BK channel activators and their therapeutic perspectives

Frontiers in Physiology

Volumn 5, Issue OCT, 2014, Pages

  Bentzen, Bo H ^a,b   Olesen, Søren Peter ^a   Rønn, Lars C B ^c   Grunnet, Morten ^b,c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Acesion Pharma   (Denmark)

^c H LUNDBECK A S   (Denmark)

Author keywords

Activators; BK; High conductance calcium activated potassium channels; KCa1.1; KCNMA1; MaxiK; Openers; Pharmacology

Indexed keywords

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; 1 (5 CHLORO 2 HYDROXYPHENYL) 5 TRIFLUOROMETHYL 2 BENZIMIDAZOLONE; ANDOLAST; BETA DEFENSIN 2; BMS 223131; CALCIUM CHANNEL; CYM 04; FLINDOKALNER; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; NS 11021; NS 1608; NS 19504; NS 8; PAXILLINE; POTASSIUM CHANNEL STIMULATING AGENT; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SILDENAFIL; TA 1702; TERPENE DERIVATIVE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG;

ANTIHYPERTENSIVE ACTIVITY; ASTHMA; BLADDER DYSFUNCTION; BLADDER FUNCTION; BRAIN ISCHEMIA; CALCIUM BINDING; CELL PROTECTION; CENTRAL NERVOUS SYSTEM; CONCENTRATION RESPONSE; DRUG BINDING SITE; DRUG POTENTIATION; DRUG PROTEIN BINDING; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HUMAN; MITOCHONDRIAL MEMBRANE; NEUROPROTECTION; NONHUMAN; OVERACTIVE BLADDER; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PROTEIN FUNCTION; REVIEW;

EID: 84908364219     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2014.00389     Document Type: Review

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