Effects of intra-ventrolateral periaqueductal grey palmitoylethanolamide on thermoceptive threshold and rostral ventromedial medulla cell activity

European Journal of Pharmacology

Volumn 676, Issue 1-3, 2012, Pages 41-50

  De Novellis, Vito ^a   Luongo, Livio ^a   Guida, Francesca ^a   Cristino, Luigia ^c   Palazzo, Enza ^a   Russo, Roberto ^b   Marabese, Ida ^a   D'Agostino, Giuseppe ^b   Calignano, Antonio ^b   Rossi, Francesca ^a   Di Marzo, Vincenzo ^c   Maione, Sabatino ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c CNR   (Italy)

Author keywords

(Rat); Pain; PEA; Periaqueductal grey; PPAR receptor; Rostral ventromedial medulla

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; CHARYBDOTOXIN; PALMIDROL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BRAIN REGION; CELL ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ELECTROENCEPHALOGRAM; LATENT PERIOD; MALE; NOCICEPTIVE PAIN; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ROSTRAL VENTROMEDIAL MEDULLA; SPIKE WAVE; TAIL FLICK TEST; UPREGULATION;

ANALGESICS; ANIMALS; BEHAVIOR, ANIMAL; GENE EXPRESSION REGULATION; MALE; MYELENCEPHALON; NEURONS; NOCICEPTION; PALMITIC ACIDS; PERIAQUEDUCTAL GRAY; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; PPAR ALPHA; RATS; RATS, WISTAR; RECEPTOR, CANNABINOID, CB1; TEMPERATURE; TRPV CATION CHANNELS;

EID: 84855570823     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.11.034     Document Type: Article

References (53)

1. A. Artmann, G. Petersen, L.I. Hellgren, J. Boberg, C. Skonberg, C. Nellemann, S.H. Hansen, and H.S. Hansen Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine Biochim. Biophys. Acta 1781 2008 200 212
2. G. Barbara, A. Alloui, J. Nargeot, P. Lory, A. Eschalier, E. Bourinet, and J. Chemin T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids J. Neurosci. 29 2009 13106 13114
3. L.A. Bee, and A.H. Dickenson Rostral ventromedial medulla control of spinal sensory processing in normal and pathophysiological states Neuroscience 147 2007 786 793 (Pubitemid 46990660)
4. A. Benani, T. Heurtaux, P. Netter, and A. Minn Activation of peroxisome proliferator activated receptor alpha in rat spinal cord after peripheral noxious stimulation Neurosci. Lett. 369 2004 59 63 (Pubitemid 39369503)
5. J. Berger, and D.E. Moller The mechanisms of action of PPARs Annu. Rev. Med. 53 2002 409 435 (Pubitemid 34177889)
6. H. Cadas, E. di Tomaso, and D. Piomelli Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain J. Neurosci. 17 1997 1226 1242 (Pubitemid 27073726)
7. A. Calignano, G. La Rana, A. Giuffrida, and D. Piomelli Control of pain initiation by endogenous cannabinoids Nature 394 1998 277 281 (Pubitemid 28335039)
8. S. Conti, B. Costa, M. Colleoni, D. Parolaro, and G. Giagnoni Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat Br. J. Pharmacol. 135 2002 181 187 (Pubitemid 34102111)
9. D.N. Cortright, and A. Szallasi TRP channels and pain Curr. Pharm. Des. 15 2009 1736 1749 (Review)
10. 1 and PPARgamma receptors and neurotrophic factors Pain 139 2008 541 550
11. G. D'Agostino, G. La Rana, R. Russo, O. Sasso, A. Iacono, E. Esposito, G. Mattace Raso, S. Cuzzocrea, J. Lo Verme, D. Piomelli, R. Meli, and A. Calignano Acute intracerebroventricular administration of palmitoylethanolamide, an endogenous peroxisome proliferator-activated receptor-alpha agonist, modulates carrageenan-induced paw edema in mice J. Pharmacol. Exp. Ther. 322 2007 1137 1143 (Pubitemid 47295805)
12. D. De Filippis, L. Luongo, M. Cipriano, E. Palazzo, M.P. Cinelli, V. de Novellis, S. Maione, and T. Iuvone Palmitoyletanolamide reduces granuloma-induced by modulation of mast cell activation in rats Mol. Pain 7 2011 3
13. 1 cannabinoid and metabotropic glutamate subtype 5 receptors modulate changes in rostral ventromedial medulla neuronal activities induced by subcutaneous formalin in the rat Neuroscience 134 2005 269 281 (Pubitemid 40943653)
14. 1 receptor antagonist, associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats Neuropharmacology 55 2008 1105 1113
15. L. De Petrocellis, J.B. Davis, and V. Di Marzo Palmitoylethanolamide enhances anandamide stimulation of human vanilloid VR1 receptors FEBS Lett. 506 2001 253 256 (Pubitemid 32964824)
16. V. Di Marzo, A. Fontana, H. Cadas, S. Schinelli, G. Cimino, J.C. Schwartz, and D. Piomelli Formation and inactivation of endogenous cannabinoid anandamide in central neurons Nature 372 1994 686 691
17. V. Di Marzo, D. Melck, P. Orlando, T. Bisogno, O. Zagoory, M. Bifulco, Z. Vogel, and L. De Petrocellis Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells Biochem. J. 358 2001 249 255 (Pubitemid 32778120)
18. W.P. Farquhar-Smith, and A.S. Rice A novel neuroimmune mechanism in cannabinoid-mediated attenuation of nerve growth factor-induced hyperalgesia Anesthesiology 99 2003 1391 1401 (Pubitemid 37475187)
19. H.L. Fields, J. Bry, I. Hentall, and G. Zorman The activity of neurons in the rostral medulla of the rat during withdrawal from noxious heart J. Neurosci. 3 1983 2545 2552 (Pubitemid 14187131)
20. H.L. Fields, M.M. Heinricher, and P. Mason Neurotransmitters in nociceptive modulatory circuits Annu. Rev. Neurosci. 14 1991 219 245
21. H.L. Fields, A. Malick, and R. Burstein Dorsal horn projection targets of ON and OFF cells in the rostral ventromedial medulla J. Neurophysiol. 74 1995 1742 1759
22. H.L. Fields, A.I. Basbaum, and M.M. Heinricher Central nervous system mechanisms of pain modulation S. McMahon, M. Koltzenburg, Wall and Melzack's Textbook of Pain 5th ed. 2006 Elsevier London 125 142
23. C.J. Fowler, K.O. Jonsson, and G. Tiger Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide Biochem. Pharmacol. 62 2001 517 526 (Pubitemid 32738763)
24. M.M. Heinricher, N.M. Barbaro, and H.L. Fields Putative nociceptive modulating neurons in the rostral ventromedial medulla of the rat: firing of ON and OFF cells is related to nociceptive responsiveness Somatosens. Mot. Res. 6 1989 427 439 (Pubitemid 19165929)
25. M.M. Heinricher, I. Tavares, J.L. Leith, and B.M. Lumb Descending control of nociception: specificity, recruitment and plasticity Brain Res. Rev. 60 2009 214 225 (Review)
26. Z. Helyes, J. Németh, M. Thán, K. Bölcskei, E. Pintér, and J. Szolcsányi Inhibitory effect of anandamide on resiniferatoxin-induced sensory neuropeptide release in vivo and neuropathic hyperalgesia in the rat Life Sci. 73 2003 2345 2353 (Pubitemid 36980829)
27. M.D. Jhaveri, D. Richardson, I. Robinson, M.J. Garle, A. Patel, Y. Sun, D.R. Sagar, A.J. Bennett, S.P. Alexander, D.A. Kendall, D.A. Barrett, and V. Chapman Inhibition of fatty acid amide hydrolase and cyclooxygenase-2 increases levels of endocannabinoid related molecules and produces analgesia via peroxisome proliferator-activated receptor-alpha in a model of inflammatory pain Neuropharmacology 55 2008 85 93
28. T. Kainu, A.C. Wikstrom, J.A. Gustafsson, and M. Pelto-Huikko Localization of the peroxisome proliferator-activated receptor in the brain Neuroreport 5 1994 2481 2485
29. K. Kaneko, T. Yamada, S. Tsukita, K. Takahashi, Y. Ishigaki, Y. Oka, and H. Katagiri Obesity alters circadian expressions of molecular clock genes in the brainstem Brain Res. 1263 2009 58 68
30. S. Kathuria, D. Gaetani, F. Fegley, A. Valino, A. Duranti, M. Tontini, G. Mor, G. Tarzia, A. La Rana, A. Calignano, M. Giustino, M. Tattoli, M. Palmery, V. Cuomo, and D. Piomelli Modulation of anxiety through blockade of anandamide hydrolysis Nat. Med. 9 2003 76 81 (Pubitemid 36098263)
31. 1 Agonist) therapy for pain relief: farewell or revival? Clin. J. Pain 24 2008 142 154 (Review) (Pubitemid 351156516)
32. R. Kostadinova, W. Wahli, and L. Michalik PPARs in diseases: control mechanisms of inflammation Curr. Med. Chem. 12 2005 2995 3009 (Pubitemid 41672488)
33. D.M. Lambert, and V. Di Marzo The palmitoylethanolamide and oleamide enigmas: are these two fatty acid amides cannabimimetic? Curr. Med. Chem. 6 1999 757 773 (Pubitemid 29399503)
34. D.M. Lambert, S. Vandevoorde, K.O. Jonsson, and C.J. Fowler The palmitoylethanolamide family: a new class of anti-inflammatory agents? Curr Med Chem 9 6 2002 663 674 (Pubitemid 34296196)
35. J. Lo Verme, J. Fu, G. Astarita, G. La Rana, R. Russo, A. Calignano, and D. Piomelli The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide Mol. Pharmacol. 67 2005 15 29
36. J. Lo Verme, R. Russo, G. La Rana, J. Fu, J. Farthing, G. Mattace-Raso, R. Meli, A. Hohmann, A. Calignano, and D. Piomelli Rapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-alpha J. Pharmacol. Exp. Ther. 319 2006 1051 1061
37. S. Maione, T. Bisogno, V. de Novellis, E. Palazzo, L. Cristino, M. Valenti, S. Petrosino, V. Guglielmotti, F. Rossi, and V. Di Marzo Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 receptors Pharmacol. Exp. Ther. 316 2006 969 982 (Pubitemid 43345268)
38. D.J. Mangelsdorf, C. Thummel, M. Beato, P. Herrlich, G. Schütz, K. Umesono, B. Blumberg, P. Kastner, M. Mark, P. Chambon, and R.M. Evans The nuclear receptor superfamily: the second decade Cell 83 6 1995 835 839 (Review)
39. J.L. Moreau, and H.L. Fields Evidence for GABA involvement in midbrain control of medullary neurons that modulate nociceptive transmission Brain Res. 397 1986 37 44
40. S. Moreno, S. Farioli-Vecchioli, and M.P. Ceru Immunolocalization of peroxisome proliferatoractivated receptors and retinoid X receptors in the adult rat CNS Neuroscience 123 2004 131 145 (Pubitemid 37518482)
41. E. Palazzo, V. de Novellis, I. Marabese, D. Cuomo, F. Rossi, L. Berrino, F. Rossi, and S. Maione Interaction between vanilloid and glutamate receptors in the central modulation of nociception Eur. J. Pharmacol. 439 2002 69 75 (Pubitemid 34286608)
42. 1 receptors in descending modulation of pain Mol. Cell. Endocrinol. 286 2008 79 83 (Review)
43. G. Paxinos, and C. Watson The Rat Brain in Stereotaxic Coordinates 1986 Academic Press London
44. S. Petrosino, E. Palazzo, V. de Novellis, T. Bisogno, F. Rossi, S. Maione, and V. Di Marzo Changes in spinal and supraspinal endocannabinoid levels in neuropathic rats Neuropharmacology 52 2007 415 422 (Pubitemid 46127787)
45. G. Re, R. Barbero, A. Miolo, and V. Di Marzo Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals Vet. J. 173 1 2007 21 30 (Review)
46. K. Rea, M. Roche, and D.P. Finn Supraspinal modulation of pain by cannabinoids: the role of GABA and glutamate Br. J. Pharmacol. 152 2007 633 648 (Pubitemid 350034981)
47. J. Sandkühler, and G.F. Gebhart Relative contributions of the nucleus raphe magnus and adjacent medullary reticular formation to the inhibition by stimulation in the periaqueductal gray of a spinal nociceptive reflex in the pentobarbital-anesthetized rat Brain Res. 305 1984 77 87 (Pubitemid 14117846)
48. D. Smart, K.O. Jonsson, S. Vandevoorde, D.M. Lambert, and C.J. Fowler 'Entourage' effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism Br. J. Pharmacol. 136 2002 452 458 (Pubitemid 34620526)
49. K. Starowicz, S. Maione, L. Cristino, E. Palazzo, I. Marabese, F. Rossi, V. de Novellis, and V. Di Marzo Tonic endovanilloid facilitation of glutamate release in brainstem descending antinociceptive pathways J. Neurosci. 27 2007 13739 13749 (Pubitemid 350278253)
50. P. Tontonoz, E. Hu, and B.M. Spiegelman Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor Cell 79 1994 1147 1156 Erratum in: Cell 1995 24;80(6):following 957
51. N. Ueda, R.A. Puffenbarger, S. Yamamoto, and D.G. Deutsch The fatty acid amide hydrolase (FAAH) Chem. Phys. Lipids 108 2000 107 121 Review
52. H. Vanegas, N.M. Barbaro, and H.L. Fields Tail-flick related activity in medullospinal neurons Brain Res. 321 1984 135 141 (Pubitemid 15176903)
53. W. Zhao, O. Fong, E.S. Muise, J.R. Thompson, D. Weingarth, S. Qian, and T.M. Fong Genome-wide expression profiling revealed peripheral effects of cannabinoid receptor 1 inverse agonists in improving insulin sensitivity and metabolic parameters Mol. Pharmacol. 78 2010 350 359