AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation

Journal of Molecular Neuroscience

Volumn 17, Issue 1, 2001, Pages 45-58

  Culmsee, C ^a   Monroe, J ^a   Kemp, B E ^a   Mattson, M P ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

AICAR; Alzheimer; AMPK; Amyloid; Antisense; Apoptosis; Glutamate; Hippocampus; Ischemia

Indexed keywords

ADENOSINE PHOSPHATE; AMYLOID BETA PROTEIN; ANTISENSE OLIGODEOXYNUCLEOTIDE; GLUCOSE; GLUTAMIC ACID; PROTEIN KINASE;

ADOLESCENT; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN DEVELOPMENT; BRAIN HYPOXIA; BRAIN PROTECTION; CELL METABOLISM; CELL SURVIVAL; CONTROLLED STUDY; DEGENERATIVE DISEASE; EMBRYO; ENZYME ACTIVE SITE; ENZYME SUBUNIT; GENE EXPRESSION; HIPPOCAMPUS; ISCHEMIA; NERVE CELL; NONHUMAN; OXIDATIVE STRESS; RAT;

AMINOIMIDAZOLE CARBOXAMIDE; ANIMALS; APOPTOSIS; BRAIN; CELL SURVIVAL; CELLS, CULTURED; GLUCOSE; HYPOGLYCEMIC AGENTS; IMMUNOHISTOCHEMISTRY; MALE; MULTIENZYME COMPLEXES; NEURONS; NEUROPROTECTIVE AGENTS; OLIGONUCLEOTIDES, ANTISENSE; PROTEIN SUBUNITS; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; RIBONUCLEOTIDES; TRIAZINES; TRIAZOLES; XANTHINES;

ANIMALIA;

EID: 0034803430     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:17:1:45     Document Type: Article

References (59)

1. 4-Hydroxynonenal, a product of lipid peroxidation, damages cholinergic neurons and impairs visuospatial memory in rats
2. The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase
3. A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis
4. NGF and bFGF protect rat and human central neurons against hypoglycemic damage by stabilizing calcium homeostasis
5. Brain 5-aminoimidazole-4-carboxamide riboside (AICAR) administration reduces cerebral ischemic damage in the Mongolian gerbil
6. Role of the AMP-activated protein kinase in the cellular stress response
7. 5-Aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?
8. 5′-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC
9. Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)CoA reductase inhibitors mediated by endothelial nitric oxide synthase
10. Activation of rat liver cytosolic 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase by adenosine 5′-monophosphate
11. AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes
12. Sustained protection by acadesine against ischemia- and reperfusion-induced injury. Studies in the transplanted rat heart
13. Acadesine and myocardial protection. Studies of time of administration and dose-response relations in the rat
14. Protection against injury during ischemia and reperfusion by acadesine derivatives GP-1-468 and GP-1-668. Studies in the transplanted rat heart
15. Non-catalytic β-and γ-subunit isoforms of the 5′-AMP-activated protein kinase
16. Catalytic subunits of the porcine and rat 5′-AMP-activated protein kinase are members of the SNF1 protein kinase family
17. Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism
18. Secreted forms of β-amyloid precursor protein protect hippocampal neurons against amyloid β-peptide-induced oxidative injury
19. Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease
20. The AMP-activated protein kinase: Fuel gauge of the mammalian cell?
21. Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase
22. Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase
23. Dealing with energy demand: The AMP-activated protein kinase
24. Timely administration of AICA riboside reduces reperfusion injury in rabbits
25. Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis
26. Characterization of 5′AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia
27. Raf, but not MEK or ERK, is sufficient for differentiation of hippocampal neuronal cells
28. The 5′-AMP-activated protein kinase inhibits the transcriptional stimulation by glucose in liver cells, acting through the glucose response complex
29. 2+ homeostasis and cell death
30. The early events of oxygen and glucose deprivation: Setting the scene for neuronal death?
31. Roles for mitotic history in the generation and degeneration of hippocampal neuroarchitecture
32. )β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
33. Growth factors prevent mitochondrial dysfunction, loss of calcium homeostasis and cell injury, but not ATP depletion in hippocampal neurons deprived of glucose
34. 2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons
35. Activation of NF-κB protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration
36. Isoform-specific purification and substrate specificity of the 5′-AMP-activated protein kinase
37. Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death
38. Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase
39. Evidence that AMP triggers phosphorylation as well as direct allosteric activation of rat liver AMP-activated protein kinase. A sensitive mechanism to protect the cell against ATP depletion
40. Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle
41. Brain damage caused by ischemia: Pathophysiological and pharmacological aspects
42. Effect of exercise intensity on skeletal muscle malonyl-CoA and acetyl-CoA carboxylase
43. 5-Amino-4-imidazolecarboxamide riboside (Z-riboside) metabolism in eukaryotic cells
44. AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release
45. Metyrapone, an inhibitor of glucocorticoid production, reduces brain injury induced by focal and global ischemia and seizures
46. Identification of Raf-1 Ser621 kinase activity from NIH 3T3 cells as AMP-activated protein kinase
47. Mammalian 5′-AMP-activated protein kinase non-catalytic subunits are homologs of proteins that interact with yeast Snf1 protein kinase
48. Mammalian AMP-activated protein kinase subfamily
49. AMP-activated protein kinase isoenzyme family: Subunit structure and chromosomal location
50. Inhibition of glucocorticoid-induced apoptosis with 5-aminoimidazole-4-carboxamide ribonucleoside, a cell-permeable activator of AMP-activated protein kinase
51. Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase
52. Acadesine extends the window of protection afforded by ischaemic preconditioning
53. Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system
54. Contraction-induced changes in acetyl-CoA carboxylase and 5′-AMP-activated kinase in skeletal muscle
55. Control of hepatic fatty acid oxidation by 5′-AMP-activated protein kinase involves a malonyl-CoA-dependent and a malonyl-CoA-independent mechanism
56. Bcl-2 targets the protein kinase Raf-1 to mitochondria
57. Bc1-2, Raf-1 and mitochondrial regulation of apoptosis
58. Specificity determinants for the AMP-activated protein kinase and its plant homologue analysed using synthetic peptides
59. Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischemic brain injury in vivo