PI3K-p110-alpha-subtype signalling mediates survival, proliferation and neurogenesis of cortical progenitor cells via activation of mTORC2

Journal of Neurochemistry

Volumn 130, Issue 2, 2014, Pages 255-267

  Wahane, Shalaka Dhanraj ^a   Hellbach, Nicole ^a   Prentzell, Mirja Tamara ^a   Weise, Stefan Christopher ^a   Vezzali, Riccardo ^a   Kreutz, Clemens ^a   Timmer, Jens ^a   Krieglstein, Kerstin ^a   Thedieck, Kathrin ^a,b,c   Vogel, Tanja ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c UNIVERSITY OF OLDENBURG   (Germany)

Author keywords

brain; cerebral cortex; insulin; neuron; PI3K isoform; PI3K subunit

Indexed keywords

ISOPROTEIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE P110 ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE P110 BETA; PROTEIN KINASE B; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN CORTEX; BRAIN DEVELOPMENT; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME INDUCTION; GENE INDUCTION; MOUSE; MOUSE EMBRYO; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

BRAIN; CEREBRAL CORTEX; INSULIN; NEURON; PI3K-ISOFORM; PI3K-SUBUNIT;

ANIMALS; BLOTTING, WESTERN; CELL PROLIFERATION; CELL SURVIVAL; CEREBRAL CORTEX; FEMALE; IMMUNOHISTOCHEMISTRY; INSULIN-LIKE GROWTH FACTOR I; MICE; MICROARRAY ANALYSIS; MULTIPROTEIN COMPLEXES; NEURAL STEM CELLS; NEUROGENESIS; PHOSPHATIDYLINOSITOL 3-KINASES; PREGNANCY; PRIMARY CELL CULTURE; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, IGF TYPE 1; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRANSFORMING GROWTH FACTOR BETA;

EID: 84903985731     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12718     Document Type: Article

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