Maternal infection and immune involvement in autism

Trends in Molecular Medicine

Volumn 17, Issue 7, 2011, Pages 389-394

  Patterson, Paul H ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTISM; AUTOIMMUNE DISEASE; CEREBROSPINAL FLUID; GASTROINTESTINAL TRACT; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; IMMUNE SYSTEM; IMMUNOREACTIVITY; INFECTION RISK; MARE; MATERNAL DISEASE; MATERNAL INFECTION; NEUROPATHY; NONHUMAN; PREGNANCY; PRIMATE; PROGENY; REVIEW; RODENT;

ANIMALS; AUTISTIC DISORDER; AUTOIMMUNITY; BRAIN; DISEASE MODELS, ANIMAL; FEMALE; FETAL DEVELOPMENT; GASTROINTESTINAL TRACT; GENE-ENVIRONMENT INTERACTION; HUMANS; PHENOTYPE; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PRENATAL EXPOSURE DELAYED EFFECTS; RISK FACTORS;

ANIMALIA; RODENTIA;

EID: 79959964671     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2011.03.001     Document Type: Review

References (47)

1. Brown A.S., Derkits E.J. Prenatal infection and schizophrenia: a review of epidemiologic and translational studies. Am. J. Psychiatry 2010, 167:261-280.
2. Brown A.S., Patterson P.H. Maternal infection and schizophrenia: implications for prevention. Schiz. Bull. 2011, 37:284-290.
3. Atladottir H.O., et al. Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders. J. Autism Devel. Dis. 2010, 40:1423-1430.
4. Patterson P.H. Immune involvement in schizophrenia and autism: etiology, pathology and animal models. Behav. Brain Res. 2009, 204:313-321.
5. Vargas D.L., et al. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann. Neurol. 2005, 57:67-81.
6. Chez M.G., et al. Elevation of tumor necrosis factor-alpha in cerebrospinal fluid of autistic children. Pediat. Neurol. 2007, 36:361-365.
7. Morgan J.T., et al. Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism. Biol. Psychiatry 2010, 68:e368-e376.
8. Lintas C., et al. Genome-wide expression studies in Autism spectrum disorder, Rett syndrome, and Down syndrome. Neurobiol. Disease 2011, 10.1016/j.nbd2010.11.010.
9. Careaga M., et al. Immune dysfunction in autism: a pathway to treatment. J. Amer. Soc. Exper. NeuroTherap. 2010, 7:283-292.
10. Ashwood P., et al. Associations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders. J. Neuroimmunol. 2010, 232(1-2):196-199.
11. Ashwood P., et al. Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain Behav. Immun. 2011, 25:40-45.
12. Ashwood, P. et al. Altered T cell responses in children with autism. Brain Behav. Immun. doi:10.1016/j.bbi.2010.09.002.
13. Enstrom A.M., et al. Differential monocyte responses to TLR ligands in children with autism spectrum disorders. Brain Behav. Immun. 2010, 24:64-71.
14. Buie T., et al. Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report. Pediatrics 2010, 125(Suppl. 1):S1.
15. Ashwood P., et al. Autism, gastrointestinal disturbance, and immune dysfunction: what is the link?. Autism: Oxidative Stress, Inflammation, and Immune Abnormalities 2010, 278. CRC Press, Boca Raton. A. Chauhan, V. Chauhan, T.W. Brown (Eds.).
16. deMagistris L., et al. Alterations of the intestinal barrier in patients with autism spectrum disorders and in their fist-degree relatives. J. Pediatr. Gastroenterol. Nutr. 2010, 51:418-424.
17. Feingold S.M., et al. Pyrosequencing study of fecal microflora of autistic and control children. Anaerobe 2010, 16:444-453.
18. Atladotiir H.O., et al. Association of family history of autoimmune diseases and autism spectrum disorders. Pediatrics 2010, 124:687-694.
19. Martin L.A., et al. Stereotypes and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism. Brain Behav. Immun. 2008, 22:806-816.
20. Singer H.S., et al. Prenatal exposure of antibodies from mothers of children with autism produces neurobehavioral alterations: a pregnant dam mouse model. J. Neuroimmunol. 2009, 211:39-48.
21. Meyer U., Feldon J. Epidemiology-driven neurodevelopmental animal models of schizophrenia. Progr. Neurobiol. 2010, 90:285-326.
22. Malkova, N. et al. (2010) Maternal immune activation causes a deficit in social and communicative behavior in male mouse offspring. Program No. 561.29, Neurosci. Mtg Planner, San Diego: Soc. Neurosci. http://www.sfn.org/am2010/pdf/final_program/final_program_b5.pdf.
23. Smith S.E.P., et al. Maternal immune activation alters fetal brain development through interleukin-6. J. Neurosci. 2007, 27:10695-10702.
24. Silverman J.L., et al. Behavioral phenotyping assays for mouse models of autism. Nat. Rev. Neurosci. 2010, 11:490-502.
25. Shi L., et al. Activation of the maternal immune response alters cerebellar development in the offspring. Brain Behav. Immun. 2009, 23:116-123.
26. Moreno J.L., et al. Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring. J. Neurosci. 2011, 31:1863-1872.
27. Meyer U., et al. The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology. J. Neurosci. 2006, 26:4752-4762.
28. Meyer, U. et al. (2011) Schizophrenia and autism: both shared and disorder-specific pathogenesis via perinatal inflammation? Pediatric Res., PMID: 21289540.
29. Meyer U., et al. Adult behavioral and pharmacological dysfunctions following disruption of the fetal brain balance between pro-inflammatory and IL-10-mediated anti-inflammatory signaling. Molec. Psychiatry 2008, 13:208-221.
30. Mandal, M. et al. (2011) Maternal immune stimulation during pregnancy affects adaptive immunity in offspring to promote development of TH17 cells. Brain Behav. Immun., doi:10.1016/j.bbi.2010.09.011.
31. Hsiao, E. and Patterson, P.H. (2011) Activation of the maternal immune system induces endocrine changes in the placenta via IL-6. Brain Behav. Immun., doi:10.1016/j.bbi.2010.12.017.
32. Girard S., et al. IL-1 receptor antagonist protects against placental and neurodevelopmental defects induced by maternal inflammation. J. Immunol. 2010, 184:3997-4005.
33. Anderson G.M., et al. Placental trophoblast inclusions in autism spectrum disorder. Biol. Psychiatry 2007, 61:487-491.
34. Limperopoulos C., et al. Positive screening for autism in ex-preterm infants: prevalence and risk factors. Pediatrics 2008, 121:758-765.
35. Hsiao E., et al. Modeling an autism risk factor in mice leads to permanent changes in the immune system. Internl. Soc. Autism Res. 2010, 130:124.
36. Short S.J., et al. Maternal influenza infection during pregnancy impacts postnatal brain development in the rhesus monkey. Biol. Psychiatry 2010, 67:965-973.
37. Ehninger, D. et al. (2010) Gestational immune activation and TSC2 haploinsufficiency cooperate to disrupt social behavior in mice. Molec. Psychiatry, doi:10.1038/mp.2010.115.
38. Kilpinen H., et al. Association of DISC1 with autism and Asperger syndrome. Molec. Psychiatry 2008, 13:187-196.
39. Abazyan B., et al. Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology. Biol. Psychiatry 2010, 68:1172-1181.
40. Watanabe Y., et al. Cytokine hypothesis of schizophrenia pathogenesis: evidence from human studies and animal models. Psychiatry Clin. Neurosci. 2010, 64:217-230.
41. Piontkewitz Y., et al. Clozapine administration in adolescence prevents postpubertal emergence of brain structural pathology in an animal model of schizophrenia. Biol. Psychiatry 2009, 66:1038-1046.
42. Li Q., et al. Prenatal immune challenge is an environmental risk factor for brain and behavior change relevant to schizophrenia: evidence from MRI in a mouse model. PLoS ONE 2009, 4:e6354.
43. Silva A., Ehninger D. Adult reversal of cognitive phenotypes in neurodevelopmental disorders. J. Neurodev. Disorders 2009, 1:150-157.
44. Ito H.T., et al. Maternal immune activation alters nonspatial information processing in the hippocampus of the offspring. Brain Behav. Immun. 2010, 24:930-941.
45. Dickerson D.D., et al. Abnormal long-range neural synchrony in a maternal immune activation animal model of schizophrenia. J. Neurosci. 2010, 30:12424-12431.
46. Alarcorn M., et al. Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene. Amer. J. Hum. Gen. 2008, 82:150-159.
47. Campbell D.B., et al. Distinct genetic risk based on association of MET in families with co-occurring autism and gastrointestinal conditions. Pediatrics 2009, 123:1018-1024.