Combined data preprocessing and multivariate statistical analysis characterizes fed-batch culture of mouse hybridoma cells for rational medium design

Journal of Biotechnology

Volumn 150, Issue 1, 2010, Pages 94-100

  Selvarasu, Suresh ^a   Kim, Do Yun ^a   Karimi, Iftekhar A ^b   Lee, Dong Yup ^a,b  

^a AGENCY FOR SCIENCE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Data preprocessing; Hybridoma mouse cells; Mammalian cell culture; Medium design; Multivariate statistical analysis

Indexed keywords

DATA PREPROCESSING; MAMMALIAN CELL CULTURE; MEDIUM DESIGN; MOUSE CELLS; MULTIVARIATE STATISTICAL ANALYSIS;

AMINO ACIDS; ANIMAL CELL CULTURE; BATCH CELL CULTURE; CELL CULTURE; CELL GROWTH; CURVE FITTING; DESIGN; ELECTRON EMISSION; GROWTH KINETICS; MAMMALS; MEASUREMENT ERRORS; MONOCLONAL ANTIBODIES; ORGANIC ACIDS; PHOSPHATASES; PRINCIPAL COMPONENT ANALYSIS; PRODUCTION; STATISTICS; TOXIC MATERIALS;

MULTIVARIANT ANALYSIS;

AMMONIA; ARGININE; ASPARAGINE; GLYCINE; HISTIDINE; ISOLEUCINE; LACTIC ACID; LYSINE; METHIONINE; MONOCLONAL ANTIBODY; PHENYLALANINE; SERINE; THREONINE; TYROSINE; VALINE;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL VIABILITY; FED BATCH CULTURE; GLUCOSE INTAKE; HYBRIDOMA CELL CULTURE; INFORMATION PROCESSING; METABOLITE; METHODOLOGY; MOUSE; MULTIVARIATE ANALYSIS; NONHUMAN; PARTIAL LEAST SQUARES REGRESSION; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; TOXIC WASTE;

AMINO ACIDS; AMMONIA; ANIMALS; ANTIBODIES, MONOCLONAL; CELL CULTURE TECHNIQUES; COMPUTATIONAL BIOLOGY; HYBRIDOMAS; LACTIC ACID; LEAST-SQUARES ANALYSIS; MICE; MULTIVARIATE ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; SYSTEMS BIOLOGY;

MAMMALIA;

EID: 77957362549     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2010.07.016     Document Type: Article

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