Improving baculovirus production at high cell density through manipulation of energy metabolism

Metabolic Engineering

Volumn 12, Issue 1, 2010, Pages 39-52

  Carinhas, Nuno ^a   Bernal, Vicente ^a   Monteiro, Francisca ^a   Carrondo, Manuel J T ^a,b   Oliveira, Rui ^b   Alves, Paula M ^a  

^a INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^b UNIVERSIDADE NOVA DE LISBOA   (Portugal)

Author keywords

Ketoglutarate; Baculovirus; Energy metabolism; Gene therapy; High cell density production; Metabolic flux analysis; Pyruvate; Sf 9 insect cells

Indexed keywords

BACULOVIRUS; ENERGY METABOLISM; GENE THERAPY; HIGH CELL DENSITY PRODUCTION; METABOLIC FLUX ANALYSIS; PYRUVATE; SF-9 INSECT CELLS;

ADENOSINETRIPHOSPHATE; BIOCHEMISTRY; CELLS; GENETIC ENGINEERING; MANUFACTURE; METABOLISM;

CELL CULTURE;

2 OXOGLUTARIC ACID; ADENOSINE TRIPHOSPHATASE; BACULOVIRUS VECTOR; PYRUVIC ACID; TRICARBOXYLIC ACID;

ANIMAL CELL; ARTICLE; BACULOVIRUS; CELL DENSITY; CITRIC ACID CYCLE; CONTROLLED STUDY; ENERGY METABOLISM; GLYCOLYSIS; LEPIDOPTERA; NITROGEN METABOLISM; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS;

ANIMALS; BACULOVIRIDAE; CELL CULTURE TECHNIQUES; CELL LINE; HUMANS; RECOMBINANT PROTEINS; SPODOPTERA;

HEXAPODA; SPODOPTERA FRUGIPERDA;

EID: 70449527810     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2009.08.008     Document Type: Article

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