Are big potassium-type Ca2+-activated potassium channels a viable target for the treatment of epilepsy?

Expert Opinion on Therapeutic Targets

Volumn 19, Issue 7, 2015, Pages 911-926

  Leo, Antonio ^a   Citraro, Rita ^a   Constanti, Andrew ^b   De Sarro, Giovambattista ^a   Russo, Emilio ^a  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Antiepileptic drug; Big potassium channel modulators; Big potassium channels; Epilepsy; Seizures

Indexed keywords

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; ACETAZOLAMIDE; ANDOLAST; ANTICONVULSIVE AGENT; BK CHANNEL ACTIVATOR; BK CHANNEL INHIBITOR; CALCIUM; CANNABIDIOL; CANNABINOID DERIVATIVE; CHARYBDOTOXIN; CHLORZOXAZONE; CYCLOOXYGENASE 2 INHIBITOR; DOCOSAHEXAENOIC ACID; ETHOSUXIMIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IBERIOTOXIN; INSULIN; ISOPIMARIC ACID; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; LEPTIN; PAXILLINE; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL STIMULATING AGENT; RILUZOLE; TAMOXIFEN; UNCLASSIFIED DRUG; VINPOCETINE; ZONISAMIDE;

ANTICONVULSANT ACTIVITY; ANTICONVULSANT THERAPY; CALCIUM SIGNALING; CENTRAL NERVOUS SYSTEM; CHEMICAL STRUCTURE; DRUG EFFICACY; DRUG TARGETING; EPILEPSY; EPILEPTOGENESIS; HUMAN; MOLECULAR PATHOLOGY; NEUROMODULATION; NEUROPHARMACOLOGY; NEUROTRANSMITTER RELEASE; NONHUMAN; PROTEIN STRUCTURE; REVIEW; ANIMAL; BRAIN; DRUG EFFECTS; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; ANTICONVULSANTS; BRAIN; CALCIUM; CALCIUM SIGNALING; EPILEPSY; HUMANS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MOLECULAR TARGETED THERAPY;

EID: 84931072538     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.2015.1026258     Document Type: Review

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