Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease

Journal of Clinical Investigation

Volumn 120, Issue 10, 2010, Pages 3617-3628

  Qin, Shan ^a,b,c   Taglienti, Mary ^a,b,c   Nauli, Surya M ^b,d   Contrino, Leah ^b,d   Takakura, Ayumi ^b,d   Zhou, Jing ^b,d   Kreidberg, Jordan A ^a,b,c  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD STEM CELL INSTITUTE   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CBL PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; VERY LATE ACTIVATION ANTIGEN 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EMBRYO; FEMALE; GLYCOSYLATION; GOLGI COMPLEX; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KIDNEY POLYCYSTIC DISEASE; MALE; MOUSE; NONHUMAN; NULL CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; UBIQUITINATION; WESTERN BLOTTING;

ANIMALS; CELL LINE; CILIA; DISEASE MODELS, ANIMAL; GLYCOSYLATION; GOLGI APPARATUS; INTEGRIN ALPHA3BETA1; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MORPHOGENESIS; POLYCYSTIC KIDNEY, AUTOSOMAL DOMINANT; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-CBL; PROTO-ONCOGENE PROTEINS C-MET; SIGNAL TRANSDUCTION; TRPP CATION CHANNELS; UBIQUITINATION;

EID: 77957847881     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI41531     Document Type: Article

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