The most elegant immunological experiment of the XIX century

Nature Immunology

Volumn 1, Issue 2, 2000, Pages 93-94

  Silverstein, Arthur M ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPHTHERIA ANTIBODY; TETANUS ANTIBODY;

ANIMAL; ART; ARTICLE; DIPHTHERIA; HISTORY; HUMAN; IMMUNIZATION; IMMUNOLOGY; MILK; PASSIVE IMMUNIZATION; TETANUS;

ANIMALS; DIPHTHERIA; DIPHTHERIA ANTITOXIN; HISTORY, 19TH CENTURY; HUMANS; IMMUNITY, MATERNALLY-ACQUIRED; IMMUNIZATION; MILK; PORTRAITS; TETANUS; TETANUS ANTITOXIN;

EID: 0034252308     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/77874     Document Type: Article

References (13)

1. Behring, E. and Kitasato, S. Deutsch.med.Wochenschr. 16, 1113-1114 (1890).
2. In Les Virus (Alcan, Paris, 1891), S. Arloing says (p 285),"When the father is cured of a virulent infec­tion, when he participates in the act of insemination he may transmit a part of the immunity which he enjoys. The male ovule… has been dynamically modified… it carries a vaccinating substance which spreads in all of the cells of the embryo and fetus.”
3. Fournier, E. Heredo-syphilis de Seconde Generation (Rueff, Paris, 1905).At the time, it was speculated that not only could disease be transmitted by way of an “altered zygote,” but even across genera­tions.
4. Ehrlich, P. Deutsch.med.Wochenschr. 17, 976-979 & 1218-1219 (1891). (Translation: Ehrlich, P. in Collected Papers Vol. 2, 21-26 & 27-30, respectively, Pergamon, London, 1956-1960.)
5. The story of Ehrlich’s work in this area is presented in greater detail in Silverstein, A.M. Cell Immunol. 174, 1-6 (1996).
6. Ehrlich, P. Z. Hyg. Infektkr. 12, 183-203 (1892). (Translation: Ehrlich, P. in Collected Papers Vol. 2, 31-44, Pergamon, London, 1956-1960.)
7. Ehrlich, P. in Collected PapersVol.2, 35 (Pergamon, London, 1956-1960).
8. Ehrlich P. and Hubener, W. Z. Hyg. Infektkr. 18, 51-64 (1894). (Translation: Ehrlich, P. in Collected Papers Vol. 2, 63-71, Pergamon, London, 1956-1960.)
9. Brieger, L. Ehrlich, P. Deutsch.med.Wochenschr. 18, 393-394 (1892). (Translation: Ehrlich, P. in Collected PapersVol. 2, 45-47, Pergamon, London, 1956-1960.)
10. It would take over 60 years before Ita Askonas et al. (J. Biochem. 56, 597-601, 1954) would confirm this earlier work.They showed that both rabbit and goat antibodies come directly via a transudate of the blood.
11. See, for example, Brambell, F.W.R. The Transmission of Passive Immunity from Mother to Young (North Holland, Amsterdam, 1970), Solomon, J.B. Foetal and Neonatal Immunology (North Holland, Amsterdam, 1971) & Hemmings, WA. (ed.) Maternofoetal Transmission of Immunity (Cambridge University Press, Cambridge, 1976).
12. Brieger, L. and Ehrlich, P. Z. Hyg. Infektkr. 13, 336-346 (1892). (Translation: Ehrlich, P. in Collected Papers Vol. 2, 48-55, Pergamon, London, 1956-1960.)
13. Dixon, F.J., Maurer, P.H., and Deichmiller, M.P. J.Immunol. 72, 179-186 (1954).