Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number

Science

Volumn 311, Issue 5763, 2006, Pages 1008-1012

  Flavell, Steven W ^a   Cowan, Christopher W ^a,b   Kim, Tae Kyung ^a   Greer, Paul L ^a   Lin, Yingxi ^a   Paradis, Suzanne ^a   Griffith, Eric C ^a   Hu, Linda S ^a   Chen, Chinfei ^a   Greenberg, Michael E ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CELLS; ENZYMES; GENES; NEUROPHYSIOLOGY; PHOSPHORESCENCE;

CALCIUM/CALMODULIN-REGULATED PHOSPHATASE CALCINEURIN; GENETIC PROGRAM; MYOCYTE ENHANCER FACTOR 2 (MEF2); SYNAPSES;

NEUROLOGY;

CALCINEURIN; CALCIUM; MYOCYTE ENHANCER FACTOR 2;

BIOLOGY;

ANIMAL CELL; ARC GENE; ARTICLE; BRAIN NERVE CELL; CALCIUM TRANSPORT; CONTROLLED STUDY; EMBRYO; EXCITATION; GENE; GENETIC TRANSCRIPTION; HIPPOCAMPUS; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; RAT; RNA INTERFERENCE; SYNAPSE; SYNAPTOGENESIS; SYNGAP GENE;

ANIMALS; CALCINEURIN; CALCIUM; CELLS, CULTURED; CYTOSKELETAL PROTEINS; DENDRITES; EXCITATORY POSTSYNAPTIC POTENTIALS; GENE EXPRESSION REGULATION; GLUTAMIC ACID; GTPASE-ACTIVATING PROTEINS; HIPPOCAMPUS; MUTATION; MYOGENIC REGULATORY FACTORS; NERVE TISSUE PROTEINS; NEURONS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHORYLATION; RATS; RATS, LONG-EVANS; RECOMBINANT FUSION PROTEINS; RNA INTERFERENCE; SYNAPSES; SYNAPTIC TRANSMISSION; TRANSCRIPTION, GENETIC; TRANSFECTION;

ANIMALIA; MAMMALIA;

EID: 33144467591     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1122511     Document Type: Article

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19. We thank members of the Greenberg lab for helpful suggestions; S. Cohen and D. Chu for help with experiments; S. Vasquez for preparing primary neuronal cell cultures; M. Salanga and the Neurobiology Program Imaging center for assistance with confocal microscopy; P. Worley for providing antibodies; J. Liu, E. Olson, and A. Rao for providing plasmids; and A. Bonni for exchanging information before publication. M.E.G. acknowledges the generous support of the F. M. Kirby Foundation to the Neurobiology Program of Children's Hospital. Supported by a National Research Service Award grant (AG05870) from the National Institute of Aging (C.W.C), a Lefler Foundation postdoctoral fellowship (C.W.C.), and Mental Retardation Research Center grant HD18655 and NIH grant N528829 (M.E.G.).