Childhood Serum Anti-Fetal Brain Antibodies Do Not Predict Autism

Pediatric Neurology

Volumn 41, Issue 4, 2009, Pages 288-290

  Morris, Christina M ^a   Zimmerman, Andrew W ^b   Singer, Harvey S ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KENNEDY KRIEGER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; AUTOANTIBODY; BIOLOGICAL MARKER; BRAIN ANTIBODY; IMMUNOGLOBULIN G; MATERNAL ANTIBODY;

ANTIBODY BLOOD LEVEL; ARTICLE; AUTISM; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOREACTIVITY; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; WESTERN BLOTTING;

ACTINS; ADOLESCENT; AUTISTIC DISORDER; AUTOANTIBODIES; BIOLOGICAL MARKERS; BLOTTING, WESTERN; BRAIN; CHILD; CHILD, PRESCHOOL; FETAL PROTEINS; FETUS; HUMANS; IMMUNOGLOBULIN G;

EID: 69849086849     PISSN: 08878994     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pediatrneurol.2009.04.014     Document Type: Article

References (24)

1. Comi A.M., Zimmerman A.W., Frye V.H., Law P.A., and Peeden J.N. Familial clustering of autoimmune disorders and evaluation of medical risk factors in autism. J Child Neurol 14 (1999) 388-394
2. Croen L.A., Grether J.K., Yoshida C.K., Odouli R., and Van de Water J. Maternal autoimmune diseases, asthma, and allergies, and childhood autism spectrum disorders: a case-control study. Arch Pediatr Adolesc Med 159 (2005) 151-157
3. Plioplys A.V., Greaves A., and Yoshida W. Anti-CNS antibodies in childhood neurologic diseases. Neuropediatrics 20 (1989) 93-102
4. Ma D.Q., Cuccaro M.L., Jaworski J.M., et al. Dissecting the locus heterogeneity of autism: significant linkage to chromosome 12q14. Mol Psychiatry 12 (2007) 376-384
5. Warren R.P., Odell J.D., Warren W.L., et al. Strong association of the third hypervariable region of HLA-DRβ1 with autism. J Neuroimmunol 67 (1996) 97-102
6. Singer H.S., Morris C.M., Williams P.N., Yoon D.Y., Hong J.J., and Zimmerman A.W. Antibrain antibodies in children with autism and their unaffected siblings. J Neuroimmunol 178 (2006) 149-155
7. Silva S.C., Correia C., Fesel C., et al. Autoantibody repertoires to brain tissue in autism nuclear families. J Neuroimmunol 152 (2004) 176-182
8. Singh V.K., and Rivas W.H. Prevalence of serum antibodies to caudate nucleus in autistic children. Neurosci Lett 355 (2004) 53-56
9. Singh V.K., Warren R.P., Odell J.D., Warren W.L., and Cole P. Antibodies to myelin basic protein in children with autistic behavior. Brain Behav Immun 7 (1993) 97-103
10. Dalton P., Deacon R., Blamire A., et al. Maternal neuronal antibodies associated with autism and a language disorder. Ann Neurol 53 (2003) 533-537
11. Singer H.S., Morris C.M., Gause C.D., Gillin P.K., Crawford S., and Zimmerman A.W. Antibodies against fetal brain in sera of mothers with autistic children. J Neuroimmunol 194 (2008) 165-172
12. Heuer L., Ashwood P., and Van de Water J. The immune system in autism: is there a connection. In: Zimmerman A.W. (Ed). Autism: current theories and evidence (2008), Humana Press, Totowa, NJ 271-288
13. Garty B.Z., Ludomirsky A., Danon Y.L., Peter J.B., and Douglas S.D. Placental transfer of immunoglobulin G subclasses. Clin Diagn Lab Immunol 1 (1994) 667-669
14. Neri F., Chimini L., Bonomi F., et al. Neuropsychological development of children born to patients with systemic lupus erythematosus. Lupus 13 (2004) 805-811
15. Braunschweig D., Ashwood P., Krakowiak P., et al. Autism: Maternally derived antibodies specific for fetal brain proteins. Neurotoxicology 29 (2008) 226-231
16. Croen L.A., Braunschweig D., Haapanen L., et al. Maternal mid-pregnancy autoantibodies to fetal brain protein: the Early Markers for Autism Study. Biol Psychiatry 64 (2008) 583-588
17. Singer H.S., Morris C., Gause C., Pollard M., Zimmerman A.W., and Pletnikov M. Prenatal exposure to antibodies from mothers of children with autism produces neurobehavioral alterations: a pregnant dam mouse model. J Neuroimmunol (2009) April 9 [Epub ahead of print]
18. Martin L.A., Ashwood P., Braunschweig D., Cabanlit M., Van de Water J., and Amaral D.G. Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism. Brain Behav Immun 22 (2008) 806-816
19. Schopler E., Reichler R.J., and Renner B.R. The Childhood Autism Rating Scale (CARS): for diagnostic screening and classification of autism (1986), Irvington, New York
20. American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-IV. 4th ed. (1994), American Psychiatric Association, Washington, DC
21. Raux M., Finkielsztejn L., Salmon-Céron D., et al. Development and standardization of methods to evaluate the antibody response to an HIV-1 candidate vaccine in secretions and sera of seronegative vaccine recipients. J Immunol Methods 222 (1999) 111-124
22. Mishima T., Kurasawa G., Ishikawa G., et al. Endothelial expression of Fc gamma receptor IIb in the full-term human placenta. Placenta 28 (2007) 170-174
23. Wills S., Cabanlit M., Bennett J., Ashwood P., Amaral D.G., and Van de Water J. Detection of autoantibodies to neural cells of the cerebellum in the plasma of subjects with autism spectrum disorders. Brain Behav Immun 23 (2009) 64-74
24. Connolly A.M., Chez M., Streif E.M., et al. Brain-derived neurotrophic factor and autoantibodies to neural antigens in sera of children with autistic spectrum disorders, Landau-Kleffner syndrome, and epilepsy. Biol Psychiatry 59 (2006) 354-363