Regulation of brain mitochondrial H2O2 production by membrane potential and NAD(P)H redox state

Journal of Neurochemistry

Volumn 86, Issue 5, 2003, Pages 1101-1107

  Starkov, Anatoly A ^a   Fiskum, Gary ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Brain mitochondria; Hydrogen peroxide; Membrane potential; Reactive oxygen species

Indexed keywords

CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; CATION; HYDROGEN PEROXIDE; OLIGOMYCIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; ROTENONE; TETRAPHENYLPHOSPHONIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOFLUORESCENCE; BRAIN MITOCHONDRION; CELL ENERGY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; DEPOLARIZATION; ELECTRODE; ENCEPHALE ISOLE; HYPOTHESIS; LIPOPHILICITY; MALE; MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATION; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; RESPIRATORY CHAIN; SUBSTRATE INDUCED RESPIRATION;

ANIMALIA;

EID: 0042433242     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01908.x     Document Type: Article

References (33)

1. Barja G. and Herrero A. (1998) Localization at complex I and mechanism of the higher free radical production of brain nonsynaptic mitochondria in the short-lived rat than in the longevous pigeon. J. Bioenerg. Biomembr. 30, 235-243.
2. Beck D. P., Broyles J. L. and Von Korff R. W. (1977) Role of malate transport in regulating metabolism in mitochondria isolated from rabbit brain. J. Neurochem. 29, 487-493.
3. Camici P., Marraccini P., Lorenzoni R., Ferrannini E., Buzzigoli G., Marzilli M. and L'Abbate A. (1991) Metabolic markers of stress-induced myocardial ischemia. Circulation 83, III8-13.
4. Echtay K. S. et al. (2002) Superoxide activates mitochondrial uncoupling proteins. Nature 415, 96-99.
5. + channel opening decreases reactive oxygen species generation. FEBS Lett. 536, 51-55.
6. Fiskum G. (2000) Mitochondrial participation in ischemic and traumatic neural cell death. J. Neurotrauma 17, 843-855.
7. Genova M. L., Ventura B., Giuliano G., Bovina C., Formiggini G., Parenti C. G. and Lenaz G. (2001) The site of production of superoxide radical in mitochondrial Complex I is not a bound ubisemiquinone but presumably iron-sulfur cluster N2. FEBS Lett. 505, 364-368.
8. 2 formation by rat heart mitochondria on substrate availability and donor age. J. Bioenerg. Biomembr. 29, 89-95.
9. Hashimoto K., Angiolillo P. and Rottenberg H. (1984) Membrane potential and surface potential in mitochondria. Binding of a cationic spin probe. Biochim Biophys. Acta 764, 55-62.
10. 2 production of heart mitochondria and aging rate are slower in canaries and parakeets than in mice: sites of free radical generation and mechanisms involved. Mech. Ageing Dev. 103, 133-146.
11. Hoyer S. and Krier C. (1986) Ischemia and aging brain. Studies on glucose and energy metabolism in rat cerebral cortex. Neurobiol. Aging 7, 23-29.
12. Kamo N., Muratsugu M., Hongoh R. and Kobatake Y. (1979) Membrane potential of mitochondria measured with an electrode sensitive to tetraphenyl phosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state. J. Membr. Biol. 49, 105-121.
13. Kerpel-Fronius S., Beck D. P. and Von Korff R. W. (1977) Studies on the metabolism of glutamate and glutamine by mitochondria from rabbit brain: complications due to isotopic exchange reactions. J. Neurochem. 28, 871-875.
14. Kim-Han J. S., Reichert S. A., Quick K. L. and Dugan L. L. (2001) BMCPI: a mitochondrial uncoupling protein in neurons which regulates mitochondrial function and oxidant production. J. Neurochem. 79, 658-668.
15. Korshunov S. S., Skulachev V. P. and Starkov A. A. (1997) High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. FEBS Lett. 416, 15-18.
16. Krishnamoorthy G. and Hinkle P. C. (1988) Studies on the electron transfer pathway, topography of iron-sulfur centers, and site of coupling in NADH-Q oxidoreductase. J. Biol. Chem. 263, 17566-17575.
17. Kushnareva Y. E., Murphy A. N. and Andreyev A. Y. (2002) Complex I mediated reactive oxygen species generation: Modulation by Cytochrome c and NAD(P)+ oxidation-reduction state. Biochem. J. 368, 545-553.
18. Liu Y., Fiskum G. and Schubert D. (2002) Generation of reactive oxygen species by the mitochondrial electron transport chain. J. Neurochem. 80, 780-787.
19. Nicholls D. G. and Budd S. L. (2000) Mitochondria and neuronal survival. Physiol. Rev. 80, 315-360.
20. Ramsay R. R. and Singer T. P. (1992) Relation of superoxide generation and lipid peroxidation to the inhibition of NADH-Q oxidoreductase by rotenone, piericidin A, and MPP+. Biochem. Biophys. Res. Commun 189, 47-52.
21. Rolfe D. F., Hulbert A. J. and Brand M. D. (1994) Characteristics of mitochondrial proton leak and control of oxidative phosphorylation in the major oxygen-consuming tissues of the rat. Biochim. Biophys. Acta 1188, 405-416.
22. Rosen G. M., Tsai P., Weaver J. M., Porasuphatana S., Roman L. J., Starkov A. A., Fiskum G. and Pou S. (2002) Tetrahydrobiopterin: Its role in the regulation of neuronal nitric oxide synthase-generated superoxide. J. Biol. Chem. 277, 40275-40280.
23. Rosenthal R. E., Hamud F., Fiskum G., Varghese P. J. and Sharpe S. (1987) Cerebral ischemia and reperfusion: prevention of brain mitochondrial injury by lidoflazine. J. Cereb. Blood Flow Metab. 7, 752-758.
24. Rosenthal M., Feng Z. C., Raffin C. N., Harrison M. and Sick T. J. (1995) Mitochondrial hyperoxidation signals residual intracellular dysfunction after global ischemia in rat neocortex. J. Cereb. Blood Flow Metab. 15, 655-665.
25. Rottenberg H. (1984) Membrane potential and surface potential in mitochondria: uptake and binding of lipophilic cations. J. Membr. Biol. 81, 127-138.
26. Sanchez-Ramos J. R., Hollinden G. E., Sick T. J. and Rosenthal M. (1988) 1-Methyl-4-phenylpyridinium (MPP+) increases oxidation of cytochrome-b in rat striatal slices. Brain Res. 443, 183-189.
27. Sherer T. B., Betarbet R. and Greenamyre J. T. (2002) Environment, mitochondria, and Parkinson's disease. Neuroscientist 8, 192-197.
28. Skulachev V. P. (1991) Fatty acid circuit as a physiological mechanism of uncoupling of oxidative phosphorylation. FEBS Lett. 294, 158-162.
29. Starkov A. A., Polster B. M. and Fiskum G. (2002) Regulation of hydrogen peroxide production by brain mitochondria by calcium and Bax. J. Neurochem. 83, 220-228.
30. Turrens J. F. (1997) Superoxide production by the mitochondrial respiratory chain. Biosci. Rep. 17, 3-8.
31. Von Korff R. W. and Kerpel-Fronius S. (1975) The effect of cosubstrates on tricarboxylic acid cycle dynamics during pyruvate oxidation: the formation of alpha-ketoglutarate and utilization of glutamate by mitochondria from rabbit brain. J. Neurochem. 25, 767-778.
32. Von Korff R. W., Steinman S. and Welch A. S. (1971) Metabolic characteristics of mitochondria isolated from rabbit brain. J. Neurochem., 18, 1577-1587.
33. Votyakova T. V. and Reynolds I. J. (2001) DeltaPsi(m)-Dependent and -independent production of reactive oxygen species by rat brain mitochondria. J. Neurochem. 79, 266-277.