메뉴 건너뛰기




Volumn 46, Issue 8, 2014, Pages 881-885

Most genetic risk for autism resides with common variation

(19)  Gaugler, Trent a   Klei, Lambertus b   Sanders, Stephan J c,d   Bodea, Corneliu A a   Goldberg, Arthur P e   Lee, Ann B a   Mahajan, Milind e   Manaa, Dina e   Pawitan, Yudi f   Reichert, Jennifer e   Ripke, Stephan g   Sandin, Sven f   Sklar, Pamela e   Svantesson, Oscar f   Reichenberg, Abraham e   Hultman, Christina M f   Devlin, Bernie b   Roeder, Kathryn a,h   Buxbaum, Joseph D e  


Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; AUTISM; CHROMOSOME SIZE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HERITABILITY; HUMAN; LOSS OF FUNCTION MUTATION; PRIORITY JOURNAL; RECURRENCE RISK; SWEDEN; ADOLESCENT; ADULT; AGED; CHILD; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; MUTATION; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; YOUNG ADULT;

EID: 84905582433     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3039     Document Type: Article
Times cited : (828)

References (35)
  • 1
    • 84860297457 scopus 로고    scopus 로고
    • De novo gene disruptions in children on the autistic spectrum
    • Iossifov, I. et al. De novo gene disruptions in children on the autistic spectrum. Neuron 74, 285-299 (2012
    • (2012) Neuron , vol.74 , pp. 285-299
    • Iossifov, I.1
  • 2
    • 84860712363 scopus 로고    scopus 로고
    • Patterns and rates of exonic de novo mutations in autism spectrum disorders
    • Neale, B.M. et al. Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature 485, 242-245 (2012
    • (2012) Nature , vol.485 , pp. 242-245
    • Neale, B.M.1
  • 3
    • 84860741138 scopus 로고    scopus 로고
    • Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations
    • O'Roak, B.J. et al. Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations. Nature 485, 246-250 (2012
    • (2012) Nature , vol.485 , pp. 246-250
    • O'Roak, B.J.1
  • 4
    • 84860780495 scopus 로고    scopus 로고
    • De novo mutations revealed by whole-exome sequencing are strongly associated with autism
    • Sanders, S.J. et al. De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature 485, 237-241 (2012
    • (2012) Nature , vol.485 , pp. 237-241
    • Sanders, S.J.1
  • 5
    • 34247481814 scopus 로고    scopus 로고
    • Strong association of de novo copy number mutations with autism
    • Sebat, J. et al. Strong association of de novo copy number mutations with autism. Science 316, 445-449 (2007
    • (2007) Science , vol.316 , pp. 445-449
    • Sebat, J.1
  • 6
    • 67349182343 scopus 로고    scopus 로고
    • Autism genome-wide copy number variation reveals ubiquitin and neuronal genes
    • Glessner, J.T. et al. Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Nature 459, 569-573 (2009
    • (2009) Nature , vol.459 , pp. 569-573
    • Glessner, J.T.1
  • 7
    • 79958074870 scopus 로고    scopus 로고
    • Multiple recurrent de novo CNVs including duplications of the 7q11.23 Williams syndrome region are strongly associated with autism
    • Sanders, S.J. et al. Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism. Neuron 70, 863-885 (2011
    • (2011) Neuron , vol.70 , pp. 863-885
    • Sanders, S.J.1
  • 8
    • 84899918742 scopus 로고    scopus 로고
    • Convergence of genes and cellular pathways dysregulated in autism spectrum disorders
    • Pinto, D. et al. Convergence of genes and cellular pathways dysregulated in autism spectrum disorders. Am. J. Hum. Genet. 94, 677-694 (2014
    • (2014) Am. J. Hum. Genet , vol.94 , pp. 677-694
    • Pinto, D.1
  • 9
    • 84871298155 scopus 로고    scopus 로고
    • Common genetic variants, acting additively, are a major source of risk for autism
    • Klei, L. et al. Common genetic variants, acting additively, are a major source of risk for autism. Mol. Autism 3, 9 (2012
    • (2012) Mol. Autism , vol.3 , pp. 9
    • Klei, L.1
  • 10
    • 84883465830 scopus 로고    scopus 로고
    • Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
    • Lee, S.H. et al. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat. Genet. 45, 984-994 (2013
    • (2013) Nat. Genet , vol.45 , pp. 984-994
    • Lee, S.H.1
  • 11
    • 82255192290 scopus 로고    scopus 로고
    • The conundrums of understanding genetic risks for autism spectrum disorders
    • State, M.W. & Levitt, P. The conundrums of understanding genetic risks for autism spectrum disorders. Nat. Neurosci. 14, 1499-1506 (2011
    • (2011) Nat. Neurosci , vol.14 , pp. 1499-1506
    • State, M.W.1    Levitt, P.2
  • 12
    • 84862493260 scopus 로고    scopus 로고
    • Genetic architecture in autism spectrum disorder
    • Devlin, B. & Scherer, S.W. Genetic architecture in autism spectrum disorder. Curr. Opin. Genet. Dev. 22, 229-237 (2012
    • (2012) Curr. Opin. Genet. Dev , vol.22 , pp. 229-237
    • Devlin, B.1    Scherer, S.W.2
  • 13
    • 84867829870 scopus 로고    scopus 로고
    • Individual common variants exert weak effects on the risk for autism spectrum disorderspi
    • Anney, R. et al. Individual common variants exert weak effects on the risk for autism spectrum disorderspi. Hum. Mol. Genet. 21, 4781-4792 (2012
    • (2012) Hum. Mol. Genet , vol.21 , pp. 4781-4792
    • Anney, R.1
  • 14
    • 67349112868 scopus 로고    scopus 로고
    • Common genetic variants on 5p14.1 associate with autism spectrum disorders
    • Wang, K. et al. Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature 459, 528-533 (2009
    • (2009) Nature , vol.459 , pp. 528-533
    • Wang, K.1
  • 15
    • 70349956425 scopus 로고    scopus 로고
    • A genome-wide linkage and association scan reveals novel loci for autism
    • Weiss, L.A. et al. A genome-wide linkage and association scan reveals novel loci for autism. Nature 461, 802-808 (2009
    • (2009) Nature , vol.461 , pp. 802-808
    • Weiss, L.A.1
  • 16
    • 68449086236 scopus 로고    scopus 로고
    • International Schizophrenia Consortium Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
    • International Schizophrenia Consortium. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460, 748-752 (2009
    • (2009) Nature , vol.460 , pp. 748-752
  • 17
    • 84883465830 scopus 로고    scopus 로고
    • Cross-Disorder Group of the Psychiatric Genomics Consortium. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
    • Cross-Disorder Group of the Psychiatric Genomics Consortium. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat. Genet. 45, 984-994 (2013
    • (2013) Nat. Genet , vol.45 , pp. 984-994
  • 18
    • 84892620880 scopus 로고    scopus 로고
    • CNVs conferring risk of autism or schizophrenia affect cognition in controls
    • Stefansson, H. et al. CNVs conferring risk of autism or schizophrenia affect cognition in controls. Nature 505, 361-366 (2014
    • (2014) Nature , vol.505 , pp. 361-366
    • Stefansson, H.1
  • 19
    • 84860347597 scopus 로고    scopus 로고
    • Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries
    • Talkowski, M.E. et al. Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries. Cell 149, 525-537 (2012
    • (2012) Cell , vol.149 , pp. 525-537
    • Talkowski, M.E.1
  • 20
    • 80051944739 scopus 로고    scopus 로고
    • Genetic heritability and shared environmental factors among twin pairs with autism
    • Hallmayer, J. et al. Genetic heritability and shared environmental factors among twin pairs with autism. Arch. Gen. Psychiatry 68, 1095-1102 (2011
    • (2011) Arch. Gen. Psychiatry , vol.68 , pp. 1095-1102
    • Hallmayer, J.1
  • 21
    • 84899784475 scopus 로고    scopus 로고
    • The familial risk of autism
    • in the press)
    • Sandin, S. et al. The familial risk of autism. J. Am. Med. Assoc. (in the press) (2014
    • (2014) J. Am. Med. Assoc
    • Sandin, S.1
  • 24
    • 78149436551 scopus 로고    scopus 로고
    • Synthetic associations in the context of genome-wide association scan signals
    • Orozco, G., Barrett, J.C. & Zeggini, E. Synthetic associations in the context of genome-wide association scan signals. Hum. Mol. Genet. 19, R137-R144 (2010
    • (2010) Hum. Mol. Genet , vol.19
    • Orozco, G.1    Barrett, J.C.2    Zeggini, E.3
  • 25
    • 79851487367 scopus 로고    scopus 로고
    • Synthetic associations created by rare variants do not explain most GWAS results
    • Wray, N.R., Purcell, S.M. & Visscher, P.M. Synthetic associations created by rare variants do not explain most GWAS results. PLoS Biol. 9, e1000579 (2011
    • (2011) PLoS Biol , vol.9
    • Wray, N.R.1    Purcell, S.M.2    Visscher, P.M.3
  • 26
    • 84879536607 scopus 로고    scopus 로고
    • Refining genetically inferred relationships using treelet covariance smoothing
    • Crossett, A., Lee, A.B., Klei, L., Devlin, B. & Roeder, K. Refining genetically inferred relationships using treelet covariance smoothing. Ann. Appl. Stat. 7, 669-690 (2013
    • (2013) Ann. Appl. Stat , vol.7 , pp. 669-690
    • Crossett, A.1    Lee, A.B.2    Klei, L.3    Devlin, B.4    Roeder, K.5
  • 27
    • 84872722295 scopus 로고    scopus 로고
    • Rare complete knockouts in humans: Population distribution and significant role in autism spectrum disorders
    • Lim, E.T. et al. Rare complete knockouts in humans: Population distribution and significant role in autism spectrum disorders. Neuron 77, 235-242 (2013
    • (2013) Neuron , vol.77 , pp. 235-242
    • Lim, E.T.1
  • 28
    • 84888389414 scopus 로고    scopus 로고
    • Evaluating empirical bounds on complex disease genetic architecture
    • Agarwala, V., Flannick, J., Sunyaev, S. & Altshuler, D. Evaluating empirical bounds on complex disease genetic architecture. Nat. Genet. 45, 1418-1427 (2013
    • (2013) Nat. Genet , vol.45 , pp. 1418-1427
    • Agarwala, V.1    Flannick, J.2    Sunyaev, S.3    Altshuler, D.4
  • 29
    • 84856405512 scopus 로고    scopus 로고
    • The mystery of missing heritability: Genetic interactions create phantom heritability
    • Zuk, O., Hechter, E., Sunyaev, S.R. & Lander, E.S. The mystery of missing heritability: Genetic interactions create phantom heritability. Proc. Natl. Acad. Sci. USA 109, 1193-1198 (2012
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 1193-1198
    • Zuk, O.1    Hechter, E.2    Sunyaev, S.R.3    Lander, E.S.4
  • 31
    • 0030855087 scopus 로고    scopus 로고
    • The heritability of iq
    • Devlin, B., Daniels, M & Roeder, K. The heritability of IQ. Nature 388, 468-471 (1997
    • (1997) Nature , vol.388 , pp. 468-471
    • Devlin, B.1    Daniels, M.2    Roeder, K.3
  • 32
    • 78349293844 scopus 로고    scopus 로고
    • The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood
    • Lichtenstein, P., Carlstrom, E., Rastam, M., Gillberg, C. & Anckarsater, H. The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood. Am. J. Psychiatry 167, 1357-1363 (2010
    • (2010) Am. J. Psychiatry , vol.167 , pp. 1357-1363
    • Lichtenstein, P.1    Carlstrom, E.2    Rastam, M.3    Gillberg, C.4    Anckarsater, H.5
  • 33
    • 84855331271 scopus 로고    scopus 로고
    • Autism spectrum disorders and autistic like traits: Similar etiology in the extreme end and the normal variation
    • Lundström, S. et al. Autism spectrum disorders and autistic like traits: Similar etiology in the extreme end and the normal variation. Arch. Gen. Psychiatry 69, 46-52 (2012
    • (2012) Arch. Gen. Psychiatry , vol.69 , pp. 46-52
    • Lundström, S.1
  • 34
    • 79958032110 scopus 로고    scopus 로고
    • Rare de novo and transmitted copy-number variation in autistic spectrum disorders
    • Levy, D. et al. Rare de novo and transmitted copy-number variation in autistic spectrum disorders. Neuron 70, 886-897 (2011
    • (2011) Neuron , vol.70 , pp. 886-897
    • Levy, D.1
  • 35
    • 84889583293 scopus 로고    scopus 로고
    • Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism
    • Willsey, A.J. et al. Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism. Cell 155, 997-1007 (2013
    • (2013) Cell , vol.155 , pp. 997-1007
    • Willsey, A.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.