Autism after infection, febrile episodes, and antibiotic use during pregnancy: An exploratory study

Pediatrics

Volumn 130, Issue 6, 2012, Pages

  Atladóttir, Hjördis Ósk ^a   Henriksen, Tine Brink ^b   Schendel, Diana E ^c   Parner, Erik T ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c NATIONAL CENTER ON BIRTH DEFECTS AND DEVELOPMENTAL DISABILITIES   (United States)

Author keywords

Antibiotics; Autism; Autistic disorder; Fever; Infection; Pregnancy

Indexed keywords

ANTIBIOTIC AGENT; CEPHALOSPORIN; MACROLIDE; PENICILLIN G; SULFONAMIDE;

ADOLESCENT; ADULT; ANTIBIOTIC THERAPY; ARTICLE; AUTISM; CHILD; CHILD PSYCHIATRY; CONDYLOMA ACUMINATUM; COUGHING; CYSTITIS; DISEASE ASSOCIATION; DRUG USE; EXPLORATORY RESEARCH; FEMALE; FEVER; GENITAL HERPES; HERPES LABIALIS; HUMAN; INFLUENZA; MAJOR CLINICAL STUDY; MALE; MATERNAL CARE; PREGNANCY OUTCOME; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; PSYCHOLOGIC ASSESSMENT; PYELONEPHRITIS; RESPIRATORY TRACT INFECTION; RISK ASSESSMENT; RISK FACTOR; SCHOOL CHILD; SELF REPORT; TREATMENT OUTCOME; URINARY TRACT INFECTION; VAGINA MYCOSIS; VIRAL RESPIRATORY TRACT INFECTION;

ADOLESCENT; ANTI-BACTERIAL AGENTS; AUTISTIC DISORDER; CHILD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; COHORT STUDIES; DENMARK; FEMALE; FEVER OF UNKNOWN ORIGIN; HUMANS; IMMUNITY, ACTIVE; INFANT, NEWBORN; INFLUENZA, HUMAN; MALE; POSTPARTUM PERIOD; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PRENATAL EXPOSURE DELAYED EFFECTS; RISK FACTORS;

EID: 84870499875     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2012-1107     Document Type: Article

References (25)

1. World Health Organization. International Classification of Diseases, 10th Revision. Geneva, Switzerland: World Health Organization; 1993
2. Patterson PH. Maternal infection and immune involvement in autism. Trends Mol Med. 2011;17(7):389-394
3. Shi L, Fatemi SH, Sidwell RW, Patterson PH. Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring. J Neurosci. 2003;23(1):297-302 (Pubitemid 36050430)
4. Smith SE, Li J, Garbett K, Mirnics K, Patterson PH. Maternal immune activation alters fetal brain development through interleukin-6. J Neurosci. 2007;27(40):10695-10702 (Pubitemid 47535869)
5. Gardener H, Spiegelman D, Buka SL. Prenatal risk factors for autism: comprehensive meta-analysis. Br J Psychiatry. 2009;195(1):7-14
6. Buchmayer S, Johansson S, Johansson A, Hultman CM, Sparén P, Cnattingius S. Can association between preterm birth and autism be explained by maternal or neonatal morbidity? Pediatrics. 2009;124(5). Available at: www.pediatrics.org/cgi/content/full/124/5/e817
7. Atladóttir HO, Thorsen P, Østergaard L, et al. Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders. J Autism Dev Disord. 2010;40(12):1423-1430
8. Olsen J, Melbye M, Olsen SF, et al. The Danish National Birth Cohort - its background, structure and aim. Scand J Public Health. 2001;29(4):300-307 (Pubitemid 33731020)
9. Jacobsen TN, Nohr EA, Frydenberg M. Selection by socioeconomic factors into the Danish National Birth Cohort. Eur J Epidemiol. 2010;25(5):349-355
10. Pedersen CB, Gøtzsche H, Møller JO, Mortensen PB. The Danish Civil Registration System. A cohort of eight million persons. Dan Med Bull. 2006;53(4):441-449 (Pubitemid 44816920)
11. Andersen TF, Madsen M, Jørgensen J, Mellemkjoer L, Olsen JH. The Danish National Hospital Register. A valuable source of data for modern health sciences. Dan Med Bull. 1999;46(3):263-268 (Pubitemid 29299976)
12. Munk-Jørgensen P, Mortensen PB. The Danish Psychiatric Central Register. Dan Med Bull. 1997;44(1):82-84 (Pubitemid 27110215)
13. Lauritsen MB, Jørgensen M, Madsen KM, et al. Validity of childhood autism in the Danish Psychiatric Central Register: findings from a cohort sample born 1990-1999. J Autism Dev Disord. 2010;40(2):139-148
14. Parner ET, Schendel DE, Thorsen P. Autism prevalence trends over time in Denmark: changes in prevalence and age at diagnosis. Arch Pediatr Adolesc Med. 2008;162(12):1150-1156
15. Autism and Developmental Disabilities Monitoring Network Surveillance Year 2006 Principal Investigators; Centers for Disease Control and Prevention (CDC). Prevalence of autism spectrum disorders - Autism and Developmental Disabilities Monitoring Network, United States, 2006. MMWR Surveill Summ. 2009;58(10):1-20
16. Petersen DJ, Bilenberg N, Hoerder K, Gillberg C. The population prevalence of child psychiatric disorders in Danish 8- to 9-year-old children. Eur Child Adolesc Psychiatry. 2006;15(2):71-78 (Pubitemid 43352180)
17. Knudsen LB, Olsen J. The Danish Medical Birth Registry. Dan Med Bull. 1998;45(3):320-323 (Pubitemid 28313542)
18. Juel K, Helweg-Larsen K. The Danish registers of causes of death. Dan Med Bull. 1999;46(4):354-357 (Pubitemid 29439149)
19. Brown AS, Begg MD, Gravenstein S, et al. Serologic evidence of prenatal influenza in the etiology of schizophrenia. Arch Gen Psychiatry. 2004;61(8):774-780 (Pubitemid 39031117)
20. Main PA, Angley MT, Thomas P, O'Doherty CE, Fenech M. Folate and methionine metabolism in autism: a systematic review. Am J Clin Nutr. 2010;91(6):1598-1620
21. Roth C, Magnus P, Schjølberg S, et al. Folic acid supplements in pregnancy and severe language delay in children. JAMA. 2011;306(14):1566-1573
22. Schmidt RJ, Hansen RL, Hartiala J, et al. Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism. Epidemiology. 2011;22(4):476-485
23. Nohr EA, Frydenberg M, Henriksen TB, Olsen J. Does low participation in cohort studies induce bias? Epidemiology. 2006;17(4):413-418 (Pubitemid 44305514)
24. Collier SA, Rasmussen SA, Feldkamp ML, Honein MA; National Birth Defects Prevention Study. Prevalence of self-reported infection during pregnancy among control mothers in the National Birth Defects Prevention Study. Birth Defects Res A Clin Mol Teratol. 2009;85(3):193-201
25. Olesen C, Søndergaard C, Thrane N, Nielsen GL, de Jong-van den Berg L, Olsen J; EuroMAP Group. Do pregnant women report use of dispensed medications? Epidemiology. 2001;12(5):497-501 (Pubitemid 32761987)