Kv7 potassium channel activation with ICA-105665 reduces photoparoxysmal EEG responses in patients with epilepsy

Epilepsia

Volumn 54, Issue 8, 2013, Pages 1437-1443

  Kasteleijn Nolst Trenité, Dorotheé G A ^a,b   Biton, Victor ^c   French, Jacqueline A ^d   Abou Khalil, Bassel ^e   Rosenfeld, William E ^f   Diventura, Bree ^g   Moore, Elizabeth L ^h   Hetherington, Seth V ^h   Rigdon, Greg C ^h  

^a UTRECHT UNIVERSITY   (Netherlands)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c Arkansas Epilepsy Program   (United States)

^d NEW YORK UNIVERSITY   (United States)

^e VANDERBILT UNIVERSITY   (United States)

^f Comprehensive Epilepsy Care Center for Children and Adults ^*  (United States)

^g The Epilepsy Study Consortium   (United States)

^h Icagen Inc   (United States)

Author keywords

Epilepsy; ICA 105665; Ion channel; Kv7 potassium channel; Photoparoxysmal response; Photosensitivity; Proof of concept model

Indexed keywords

CARBAMAZEPINE; CLONAZEPAM; ETIRACETAM; ICA 105665; LAMOTRIGINE; PHENOBARBITAL; PHENYTOIN; PLACEBO; POTASSIUM CHANNEL; POTASSIUM CHANNEL KV7; TOPIRAMATE; UNCLASSIFIED DRUG;

ABSENCE; ADULT; ANTICONVULSANT ACTIVITY; AREA UNDER THE CURVE; ARTICLE; ATAXIA; CENTRAL NERVOUS SYSTEM; CLINICAL ARTICLE; CLINICAL PROTOCOL; COHORT ANALYSIS; CONTROLLED STUDY; DIZZINESS; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; DRUG PENETRATION; DRUG SAFETY; DRUG WITHDRAWAL; ELECTROENCEPHALOGRAPHY; EPILEPTIC DISCHARGE; EYELID MOVEMENT; FATIGUE; FEMALE; GENERALIZED EPILEPSY; HUMAN; MALE; MAXIMUM PLASMA CONCENTRATION; MULTICENTER STUDY; MUSCLE TWITCH; MYOCLONUS EPILEPSY; PHASE 2 CLINICAL TRIAL; PHOTOSENSITIVE EPILEPSY; PHOTOSENSITIVITY; PHOTOSTIMULATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SINGLE BLIND PROCEDURE; SINGLE DRUG DOSE; SOMNOLENCE; TIME TO MAXIMUM PLASMA CONCENTRATION; TONIC CLONIC SEIZURE; TREATMENT RESPONSE; TREMOR;

EPILEPSY; ICA-105665; ION CHANNEL; KV7 POTASSIUM CHANNEL; PHOTOPAROXYSMAL RESPONSE; PHOTOSENSITIVITY; PROOF OF CONCEPT MODEL;

ADOLESCENT; ADULT; ANTICONVULSANTS; AREA UNDER CURVE; COHORT STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROENCEPHALOGRAPHY; EPILEPSY; EVOKED POTENTIALS; FEMALE; HUMANS; KCNQ POTASSIUM CHANNELS; MALE; MIDDLE AGED; PHOTIC STIMULATION; SINGLE-BLIND METHOD; TIME FACTORS; YOUNG ADULT;

EID: 84881157383     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/epi.12224     Document Type: Article

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