Optimizing eukaryotic cell hosts for protein production through systems biotechnology and genome-scale modeling

Biotechnology Journal

Volumn 10, Issue 7, 2015, Pages 939-949

  Gutierrez, Jahir M ^a,b   Lewis, Nathan E ^b,c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Eukaryotic cell engineering; Genome scale models; Metabolic networks; Recombinant protein production; Systems Biology

Indexed keywords

BIOTECHNOLOGY; CELL CULTURE; CELLS; CYTOLOGY; GENES; METABOLIC ENGINEERING; METABOLISM; MOBILE SECURITY; PHYSIOLOGY; PROTEINS; RECOMBINANT PROTEINS;

CHINESE HAMSTER OVARY CELLS; GENETIC MODIFICATIONS; GENOME-SCALE MODEL; METABOLIC CAPABILITIES; METABOLIC NETWORK; RECOMBINANT PROTEIN PRODUCTIONS; SYSTEMS BIOLOGY; SYSTEMS BIOTECHNOLOGY;

CELL ENGINEERING;

CELL CULTURE; CELL DENSITY; CELL ENGINEERING; CELL FUNCTION; DNA MODIFICATION; ENERGY TRANSFER; EUKARYOTIC CELL; GENOME; HOST CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW; TREND STUDY; ANIMAL; BIOSYNTHESIS; CHO CELL LINE; CRICETULUS; GENETICS; HAMSTER; HUMAN;

CRICETULUS GRISEUS; EUKARYOTA; HEXAPODA;

RECOMBINANT PROTEIN;

ANIMALS; CELL ENGINEERING; CHO CELLS; CRICETINAE; CRICETULUS; GENOME; HUMANS; RECOMBINANT PROTEINS;

EID: 84935689947     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201400647     Document Type: Review

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