The chemical uncoupler 2,4-dinitrophenol (DNP) protects against diet-induced obesity and improves energy homeostasis in mice at thermoneutrality

Journal of Biological Chemistry

Volumn 289, Issue 28, 2014, Pages 19341-19350

  Goldgof, Margalit ^a   Xiao, Cuiying ^a   Chanturiya, Tatyana ^a   Jou, William ^a   Gavrilova, Oksana ^a   Reitman, Marc L ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEATING; MAMMALS; MEDICAL PROBLEMS; PHENOLS; PHYSIOLOGY; POLYOLS; SLUDGE DISPOSAL; TISSUE; TOXICITY;

2 ,4-DINITROPHENOL; BENEFICIAL EFFECTS; CHEMICAL UNCOUPLERS; DIET-INDUCED OBESITY; ENERGY EXPENDITURE; ENERGY HOMEOSTASIS; ENVIRONMENTAL TEMPERATURE; GLUCOSE HOMEOSTASIS;

NUTRITION;

2,4 DINITROPHENOL; 3 HYDROXYBUTYRIC ACID; ACETOACETIC ACID; ADIPONECTIN; CHOLESTEROL; FATTY ACID; FIBROBLAST GROWTH FACTOR 21; GLUCOSE; INSULIN; LACTIC ACID; LIOTHYRONINE; SOMATOMEDIN C; THYROXINE; TRIACYLGLYCEROL; UNCOUPLING PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BIOACCUMULATION; BROWN ADIPOSE TISSUE; CALORIMETRY; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; ENERGY EXPENDITURE; ENVIRONMENTAL TEMPERATURE; FAT MASS; FATTY LIVER; FEMALE; FOOD INTAKE; GENE EXPRESSION; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; LIOTHYRONINE BLOOD LEVEL; LIPID DIET; LIPID METABOLISM; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; THERMAL ANALYSIS; THERMOGENESIS; THYROXINE BLOOD LEVEL; WEIGHT REDUCTION;

2,4-DINITROPHENOL; ADIPOCYTE; BROWN ADIPOSE TISSUE; CL316243; DRUG DEVELOPMENT; ENERGY METABOLISM; OBESITY; THERMONEUTRALITY; THERMOREGULATION; UNCOUPLING PROTEIN;

2,4-DINITROPHENOL; ADIPOSE TISSUE, BROWN; ADIPOSITY; ANIMALS; BODY TEMPERATURE REGULATION; DIET; EATING; ENERGY METABOLISM; GENE EXPRESSION REGULATION; ION CHANNELS; MICE; MITOCHONDRIAL PROTEINS; OBESITY; UNCOUPLING AGENTS;

EID: 84904177872     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.568204     Document Type: Article

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