메뉴 건너뛰기




Volumn 31, Issue , 2013, Pages 54-68

Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development

Author keywords

Autism; Chemokine; Development; Inflammation; Maternal infection; Microglia; Neuroimmunology; Poly(I:C); Schizophrenia; Serum

Indexed keywords

EOTAXIN; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TUMOR NECROSIS FACTOR ALPHA;

EID: 84877352822     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2012.07.008     Document Type: Article
Times cited : (272)

References (81)
  • 2
    • 84862208120 scopus 로고    scopus 로고
    • Maternal immune activation by poly(I:C) induces expression of cytokines IL-1beta and IL-13, chemokine MCP-1 and colony stimulating factor VEGF in fetal mouse brain
    • Arrode-Bruses G., Bruses J.L. Maternal immune activation by poly(I:C) induces expression of cytokines IL-1beta and IL-13, chemokine MCP-1 and colony stimulating factor VEGF in fetal mouse brain. J Neuroinflammation 2012, 9:83.
    • (2012) J Neuroinflammation , vol.9 , pp. 83
    • Arrode-Bruses, G.1    Bruses, J.L.2
  • 3
    • 78649322790 scopus 로고    scopus 로고
    • Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome
    • Ashwood P., Krakowiak P., Hertz-Picciotto I., Hansen R., Pessah I., Van de Water J. Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain Behav. Immun. 2011, 25:40-45.
    • (2011) Brain Behav. Immun. , vol.25 , pp. 40-45
    • Ashwood, P.1    Krakowiak, P.2    Hertz-Picciotto, I.3    Hansen, R.4    Pessah, I.5    Van de Water, J.6
  • 5
    • 77954213032 scopus 로고    scopus 로고
    • Plasma cytokine profiles in Fragile X subjects: is there a role for cytokines in the pathogenesis?
    • Ashwood P., Nguyen D.V., Hessl D., Hagerman R.J., Tassone F. Plasma cytokine profiles in Fragile X subjects: is there a role for cytokines in the pathogenesis?. Brain Behav. Immun. 2010, 24:898-902.
    • (2010) Brain Behav. Immun. , vol.24 , pp. 898-902
    • Ashwood, P.1    Nguyen, D.V.2    Hessl, D.3    Hagerman, R.J.4    Tassone, F.5
  • 7
    • 33847111695 scopus 로고    scopus 로고
    • The neuropoietic cytokine family in development, plasticity, disease and injury
    • Bauer S., Kerr B.J., Patterson P.H. The neuropoietic cytokine family in development, plasticity, disease and injury. Nat. Rev. Neurosci. 2007, 8:221-232.
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 221-232
    • Bauer, S.1    Kerr, B.J.2    Patterson, P.H.3
  • 9
    • 84865839322 scopus 로고    scopus 로고
    • Epidemiologic studies of exposure to prenatal infection and risk of schizophrenia and autism. Dev Neurobiol. [Epub ahead of print].
    • Brown, A.S., 2012. Epidemiologic studies of exposure to prenatal infection and risk of schizophrenia and autism. Dev Neurobiol. [Epub ahead of print]. doi:10.1002/dneu.22024.
    • (2012)
    • Brown, A.S.1
  • 11
    • 77649167678 scopus 로고    scopus 로고
    • Prenatal infection and schizophrenia: a review of epidemiologic and translational studies
    • Brown A.S., Derkits E.J. Prenatal infection and schizophrenia: a review of epidemiologic and translational studies. The American journal of psychiatry 2010, 167:261-280.
    • (2010) The American journal of psychiatry , vol.167 , pp. 261-280
    • Brown, A.S.1    Derkits, E.J.2
  • 12
    • 79952123263 scopus 로고    scopus 로고
    • Maternal infection and schizophrenia: implications for prevention
    • Brown A.S., Patterson P.H. Maternal infection and schizophrenia: implications for prevention. Schizophr. Bull. 2011, 37:284-290.
    • (2011) Schizophr. Bull. , vol.37 , pp. 284-290
    • Brown, A.S.1    Patterson, P.H.2
  • 13
    • 77954938884 scopus 로고    scopus 로고
    • Immune dysfunction in autism: a pathway to treatment
    • Careaga M., Van de Water J., Ashwood P. Immune dysfunction in autism: a pathway to treatment. Neurotherapeutics 2010, 7:283-292.
    • (2010) Neurotherapeutics , vol.7 , pp. 283-292
    • Careaga, M.1    Van de Water, J.2    Ashwood, P.3
  • 14
    • 34249864530 scopus 로고    scopus 로고
    • Elevation of tumor necrosis factor-alpha in cerebrospinal fluid of autistic children
    • Chez M.G., Dowling T., Patel P.B., Khanna P., Kominsky M. Elevation of tumor necrosis factor-alpha in cerebrospinal fluid of autistic children. Pediatr. Neurol. 2007, 36:361-365.
    • (2007) Pediatr. Neurol. , vol.36 , pp. 361-365
    • Chez, M.G.1    Dowling, T.2    Patel, P.B.3    Khanna, P.4    Kominsky, M.5
  • 15
    • 34948867658 scopus 로고    scopus 로고
    • Extrapolating brain development from experimental species to humans
    • Clancy B., Finlay B.L., Darlington R.B., Anand K.J. Extrapolating brain development from experimental species to humans. Neurotoxicology 2007, 28:931-937.
    • (2007) Neurotoxicology , vol.28 , pp. 931-937
    • Clancy, B.1    Finlay, B.L.2    Darlington, R.B.3    Anand, K.J.4
  • 17
    • 52049098912 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced increases in cytokines in discrete mouse brain regions are detectable using Luminex xMAP technology
    • Datta S.C., Opp M.R. Lipopolysaccharide-induced increases in cytokines in discrete mouse brain regions are detectable using Luminex xMAP technology. J. Neurosci. Methods 2008, 175:119-124.
    • (2008) J. Neurosci. Methods , vol.175 , pp. 119-124
    • Datta, S.C.1    Opp, M.R.2
  • 18
    • 79959379095 scopus 로고    scopus 로고
    • Repertoire of microglial and macrophage responses after spinal cord injury
    • David S., Kroner A. Repertoire of microglial and macrophage responses after spinal cord injury. Nat. Rev. Neurosci. 2011, 12:388-399.
    • (2011) Nat. Rev. Neurosci. , vol.12 , pp. 388-399
    • David, S.1    Kroner, A.2
  • 19
    • 0029046528 scopus 로고
    • Prenatal development of monozygotic twins and concordance for schizophrenia
    • Davis J.O., Phelps J.A., Bracha H.S. Prenatal development of monozygotic twins and concordance for schizophrenia. Schizophr Bull. 1995, 21:357-366.
    • (1995) Schizophr Bull. , vol.21 , pp. 357-366
    • Davis, J.O.1    Phelps, J.A.2    Bracha, H.S.3
  • 20
    • 70349838218 scopus 로고    scopus 로고
    • Cytokines and CNS development
    • Deverman B.E., Patterson P.H. Cytokines and CNS development. Neuron 2009, 64:61-78.
    • (2009) Neuron , vol.64 , pp. 61-78
    • Deverman, B.E.1    Patterson, P.H.2
  • 21
    • 80053900477 scopus 로고    scopus 로고
    • Cytokine and chemokine responses in serum and brain after single and repeated injections of lipopolysaccharide: multiplex quantification with path analysis
    • Erickson M.A., Banks W.A. Cytokine and chemokine responses in serum and brain after single and repeated injections of lipopolysaccharide: multiplex quantification with path analysis. Brain Behav. Immun. 2011, 25:1637-1648.
    • (2011) Brain Behav. Immun. , vol.25 , pp. 1637-1648
    • Erickson, M.A.1    Banks, W.A.2
  • 22
    • 0036024265 scopus 로고    scopus 로고
    • Human influenza viral infection in utero alters glial fibrillary acidic protein immunoreactivity in the developing brains of neonatal mice
    • Fatemi S.H., Emamian E.S., Sidwell R.W., Kist D.A., Stary J.M., Earle J.A., Thuras P. Human influenza viral infection in utero alters glial fibrillary acidic protein immunoreactivity in the developing brains of neonatal mice. Mol. Psychiatry 2002, 7:633-640.
    • (2002) Mol. Psychiatry , vol.7 , pp. 633-640
    • Fatemi, S.H.1    Emamian, E.S.2    Sidwell, R.W.3    Kist, D.A.4    Stary, J.M.5    Earle, J.A.6    Thuras, P.7
  • 24
    • 0032572605 scopus 로고    scopus 로고
    • Differential expression of synaptosome-associated protein 25kDa [SNAP-25] in hippocampi of neonatal mice following exposure to human influenza virus in utero
    • Fatemi S.H., Sidwell R., Kist D., Akhter P., Meltzer H.Y., Bailey K., Thuras P., Sedgwick J. Differential expression of synaptosome-associated protein 25kDa [SNAP-25] in hippocampi of neonatal mice following exposure to human influenza virus in utero. Brain Res. 1998, 800:1-9.
    • (1998) Brain Res. , vol.800 , pp. 1-9
    • Fatemi, S.H.1    Sidwell, R.2    Kist, D.3    Akhter, P.4    Meltzer, H.Y.5    Bailey, K.6    Thuras, P.7    Sedgwick, J.8
  • 26
    • 79955603399 scopus 로고    scopus 로고
    • Common proteomic changes in the hippocampus in schizophrenia and bipolar disorder and particular evidence for involvement of cornu ammonis regions 2 and 3
    • Focking M., Dicker P., English J.A., Schubert K.O., Dunn M.J., Cotter D.R. Common proteomic changes in the hippocampus in schizophrenia and bipolar disorder and particular evidence for involvement of cornu ammonis regions 2 and 3. Arch. Gen. Psychiatry. 2011, 68:477-488.
    • (2011) Arch. Gen. Psychiatry. , vol.68 , pp. 477-488
    • Focking, M.1    Dicker, P.2    English, J.A.3    Schubert, K.O.4    Dunn, M.J.5    Cotter, D.R.6
  • 27
    • 75749157812 scopus 로고    scopus 로고
    • Comparison of multiplex immunoassay platforms
    • Fu Q., Zhu J., Van Eyk J.E. Comparison of multiplex immunoassay platforms. Clin. Chem. 2010, 56:314-318.
    • (2010) Clin. Chem. , vol.56 , pp. 314-318
    • Fu, Q.1    Zhu, J.2    Van Eyk, J.E.3
  • 28
    • 34047138977 scopus 로고    scopus 로고
    • Influence of poly I:C on sickness behaviors, plasma cytokines, corticosterone and central monoamine activity: moderation by social stressors
    • Gandhi R., Hayley S., Gibb J., Merali Z., Anisman H. Influence of poly I:C on sickness behaviors, plasma cytokines, corticosterone and central monoamine activity: moderation by social stressors. Brain Behav. Immun. 2007, 21:477-489.
    • (2007) Brain Behav. Immun. , vol.21 , pp. 477-489
    • Gandhi, R.1    Hayley, S.2    Gibb, J.3    Merali, Z.4    Anisman, H.5
  • 29
    • 84862188749 scopus 로고    scopus 로고
    • Novel roles for immune molecules in neural development: implications for neurodevelopmental disorders
    • Garay P.A., McAllister A.K. Novel roles for immune molecules in neural development: implications for neurodevelopmental disorders. Frontiers synaptic neurosci. 2010, 2(136):1-16.
    • (2010) Frontiers synaptic neurosci. , vol.2 , Issue.136 , pp. 1-16
    • Garay, P.A.1    McAllister, A.K.2
  • 30
    • 12344280393 scopus 로고    scopus 로고
    • Maternal poly I:C exposure during pregnancy regulates TNF alpha, BDNF, and NGF expression in neonatal brain and the maternal-fetal unit of the rat
    • Gilmore J.H., Jarskog L.F., Vadlamudi S. Maternal poly I:C exposure during pregnancy regulates TNF alpha, BDNF, and NGF expression in neonatal brain and the maternal-fetal unit of the rat. J Neuroimmunol 2005, 159:106-112.
    • (2005) J Neuroimmunol , vol.159 , pp. 106-112
    • Gilmore, J.H.1    Jarskog, L.F.2    Vadlamudi, S.3
  • 31
    • 2942683385 scopus 로고    scopus 로고
    • Prenatal infection and risk for schizophrenia: IL-1b, IL-6, and TNFa inhibit cortcial neuron dendrtie development
    • Gilmore J.H., Jarskog L.F., Vadlamudi S., Lauder J.M. Prenatal infection and risk for schizophrenia: IL-1b, IL-6, and TNFa inhibit cortcial neuron dendrtie development. Neuropsychopharmacology 2004, 29:1221-1229.
    • (2004) Neuropsychopharmacology , vol.29 , pp. 1221-1229
    • Gilmore, J.H.1    Jarskog, L.F.2    Vadlamudi, S.3    Lauder, J.M.4
  • 33
    • 84860222551 scopus 로고    scopus 로고
    • Inflammation during fetal and neonatal life: implications for neurologic and neuropsychiatric disease in children and adults
    • Hagberg H., Gressens P., Mallard C. Inflammation during fetal and neonatal life: implications for neurologic and neuropsychiatric disease in children and adults. Ann. Neurol. 2012, 71:444-457.
    • (2012) Ann. Neurol. , vol.71 , pp. 444-457
    • Hagberg, H.1    Gressens, P.2    Mallard, C.3
  • 35
    • 79954718560 scopus 로고    scopus 로고
    • Activation of the maternal immune system induces endocrine changes in the placenta via IL-6
    • Hsiao E.Y., Patterson P.H. Activation of the maternal immune system induces endocrine changes in the placenta via IL-6. Brain Behav. Immun. 2011, 25:604-615.
    • (2011) Brain Behav. Immun. , vol.25 , pp. 604-615
    • Hsiao, E.Y.1    Patterson, P.H.2
  • 36
    • 77954212567 scopus 로고    scopus 로고
    • Maternal immune activation alters nonspatial information processing in the hippocampus of adult offspring
    • Ito H.T., Smith S.E.P., Hsiao E., Patterson P.H. Maternal immune activation alters nonspatial information processing in the hippocampus of adult offspring. Brain Behav. Immun. 2010, 24:930-941.
    • (2010) Brain Behav. Immun. , vol.24 , pp. 930-941
    • Ito, H.T.1    Smith, S.E.P.2    Hsiao, E.3    Patterson, P.H.4
  • 37
    • 80052322761 scopus 로고    scopus 로고
    • Brain region-specific decrease in the activity and expression of protein kinase A in the frontal cortex of regressive autism
    • Ji L., Chauhan V., Flory M.J., Chauhan A. Brain region-specific decrease in the activity and expression of protein kinase A in the frontal cortex of regressive autism. PLoS One 2011, 6:e23751.
    • (2011) PLoS One , vol.6
    • Ji, L.1    Chauhan, V.2    Flory, M.J.3    Chauhan, A.4
  • 38
    • 77954805268 scopus 로고    scopus 로고
    • The acute phase response and soman-induced status epilepticus: temporal, regional and cellular changes in rat brain cytokine concentrations
    • Johnson E.A., Kan R.K. The acute phase response and soman-induced status epilepticus: temporal, regional and cellular changes in rat brain cytokine concentrations. J Neuroinflammation 2010, 7:40.
    • (2010) J Neuroinflammation , vol.7 , pp. 40
    • Johnson, E.A.1    Kan, R.K.2
  • 39
    • 0036113566 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6): a possible neuromodulator induced by neuronal activity
    • Juttler E., Tarabin V., Schwaninger M. Interleukin-6 (IL-6): a possible neuromodulator induced by neuronal activity. Neuroscientist 2002, 8:268-275.
    • (2002) Neuroscientist , vol.8 , pp. 268-275
    • Juttler, E.1    Tarabin, V.2    Schwaninger, M.3
  • 40
    • 79951504901 scopus 로고    scopus 로고
    • Central nervous system cytokine gene expression: modulation by lead
    • Kasten-Jolly J., Heo Y., Lawrence D.A. Central nervous system cytokine gene expression: modulation by lead. J. Biochem. Mol. Toxicol. 2011, 25:41-54.
    • (2011) J. Biochem. Mol. Toxicol. , vol.25 , pp. 41-54
    • Kasten-Jolly, J.1    Heo, Y.2    Lawrence, D.A.3
  • 46
    • 84858740384 scopus 로고    scopus 로고
    • Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism
    • Malkova N.V., Yu C.Z., Hsiao E.Y., Moore M.J., Patterson P.H. Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism. Brain Behav. Immun. 2012, 26:607-616.
    • (2012) Brain Behav. Immun. , vol.26 , pp. 607-616
    • Malkova, N.V.1    Yu, C.Z.2    Hsiao, E.Y.3    Moore, M.J.4    Patterson, P.H.5
  • 47
    • 79957917993 scopus 로고    scopus 로고
    • Maternal immune stimulation during pregnancy affects adaptive immunity in offspring to promote development of TH17 cells
    • Mandal M., Marzouk A.C., Donnelly R., Ponzio N.M. Maternal immune stimulation during pregnancy affects adaptive immunity in offspring to promote development of TH17 cells. Brain Behav. Immun. 2011, 25:863-871.
    • (2011) Brain Behav. Immun. , vol.25 , pp. 863-871
    • Mandal, M.1    Marzouk, A.C.2    Donnelly, R.3    Ponzio, N.M.4
  • 48
    • 59249085094 scopus 로고    scopus 로고
    • Evidence for a cytokine model of cognitive function
    • McAfoose J., Baune B.T. Evidence for a cytokine model of cognitive function. Neurosci. Biobehav. Rev. 2009, 33:355-366.
    • (2009) Neurosci. Biobehav. Rev. , vol.33 , pp. 355-366
    • McAfoose, J.1    Baune, B.T.2
  • 49
    • 77649274922 scopus 로고    scopus 로고
    • Epidemiology-driven neurodevelopmental animal models of schizophrenia
    • Meyer U., Feldon J. Epidemiology-driven neurodevelopmental animal models of schizophrenia. Prog. Neurobiol. 2010, 90:285-326.
    • (2010) Prog. Neurobiol. , vol.90 , pp. 285-326
    • Meyer, U.1    Feldon, J.2
  • 50
    • 79954578712 scopus 로고    scopus 로고
    • Schizophrenia and autism: both shared and disorder-specific pathogenesis via perinatal inflammation?
    • Meyer U., Feldon J., Dammann O. Schizophrenia and autism: both shared and disorder-specific pathogenesis via perinatal inflammation?. Pediatr. Res. 2011, 69:26R-33R.
    • (2011) Pediatr. Res. , vol.69
    • Meyer, U.1    Feldon, J.2    Dammann, O.3
  • 51
    • 67649464224 scopus 로고    scopus 로고
    • In-vivo rodent models for the experimental investigation of prenatal immune activation effects in neurodevelopmental brain disorders
    • Meyer U., Feldon J., Fatemi S.H. In-vivo rodent models for the experimental investigation of prenatal immune activation effects in neurodevelopmental brain disorders. Neurosci. Biobehav. Rev. 2009, 33:1061-1079.
    • (2009) Neurosci. Biobehav. Rev. , vol.33 , pp. 1061-1079
    • Meyer, U.1    Feldon, J.2    Fatemi, S.H.3
  • 52
    • 33646831799 scopus 로고    scopus 로고
    • Immunological stress at the maternal-foetal interface. a link between neurodevelopment and adult psychopathology
    • Meyer U., Feldon J., Schedlowski M., Yee B.K. Immunological stress at the maternal-foetal interface. a link between neurodevelopment and adult psychopathology. Brain Behav. Immun. 2006, 20:378-388.
    • (2006) Brain Behav. Immun. , vol.20 , pp. 378-388
    • Meyer, U.1    Feldon, J.2    Schedlowski, M.3    Yee, B.K.4
  • 53
    • 77649235467 scopus 로고    scopus 로고
    • Chronic clozapine treatment improves prenatal infection-induced working memory deficits without influencing adult hippocampal neurogenesis
    • Meyer U., Knuesel I., Nyffeler M., Feldon J. Chronic clozapine treatment improves prenatal infection-induced working memory deficits without influencing adult hippocampal neurogenesis. Psychopharmacology (Berl) 2010, 208:531-543.
    • (2010) Psychopharmacology (Berl) , vol.208 , pp. 531-543
    • Meyer, U.1    Knuesel, I.2    Nyffeler, M.3    Feldon, J.4
  • 54
    • 33646926705 scopus 로고    scopus 로고
    • The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology
    • Meyer U., Nyffeler M., Engler A., Urwyler A., Schedlowski M., Knuesel I., Yee B.K., Feldon J. The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology. J. Neurosci. 2006, 26:4752-4762.
    • (2006) J. Neurosci. , vol.26 , pp. 4752-4762
    • Meyer, U.1    Nyffeler, M.2    Engler, A.3    Urwyler, A.4    Schedlowski, M.5    Knuesel, I.6    Yee, B.K.7    Feldon, J.8
  • 55
    • 36949028725 scopus 로고    scopus 로고
    • Relative prenatal and postnatal maternal contributions to schizophrenia-related neurochemical dysfunction after in utero immune challenge
    • Meyer U., Nyffeler M., Schwendener S., Knuesel I., Yee B.K., Feldon J. Relative prenatal and postnatal maternal contributions to schizophrenia-related neurochemical dysfunction after in utero immune challenge. Neuropsychopharmacology 2008, 33:441-456.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 441-456
    • Meyer, U.1    Nyffeler, M.2    Schwendener, S.3    Knuesel, I.4    Yee, B.K.5    Feldon, J.6
  • 56
    • 33747588330 scopus 로고    scopus 로고
    • Prenatal and postnatal maternal contributions in the infection model of schizophrenia
    • Meyer U., Schwendener S., Feldon J., Yee B.K. Prenatal and postnatal maternal contributions in the infection model of schizophrenia. Exp. Brain Res. 2006, 173:243-257.
    • (2006) Exp. Brain Res. , vol.173 , pp. 243-257
    • Meyer, U.1    Schwendener, S.2    Feldon, J.3    Yee, B.K.4
  • 58
    • 84856690921 scopus 로고    scopus 로고
    • Early TBI-induced cytokine alterations are similarly detected by two distinct methods of multiplex assay
    • Mukherjee S., Katki K., Arisi G.M., Foresti M.L., Shapiro L.A. Early TBI-induced cytokine alterations are similarly detected by two distinct methods of multiplex assay. Front Mol. Neurosci. 2011, 4:21.
    • (2011) Front Mol. Neurosci. , vol.4 , pp. 21
    • Mukherjee, S.1    Katki, K.2    Arisi, G.M.3    Foresti, M.L.4    Shapiro, L.A.5
  • 59
    • 0033659799 scopus 로고    scopus 로고
    • Cytokine and growth factor involvement in schizophrenia-support for the developmental model
    • Nawa H., Takahashi M., Patterson P.H. Cytokine and growth factor involvement in schizophrenia-support for the developmental model. Mol. Psychiatry 2000, 5:594-603.
    • (2000) Mol. Psychiatry , vol.5 , pp. 594-603
    • Nawa, H.1    Takahashi, M.2    Patterson, P.H.3
  • 62
    • 67749114055 scopus 로고    scopus 로고
    • Immune involvement in schizophrenia and autism: etiology, pathology and animal models
    • Patterson P.H. Immune involvement in schizophrenia and autism: etiology, pathology and animal models. Behav. Brain Res. 2009, 204:313-321.
    • (2009) Behav. Brain Res. , vol.204 , pp. 313-321
    • Patterson, P.H.1
  • 63
    • 79959964671 scopus 로고    scopus 로고
    • Maternal infection and immune involvement in autism
    • Patterson P.H. Maternal infection and immune involvement in autism. Trends Mol. Med. 2011, 17:389-394.
    • (2011) Trends Mol. Med. , vol.17 , pp. 389-394
    • Patterson, P.H.1
  • 64
    • 79954610221 scopus 로고    scopus 로고
    • Modeling autistic features in animals
    • Patterson P.H. Modeling autistic features in animals. Pediatr. Res. 2011, 69:34R-40R.
    • (2011) Pediatr. Res. , vol.69
    • Patterson, P.H.1
  • 65
    • 70350721661 scopus 로고    scopus 로고
    • Clozapine administration in adolescence prevents postpubertal emergence of brain structural pathology in an animal model of schizophrenia
    • Piontkewitz Y., Assaf Y., Weiner I. Clozapine administration in adolescence prevents postpubertal emergence of brain structural pathology in an animal model of schizophrenia. Biol. Psychiatry 2009, 66:1038-1046.
    • (2009) Biol. Psychiatry , vol.66 , pp. 1038-1046
    • Piontkewitz, Y.1    Assaf, Y.2    Weiner, I.3
  • 66
    • 67650966680 scopus 로고    scopus 로고
    • Microglial physiology: unique stimuli, specialized responses
    • Ransohoff R.M., Perry V.H. Microglial physiology: unique stimuli, specialized responses. Annu. Rev. Immunol. 2009, 27:119-145.
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 119-145
    • Ransohoff, R.M.1    Perry, V.H.2
  • 67
    • 58249135361 scopus 로고    scopus 로고
    • Autism spectrum disorders and childhood-onset schizophrenia: clinical and biological contributions to a relation revisited
    • Rapoport J., Chavez A., Greenstein D., Addington A., Gogtay N. Autism spectrum disorders and childhood-onset schizophrenia: clinical and biological contributions to a relation revisited. J. Am. Acad. Child Adolesc Psychiatry 2009, 48:10-18.
    • (2009) J. Am. Acad. Child Adolesc Psychiatry , vol.48 , pp. 10-18
    • Rapoport, J.1    Chavez, A.2    Greenstein, D.3    Addington, A.4    Gogtay, N.5
  • 69
    • 0037218688 scopus 로고    scopus 로고
    • Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring
    • Shi L., Fatemi S.H., Sidwell R.W., Patterson P.H. Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring. J. Neurosci. 2003, 23:297-302.
    • (2003) J. Neurosci. , vol.23 , pp. 297-302
    • Shi, L.1    Fatemi, S.H.2    Sidwell, R.W.3    Patterson, P.H.4
  • 70
    • 56949092229 scopus 로고    scopus 로고
    • Activation of the maternal immune system alters cerebellar development in the offspring
    • Shi L., Smith S.E., Malkova N., Tse D., Su Y., Patterson P.H. Activation of the maternal immune system alters cerebellar development in the offspring. Brain Behav. Immun. 2009, 23:116-123.
    • (2009) Brain Behav. Immun. , vol.23 , pp. 116-123
    • Shi, L.1    Smith, S.E.2    Malkova, N.3    Tse, D.4    Su, Y.5    Patterson, P.H.6
  • 71
    • 14644431849 scopus 로고    scopus 로고
    • Maternal influenza infection is likely to alter fetal brain development indirectly: the virus is not detected in the fetus
    • Shi L., Tu N., Patterson P.H. Maternal influenza infection is likely to alter fetal brain development indirectly: the virus is not detected in the fetus. Int. J. Dev. Neurosci. 2005, 23:299-305.
    • (2005) Int. J. Dev. Neurosci. , vol.23 , pp. 299-305
    • Shi, L.1    Tu, N.2    Patterson, P.H.3
  • 73
    • 35148872226 scopus 로고    scopus 로고
    • Maternal immune activation alters fetal brain development through interleukin-6
    • Smith S.E., Li J., Garbett K., Mirnics K., Patterson P.H. Maternal immune activation alters fetal brain development through interleukin-6. J. Neurosci. 2007, 27:10695-10702.
    • (2007) J. Neurosci. , vol.27 , pp. 10695-10702
    • Smith, S.E.1    Li, J.2    Garbett, K.3    Mirnics, K.4    Patterson, P.H.5
  • 74
    • 79954439709 scopus 로고    scopus 로고
    • The contribution of TNFalpha to synaptic plasticity and nervous system function
    • Stellwagen D. The contribution of TNFalpha to synaptic plasticity and nervous system function. Adv. Exp. Med. Biol. 2011, 691:541-557.
    • (2011) Adv. Exp. Med. Biol. , vol.691 , pp. 541-557
    • Stellwagen, D.1
  • 76
    • 80755150149 scopus 로고    scopus 로고
    • Is Autism, at Least in Part, a Disorder of Fetal Programming?
    • Szatmari P. Is Autism, at Least in Part, a Disorder of Fetal Programming?. Arch. Gen. Psychiatry 2011, 68:1091-1092.
    • (2011) Arch. Gen. Psychiatry , vol.68 , pp. 1091-1092
    • Szatmari, P.1
  • 78
    • 1542328794 scopus 로고    scopus 로고
    • Intratracheal double-stranded RNA plus interferon-gamma: a model for analysis of the acute phase response to respiratory viral infections
    • Traynor T.R., Majde J.A., Bohnet S.G., Krueger J.M. Intratracheal double-stranded RNA plus interferon-gamma: a model for analysis of the acute phase response to respiratory viral infections. Life Sci. 2004, 74:2563-2576.
    • (2004) Life Sci. , vol.74 , pp. 2563-2576
    • Traynor, T.R.1    Majde, J.A.2    Bohnet, S.G.3    Krueger, J.M.4
  • 79
  • 80
    • 0038624724 scopus 로고    scopus 로고
    • The " two-headed" latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatment
    • Weiner I. The " two-headed" latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatment. Psychopharmacology (Berl) 2003, 169:257-297.
    • (2003) Psychopharmacology (Berl) , vol.169 , pp. 257-297
    • Weiner, I.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.