NMDA and AMPA/kainate receptors are involved in the anticonvulsant activity of riluzole in DBA/2 mice

European Journal of Pharmacology

Volumn 408, Issue 1, 2000, Pages 25-34

  De Sarro, Giovambattista ^a   Siniscalchi, Antonio ^a   Ferreri, Guido ^a   Gallelli, Luca ^a   De Sarro, Angela ^b  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

AMPA ( amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid); Audiogenic seizure; DBA 2 mouse; Epilepsy; Glycine NMDA receptor; Riluzole

Indexed keywords

4 (3 PHOSPHONOALLYL) 2 PIPERAZINECARBOXYLIC ACID; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; ANIRACETAM; DEXTRO SERINE; GLYCINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RILUZOLE;

ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; ATAXIA; AUDIOGENIC SEIZURE; CLONIC SEIZURE; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; LOCOMOTION; MALE; MOUSE; MOUSE STRAIN; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; TONIC SEIZURE;

ACOUSTIC STIMULATION; ANIMALS; ANTICONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALE; MICE; MICE, INBRED DBA; RECEPTORS, AMPA; RECEPTORS, GLYCINE; RECEPTORS, KAINIC ACID; RECEPTORS, N-METHYL-D-ASPARTATE; RILUZOLE; SEIZURES;

EID: 0034634383     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00709-3     Document Type: Article

References (63)

1. A controlled trial of riluzole in amyotrophic lateral sclerosis
2. + channels in myelinated nerve fibre
3. A field potential analysis on the effects of lamotrigine, GP47779 and felbamate in neocortical slices
4. Is pharmacological neuroprotection dependent on reduced glutamate release?
5. Electrophisiology of the neuroprotective agent riluzole on striatal spiny neurons
6. Evaluation of anticonvulsant drugs in DBA/2 mice with sound-induced seizures
7. Riluzole inhibits the release of glutamate in the caudate nucleus of the cat in vivo
8. Effect of NMDA- and strychnine-insensitive glycine site antagonists on NMDA-mediated convulsions and learning
9. Neuroprotective effects of riluzole in ALS CSF toxicity
10. Glutamate antagonists have different effects on spontaneous locomotor activity in rats
11. Inhibition by riluzole of electrophysiological responses mediated by rat kainate and NMDA receptors expressed in Xenopus oocytes
12. Anticonvulsant actions of DS 103-282: Pharmacological studies in rodents and the baboon, Papio papio
13. Anticonvulsant effects of some calcium entry blockers in DBA/2 mice
14. Anticonvulsant effects of U-54494A and U-50488H in genetically epilepsy-prone rats and DBA/2 mice: A possible involvement of glycine/NMDA receptor complex
15. Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice
16. Fenbufen pretreatment potentiates the anticonvulsant activity of CPPene and NBQX in DBA/2 mice
17. Anticonvulsant activity of 5,7 DCKA, NBQX and Felbamate against some chemoconvulsants in DBA/2 mice
18. The pharmacology and mechanism of action of riluzole
19. Seizure susceptibility in DBA and C57 mice: The effects of various convulsants
20. Protective effect of riluzole on excitatory amino acid-mediated neurotoxicity in motoneuron-enriched cultures
21. Amyotrophic lateral sclerosis: Current and future treatment strategies
22. Block of the rat brain IIA sodium channel a subunit by the neuroprotective drug riluzole
23. Quinoxalinediones: Potent competitive non-NMDA glutamate receptor antagonists
24. Ibotenic acid stimulated D-(3H)-aspartate release from cultured cerebellar granule cells
25. Effects of depolarizing stimuli on calcium homeostasis in cultured rat motoneurons
26. ALS therapy: Targets for the future
27. Glycine potentiates the NMDA response in cultured mouse brain neurons
28. Riluzole series. Synthesis and in vivo 'antiglutamate' activity of 6-substituted-2-benzothiazolamines and 3-substituted-2-imino-benzothiazolines
29. Riluzole blocks dopamine release evoked by N-methyl-D-aspartate, kainate and veratridine in the rat striatum
30. Ligands of the NMDA receptor-associated glycine recognition site and motor behavior
31. Behavioral effects mediated by the modulatory glycine site of the NMDA receptor in the antedorsal striatum and nucleus accumbens
32. The contribution of the different binding sites of the N-methyl-D-aspartate (NMDA) receptor to the expression of behavior
33. Glycine site antagonists abolish dopamine D2 but not D1 receptor mediated catalepsy in rats
34. Riluzole, a glutamate release inhibitor, and motor behavior
35. Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis/Riluzole Study Group II
36. Glycine potentiates strychnine-induced convulsions: Role of NMDA-receptors
37. A simplified method of evaluating dose-effect experiments
38. Comparison of competitive and uncompetitive NMDA receptor antagonists with regard to monoaminergic neuronal activity and behavioural effects in rats
39. Riluzole, a novel antiglutamate, prevents memory loss and hippocampal neuronal damage in ischaemic gerbils
40. Riluzole
41. The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1
42. Effect of Riluzole on quinolinate-induced neuronal damage in rats: Comparison with blockers of glutamatergic neurotransmission
43. Glutamate: Its role in learning, memory, and the aging brain
44. The riluzole early access profram: Descriptive analysis of 844 patients in France. ALS/riluzole Study Group III
45. Excitatory amino acid neurotoxicity and neurodegenerative disease
46. 2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission-I
47. 3H]glycine site as the modulatory site of the N-methyl-D-aspartate receptor complex
48. Glycine potentiates the anticonvulsant action of diazepam and phenobarbital in kindled amygdaloid seizures of rats
49. Glycine potentiates of anticonvulsant drugs in pentylenetetrazol seizures in rats
50. Anticonvulsant drug potentiation by glycine in maximal electroshock seizures is mimicked by D-serine and antagonized by 7-chlorokynurenic acid
51. Potentiation by glycine of anticonvulsant drugs in maximal electroshock seizures in rats
52. Neuroprotective actions of riluzole in rodent models of global and focal cerebral ischaemia
53. The NMDA receptor, NMDA antagonists and epilepsy therapy
54. Therapeutic potential of excitatory amino acid antagonists: Channel blockers and 2,3-benzodiazepines
55. Anticonvulsant and sleep-waking influences of riluzole in a rat model of absence epilepsy
56. Synergistic anticonvulsant effects of GABA-T inhibitors and glycine
57. A review of mouse mutants as genetic models of epilepsy
58. Modulation of seizure susceptibility in the mouse by the strychnine-insensitive glycine recognition site of the NMDA receptor/ion channel complex
59. Effects of riluzole on rat cortical neurons: An in vitro electrophysiological study
60. Neuroprotective effects of riluzole: An electrophysiological and histological analysis in an in vitro model of ischemia
61. Blockade of glutamatergic transmission and neuroprotection, the strange case of riluzole
62. Glycine potentiates the action of some anticonvulsant drugs in some seizure models
63. Riluzole interacts with voltage-activated sodium and potassium currents in cultured rat cortical neurons