The mitochondrial uncoupler DNP triggers brain cell mTOR signaling network reprogramming and CREB pathway up-regulation

Journal of Neurochemistry

Volumn 134, Issue 4, 2015, Pages 677-692

  Liu, Dong ^a   Zhang, Yongqing ^a   Gharavi, Robert ^a   Park, Hee Ra ^b   Lee, Jaewon ^b   Siddiqui, Sana ^a   Telljohann, Richard ^a   Nassar, Matthew R ^a   Cutler, Roy G ^a   Becker, Kevin G ^a   Mattson, Mark P ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b Pusan National University   (South Korea)

Author keywords

2,4 dinitrophenol; autophagy; BDNF; CREB; insulin signaling; mTOR

Indexed keywords

2,4 DINITROPHENOL; ACTIVATING TRANSCRIPTION FACTOR 4; BRAIN DERIVED NEUROTROPHIC FACTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; INSULIN; JANUS KINASE 1; JANUS KINASE 2; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; MESSENGER RNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 9; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; S6 KINASE; TUBERIN; CREB1 PROTEIN, MOUSE; MTOR PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE; UNCOUPLING PROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BIOENERGY; BRAIN CELL; BRAIN CORTEX; CALCIUM CELL LEVEL; CELL SURVIVAL; CELL VIABILITY; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; DOWN REGULATION; ENERGY EXPENDITURE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; IMMUNOBLOTTING; INTRACELLULAR SIGNALING; LEARNING; MALE; MAPK9 GENE; MEMORY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; MOLECULAR WASTE DISPOSAL; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; NUCLEAR REPROGRAMMING; OXIDATIVE PHOSPHORYLATION UNCOUPLING; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TASK PERFORMANCE; TSC2 GENE; UPREGULATION; ANIMAL; BIOSYNTHESIS; BRAIN; C57BL MOUSE; DRUG EFFECTS; METABOLISM; MITOCHONDRION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

MAMMALIA; MUS;

2,4-DINITROPHENOL; ANIMALS; BRAIN; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; UNCOUPLING AGENTS; UP-REGULATION;

EID: 84937815930     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.13176     Document Type: Article

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