The impact of anti-apoptotic gene Bcl-2Δ expression on CHO central metabolism

Metabolic Engineering

Volumn 25, Issue , 2014, Pages 92-102

  Templeton, Neil ^a   Lewis, Abasha ^b   Dorai, Haimanti ^c   Qian, Elaine A ^a   Campbell, Marguerite P ^c   Smith, Kevin D ^c   Lang, Steven E ^c   Betenbaugh, Michael J ^b   Young, Jamey D ^a,d  

^a VANDERBILT UNIVERSITY   (United States)

^b Johns Hopkins University   (United States)

^c Janssen Pharmaceutical J and J Biologics Research Biotechnology CoE   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Bcl 2; Central metabolism; Chinese hamster ovary (CHO); Lactate; Metabolic flux analysis (MFA); Mitochondria

Indexed keywords

CARBON; CELL CULTURE; CELL DEATH; CLONE CELLS; METABOLISM; MITOCHONDRIA; PHYSIOLOGY;

BCL-2; CENTRAL METABOLISMS; CHINESE HAMSTER OVARY; LACTATE; METABOLIC FLUX ANALYSIS;

GENE EXPRESSION;

CARBON 13; CASPASE; ISOCITRATE DEHYDROGENASE; LACTIC ACID; PROTEIN BCL 2; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; APOPTOSIS REGULATORY PROTEIN; MITOCHONDRIAL PROTEIN;

ANIMAL CELL; ARTICLE; BIOMASS; CELL DENSITY; CELL METABOLISM; CHO CELL LINE; CLONE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GENETIC TRANSFECTION; METABOLIC ENGINEERING; METABOLIC FLUX ANALYSIS; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; STOICHIOMETRY; ANIMAL; CRICETULUS; GENETICS; HAMSTER; METABOLISM; PHYSIOLOGY; PROCEDURES; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; CHO CELLS; CRICETINAE; CRICETULUS; LACTIC ACID; METABOLIC FLUX ANALYSIS; MITOCHONDRIAL PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRUVIC ACID; SIGNAL TRANSDUCTION;

EID: 84904576184     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2014.06.010     Document Type: Article

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