDNA loss and mitochondrial dysfunction
-
Furda AM, Marrangoni AM, Lokshin A, Van Houten B (2012b) Oxidants and not alkylating agents induce rapid mtDNA loss and mitochondrial dysfunction. DNA Repair (Amst.) 11, 684-692.
-
(2012)
DNA Repair (Amst.)
, vol.11
, pp. 684-692
-
-
Furda, A.M.1
Marrangoni, A.M.2
Lokshin, A.3
Van Houten, B.4
-
16
-
-
55549116359
-
DNA damage and ageing: new-age ideas for an age-old problem
-
Garinis GA, van der Horst GT, Vijg J, Hoeijmakers JH (2008) DNA damage and ageing: new-age ideas for an age-old problem. Nat. Cell Biol. 10, 1241-1247.
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 1241-1247
-
-
Garinis, G.A.1
van der Horst, G.T.2
Vijg, J.3
Hoeijmakers, J.H.4
-
17
-
-
84856404122
-
A mouse model of accelerated liver aging caused by a defect in DNA repair
-
Gregg SQ, Gutierrez V, Robinson AR, Woodell T, Nakao A, Ross MA, Michalopoulos GK, Rigatti L, Rothermel CE, Kamileri I, Garinis GA, Stolz DB, Niedernhofer LJ (2012) A mouse model of accelerated liver aging caused by a defect in DNA repair. Hepatology 55, 609-621.
-
(2012)
Hepatology
, vol.55
, pp. 609-621
-
-
Gregg, S.Q.1
Gutierrez, V.2
Robinson, A.R.3
Woodell, T.4
Nakao, A.5
Ross, M.A.6
Michalopoulos, G.K.7
Rigatti, L.8
Rothermel, C.E.9
Kamileri, I.10
Garinis, G.A.11
Stolz, D.B.12
Niedernhofer, L.J.13
-
18
-
-
0034646304
-
Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice
-
Gu Y, Sekiguchi J, Gao Y, Dikkes P, Frank K, Ferguson D, Hasty P, Chun J, Alt FW (2000) Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice. Proc Natl Acad Sci U.S.A. 97, 2668-2673.
-
(2000)
Proc Natl Acad Sci U.S.A.
, vol.97
, pp. 2668-2673
-
-
Gu, Y.1
Sekiguchi, J.2
Gao, Y.3
Dikkes, P.4
Frank, K.5
Ferguson, D.6
Hasty, P.7
Chun, J.8
Alt, F.W.9
-
19
-
-
0037470542
-
Aging and genome maintenance: lessons from the mouse?
-
Hasty P, Campisi J, Hoeijmakers J, van Steeg H, Vijg J (2003) Aging and genome maintenance: lessons from the mouse? Science 299, 1355-1359.
-
(2003)
Science
, vol.299
, pp. 1355-1359
-
-
Hasty, P.1
Campisi, J.2
Hoeijmakers, J.3
van Steeg, H.4
Vijg, J.5
-
20
-
-
33847313312
-
Characterisation of Ercc1 deficiency in the liver and in conditional Ercc1-deficient primary hepatocytes in vitro
-
Kirschner K, Singh R, Prost S, Melton DW (2007) Characterisation of Ercc1 deficiency in the liver and in conditional Ercc1-deficient primary hepatocytes in vitro. DNA Repair (Amst.) 6, 304-316.
-
(2007)
DNA Repair (Amst.)
, vol.6
, pp. 304-316
-
-
Kirschner, K.1
Singh, R.2
Prost, S.3
Melton, D.W.4
-
21
-
-
65649138401
-
The comet assay: a sensitive method for detecting DNA damage in individual cells
-
Liao W, McNutt MA, Zhu WG (2009) The comet assay: a sensitive method for detecting DNA damage in individual cells. Methods 48, 46-53.
-
(2009)
Methods
, vol.48
, pp. 46-53
-
-
Liao, W.1
McNutt, M.A.2
Zhu, W.G.3
-
22
-
-
0027278557
-
Instability and decay of the primary structure of DNA
-
Lindahl T (1993) Instability and decay of the primary structure of DNA. Nature 362, 709-715.
-
(1993)
Nature
, vol.362
, pp. 709-715
-
-
Lindahl, T.1
-
23
-
-
33744723129
-
Possible acceleration of aging by adjuvant chemotherapy: a cause of early onset frailty?
-
Maccormick RE (2006) Possible acceleration of aging by adjuvant chemotherapy: a cause of early onset frailty? Med. Hypotheses 67, 212-215.
-
(2006)
Med. Hypotheses
, vol.67
, pp. 212-215
-
-
Maccormick, R.E.1
-
24
-
-
84871195942
-
5-Aza-2′-deoxycytidine-induced genome rearrangements are mediated by DNMT1
-
Maslov AY, Lee M, Gundry M, Gravina S, Strogonova N, Tazearslan C, Bendebury A, Suh Y, Vijg J (2012) 5-Aza-2′-deoxycytidine-induced genome rearrangements are mediated by DNMT1. Oncogene 31, 5172-5179.
-
(2012)
Oncogene
, vol.31
, pp. 5172-5179
-
-
Maslov, A.Y.1
Lee, M.2
Gundry, M.3
Gravina, S.4
Strogonova, N.5
Tazearslan, C.6
Bendebury, A.7
Suh, Y.8
Vijg, J.9
-
25
-
-
77951938325
-
Aging and oxidatively damaged nuclear DNA in animal organs
-
Moller P, Lohr M, Folkmann JK, Mikkelsen L, Loft S (2010) Aging and oxidatively damaged nuclear DNA in animal organs. Free Radic. Biol. Med. 48, 1275-1285.
-
(2010)
Free Radic. Biol. Med.
, vol.48
, pp. 1275-1285
-
-
Moller, P.1
Lohr, M.2
Folkmann, J.K.3
Mikkelsen, L.4
Loft, S.5
-
26
-
-
0023775744
-
Age-dependent accumulation of alkali-labile sites in DNA of post-mitotic but not in that of mitotic rat liver cells
-
Mullaart E, Boerrigter ME, Brouwer A, Berends F, Vijg J (1988) Age-dependent accumulation of alkali-labile sites in DNA of post-mitotic but not in that of mitotic rat liver cells. Mech. Ageing Dev. 45, 41-49.
-
(1988)
Mech. Ageing Dev.
, vol.45
, pp. 41-49
-
-
Mullaart, E.1
Boerrigter, M.E.2
Brouwer, A.3
Berends, F.4
Vijg, J.5
-
27
-
-
0025267079
-
Spontaneous DNA breaks in the rat brain during development and aging
-
Mullaart E, Boerrigter ME, Boer GJ, Vijg J (1990) Spontaneous DNA breaks in the rat brain during development and aging. Mutat. Res. 237, 9-15.
-
(1990)
Mutat. Res.
, vol.237
, pp. 9-15
-
-
Mullaart, E.1
Boerrigter, M.E.2
Boer, G.J.3
Vijg, J.4
-
28
-
-
0030745912
-
In vitro repair of oxidative DNA damage by human nucleotide excision repair system: possible explanation for neurodegeneration in xeroderma pigmentosum patients
-
Reardon JT, Bessho T, Kung HC, Bolton PH, Sancar A (1997) In vitro repair of oxidative DNA damage by human nucleotide excision repair system: possible explanation for neurodegeneration in xeroderma pigmentosum patients. Proc. Natl. Acad. Sci. U.S.A. 94, 9463-9468.
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 9463-9468
-
-
Reardon, J.T.1
Bessho, T.2
Kung, H.C.3
Bolton, P.H.4
Sancar, A.5
-
29
-
-
33744721699
-
Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells
-
Santos JH, Meyer JN, Mandavilli BS, Van Houten B (2006) Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells. Methods Mol. Biol. 314, 183-199.
-
(2006)
Methods Mol. Biol.
, vol.314
, pp. 183-199
-
-
Santos, J.H.1
Meyer, J.N.2
Mandavilli, B.S.3
Van Houten, B.4
-
30
-
-
0035890838
-
Correction of liver dysfunction in DNA repair-deficient mice with an ERCC1 transgene
-
Selfridge J, Hsia KT, Redhead NJ, Melton DW (2001) Correction of liver dysfunction in DNA repair-deficient mice with an ERCC1 transgene. Nucleic Acids Res. 29, 4541-4550.
-
(2001)
Nucleic Acids Res.
, vol.29
, pp. 4541-4550
-
-
Selfridge, J.1
Hsia, K.T.2
Redhead, N.J.3
Melton, D.W.4
-
31
-
-
0028305008
-
Substrate specificity of Fpg protein. Recognition and cleavage of oxidatively damaged DNA
-
Tchou J, Bodepudi V, Shibutani S, Antoshechkin I, Miller J, Grollman AP, Johnson F (1994) Substrate specificity of Fpg protein. Recognition and cleavage of oxidatively damaged DNA. J. Biol. Chem. 269, 15318-15324.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 15318-15324
-
-
Tchou, J.1
Bodepudi, V.2
Shibutani, S.3
Antoshechkin, I.4
Miller, J.5
Grollman, A.P.6
Johnson, F.7
-
32
-
-
0034713926
-
Measuring gene-specific nucleotide excision repair in human cells using quantitative amplification of long targets from nanogram quantities of DNA
-
Van Houten B, Cheng S, Chen Y (2000) Measuring gene-specific nucleotide excision repair in human cells using quantitative amplification of long targets from nanogram quantities of DNA. Mutat. Res. 460, 81-94.
-
(2000)
Mutat. Res.
, vol.460
, pp. 81-94
-
-
Van Houten, B.1
Cheng, S.2
Chen, Y.3
-
33
-
-
34047115379
-
-
Oxford: Oxford University Press
-
Vijg J (2007) Aging of the Genome. Oxford: Oxford University Press.
-
(2007)
Aging of the Genome
-
-
Vijg, J.1
-
34
-
-
0032827888
-
Deletion of Ku86 causes early onset of senescence in mice
-
Vogel H, Lim DS, Karsenty G, Finegold M, Hasty P (1999) Deletion of Ku86 causes early onset of senescence in mice. Proc. Natl. Acad. Sci. U.S.A. 96, 10770-10775.
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 10770-10775
-
-
Vogel, H.1
Lim, D.S.2
Karsenty, G.3
Finegold, M.4
Hasty, P.5
-
35
-
-
84864010124
-
The oxidative DNA lesions 8,5′-cyclopurines accumulate with aging in a tissue-specific manner
-
Wang J, Clauson CL, Robbins PD, Niedernhofer LJ, Wang Y (2012) The oxidative DNA lesions 8, 5′-cyclopurines accumulate with aging in a tissue-specific manner. Aging Cell 11, 714-716.
-
(2012)
Aging Cell
, vol.11
, pp. 714-716
-
-
Wang, J.1
Clauson, C.L.2
Robbins, P.D.3
Niedernhofer, L.J.4
Wang, Y.5
-
36
-
-
12644266319
-
Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence
-
Weeda G, Donker I, de Wit J, Morreau H, Janssens R, Vissers CJ, Nigg A, van Steeg H, Bootsma D, Hoeijmakers JH (1997) Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence. Curr. Biol. 7, 427-439.
-
(1997)
Curr. Biol.
, vol.7
, pp. 427-439
-
-
Weeda, G.1
Donker, I.2
de Wit, J.3
Morreau, H.4
Janssens, R.5
Vissers, C.J.6
Nigg, A.7
van Steeg, H.8
Bootsma, D.9
Hoeijmakers, J.H.10
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