Polarization of Th2 response is decreased during pregnancy in systemic lupus erythematosus

Reumatismo

Volumn 64, Issue 5, 2012, Pages 314-320

  Iaccarino, L ^a   Ghirardello, A ^a   Zen, M ^a   Villalta, D ^b   Tincani, A ^c   Punzi, L ^a   Doria, A ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b S Maria Degli Angeli Regional Hospital   (Italy)

^c UNIVERSITY OF BRESCIA   (Italy)

Author keywords

Lupus cytokines; Lupus pregnancy; Systemic lupus erythematosus

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BLOOD SAMPLING; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIRST TRIMESTER PREGNANCY; HUMAN; PREGNANCY; PROTEIN BLOOD LEVEL; SECOND TRIMESTER PREGNANCY; SYSTEMIC LUPUS ERYTHEMATOSUS; TH2 CELL; THIRD TRIMESTER PREGNANCY;

EID: 84871432078     PISSN: 00487449     EISSN: None     Source Type: Journal    
DOI: 10.4081/reumatismo.2012.314     Document Type: Article

References (40)

1. Romagnani S. The Th1/Th2 paradigm. Immunol Today. 1997; 18: 263-6.
2. Cutolo M, Sulli A, Seriolo B, et al. Estrogens, the immune response and autoimmunity. Clin Exp Rheumatol. 1995; 13: 217-26.
3. Zen M, Ghirardello A, Iaccarino L, et al. Hormones, immune response, and pregnancy in healthy women and SLE patients. Swiss Med Wkly. 2010; 140: 187-201.
4. Doria A, Iaccarino L, Arienti S, et al. Th2 immune deviation induced by pregnancy: the two faces of autoimmune rheumatic diseases. Reprod Toxicol. 2006; 22: 234-41.
5. Lin H, Mosmann TR, Guilbert L, et al. Synthesis of T helper 2-type cytokines at the maternal-fetal interface. J Immunol. 1993; 151: 4562-73.
6. Rodriguez E, Guevara J, Paez A, et al. The altered expression of inflammation-related molecules and secretion of IL-6 and IL-8 by HUVEC from newborns with maternal inactive systemic lupus erythematosus is modified by estrogens. Lupus. 2008; 17: 1086-95.
7. Doria A, Ghirardello A, Iaccarino L, et al. Pregnancy, cytokines, and disease activity in systemic lupus erythematosus. Arthritis Rheum. 2004; 51: 989-95.
8. Ostensen M, Forger F, Villiger PM. Cytokines and pregnancy in rheumatic disease. Ann N Y Acad Sci. 2006; 1069: 353-63.
9. Doria A, Cutolo M, Ghirardello A, et al. Steroid hormones and disease activity during pregnancy in systemic lupus erythematosus. Arthritis Rheum. 2002; 47: 202-9.
10. Petri M, Howard D, Repke J. Frequency of lupus flare in pregnancy. The Hopkins Lupus Pregnancy Center experience. Arthritis Rheum. 1991; 34: 1538-45.
11. Tincani A, Bompane D, Danieli E, Doria A. Pregnancy, lupus and antiphospholipid syndrome (Hughes syndrome). Lupus. 2006; 15: 156-60.
12. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997; 40: 1725.
13. Witter FR. Management of the high-risk lupus pregnant patient. Rheum Dis Clin North Am. 2007; 33: 253-65.
14. Griffiths B, Mosca M, Gordon C. Assessment of patients with systemic lupus erythematosus and the use of lupus disease activity indices. Best Pract Res Clin Rheumatol. 2005; 19: 685-708.
15. Olesinska M, Wiesik-Szewczyk E, Chwalinska-Sadowska H. Evaluation of systemic lupus erythematosus activity during pregnancy. Pol Arch Med Wewn. 2007; 117: 312-6.
16. Toedeter G, Hayden K, Wagner C, Brodmerkel C. Simultaneous detection of eight analytes in human serum by two commercially available platforms for multiplex cytokine analysis. Clin Vaccina Immunol. 2008; 15: 42-8.
17. Peeva E, Zouali M. Spotlight on the role of hormonal factors in the emergence of autoreactive B-lymphocytes. Immunol Lett. 2005; 101: 123-43.
18. Cohen-Solal JF, Jeganathan V, Grimaldi CM, et al. Sex hormones and SLE: influencing the fate of autoreactive B cells. Curr Top Microbiol Immunol. 2006; 305: 67-88.
19. Piccinni MP, Giudizi MG, Biagiotti R, et al. Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones. J Immunol. 1995; 155: 128-33.
20. Canellada A, Blois S, Gentile T, Margni Idehu RA. In vitro modulation of protective antibody responses by estrogen, progesterone and interleukin-6. Am J Reprod Immunol. 2002; 48: 334-43.
21. Diehl S Rincon M. The two faces of IL-6 on Th1/Th2 differentiation. Mol Immunol. 2002; 39: 531-6.
22. de Waal Malefyt R, Yssel H, de Vries JE. Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation. J Immunol. 1993; 150: 4754-65.
23. Hagiwara E, Gourley MF, Lee S, Klinman DK. Disease severity in patients with systemic lupus erythematosus correlates with an increased ratio of interleukin-10: interferon-gamma-secreting cells in the peripheral blood. Arthritis Rheum. 1996; 39: 379-85.
24. Horwitz DA, Gray JD, Behrendsen SC, et al. Decreased production of interleukin-12 and other Th1-type cytokines in patients with recent-onset systemic lupus erythematosus. Arthritis Rheum. 1998; 41: 838-44.
25. Chun HY, Chung JW, Kim HA, et al. Cytokine IL-6 and IL-10 as biomarkers in systemic lupus erythematosus. J Clin Immunol. 2007; 27: 461-6.
26. Stuart RA, Littlewood AJ, Maddison PJ, Hall ND. Elevated serum interleukin-6 levels associated with active disease in systemic connective tissue disorders. Clin Exp Rheumatol. 1995; 13: 17-22.
27. Lacki JK, Samborski W, Mackiewicz SH. Interleukin-10 and interleukin-6 in lupus erythematosus and rheumatoid arthritis, correlations with acute phase proteins. Clin Rheumatol. 1997; 16: 275-8.
28. Park YB, Lee SK, Kim DS, et al. Elevated interleukin-10 levels correlated with disease activity in systemic lupus erythematosus. Clin Exp Rheumatol. 1998; 16: 283-8.
29. Mohan AK, Edwards ET, Cote TR, et al. Drug-induced systemic lupus erythematosus and TNF-alpha blockers. Lancet. 2002; 360: 646-6.
30. Herrera-Esparza R, Barbosa-Cisneros O, Villalobos-Hurtado R, Avalos-Diaz E. Renal expression of IL-6 and TNF-alpha genes in lupus nephritis. Lupus. 1998; 7: 154-8.
31. Zampieri S, Alaibac M, Iaccarino L, et al. Tumour necrosis factor alpha is expressed in refractory skin lesions from patients with subacute cutaneous lupus erythematosus. Ann Rheum Dis. 2006; 65: 545-8.
32. Aringer M, Graninger WB, Steiner G, Smolen JS. Safety and efficacy of tumor necrosis factor alpha blockade in systemic lupus erythematosus: an open-label study. Arthritis Rheum. 2004; 50: 3161-9.
33. Torricelli M, Bellisai F, Novembri R, et al. High levels of maternal serum IL-17 and activin a in pregnant women affected by SLE. Am J Reprod Immunol. 2011; 66: 84-9.
34. Muñoz-Valle JF, Vazquez-Del Mercado M, Garcia-Iglesias T, et al. T(H)1/T(H)2 cytokine profile, metalloprotease-9 activity and hormonal status in pregnant rheumatoid arthritis and systemic lupus erythematosus patients. Clin Exp Immunol. 2003; 131: 377-84.
35. Ruiz-Irastorza G, Lima F, Alves J, et al. Increased rate of lupus flare during pregnancy and the puerperium: a prospective study of 78 pregnancies. Br J Rheumatol. 1996; 35: 133-8.
36. Clowse ME, Magder LS, Witter F, Petri M. The impact of increased lupus activity on obstetric outcomes. Arthritis Rheum. 2005; 52: 514-21.
37. Iizasa H, Matsushima K. IL-8/CXCL8. In: Cytokine Reference 2000; vol 1 2nd ed, 1062. Eds. Oppenheim JJ, Feldman M, Durum SK, Hirano T, Vilcek J, Nicola NA. San Diego: Academic Press.
38. Jovanoìc M, Stefanoska I, Radojcic L, Vìcovac L. Interleukin-8 (CXCL8) stimulates trophoblast cell migration and invasion by increasing levels of matrix metalloproteinase (MMP) and MMP9 and integrins α5 and β1. Reprod Res. 2010; 139: 789-8.
39. Otun HA, Lash GE, Innes BA, et al. Effect of tumor necrosis factor-α in combination with interferon-γ on first trimester extravillous trophoblast invasion. J Reprod Immunol. 2011; 88: 1-11.
40. Mulla MJ, Brosens JJ, Chamley LW, et al. Antiphospholipid antibodies induce a pro-inflammatory response in first trimester trophoblast via the TLR4/MyD88 pathway. Am J Reprod Immunol. 2009; 62: 96-111.