A charged residue in S4 regulates coupling among the activation gate, voltage, and Ca2+ sensors in BK channels

Journal of Neuroscience

Volumn 34, Issue 37, 2014, Pages 12280-12288

  Zhang, Guohui ^a,b   Yang, Huanghe ^c   Liang, Hongwu ^a   Yang, Junqiu ^a   Shi, Jingyi ^a   McFarland, Kelli ^a   Chen, Yihan ^d   Cui, Jianmin ^a,b  

^a WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

^b MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d TONGJI UNIVERSITY   (China)

Author keywords

BK channels; Coupling; Intersubunit interaction; Pore gate; Voltage sensor

Indexed keywords

BRUCHPILOT; CALCIUM ION; CAVEOLIN 3; ELKS 4790; ELKS 1 PROTEIN; ELKS 2 PROTEIN; ELKS 30; ELKS PROTEIN; GLUTAMATE DECARBOXYLASE 1; GLUTAMATE DECARBOXYLASE 2; LIPRIN ALPHA 3; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN 2; NEUROTRANSMITTER; PROTEIN; RAB3 INTERACTING MOLECULE; RAB3 INTERACTING MOLECULE BINDING PROTEIN; SYNAPSIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; AMINO ACID; CALCIUM; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL;

ACTION POTENTIAL; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM TRANSPORT; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EXOCYTOSIS; FEMALE; GENE EXPRESSION; GENETIC TRANSFECTION; GENOTYPE; HIPPOCAMPUS; IMMUNOFLUORESCENCE; LETHAL GENE; LETHALITY; MALE; MEMBRANE CAPACITANCE; MEMBRANE ELECTROPHYSIOLOGY; MEMBRANE RESISTANCE; MEMBRANE STEADY POTENTIAL; MORPHOLOGY; MOUSE; NERVE CELL; NERVE ENDING; NEUROTRANSMITTER RELEASE; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; SOUTHERN BLOTTING; SURVIVAL; SYNAPSE MORPHOLOGY; SYNAPSE VESICLE; SYNAPTIC TRANSMISSION; SYNAPTOSOME; VERTEBRATE; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CHANNEL GATING; CHEMISTRY; MEMBRANE POTENTIAL; METABOLISM; OOCYTE; PHYSIOLOGY; STATIC ELECTRICITY; STRUCTURE ACTIVITY RELATION; XENOPUS LAEVIS;

AMINO ACIDS; ANIMALS; CALCIUM; CELLS, CULTURED; ION CHANNEL GATING; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MEMBRANE POTENTIALS; OOCYTES; STATIC ELECTRICITY; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 84907015944     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1174-14.2014     Document Type: Article

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