-
1
-
-
84877927481
-
mTOR in aging, metabolism, and cancer
-
Cornu, M., Albert, V., and Hall, M. N. (2013) mTOR in aging, metabolism, and cancer. Curr. Opin. Genet. Dev. 23, 53-62
-
(2013)
Curr. Opin. Genet. Dev.
, vol.23
, pp. 53-62
-
-
Cornu, M.1
Albert, V.2
Hall, M.N.3
-
2
-
-
84859778293
-
mTOR signaling in growth control and disease
-
Laplante, M., and Sabatini, D. M. (2012) mTOR signaling in growth control and disease. Cell 149, 274-293
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
3
-
-
84862908818
-
AMPK and mTOR in cellular energy homeostasis and drug targets
-
Inoki, K., Kim, J., and Guan, K. L. (2012) AMPK and mTOR in cellular energy homeostasis and drug targets. Annu. Rev. Pharmacol. Toxicol. 52, 381-400
-
(2012)
Annu. Rev. Pharmacol. Toxicol.
, vol.52
, pp. 381-400
-
-
Inoki, K.1
Kim, J.2
Guan, K.L.3
-
4
-
-
84881479778
-
Targeting the PI3K/AKT/mTOR signaling pathway in glioblastoma: Novel therapeutic agents and advances in understanding
-
Sami, A., and Karsy, M. (2013) Targeting the PI3K/AKT/mTOR signaling pathway in glioblastoma: novel therapeutic agents and advances in understanding. Tumour Biol. 34, 1991-2002
-
(2013)
Tumour Biol.
, vol.34
, pp. 1991-2002
-
-
Sami, A.1
Karsy, M.2
-
5
-
-
7944235758
-
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
-
Jacinto, E., Loewith, R., Schmidt, A., Lin, S., Ruegg, M. A., Hall, A., and Hall, M. N. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat.Cell Biol. 6, 1122-1128
-
(2004)
Nat.Cell Biol.
, vol.6
, pp. 1122-1128
-
-
Jacinto, E.1
Loewith, R.2
Schmidt, A.3
Lin, S.4
Ruegg, M.A.5
Hall, A.6
Hall, M.N.7
-
6
-
-
0036753494
-
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
-
Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J. L., Bonenfant, D., Oppliger, W., Jenoe, P., and Hall, M. N. (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol.Cell 10, 457-468
-
(2002)
Mol.Cell
, vol.10
, pp. 457-468
-
-
Loewith, R.1
Jacinto, E.2
Wullschleger, S.3
Lorberg, A.4
Crespo, J.L.5
Bonenfant, D.6
Oppliger, W.7
Jenoe, P.8
Hall, M.N.9
-
7
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
Sarbassov, D. D., Ali, S. M., Kim, D. H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., and Sabatini, D. M. (2004) Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol. 14, 1296-1302
-
(2004)
Curr. Biol.
, vol.14
, pp. 1296-1302
-
-
Sarbassov, D.D.1
Ali, S.M.2
Kim, D.H.3
Guertin, D.A.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
8
-
-
67349241955
-
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
-
Peterson, T. R., Laplante, M., Thoreen, C. C., Sancak, Y., Kang, S. A., Kuehl, W. M., Gray, N. S., and Sabatini, D. M. (2009) DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 137, 873-886
-
(2009)
Cell
, vol.137
, pp. 873-886
-
-
Peterson, T.R.1
Laplante, M.2
Thoreen, C.C.3
Sancak, Y.4
Kang, S.A.5
Kuehl, W.M.6
Gray, N.S.7
Sabatini, D.M.8
-
9
-
-
0037178786
-
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
-
Kim, D. H., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument-Bromage, H., Tempst, P., and Sabatini, D. M. (2002) mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110, 163-175
-
(2002)
Cell
, vol.110
, pp. 163-175
-
-
Kim, D.H.1
Sarbassov, D.D.2
Ali, S.M.3
King, J.E.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
10
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
-
Hara, K., Maruki, Y., Long, X., Yoshino, K., Oshiro, N., Hidayat, S., Tokunaga, C., Avruch, J., and Yonezawa, K. (2002) Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 110, 177-189
-
(2002)
Cell
, vol.110
, pp. 177-189
-
-
Hara, K.1
Maruki, Y.2
Long, X.3
Yoshino, K.4
Oshiro, N.5
Hidayat, S.6
Tokunaga, C.7
Avruch, J.8
Yonezawa, K.9
-
11
-
-
33749076673
-
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
-
Jacinto, E., Facchinetti, V., Liu, D., Soto, N., Wei, S., Jung, S. Y., Huang, Q., Qin, J., and Su, B. (2006) SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 127, 125-137
-
(2006)
Cell
, vol.127
, pp. 125-137
-
-
Jacinto, E.1
Facchinetti, V.2
Liu, D.3
Soto, N.4
Wei, S.5
Jung, S.Y.6
Huang, Q.7
Qin, J.8
Su, B.9
-
12
-
-
33748471980
-
mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
-
Frias, M. A., Thoreen, C. C., Jaffe, J. D., Schroder, W., Sculley, T., Carr, S. A., and Sabatini, D. M. (2006) mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. Curr. Biol. 16, 1865-1870
-
(2006)
Curr. Biol.
, vol.16
, pp. 1865-1870
-
-
Frias, M.A.1
Thoreen, C.C.2
Jaffe, J.D.3
Schroder, W.4
Sculley, T.5
Carr, S.A.6
Sabatini, D.M.7
-
13
-
-
33751079895
-
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
-
Yang, Q., Inoki, K., Ikenoue, T., and Guan, K. L. (2006) Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev. 20, 2820-2832
-
(2006)
Genes Dev.
, vol.20
, pp. 2820-2832
-
-
Yang, Q.1
Inoki, K.2
Ikenoue, T.3
Guan, K.L.4
-
14
-
-
34347210090
-
Identification of Protor as a novel Rictor-binding component of mTOR complex-2
-
Pearce, L. R., Huang, X., Boudeau, J., Pawlowski, R., Wullschleger, S., Deak, M., Ibrahim, A. F., Gourlay, R., Magnuson, M. A., and Alessi, D. R. (2007) Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem. J. 405, 513-522
-
(2007)
Biochem. J.
, vol.405
, pp. 513-522
-
-
Pearce, L.R.1
Huang, X.2
Boudeau, J.3
Pawlowski, R.4
Wullschleger, S.5
Deak, M.6
Ibrahim, A.F.7
Gourlay, R.8
Magnuson, M.A.9
Alessi, D.R.10
-
15
-
-
43249124698
-
PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis
-
Thedieck, K., Polak, P., Kim, M. L., Molle, K. D., Cohen, A., Jeno, P., Arrieumerlou, C., and Hall, M. N. (2007) PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis. PLoS One 2, e1217
-
(2007)
PLoS One
, vol.2
-
-
Thedieck, K.1
Polak, P.2
Kim, M.L.3
Molle, K.D.4
Cohen, A.5
Jeno, P.6
Arrieumerlou, C.7
Hall, M.N.8
-
16
-
-
34548509880
-
PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling
-
Woo, S. Y., Kim, D. H., Jun, C. B., Kim, Y. M., Haar, E. V., Lee, S. I., Hegg, J. W., Bandhakavi, S., Griffin, T. J., and Kim, D. H. (2007) PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling. J. Biol. Chem. 282, 25604-25612
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 25604-25612
-
-
Woo, S.Y.1
Kim, D.H.2
Jun, C.B.3
Kim, Y.M.4
Haar, E.V.5
Lee, S.I.6
Hegg, J.W.7
Bandhakavi, S.8
Griffin, T.J.9
Kim, D.H.10
-
17
-
-
84859117806
-
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
-
Lamming, D. W., Ye, L., Katajisto, P., Goncalves, M. D., Saitoh, M., Stevens, D. M., Davis, J. G., Salmon, A. B., Richardson, A., Ahima, R. S., Guertin, D. A., Sabatini, D. M., and Baur, J. A. (2012) Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science 335, 1638-1643
-
(2012)
Science
, vol.335
, pp. 1638-1643
-
-
Lamming, D.W.1
Ye, L.2
Katajisto, P.3
Goncalves, M.D.4
Saitoh, M.5
Stevens, D.M.6
Davis, J.G.7
Salmon, A.B.8
Richardson, A.9
Ahima, R.S.10
Guertin, D.A.11
Sabatini, D.M.12
Baur, J.A.13
-
18
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
Sarbassov, D. D., Ali, S. M., Sengupta, S., Sheen, J. H., Hsu, P. P., Bagley, A. F., Markhard, A. L., and Sabatini, D. M. (2006) Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol.Cell 22, 159-168
-
(2006)
Mol.Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
Sheen, J.H.4
Hsu, P.P.5
Bagley, A.F.6
Markhard, A.L.7
Sabatini, D.M.8
-
19
-
-
80155142474
-
Rapamycin passes the torch: A new generation of mTOR inhibitors
-
Benjamin, D., Colombi, M., Moroni, C., and Hall, M. N. (2011) Rapamycin passes the torch: a new generation of mTOR inhibitors. Nat. Rev. Drug Discov. 10, 868-880
-
(2011)
Nat. Rev. Drug Discov.
, vol.10
, pp. 868-880
-
-
Benjamin, D.1
Colombi, M.2
Moroni, C.3
Hall, M.N.4
-
20
-
-
65549145048
-
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
-
Thoreen, C. C., Kang, S. A., Chang, J. W., Liu, Q., Zhang, J., Gao, Y., Reichling, L. J., Sim, T., Sabatini, D. M., and Gray, N. S. (2009) An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J. Biol. Chem. 284, 8023-8032
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 8023-8032
-
-
Thoreen, C.C.1
Kang, S.A.2
Chang, J.W.3
Liu, Q.4
Zhang, J.5
Gao, Y.6
Reichling, L.J.7
Sim, T.8
Sabatini, D.M.9
Gray, N.S.10
-
21
-
-
84878532557
-
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output
-
Dibble, C. C., and Manning, B. D. (2013) Signal integration by mTORC1 coordinates nutrient input with biosynthetic output. Nat. Cell Biol. 15, 555-564
-
(2013)
Nat. Cell Biol.
, vol.15
, pp. 555-564
-
-
Dibble, C.C.1
Manning, B.D.2
-
22
-
-
78650510609
-
mTOR: From growth signal integration to cancer, diabetes, and aging
-
Zoncu, R., Efeyan, A., and Sabatini, D. M. (2011) mTOR: from growth signal integration to cancer, diabetes, and aging. Nat. Rev. Mol. Cell Biol. 12, 21-35
-
(2011)
Nat. Rev. Mol. Cell Biol.
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
-
23
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
-
Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R., Reese, C. B., and Cohen, P. (1997) Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr. Biol. 7, 261-269
-
(1997)
Curr. Biol.
, vol.7
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
Holmes, A.B.4
Gaffney, P.R.5
Reese, C.B.6
Cohen, P.7
-
24
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling
-
Inoki, K., Li, Y., Zhu, T., Wu, J., and Guan, K. L. (2002) TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling. Nat. Cell Biol. 4, 648-657
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
25
-
-
0036342294
-
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
-
Manning, B. D., Tee, A. R., Logsdon, M. N., Blenis, J., and Cantley, L. C. (2002) Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol. Cell 10, 151-162
-
(2002)
Mol. Cell
, vol.10
, pp. 151-162
-
-
Manning, B.D.1
Tee, A.R.2
Logsdon, M.N.3
Blenis, J.4
Cantley, L.C.5
-
26
-
-
0038433304
-
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
-
Garami, A., Zwartkruis, F. J., Nobukuni, T., Joaquin, M., Roccio, M., Stocker, H., Kozma, S. C., Hafen, E., Bos, J. L., and Thomas, G. (2003) Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol. Cell 11, 1457-1466
-
(2003)
Mol. Cell
, vol.11
, pp. 1457-1466
-
-
Garami, A.1
Zwartkruis, F.J.2
Nobukuni, T.3
Joaquin, M.4
Roccio, M.5
Stocker, H.6
Kozma, S.C.7
Hafen, E.8
Bos, J.L.9
Thomas, G.10
-
27
-
-
0038304516
-
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
-
Stocker, H., Radimerski, T., Schindelholz, B., Wittwer, F., Belawat, P., Daram, P., Breuer, S., Thomas, G., and Hafen, E. (2003) Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat. Cell Biol. 5, 559-565
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 559-565
-
-
Stocker, H.1
Radimerski, T.2
Schindelholz, B.3
Wittwer, F.4
Belawat, P.5
Daram, P.6
Breuer, S.7
Thomas, G.8
Hafen, E.9
-
28
-
-
0043127125
-
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
-
Inoki, K., Li, Y., Xu, T., and Guan, K. L. (2003) Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 17, 1829-1834
-
(2003)
Genes Dev.
, vol.17
, pp. 1829-1834
-
-
Inoki, K.1
Li, Y.2
Xu, T.3
Guan, K.L.4
-
29
-
-
0038643484
-
Rheb promotes cell growth as a component of the insulin/TOR signaling network
-
Saucedo, L. J., Gao, X., Chiarelli, D. A., Li, L., Pan, D., and Edgar, B. A. (2003) Rheb promotes cell growth as a component of the insulin/TOR signaling network. Nat. Cell Biol. 5, 566-571
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 566-571
-
-
Saucedo, L.J.1
Gao, X.2
Chiarelli, D.A.3
Li, L.4
Pan, D.5
Edgar, B.A.6
-
30
-
-
0042701991
-
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
-
Tee, A. R., Manning, B. D., Roux, P. P., Cantley, L. C., and Blenis, J. (2003) Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr. Biol. 13, 1259-1268
-
(2003)
Curr. Biol.
, vol.13
, pp. 1259-1268
-
-
Tee, A.R.1
Manning, B.D.2
Roux, P.P.3
Cantley, L.C.4
Blenis, J.5
-
31
-
-
77951768486
-
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
-
Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S., and Sabatini, D. M. (2010) Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141, 290-303
-
(2010)
Cell
, vol.141
, pp. 290-303
-
-
Sancak, Y.1
Bar-Peled, L.2
Zoncu, R.3
Markhard, A.L.4
Nada, S.5
Sabatini, D.M.6
-
32
-
-
59749087582
-
Rag proteins regulate amino-acid-induced mTORC1 signaling
-
Sancak, Y., and Sabatini, D. M. (2009) Rag proteins regulate amino-acid-induced mTORC1 signaling. Biochem. Soc. Trans. 37, 289-290
-
(2009)
Biochem. Soc. Trans.
, vol.37
, pp. 289-290
-
-
Sancak, Y.1
Sabatini, D.M.2
-
33
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki, K., Zhu, T., and Guan, K. L. (2003) TSC2 mediates cellular energy response to control cell growth and survival. Cell 115, 577-590
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
34
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., and Shaw, R. J. (2008) AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol.Cell 30, 214-226
-
(2008)
Mol.Cell
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
Turk, B.E.7
Shaw, R.J.8
-
35
-
-
0029103330
-
Control of p70 s6 kinase by kinase activity of FRAP in vivo
-
Brown, E. J., Beal, P. A., Keith, C. T., Chen, J., Shin, T. B., and Schreiber, S. L. (1995) Control of p70 s6 kinase by kinase activity of FRAP in vivo. Nature 377, 441-446
-
(1995)
Nature
, vol.377
, pp. 441-446
-
-
Brown, E.J.1
Beal, P.A.2
Keith, C.T.3
Chen, J.4
Shin, T.B.5
Schreiber, S.L.6
-
36
-
-
0030881836
-
Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin
-
Brunn, G. J., Hudson, C. C., Sekulic, A., Williams, J. M., Hosoi, H., Houghton, P. J., Lawrence, J. C., Jr., and Abraham, R. T. (1997) Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science 277, 99-101
-
(1997)
Science
, vol.277
, pp. 99-101
-
-
Brunn, G.J.1
Hudson, C.C.2
Sekulic, A.3
Williams, J.M.4
Hosoi, H.5
Houghton, P.J.6
Lawrence, J.C.7
Abraham, R.T.8
-
37
-
-
0032539664
-
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
-
Burnett, P. E., Barrow, R. K., Cohen, N. A., Snyder, S. H., and Sabatini, D. M. (1998) RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc. Natl. Acad. Sci. U.S.A. 95, 1432-1437
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 1432-1437
-
-
Burnett, P.E.1
Barrow, R.K.2
Cohen, N.A.3
Snyder, S.H.4
Sabatini, D.M.5
-
38
-
-
77949912176
-
Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1
-
Nascimento, E. B., Snel, M., Guigas, B., van der Zon, G. C., Kriek, J., Maassen, J. A., Jazet, I. M., Diamant, M., and Ouwens, D. M. (2010) Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1. Cell Signal. 22, 961-967
-
(2010)
Cell Signal.
, vol.22
, pp. 961-967
-
-
Nascimento, E.B.1
Snel, M.2
Guigas, B.3
Van Der Zon, G.C.4
Kriek, J.5
Maassen, J.A.6
Jazet, I.M.7
Diamant, M.8
Ouwens, D.M.9
-
39
-
-
34548359244
-
PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex
-
Fonseca, B. D., Smith, E. M., Lee, V. H., MacKintosh, C., and Proud, C. G. (2007) PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex. J. Biol. Chem. 282, 24514-24524
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 24514-24524
-
-
Fonseca, B.D.1
Smith, E.M.2
Lee, V.H.3
MacKintosh, C.4
Proud, C.G.5
-
40
-
-
34547133519
-
The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1
-
Oshiro, N., Takahashi, R., Yoshino, K., Tanimura, K., Nakashima, A., Eguchi, S., Miyamoto, T., Hara, K., Takehana, K., Avruch, J., Kikkawa, U., and Yonezawa, K. (2007) The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1. J. Biol. Chem. 282, 20329-20339
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 20329-20339
-
-
Oshiro, N.1
Takahashi, R.2
Yoshino, K.3
Tanimura, K.4
Nakashima, A.5
Eguchi, S.6
Miyamoto, T.7
Hara, K.8
Takehana, K.9
Avruch, J.10
Kikkawa, U.11
Yonezawa, K.12
-
41
-
-
47049127002
-
Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation
-
Wang, L., Harris, T. E., and Lawrence, J. C., Jr. (2008) Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation. J. Biol. Chem. 283, 15619-15627
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 15619-15627
-
-
Wang, L.1
Harris, T.E.2
Lawrence, J.C.3
-
42
-
-
34247118887
-
Signaling to translation: How signal transduction pathways control the protein synthetic machinery
-
Proud, C. G. (2007) Signaling to translation: how signal transduction pathways control the protein synthetic machinery. Biochem. J. 403, 217-234
-
(2007)
Biochem. J.
, vol.403
, pp. 217-234
-
-
Proud, C.G.1
-
43
-
-
84882884638
-
Translational Control by Amino Acids and Energy
-
Dennis, R. B. a. E., ed.
-
Thedieck, K., and Hall, M. N. (2009) Translational Control by Amino Acids and Energy. In: Dennis, R. B. a. E., ed. The Handbook of Cell Signaling, 2 Ed., pp. 2285-2293
-
(2009)
The Handbook of Cell Signaling, 2 Ed.
, pp. 2285-2293
-
-
Thedieck, K.1
Hall, M.N.2
-
44
-
-
79958696694
-
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling
-
Hsu, P. P., Kang, S. A., Rameseder, J., Zhang, Y., Ottina, K. A., Lim, D., Peterson, T. R., Choi, Y., Gray, N. S., Yaffe, M. B., Marto, J. A., and Sabatini, D. M. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-1322
-
(2011)
Science
, vol.332
, pp. 1317-1322
-
-
Hsu, P.P.1
Kang, S.A.2
Rameseder, J.3
Zhang, Y.4
Ottina, K.A.5
Lim, D.6
Peterson, T.R.7
Choi, Y.8
Gray, N.S.9
Yaffe, M.B.10
Marto, J.A.11
Sabatini, D.M.12
-
45
-
-
79958696336
-
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling
-
Yu, Y., Yoon, S. O., Poulogiannis, G., Yang, Q., Ma, X. M., Villen, J., Kubica, N., Hoffman, G. R., Cantley, L. C., Gygi, S. P., and Blenis, J. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-1326
-
(2011)
Science
, vol.332
, pp. 1322-1326
-
-
Yu, Y.1
Yoon, S.O.2
Poulogiannis, G.3
Yang, Q.4
Ma, X.M.5
Villen, J.6
Kubica, N.7
Hoffman, G.R.8
Cantley, L.C.9
Gygi, S.P.10
Blenis, J.11
-
46
-
-
79551598347
-
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
-
Kim, J., Kundu, M., Viollet, B., and Guan, K. L. (2011) AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 13, 132-141
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 132-141
-
-
Kim, J.1
Kundu, M.2
Viollet, B.3
Guan, K.L.4
-
47
-
-
84874995247
-
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1
-
Ben-Sahra, I., Howell, J. J., Asara, J. M., and Manning, B. D. (2013) Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1. Science 339, 1323-1328
-
(2013)
Science
, vol.339
, pp. 1323-1328
-
-
Ben-Sahra, I.1
Howell, J.J.2
Asara, J.M.3
Manning, B.D.4
-
48
-
-
84874961313
-
Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis
-
Robitaille, A. M., Christen, S., Shimobayashi, M., Cornu, M., Fava, L. L., Moes, S., Prescianotto-Baschong, C., Sauer, U., Jenoe, P., and Hall, M. N. (2013) Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis. Science 339, 1320-1323
-
(2013)
Science
, vol.339
, pp. 1320-1323
-
-
Robitaille, A.M.1
Christen, S.2
Shimobayashi, M.3
Cornu, M.4
Fava, L.L.5
Moes, S.6
Prescianotto-Baschong, C.7
Sauer, U.8
Jenoe, P.9
Hall, M.N.10
-
49
-
-
84859088981
-
A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 Regulation
-
Dalle Pezze, P., Sonntag, A. G., Thien, A., Prentzell, M. T., Godel, M., Fischer, S., Neumann-Haefelin, E., Huber, T. B., Baumeister, R., Shanley, D. P., and Thedieck, K. (2012) A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 Regulation. Sci. Signal. 5, ra25
-
(2012)
Sci. Signal.
, vol.5
, pp. ra25
-
-
Dalle Pezze, P.1
Sonntag, A.G.2
Thien, A.3
Prentzell, M.T.4
Godel, M.5
Fischer, S.6
Neumann-Haefelin, E.7
Huber, T.B.8
Baumeister, R.9
Shanley, D.P.10
Thedieck, K.11
-
50
-
-
84903985731
-
PI3K-p110-alpha-subtype signaling mediates survival, proliferation and neurogenesis of cortical progenitor cells via activation of mTORC2
-
Wahane, S. D., Hellbach, N., Prentzell, M. T., Weise, S. C., Vezzali, R., Kreutz, C., Timmer, J., Krieglstein, K., Thedieck, K., and Vogel, T. (2014) PI3K-p110-alpha-subtype signaling mediates survival, proliferation and neurogenesis of cortical progenitor cells via activation of mTORC2. J. Neurochem. 130, 255-267
-
(2014)
J. Neurochem.
, vol.130
, pp. 255-267
-
-
Wahane, S.D.1
Hellbach, N.2
Prentzell, M.T.3
Weise, S.C.4
Vezzali, R.5
Kreutz, C.6
Timmer, J.7
Krieglstein, K.8
Thedieck, K.9
Vogel, T.10
-
51
-
-
79953211540
-
Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/ Akt signaling
-
Tato, I., Bartrons, R., Ventura, F., and Rosa, J. L. (2011) Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/ Akt signaling. J. Biol. Chem. 286, 6128-6142
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 6128-6142
-
-
Tato, I.1
Bartrons, R.2
Ventura, F.3
Rosa, J.L.4
-
52
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov, D. D., Guertin, D. A., Ali, S. M., and Sabatini, D. M. (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
53
-
-
28844434558
-
mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
-
Hresko, R. C., and Mueckler, M. (2005) mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. J. Biol. Chem. 280, 40406-40416
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 40406-40416
-
-
Hresko, R.C.1
Mueckler, M.2
-
54
-
-
58649092475
-
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
-
Garcia-Martinez, J. M., and Alessi, D. R. (2008) mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochem. J. 416, 375-385
-
(2008)
Biochem. J.
, vol.416
, pp. 375-385
-
-
Garcia-Martinez, J.M.1
Alessi, D.R.2
-
55
-
-
47949104258
-
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation, and signaling
-
Ikenoue, T., Inoki, K., Yang, Q., Zhou, X., and Guan, K. L. (2008) Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation, and signaling. EMBO J. 27, 1919-1931
-
(2008)
EMBO J.
, vol.27
, pp. 1919-1931
-
-
Ikenoue, T.1
Inoki, K.2
Yang, Q.3
Zhou, X.4
Guan, K.L.5
-
56
-
-
78650529080
-
Second AKT: The rise of SGK in cancer signaling
-
Bruhn, M. A., Pearson, R. B., Hannan, R. D., and Sheppard, K. E. (2010) Second AKT: the rise of SGK in cancer signaling. Growth Fact. 28, 394-408
-
(2010)
Growth Fact.
, vol.28
, pp. 394-408
-
-
Bruhn, M.A.1
Pearson, R.B.2
Hannan, R.D.3
Sheppard, K.E.4
-
57
-
-
72949093349
-
The nuts and bolts of AGC protein kinases
-
Pearce, L. R., Komander, D., and Alessi, D. R. (2010) The nuts and bolts of AGC protein kinases. Nat. Rev. Mol. Cell Biol. 11, 9-22
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 9-22
-
-
Pearce, L.R.1
Komander, D.2
Alessi, D.R.3
-
58
-
-
39749100492
-
TOR regulation of AGC kinases in yeast and mammals
-
Jacinto, E., and Lorberg, A. (2008) TOR regulation of AGC kinases in yeast and mammals. Biochem. J. 410, 19-37
-
(2008)
Biochem. J.
, vol.410
, pp. 19-37
-
-
Jacinto, E.1
Lorberg, A.2
-
59
-
-
84860454425
-
Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c
-
Hagiwara, A., Cornu, M., Cybulski, N., Polak, P., Betz, C., Trapani, F., Terracciano, L., Heim, M. H., Ruegg, M. A., and Hall, M. N. (2012) Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c. Cell Metab. 15, 725-738
-
(2012)
Cell Metab.
, vol.15
, pp. 725-738
-
-
Hagiwara, A.1
Cornu, M.2
Cybulski, N.3
Polak, P.4
Betz, C.5
Trapani, F.6
Terracciano, L.7
Heim, M.H.8
Ruegg, M.A.9
Hall, M.N.10
-
60
-
-
0036583926
-
Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics
-
Ong, S. E., Blagoev, B., Kratchmarova, I., Kristensen, D. B., Steen, H., Pandey, A., and Mann, M. (2002) Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol. Cell. Proteomics 1, 376-386
-
(2002)
Mol. Cell. Proteomics
, vol.1
, pp. 376-386
-
-
Ong, S.E.1
Blagoev, B.2
Kratchmarova, I.3
Kristensen, D.B.4
Steen, H.5
Pandey, A.6
Mann, M.7
-
61
-
-
85027920901
-
A modeling-experimental approach reveals insulin receptor substrate (IRS)-dependent regulation of adenosine monosphosphate-dependent kinase (AMPK) by insulin
-
Sonntag, A. G., Dalle Pezze, P., Shanley, D. P., and Thedieck, K. (2012) A modeling-experimental approach reveals insulin receptor substrate (IRS)-dependent regulation of adenosine monosphosphate-dependent kinase (AMPK) by insulin. FEBS J. 279, 3314-3328
-
(2012)
FEBS J.
, vol.279
, pp. 3314-3328
-
-
Sonntag, A.G.1
Dalle Pezze, P.2
Shanley, D.P.3
Thedieck, K.4
-
62
-
-
84882800242
-
Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells
-
Thedieck, K., Holzwarth, B., Prentzell, M. T., Boehlke, C., Klasener, K., Ruf, S., Sonntag, A. G., Maerz, L., Grellscheid, S. N., Kremmer, E., Nitschke, R., Kuehn, E. W., Jonker, J. W., Groen, A. K., Reth, M., Hall, M. N., and Baumeister, R. (2013) Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells. Cell 154, 859-874
-
(2013)
Cell
, vol.154
, pp. 859-874
-
-
Thedieck, K.1
Holzwarth, B.2
Prentzell, M.T.3
Boehlke, C.4
Klasener, K.5
Ruf, S.6
Sonntag, A.G.7
Maerz, L.8
Grellscheid, S.N.9
Kremmer, E.10
Nitschke, R.11
Kuehn, E.W.12
Jonker, J.W.13
Groen, A.K.14
Reth, M.15
Hall, M.N.16
Baumeister, R.17
-
63
-
-
0033539067
-
Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation
-
Sahara, S., Aoto, M., Eguchi, Y., Imamoto, N., Yoneda, Y., and Tsujimoto, Y. (1999) Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation. Nature 401, 168-173
-
(1999)
Nature
, vol.401
, pp. 168-173
-
-
Sahara, S.1
Aoto, M.2
Eguchi, Y.3
Imamoto, N.4
Yoneda, Y.5
Tsujimoto, Y.6
-
64
-
-
79961217471
-
Comparison of ERLIC-TiO2, HILIC-TiO2, and SCX-TiO2 for global phosphoproteomics approaches
-
Zarei, M., Sprenger, A., Metzger, F., Gretzmeier, C., and Dengjel, J. (2011) Comparison of ERLIC-TiO2, HILIC-TiO2, and SCX-TiO2 for global phosphoproteomics approaches. J. Proteome Res. 10, 3474-3483
-
(2011)
J. Proteome Res.
, vol.10
, pp. 3474-3483
-
-
Zarei, M.1
Sprenger, A.2
Metzger, F.3
Gretzmeier, C.4
Dengjel, J.5
-
65
-
-
84893871020
-
Comparison of alternative MS/MS and bioinformatics approaches for confident phosphorylation site localization
-
Wiese, H., Kuhlmann, K., Wiese, S., Stoepel, N. S., Pawlas, M., Meyer, H. E., Stephan, C., Eisenacher, M., Drepper, F., and Warscheid, B. (2014) Comparison of alternative MS/MS and bioinformatics approaches for confident phosphorylation site localization. J. Proteome Res. 13, 1128-1137
-
(2014)
J. Proteome Res.
, vol.13
, pp. 1128-1137
-
-
Wiese, H.1
Kuhlmann, K.2
Wiese, S.3
Stoepel, N.S.4
Pawlas, M.5
Meyer, H.E.6
Stephan, C.7
Eisenacher, M.8
Drepper, F.9
Warscheid, B.10
-
66
-
-
57449099865
-
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
-
Cox, J., and Mann, M. (2008) MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat. Biotechnol. 26, 1367-1372
-
(2008)
Nat. Biotechnol.
, vol.26
, pp. 1367-1372
-
-
Cox, J.1
Mann, M.2
-
67
-
-
79953701087
-
Andromeda: A peptide search engine integrated into the MaxQuant environment
-
Cox, J., Neuhauser, N., Michalski, A., Scheltema, R. A., Olsen, J. V., and Mann, M. (2011) Andromeda: a peptide search engine integrated into the MaxQuant environment. J. Proteome Res. 10, 1794-1805
-
(2011)
J. Proteome Res.
, vol.10
, pp. 1794-1805
-
-
Cox, J.1
Neuhauser, N.2
Michalski, A.3
Scheltema, R.A.4
Olsen, J.V.5
Mann, M.6
-
68
-
-
70349091863
-
A guide to the Proteomics Identifications Database proteomics data repository
-
Vizcaino, J. A., Cote, R., Reisinger, F., Foster, J. M., Mueller, M., Rameseder, J., Hermjakob, H., and Martens, L. (2009) A guide to the Proteomics Identifications Database proteomics data repository. Proteomics 9, 4276-4283
-
(2009)
Proteomics
, vol.9
, pp. 4276-4283
-
-
Vizcaino, J.A.1
Cote, R.2
Reisinger, F.3
Foster, J.M.4
Mueller, M.5
Rameseder, J.6
Hermjakob, H.7
Martens, L.8
-
69
-
-
0242490780
-
Cytoscape: A software environment for integrated models of biomolecular interaction networks
-
Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., Amin, N., Schwikowski, B., and Ideker, T. (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13, 2498-2504
-
(2003)
Genome Res.
, vol.13
, pp. 2498-2504
-
-
Shannon, P.1
Markiel, A.2
Ozier, O.3
Baliga, N.S.4
Wang, J.T.5
Ramage, D.6
Amin, N.7
Schwikowski, B.8
Ideker, T.9
-
70
-
-
64549104807
-
ClueGO: A Cytoscape plug-in to decipher functionally grouped Gene Ontology and pathway annotation networks
-
Bindea, G., Mlecnik, B., Hackl, H., Charoentong, P., Tosolini, M., Kirilovsky, A., Fridman, W. H., Pages, F., Trajanoski, Z., and Galon, J. (2009) ClueGO: a Cytoscape plug-in to decipher functionally grouped Gene Ontology and pathway annotation networks. Bioinformatics 25, 1091-1093
-
(2009)
Bioinformatics
, vol.25
, pp. 1091-1093
-
-
Bindea, G.1
Mlecnik, B.2
Hackl, H.3
Charoentong, P.4
Tosolini, M.5
Kirilovsky, A.6
Fridman, W.H.7
Pages, F.8
Trajanoski, Z.9
Galon, J.10
-
71
-
-
58149193234
-
STRING 8 - A global view on proteins and their functional interactions in 630 organisms
-
Jensen, L. J., Kuhn, M., Stark, M., Chaffron, S., Creevey, C., Muller, J., Doerks, T., Julien, P., Roth, A., Simonovic, M., Bork, P., and von Mering, C. (2009) STRING 8 - a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Res. 37, D412-D416
-
(2009)
Nucleic Acids Res.
, vol.37
, pp. D412-D416
-
-
Jensen, L.J.1
Kuhn, M.2
Stark, M.3
Chaffron, S.4
Creevey, C.5
Muller, J.6
Doerks, T.7
Julien, P.8
Roth, A.9
Simonovic, M.10
Bork, P.11
Von Mering, C.12
-
72
-
-
0025837327
-
Mitogen-activated 70K S6 kinase. Identification of in vitro 40 S ribosomal S6 phosphorylation sites
-
Ferrari, S., Bandi, H. R., Hofsteenge, J., Bussian, B. M., and Thomas, G. (1991) Mitogen-activated 70K S6 kinase. Identification of in vitro 40 S ribosomal S6 phosphorylation sites. J. Biol. Chem. 266, 22770-22775
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 22770-22775
-
-
Ferrari, S.1
Bandi, H.R.2
Hofsteenge, J.3
Bussian, B.M.4
Thomas, G.5
-
73
-
-
0026659046
-
Rapamycin- FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
-
Chung, J., Kuo, C. J., Crabtree, G. R., and Blenis, J. (1992) Rapamycin- FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell 69, 1227-1236
-
(1992)
Cell
, vol.69
, pp. 1227-1236
-
-
Chung, J.1
Kuo, C.J.2
Crabtree, G.R.3
Blenis, J.4
-
74
-
-
34347242470
-
RAS/ERK signaling promotes sitespecific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation
-
Roux, P. P., Shahbazian, D., Vu, H., Holz, M. K., Cohen, M. S., Taunton, J., Sonenberg, N., and Blenis, J. (2007) RAS/ERK signaling promotes sitespecific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. J. Biol. Chem. 282, 14056-14064
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 14056-14064
-
-
Roux, P.P.1
Shahbazian, D.2
Vu, H.3
Holz, M.K.4
Cohen, M.S.5
Taunton, J.6
Sonenberg, N.7
Blenis, J.8
-
75
-
-
67649344456
-
Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR
-
Wang, L., Lawrence, J. C., Jr., Sturgill, T. W., and Harris, T. E. (2009) Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR. J. Biol. Chem. 284, 14693-14697
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 14693-14697
-
-
Wang, L.1
Lawrence, J.C.2
Sturgill, T.W.3
Harris, T.E.4
-
76
-
-
73649098283
-
Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation
-
Foster, K. G., Acosta-Jaquez, H. A., Romeo, Y., Ekim, B., Soliman, G. A., Carriere, A., Roux, P. P., Ballif, B. A., and Fingar, D. C. (2010) Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation. J. Biol. Chem. 285, 80-94
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 80-94
-
-
Foster, K.G.1
Acosta-Jaquez, H.A.2
Romeo, Y.3
Ekim, B.4
Soliman, G.A.5
Carriere, A.6
Roux, P.P.7
Ballif, B.A.8
Fingar, D.C.9
-
77
-
-
0034141942
-
Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI
-
Raught, B., Gingras, A. C., Gygi, S. P., Imataka, H., Morino, S., Gradi, A., Aebersold, R., and Sonenberg, N. (2000) Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI. EMBO J. 19, 434-444
-
(2000)
EMBO J.
, vol.19
, pp. 434-444
-
-
Raught, B.1
Gingras, A.C.2
Gygi, S.P.3
Imataka, H.4
Morino, S.5
Gradi, A.6
Aebersold, R.7
Sonenberg, N.8
-
78
-
-
42449138319
-
eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy
-
Ramirez-Valle, F., Braunstein, S., Zavadil, J., Formenti, S. C., and Schneider, R. J. (2008) eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy. J. Cell Biol. 181, 293-307
-
(2008)
J. Cell Biol.
, vol.181
, pp. 293-307
-
-
Ramirez-Valle, F.1
Braunstein, S.2
Zavadil, J.3
Formenti, S.C.4
Schneider, R.J.5
-
79
-
-
0028036698
-
Insulin receptor substrate-1 mediates phosphatidylinositol 3′-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation
-
Myers, M. G., Jr., Grammer, T. C., Wang, L. M., Sun, X. J., Pierce, J. H., Blenis, J., and White, M. F. (1994) Insulin receptor substrate-1 mediates phosphatidylinositol 3′-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation. J. Biol. Chem. 269, 28783-28789
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 28783-28789
-
-
Myers, M.G.1
Grammer, T.C.2
Wang, L.M.3
Sun, X.J.4
Pierce, J.H.5
Blenis, J.6
White, M.F.7
-
80
-
-
4544343980
-
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
-
Shah, O. J., Wang, Z., and Hunter, T. (2004) Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr. Biol. 14, 1650-1656
-
(2004)
Curr. Biol.
, vol.14
, pp. 1650-1656
-
-
Shah, O.J.1
Wang, Z.2
Hunter, T.3
-
81
-
-
3342958797
-
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
-
Harrington, L. S., Findlay, G. M., Gray, A., Tolkacheva, T., Wigfield, S., Rebholz, H., Barnett, J., Leslie, N. R., Cheng, S., Shepherd, P. R., Gout, I., Downes, C. P., and Lamb, R. F. (2004) The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J. Cell Biol. 166, 213-223
-
(2004)
J. Cell Biol.
, vol.166
, pp. 213-223
-
-
Harrington, L.S.1
Findlay, G.M.2
Gray, A.3
Tolkacheva, T.4
Wigfield, S.5
Rebholz, H.6
Barnett, J.7
Leslie, N.R.8
Cheng, S.9
Shepherd, P.R.10
Gout, I.11
Downes, C.P.12
Lamb, R.F.13
-
82
-
-
79955554301
-
Insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTOR: Studies on the function of Ser675 and Ser907
-
Fritsche, L., Neukamm, S. S., Lehmann, R., Kremmer, E., Hennige, A. M., Hunder-Gugel, A., Schenk, M., Haring, H. U., Schleicher, E. D., and Weigert, C. (2011) Insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTOR: studies on the function of Ser675 and Ser907. Am. J. Physiol. Endocrinol. Metab. 300, E824-E836
-
(2011)
Am. J. Physiol. Endocrinol. Metab.
, vol.300
, pp. E824-E836
-
-
Fritsche, L.1
Neukamm, S.S.2
Lehmann, R.3
Kremmer, E.4
Hennige, A.M.5
Hunder-Gugel, A.6
Schenk, M.7
Haring, H.U.8
Schleicher, E.D.9
Weigert, C.10
-
83
-
-
0344406975
-
ASAP, a novel protein complex involved in RNA processing and apoptosis
-
Schwerk, C., Prasad, J., Degenhardt, K., Erdjument-Bromage, H., White, E., Tempst, P., Kidd, V. J., Manley, J. L., Lahti, J. M., and Reinberg, D. (2003) ASAP, a novel protein complex involved in RNA processing and apoptosis. Mol. Cell. Biol. 23, 2981-2990
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 2981-2990
-
-
Schwerk, C.1
Prasad, J.2
Degenhardt, K.3
Erdjument-Bromage, H.4
White, E.5
Tempst, P.6
Kidd, V.J.7
Manley, J.L.8
Lahti, J.M.9
Reinberg, D.10
-
84
-
-
41949101770
-
SKAR links premRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs
-
Ma, X. M., Yoon, S. O., Richardson, C. J., Julich, K., and Blenis, J. (2008) SKAR links premRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. Cell 133, 303-313
-
(2008)
Cell
, vol.133
, pp. 303-313
-
-
Ma, X.M.1
Yoon, S.O.2
Richardson, C.J.3
Julich, K.4
Blenis, J.5
-
85
-
-
0942268832
-
Splicing enhances translation in mammalian cells: An additional function of the exon junction complex
-
Nott, A., Le Hir, H., and Moore, M. J. (2004) Splicing enhances translation in mammalian cells: an additional function of the exon junction complex. Genes Dev. 18, 210-222
-
(2004)
Genes Dev.
, vol.18
, pp. 210-222
-
-
Nott, A.1
Le Hir, H.2
Moore, M.J.3
-
86
-
-
0035823247
-
Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1
-
Lykke-Andersen, J., Shu, M. D., and Steitz, J. A. (2001) Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. Science 293, 1836-1839
-
(2001)
Science
, vol.293
, pp. 1836-1839
-
-
Lykke-Andersen, J.1
Shu, M.D.2
Steitz, J.A.3
-
87
-
-
49649101933
-
Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1
-
Jang, S. W., Yang, S. J., Ehlen, A., Dong, S., Khoury, H., Chen, J., Persson, J. L., and Ye, K. (2008) Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1. Cancer Res. 68, 4559-4570
-
(2008)
Cancer Res.
, vol.68
, pp. 4559-4570
-
-
Jang, S.W.1
Yang, S.J.2
Ehlen, A.3
Dong, S.4
Khoury, H.5
Chen, J.6
Persson, J.L.7
Ye, K.8
-
88
-
-
2342540912
-
The ever-increasing complexities of the exon junction complex
-
Tange, T. O., Nott, A., and Moore, M. J. (2004) The ever-increasing complexities of the exon junction complex. Curr. Opin. Cell Biol. 16, 279-284
-
(2004)
Curr. Opin. Cell Biol.
, vol.16
, pp. 279-284
-
-
Tange, T.O.1
Nott, A.2
Moore, M.J.3
-
89
-
-
27144446343
-
Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation
-
Hu, Y., Yao, J., Liu, Z., Liu, X., Fu, H., and Ye, K. (2005) Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation. EMBO J. 24, 3543-3554
-
(2005)
EMBO J.
, vol.24
, pp. 3543-3554
-
-
Hu, Y.1
Yao, J.2
Liu, Z.3
Liu, X.4
Fu, H.5
Ye, K.6
-
90
-
-
33847369060
-
The ACIN1 gene is hypermethylated in early stage lung adenocarcinoma
-
Shu, Y., Iijima, T., Sun, W., Kano, J., Ishiyama, T., Okubo, C., Anami, Y., Tanaka, R., Fukai, S., and Noguchi, M. (2006) The ACIN1 gene is hypermethylated in early stage lung adenocarcinoma. J. Thorac. Oncol. 1, 160-167
-
(2006)
J. Thorac. Oncol.
, vol.1
, pp. 160-167
-
-
Shu, Y.1
Iijima, T.2
Sun, W.3
Kano, J.4
Ishiyama, T.5
Okubo, C.6
Anami, Y.7
Tanaka, R.8
Fukai, S.9
Noguchi, M.10
-
91
-
-
84866002291
-
The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data
-
Cerami, E., Gao, J., Dogrusoz, U., Gross, B. E., Sumer, S. O., Aksoy, B. A., Jacobsen, A., Byrne, C. J., Heuer, M. L., Larsson, E., Antipin, Y., Reva, B., Goldberg, A. P., Sander, C., and Schultz, N. (2012) The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2, 401-404
-
(2012)
Cancer Discov.
, vol.2
, pp. 401-404
-
-
Cerami, E.1
Gao, J.2
Dogrusoz, U.3
Gross, B.E.4
Sumer, S.O.5
Aksoy, B.A.6
Jacobsen, A.7
Byrne, C.J.8
Heuer, M.L.9
Larsson, E.10
Antipin, Y.11
Reva, B.12
Goldberg, A.P.13
Sander, C.14
Schultz, N.15
|