K+-channel openers suppress epileptiform activities induced by 4-aminopyridine in cultured rat hippocampal neurons

Journal of Pharmacological Sciences

Volumn 108, Issue 4, 2008, Pages 517-528

  Kobayashi, Kiyoaki ^a,b   Nishizawa, Yukio ^b   Sawada, Kohei ^b   Ogura, Hiroo ^b   Miyabe, Masayuki ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b EISAI CO LTD   (Japan)

Author keywords

4 aminopyridine (4 AP); Epilepsy; Hippocampal neuron; K+ channel; Sodium binding benzofuran isophthalate (SBFI)

Indexed keywords

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; 1 EBIO; 1 ETHYL 2 BENZIMIDAZOLINONE; 4 AMINOPYRIDINE; 5,6 DICHLORO 1 ETHYL 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6,7 DICHLORO 1H INDOLE 2,3 DIONE 3 OXIME; CHLORZOXAZONE; FLUPIRTINE; ISOPIMARIC ACID; NS 309; POTASSIUM CHANNEL KCNQ2; POTASSIUM CHANNEL KCNQ3; POTASSIUM CHANNEL STIMULATING AGENT; RETIGABINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN NERVE CELL; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; EPILEPTIC DISCHARGE; FLUORESCENCE ANALYSIS; HIPPOCAMPUS; IN VITRO STUDY; NERVE EXCITABILITY; NONHUMAN; RAT;

EID: 58149161883     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.08214FP     Document Type: Article

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