Hemin inhibits the large conductance potassium channel in brain mitochondria: A putative novel mechanism of neurodegeneration

Experimental Neurology

Volumn 257, Issue , 2014, Pages 70-75

  Augustynek, Bartłomiej ^a,b   Kudin, Alexei P ^b   Bednarczyk, Piotr ^a,c   Szewczyk, Adam ^a   Kunz, Wolfram S ^b  

^a NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

^b UNIVERSITY OF BONN   (Germany)

^c WARSAW UNIVERSITY OF LIFE SCIENCES   (Poland)

Author keywords

Hemin; Intracerebral hemorrhage; Mitochondria; Neurodegeneration; ROS synthesis

Indexed keywords

CALCIUM ION; HEMIN; POTASSIUM CHANNEL;

ARTICLE; ASTROCYTOMA CELL LINE; BIOACCUMULATION; BRAIN MITOCHONDRION; CELL FUNCTION; CONTROLLED STUDY; DISEASE ACTIVITY; ELECTROENCEPHALOGRAM; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; NERVE DEGENERATION; PATCH CLAMP TECHNIQUE; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

HEMIN; INTRACEREBRAL HEMORRHAGE; MITOCHONDRIA; MITOCHONDRIAL BK(CA) CHANNEL; NEURODEGENERATION; ROS SYNTHESIS;

ANIMALS; ASTROCYTOMA; BENZIMIDAZOLES; BRAIN; CALCIUM; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; HEMIN; HUMANS; HYDROGEN PEROXIDE; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PATCH-CLAMP TECHNIQUES; PEPTIDES; POTASSIUM CHANNEL BLOCKERS; RATS; REACTIVE OXYGEN SPECIES;

EID: 84900856435     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2014.04.022     Document Type: Article

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