Two new actions of topiramate: Inhibition of depolarizing GABAA-mediated responses and activation of a potassium conductance

Neuropharmacology

Volumn 42, Issue 2, 2002, Pages 210-220

  Herrero, Ana I ^a   Del Olmo, Nuria ^a   González Escalada, José R ^a   Solís, José M ^a  

^a HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

Anions; Carbonic anhydrase; Depolarizing postsynaptic potentials; GABAA receptor; Potassium conductance; Topiramate

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ACETAZOLAMIDE; BARIUM CHLORIDE; BENZYL[3 [[1 (3,4 DICHLOROPHENYL)ETHYL]AMINO] 2 HYDROXYPROPYL]PHOSPHINIC ACID; CARBONATE DEHYDRATASE; PICROTOXIN; POTASSIUM ION; TETRODOTOXIN; TOPIRAMATE;

ACTION POTENTIAL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; HIPPOCAMPUS; HYPERPOLARIZATION; INHIBITORY POSTSYNAPTIC POTENTIAL; MEMBRANE STEADY POTENTIAL; NONHUMAN; PERFUSION; POTASSIUM CELL LEVEL; POTASSIUM CONDUCTANCE; PRESSURE; PRIORITY JOURNAL; RAT;

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ANIMALS; ANTICONVULSANTS; CARBONIC ANHYDRASES; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; FRUCTOSE; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; KINETICS; MALE; MEMBRANE POTENTIALS; PICROTOXIN; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SYNAPSES;

EID: 0036171793     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(01)00171-X     Document Type: Article

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