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Volumn 81, Issue , 2007, Pages 85-110

Mechanisms of Action of Antiepileptic Drugs

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; ION CHANNEL;

EID: 34047204206     PISSN: 00747742     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0074-7742(06)81006-8     Document Type: Review
Times cited : (167)

References (162)
  • 1
    • 0027486269 scopus 로고
    • Distribution of the anticonvulsant felbamate to cerebrospinal fluid and brain tissue of adult and neonatal rats
    • Adusumalli V.E., Wichmann J.K., Kucharczyk N., and Sofia R.D. Distribution of the anticonvulsant felbamate to cerebrospinal fluid and brain tissue of adult and neonatal rats. Drug Metab. Dispos. 21 (1993) 1079-1085
    • (1993) Drug Metab. Dispos. , vol.21 , pp. 1079-1085
    • Adusumalli, V.E.1    Wichmann, J.K.2    Kucharczyk, N.3    Sofia, R.D.4
  • 4
    • 0030682180 scopus 로고    scopus 로고
    • Levetiracetam (ucb L059) affects in vitro models of epilepsy in CA3 pyramidal neurons without altering normal synaptic transmission
    • Birnstiel S., Wulfert E., and Beck S.G. Levetiracetam (ucb L059) affects in vitro models of epilepsy in CA3 pyramidal neurons without altering normal synaptic transmission. Naunyn Schmiedebergs Arch. Pharmacol. 356 (1997) 611-618
    • (1997) Naunyn Schmiedebergs Arch. Pharmacol. , vol.356 , pp. 611-618
    • Birnstiel, S.1    Wulfert, E.2    Beck, S.G.3
  • 6
    • 0029122730 scopus 로고
    • Action of GP 47779, the active metabolite of oxcarbazepine, on the corticostriatal system. I. Modulation of corticostriatal synaptic transmission
    • Calabresi P., De Murtas M., Stefani A., Pisani A., Sancesario G., Mercuri N.B., and Bernardi G. Action of GP 47779, the active metabolite of oxcarbazepine, on the corticostriatal system. I. Modulation of corticostriatal synaptic transmission. Epilepsia 36 (1995) 990-996
    • (1995) Epilepsia , vol.36 , pp. 990-996
    • Calabresi, P.1    De Murtas, M.2    Stefani, A.3    Pisani, A.4    Sancesario, G.5    Mercuri, N.B.6    Bernardi, G.7
  • 7
    • 34047211993 scopus 로고
    • Effects of valproate on action potentials and repetitive firing of CA1 pyramidal cells in the hippocampal slice preparation
    • Abstract 17.19
    • Capek R., and Esplin B. Effects of valproate on action potentials and repetitive firing of CA1 pyramidal cells in the hippocampal slice preparation. Soc. Neurosci. Abstr. 12 (1986) 46 Abstract 17.19
    • (1986) Soc. Neurosci. Abstr. , vol.12 , pp. 46
    • Capek, R.1    Esplin, B.2
  • 8
    • 0026443902 scopus 로고
    • An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels
    • Cheung H., Kamp D., and Harris E. An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels. Epilepsy Res. 13 (1992) 107-112
    • (1992) Epilepsy Res. , vol.13 , pp. 107-112
    • Cheung, H.1    Kamp, D.2    Harris, E.3
  • 9
    • 0028086877 scopus 로고
    • Selective antagonism of the anticonvulsant effects of felbamate by glycine
    • Coffin V., Cohen-Williams M., and Barnett A. Selective antagonism of the anticonvulsant effects of felbamate by glycine. Eur. J. Pharmacol. 256 (1994) R9-R10
    • (1994) Eur. J. Pharmacol. , vol.256
    • Coffin, V.1    Cohen-Williams, M.2    Barnett, A.3
  • 10
    • 0031414052 scopus 로고    scopus 로고
    • Antiepileptic drug cellular mechanisms of action: Where does lamotrigine fit in?
    • Coulter D.A. Antiepileptic drug cellular mechanisms of action: Where does lamotrigine fit in?. J. Child Neurol. 12 Suppl. 1 (1997) S2-S9
    • (1997) J. Child Neurol. , vol.12 , Issue.SUPPL. 1
    • Coulter, D.A.1
  • 11
    • 0024324889 scopus 로고
    • Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons
    • Coulter D.A., Huguenard J.R., and Prince D.A. Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons. Ann. Neurol. 25 (1989) 582-593
    • (1989) Ann. Neurol. , vol.25 , pp. 582-593
    • Coulter, D.A.1    Huguenard, J.R.2    Prince, D.A.3
  • 12
    • 0000337336 scopus 로고
    • Selective effects of topiramate on sustained repetitive firing and spontaneous bursting in cultured hippocampal neurons
    • Coulter D.A., Sombati S., and DeLorenzo R.J. Selective effects of topiramate on sustained repetitive firing and spontaneous bursting in cultured hippocampal neurons. Epilepsia 34 Suppl. 2 (1983) 123
    • (1983) Epilepsia , vol.34 , Issue.SUPPL. 2 , pp. 123
    • Coulter, D.A.1    Sombati, S.2    DeLorenzo, R.J.3
  • 13
    • 0002273388 scopus 로고
    • Other antiepileptic drugs. Oxcarbazepine
    • Levy R.H., Mattson R.H., and Meldrum B.S. (Eds), Raven Press Ltd., New York
    • Dam M., and Ostergaard L.H. Other antiepileptic drugs. Oxcarbazepine. In: Levy R.H., Mattson R.H., and Meldrum B.S. (Eds). "Antiepileptic Drugs". 4th ed. (1995), Raven Press Ltd., New York 987-995
    • (1995) "Antiepileptic Drugs". 4th ed. , pp. 987-995
    • Dam, M.1    Ostergaard, L.H.2
  • 14
    • 0024494368 scopus 로고
    • A double-blind study comparing oxcarbazepine and carbamazepine in patients with newly diagnosed, previously untreated epilepsy
    • Dam M., Ekberg R., Loyning Y., Waltimo O., and Jakobsen K. A double-blind study comparing oxcarbazepine and carbamazepine in patients with newly diagnosed, previously untreated epilepsy. Epilepsy Res. 3 (1989) 70-76
    • (1989) Epilepsy Res. , vol.3 , pp. 70-76
    • Dam, M.1    Ekberg, R.2    Loyning, Y.3    Waltimo, O.4    Jakobsen, K.5
  • 15
    • 30744454021 scopus 로고    scopus 로고
    • Phenytoin and other hydantoins: Mechanisms of action
    • Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds), Lippincott Williams & Wilkins, Philadelphia
    • DeLorenzo R.J., and Sun D.A. Phenytoin and other hydantoins: Mechanisms of action. In: Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds). "Antiepileptic Drugs". 5th ed. (2002), Lippincott Williams & Wilkins, Philadelphia 551-564
    • (2002) "Antiepileptic Drugs". 5th ed. , pp. 551-564
    • DeLorenzo, R.J.1    Sun, D.A.2
  • 16
    • 0034128349 scopus 로고    scopus 로고
    • Effects of topiramate on sustained repetitive firing and spontaneous recurrent seizure discharges in cultured hippocampal neurons
    • DeLorenzo R.J., Sombati S., and Coulter D.A. Effects of topiramate on sustained repetitive firing and spontaneous recurrent seizure discharges in cultured hippocampal neurons. Epilepsia 41 Suppl. 1 (2000) S40-S44
    • (2000) Epilepsia , vol.41 , Issue.SUPPL. 1
    • DeLorenzo, R.J.1    Sombati, S.2    Coulter, D.A.3
  • 17
    • 0028021395 scopus 로고
    • Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice
    • De Sarro G., Ongini E., Bertorelli R., Aguglia U., and De Sarro A. Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice. Eur. J. Pharmacol. 262 (1994) 11-19
    • (1994) Eur. J. Pharmacol. , vol.262 , pp. 11-19
    • De Sarro, G.1    Ongini, E.2    Bertorelli, R.3    Aguglia, U.4    De Sarro, A.5
  • 19
    • 0023274207 scopus 로고
    • Cellular mechanisms of epilepsy: A status report
    • Dichter M.A., and Ayala G.F. Cellular mechanisms of epilepsy: A status report. Science 237 (1987) 157-164
    • (1987) Science , vol.237 , pp. 157-164
    • Dichter, M.A.1    Ayala, G.F.2
  • 20
    • 0030111251 scopus 로고    scopus 로고
    • Anesthetics produce subunit-selective actions on glutamate receptors
    • Dildy-Mayfield J.E., Eger II E.I., and Harris R.A. Anesthetics produce subunit-selective actions on glutamate receptors. J. Pharmacol. Exp. Ther. 276 (1996) 1058-1065
    • (1996) J. Pharmacol. Exp. Ther. , vol.276 , pp. 1058-1065
    • Dildy-Mayfield, J.E.1    Eger II, E.I.2    Harris, R.A.3
  • 21
    • 0343673858 scopus 로고    scopus 로고
    • Topiramate as an inhibitor of carbonic anhydrase isoenzymes
    • Dodgson S.J., Shank R.P., and Maryanoff B.E. Topiramate as an inhibitor of carbonic anhydrase isoenzymes. Epilepsia 41 Suppl. 1 (2000) S35-S39
    • (2000) Epilepsia , vol.41 , Issue.SUPPL. 1
    • Dodgson, S.J.1    Shank, R.P.2    Maryanoff, B.E.3
  • 22
    • 0002304729 scopus 로고
    • The effect of tiagabine HCl on extracellular GABA levels in the human hippocampus [abstract]
    • During M., Mattson R., Scheyer R., Rask C., Pierce M., McKelvy J., and Thomas V. The effect of tiagabine HCl on extracellular GABA levels in the human hippocampus [abstract]. Epilepsia 33 Suppl. 3 (1992) 83
    • (1992) Epilepsia , vol.33 , Issue.SUPPL. 3 , pp. 83
    • During, M.1    Mattson, R.2    Scheyer, R.3    Rask, C.4    Pierce, M.5    McKelvy, J.6    Thomas, V.7
  • 23
    • 0026709603 scopus 로고
    • The gamma-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats
    • Fink-Jensen A., Suzdak P.D., Swedberg M.D., Judge M.E., Hansen L., and Nielsen P.G. The gamma-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats. Eur. J. Pharmacol. 220 (1992) 197-201
    • (1992) Eur. J. Pharmacol. , vol.220 , pp. 197-201
    • Fink-Jensen, A.1    Suzdak, P.D.2    Swedberg, M.D.3    Judge, M.E.4    Hansen, L.5    Nielsen, P.G.6
  • 24
    • 0029975930 scopus 로고    scopus 로고
    • The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel
    • Gee N.S., Brown J.P., Dissanayake V.U., Offord J., Thurlow R., and Woodruff G.N. The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel. J. Biol. Chem. 271 (1996) 5768-5776
    • (1996) J. Biol. Chem. , vol.271 , pp. 5768-5776
    • Gee, N.S.1    Brown, J.P.2    Dissanayake, V.U.3    Offord, J.4    Thurlow, R.5    Woodruff, G.N.6
  • 25
    • 33750303042 scopus 로고    scopus 로고
    • Tiagabine: Mechanisms of action
    • Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds), Lippincott Williams & Wilkins, Philadelphia
    • Giardina W.J. Tiagabine: Mechanisms of action. In: Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds). "Antiepileptic Drugs". 5th ed. (2002), Lippincott Williams & Wilkins, Philadelphia 675-680
    • (2002) "Antiepileptic Drugs". 5th ed. , pp. 675-680
    • Giardina, W.J.1
  • 26
    • 0034076786 scopus 로고    scopus 로고
    • Cellular actions of topiramate: Blockade of kainate-evoked inward currents in cultured hippocampal neurons
    • Gibbs III J.W., Sombati S., DeLorenzo R.J., and Coulter D.A. Cellular actions of topiramate: Blockade of kainate-evoked inward currents in cultured hippocampal neurons. Epilepsia 41 Suppl. 1 (2000) S10-S16
    • (2000) Epilepsia , vol.41 , Issue.SUPPL. 1
    • Gibbs III, J.W.1    Sombati, S.2    DeLorenzo, R.J.3    Coulter, D.A.4
  • 27
    • 0026471112 scopus 로고
    • ucb L059, a novel anti-convulsant drug: Pharmacological profile in animals
    • Gower A.J., Noyer M., Verloes R., Gobert J., and Wulfert E. ucb L059, a novel anti-convulsant drug: Pharmacological profile in animals. Eur. J. Pharmacol. 222 (1992) 193-203
    • (1992) Eur. J. Pharmacol. , vol.222 , pp. 193-203
    • Gower, A.J.1    Noyer, M.2    Verloes, R.3    Gobert, J.4    Wulfert, E.5
  • 28
    • 0028823233 scopus 로고
    • Effects of levetiracetam, a novel antiepileptic drug, on convulsant activity in two genetic rat models of epilepsy
    • Gower A.J., Hirsch E., Boehrer A., Noyer M., and Marescaux C. Effects of levetiracetam, a novel antiepileptic drug, on convulsant activity in two genetic rat models of epilepsy. Epilepsy Res. 22 (1995) 207-213
    • (1995) Epilepsy Res. , vol.22 , pp. 207-213
    • Gower, A.J.1    Hirsch, E.2    Boehrer, A.3    Noyer, M.4    Marescaux, C.5
  • 29
    • 0003575617 scopus 로고
    • Oxcarbazepine
    • Meldrum B.S., and Porter R.J. (Eds), John Libbey & Co., London
    • Gram L., and Philbert A. Oxcarbazepine. In: Meldrum B.S., and Porter R.J. (Eds). "New Anticonvulsant Drugs" (1986), John Libbey & Co., London 229-235
    • (1986) "New Anticonvulsant Drugs" , pp. 229-235
    • Gram, L.1    Philbert, A.2
  • 30
    • 33645828611 scopus 로고    scopus 로고
    • Topiramate and its clinical applications in epilepsy
    • Guerrini R., and Parmeggiani L. Topiramate and its clinical applications in epilepsy. Expert Opin. Pharmacother. 7 (2006) 811-823
    • (2006) Expert Opin. Pharmacother. , vol.7 , pp. 811-823
    • Guerrini, R.1    Parmeggiani, L.2
  • 31
    • 0033957224 scopus 로고    scopus 로고
    • Felbamate block of recombinant N-methyl-D-aspartate receptors: Selectivity for the NR2B subunit
    • Harty T.P., and Rogawski M.A. Felbamate block of recombinant N-methyl-D-aspartate receptors: Selectivity for the NR2B subunit. Epilepsy Res. 39 (2000) 47-55
    • (2000) Epilepsy Res. , vol.39 , pp. 47-55
    • Harty, T.P.1    Rogawski, M.A.2
  • 32
    • 0036171793 scopus 로고    scopus 로고
    • Two new actions of topiramate: Inhibition of depolarizing GABA(A)-mediated responses and activation of a potassium conductance
    • Herrero A.I., Del Olmo N., Gonzalez-Escalada J.R., and Solis J.M. Two new actions of topiramate: Inhibition of depolarizing GABA(A)-mediated responses and activation of a potassium conductance. Neuropharmacology 42 (2002) 210-220
    • (2002) Neuropharmacology , vol.42 , pp. 210-220
    • Herrero, A.I.1    Del Olmo, N.2    Gonzalez-Escalada, J.R.3    Solis, J.M.4
  • 33
    • 4143107435 scopus 로고    scopus 로고
    • Succinimides: Mechanisms of action
    • Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds), Lippincott Williams & Wilkins, Philadelphia
    • Holland K.D., and Ferrendelli J.A. Succinimides: Mechanisms of action. In: Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds). "Antiepileptic Drugs". 5th ed. (2002), Lippincott Williams & Wilkins, Philadelphia 639-645
    • (2002) "Antiepileptic Drugs". 5th ed. , pp. 639-645
    • Holland, K.D.1    Ferrendelli, J.A.2
  • 34
    • 0015367889 scopus 로고
    • The epileptogenic action of Na-folate in the rat
    • Hommes O.R., and Obbens E.A. The epileptogenic action of Na-folate in the rat. J. Neurol. Sci. 16 (1972) 271-281
    • (1972) J. Neurol. Sci. , vol.16 , pp. 271-281
    • Hommes, O.R.1    Obbens, E.A.2
  • 35
    • 0028907754 scopus 로고
    • Gabapentin potentiates the conductance increase induced by nipecotic acid in CA1 pyramidal neurons in vitro
    • Honmou O., Kocsis J.D., and Richerson G.B. Gabapentin potentiates the conductance increase induced by nipecotic acid in CA1 pyramidal neurons in vitro. Epilepsy Res. 20 (1995) 193-202
    • (1995) Epilepsy Res. , vol.20 , pp. 193-202
    • Honmou, O.1    Kocsis, J.D.2    Richerson, G.B.3
  • 38
    • 0025309183 scopus 로고
    • Valproic acid selectively reduces the low-threshold (T) calcium current in rat nodose neurons
    • Kelly K.M., Gross R.A., and Macdonald R.L. Valproic acid selectively reduces the low-threshold (T) calcium current in rat nodose neurons. Neurosci. Lett. 116 (1990) 233-238
    • (1990) Neurosci. Lett. , vol.116 , pp. 233-238
    • Kelly, K.M.1    Gross, R.A.2    Macdonald, R.L.3
  • 39
    • 0030035708 scopus 로고    scopus 로고
    • Mechanisms of T-type calcium channel blockade by zonisamide
    • Kito M., Maehara M., and Watanabe K. Mechanisms of T-type calcium channel blockade by zonisamide. Seizure 5 (1996) 115-119
    • (1996) Seizure , vol.5 , pp. 115-119
    • Kito, M.1    Maehara, M.2    Watanabe, K.3
  • 40
    • 0028220873 scopus 로고
    • Gabapentin increases GABA-induced depolarization in rat neonatal optic nerve
    • Kocsis J.D., and Honmou O. Gabapentin increases GABA-induced depolarization in rat neonatal optic nerve. Neurosci. Lett. 169 (1994) 181-184
    • (1994) Neurosci. Lett. , vol.169 , pp. 181-184
    • Kocsis, J.D.1    Honmou, O.2
  • 42
    • 16344368695 scopus 로고    scopus 로고
    • Topiramate inhibits the initiation of plateau potentials in CA1 neurons by depressing R-type calcium channels
    • Kuzmiski J.B., Barr W., Zamponi G.W., and MacVicar B.A. Topiramate inhibits the initiation of plateau potentials in CA1 neurons by depressing R-type calcium channels. Epilepsia 46 (2005) 481-489
    • (2005) Epilepsia , vol.46 , pp. 481-489
    • Kuzmiski, J.B.1    Barr, W.2    Zamponi, G.W.3    MacVicar, B.A.4
  • 43
    • 0027507511 scopus 로고
    • Lamotrigine, phenytoin and carbamazepine interactions on the sodium current present in N4TG1 mouse neuroblastoma cells
    • Lang D.G., Wang C.M., and Cooper B.R. Lamotrigine, phenytoin and carbamazepine interactions on the sodium current present in N4TG1 mouse neuroblastoma cells. J. Pharmacol. Exp. Ther. 266 (1993) 829-835
    • (1993) J. Pharmacol. Exp. Ther. , vol.266 , pp. 829-835
    • Lang, D.G.1    Wang, C.M.2    Cooper, B.R.3
  • 44
    • 0022900644 scopus 로고
    • Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action
    • Leach M.J., Marden C.M., and Miller A.A. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia 27 (1986) 490-497
    • (1986) Epilepsia , vol.27 , pp. 490-497
    • Leach, M.J.1    Marden, C.M.2    Miller, A.A.3
  • 45
    • 3242807880 scopus 로고    scopus 로고
    • Lamotrigine: Mechanisms of action
    • Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds), Lippincott Williams & Wilkins, Philadelphia
    • Leach M.J., Randall A.D., Stefani A., and Hainsworth A.H. Lamotrigine: Mechanisms of action. In: Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds). "Antiepileptic Drugs". 5th ed (2002), Lippincott Williams & Wilkins, Philadelphia 363-369
    • (2002) "Antiepileptic Drugs". 5th ed , pp. 363-369
    • Leach, M.J.1    Randall, A.D.2    Stefani, A.3    Hainsworth, A.H.4
  • 46
    • 0027310109 scopus 로고
    • Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamictal) using primary neurological cultures from rat cortex
    • Lees G., and Leach M.J. Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamictal) using primary neurological cultures from rat cortex. Brain Res. 612 (1993) 190-199
    • (1993) Brain Res. , vol.612 , pp. 190-199
    • Lees, G.1    Leach, M.J.2
  • 49
    • 0019503690 scopus 로고
    • Valproate induced changes in GABA metabolism at the subcellular level
    • Loscher W. Valproate induced changes in GABA metabolism at the subcellular level. Biochem. Pharmacol. 30 (1981) 1364-1366
    • (1981) Biochem. Pharmacol. , vol.30 , pp. 1364-1366
    • Loscher, W.1
  • 50
    • 4243491268 scopus 로고    scopus 로고
    • Valproic acid: Mechanisms of action
    • Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds), Lippincott Williams & Wilkins, Philadelphia
    • Loscher W. Valproic acid: Mechanisms of action. In: Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds). "Antiepileptic Drugs". 5th ed. (2002), Lippincott Williams & Wilkins, Philadelphia 767-779
    • (2002) "Antiepileptic Drugs". 5th ed. , pp. 767-779
    • Loscher, W.1
  • 51
    • 0025764823 scopus 로고
    • Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain
    • Loscher W., Honack D., and Taylor C.P. Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain. Neurosci. Lett. 128 (1991) 150-154
    • (1991) Neurosci. Lett. , vol.128 , pp. 150-154
    • Loscher, W.1    Honack, D.2    Taylor, C.P.3
  • 53
    • 0024450953 scopus 로고
    • Antiepileptic drug actions
    • discussion S64-S68
    • Macdonald R.L. Antiepileptic drug actions. Epilepsia 30 Suppl. 1 (1989) S19-S28 discussion S64-S68
    • (1989) Epilepsia , vol.30 , Issue.SUPPL. 1
    • Macdonald, R.L.1
  • 54
    • 1642377949 scopus 로고    scopus 로고
    • Benzodiazepines: Mechanisms of action
    • Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds), Lippincott Williams & Wilkins, Philadelphia
    • Macdonald R.L. Benzodiazepines: Mechanisms of action. In: Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds). Antiepileptic Drugs. 5th ed. (2002), Lippincott Williams & Wilkins, Philadelphia 179-186
    • (2002) Antiepileptic Drugs. 5th ed. , pp. 179-186
    • Macdonald, R.L.1
  • 55
    • 1642377949 scopus 로고    scopus 로고
    • Carbamazepine: Mechanisms of action
    • Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds), Lippincott Williams & Wilkins, Philadelphia
    • Macdonald R.L. Carbamazepine: Mechanisms of action. In: Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds). "Antiepileptic Drugs". 5th ed. (2002), Lippincott Williams & Wilkins, Philadelphia 227-235
    • (2002) "Antiepileptic Drugs". 5th ed. , pp. 227-235
    • Macdonald, R.L.1
  • 56
    • 1442344104 scopus 로고    scopus 로고
    • Zonisamide: Mechanisms of action
    • Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds), Lippincott Williams & Wilkins, Philadelphia
    • Macdonald R.L. Zonisamide: Mechanisms of action. In: Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds). "Antiepileptic Drugs". 5th ed. (2002), Lippincott Williams & Wilkins, Philadelphia 867-872
    • (2002) "Antiepileptic Drugs". 5th ed. , pp. 867-872
    • Macdonald, R.L.1
  • 57
    • 0029057901 scopus 로고
    • Antiepileptic drug mechanisms of action
    • Macdonald R.L., and Kelly K.M. Antiepileptic drug mechanisms of action. Epilepsia 36 Suppl. 2 (1995) S2-S12
    • (1995) Epilepsia , vol.36 , Issue.SUPPL. 2
    • Macdonald, R.L.1    Kelly, K.M.2
  • 59
    • 0024415567 scopus 로고
    • Barbiturate regulation of kinetic properties of the GABAA receptor channel of mouse spinal neurones in culture
    • Macdonald R.L., Rogers C.J., and Twyman R.E. Barbiturate regulation of kinetic properties of the GABAA receptor channel of mouse spinal neurones in culture. J. Physiol. 417 (1989) 483-500
    • (1989) J. Physiol. , vol.417 , pp. 483-500
    • Macdonald, R.L.1    Rogers, C.J.2    Twyman, R.E.3
  • 60
    • 0033800837 scopus 로고    scopus 로고
    • Inhibition of neuronal hypersynchrony in vitro differentiates levetiracetam from classical antiepileptic drugs
    • Margineanu D.G., and Klitgaard H. Inhibition of neuronal hypersynchrony in vitro differentiates levetiracetam from classical antiepileptic drugs. Pharmacol. Res. 42 (2000) 281-285
    • (2000) Pharmacol. Res. , vol.42 , pp. 281-285
    • Margineanu, D.G.1    Klitgaard, H.2
  • 61
    • 0002100772 scopus 로고    scopus 로고
    • Levetiracetam: Mechanisms of action
    • Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds), Lippincott Williams & Wilkins, Philadelphia
    • Margineanu D.G., and Klitgaard H. Levetiracetam: Mechanisms of action. In: Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds). "Antiepileptic Drugs". 5th ed. (2002), Lippincott Williams & Wilkins, Philadelphia 419-427
    • (2002) "Antiepileptic Drugs". 5th ed. , pp. 419-427
    • Margineanu, D.G.1    Klitgaard, H.2
  • 62
    • 0028784616 scopus 로고
    • ucb L059, a novel anticonvulsant, reduces bicuculline-induced hyperexcitability in rat hippocampal CA3 in vivo
    • Margineanu D.G., and Wulfert E. ucb L059, a novel anticonvulsant, reduces bicuculline-induced hyperexcitability in rat hippocampal CA3 in vivo. Eur. J. Pharmacol. 286 (1995) 321-325
    • (1995) Eur. J. Pharmacol. , vol.286 , pp. 321-325
    • Margineanu, D.G.1    Wulfert, E.2
  • 63
    • 0030734833 scopus 로고    scopus 로고
    • Inhibition by levetiracetam of a non-GABAA receptor-associated epileptiform effect of bicuculline in rat hippocampus
    • Margineanu D.G., and Wulfert E. Inhibition by levetiracetam of a non-GABAA receptor-associated epileptiform effect of bicuculline in rat hippocampus. Br. J. Pharmacol. 122 (1997) 1146-1150
    • (1997) Br. J. Pharmacol. , vol.122 , pp. 1146-1150
    • Margineanu, D.G.1    Wulfert, E.2
  • 65
    • 0027381484 scopus 로고
    • Evidence for anticonvulsant and neuroprotectant action of felbamate mediated by strychnine-insensitive glycine receptors
    • McCabe R.T., Wasterlain C.G., Kucharczyk N., Sofia R.D., and Vogel J.R. Evidence for anticonvulsant and neuroprotectant action of felbamate mediated by strychnine-insensitive glycine receptors. J. Pharmacol. Exp. Ther. 264 (1993) 1248-1252
    • (1993) J. Pharmacol. Exp. Ther. , vol.264 , pp. 1248-1252
    • McCabe, R.T.1    Wasterlain, C.G.2    Kucharczyk, N.3    Sofia, R.D.4    Vogel, J.R.5
  • 66
    • 0042395138 scopus 로고    scopus 로고
    • Oxcarbazepine: Mechanisms of action
    • Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds), Lippincott Williams & Wilkins, Philadelphia
    • McLean M.J. Oxcarbazepine: Mechanisms of action. In: Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds). "Antiepileptic Drugs". 5th ed. (2002), Lippincott Williams & Wilkins, Philadelphia 451-458
    • (2002) "Antiepileptic Drugs". 5th ed. , pp. 451-458
    • McLean, M.J.1
  • 67
    • 0022516644 scopus 로고
    • Carbamazepine and 10,11-epoxycarbamazepine produce use- and voltage-dependent limitation of rapidly firing action potentials of mouse central neurons in cell culture
    • McLean M.J., and Macdonald R.L. Carbamazepine and 10,11-epoxycarbamazepine produce use- and voltage-dependent limitation of rapidly firing action potentials of mouse central neurons in cell culture. J. Pharmacol. Exp. Ther. 238 (1986) 727-738
    • (1986) J. Pharmacol. Exp. Ther. , vol.238 , pp. 727-738
    • McLean, M.J.1    Macdonald, R.L.2
  • 68
    • 0022540479 scopus 로고
    • Sodium valproate, but not ethosuximide, produces use- and voltage-dependent limitation of high frequency repetitive firing of action potentials of mouse central neurons in cell culture
    • McLean M.J., and Macdonald R.L. Sodium valproate, but not ethosuximide, produces use- and voltage-dependent limitation of high frequency repetitive firing of action potentials of mouse central neurons in cell culture. J. Pharmacol. Exp. Ther. 237 (1986) 1001-1011
    • (1986) J. Pharmacol. Exp. Ther. , vol.237 , pp. 1001-1011
    • McLean, M.J.1    Macdonald, R.L.2
  • 70
    • 0034040285 scopus 로고    scopus 로고
    • Effects of topiramate on sodium-dependent action-potential firing by mouse spinal cord neurons in cell culture
    • McLean M.J., Bukhari A.A., and Wamil A.W. Effects of topiramate on sodium-dependent action-potential firing by mouse spinal cord neurons in cell culture. Epilepsia 41 Suppl. 1 (2000) S21-S24
    • (2000) Epilepsia , vol.41 , Issue.SUPPL. 1
    • McLean, M.J.1    Bukhari, A.A.2    Wamil, A.W.3
  • 71
    • 0030323503 scopus 로고    scopus 로고
    • Action of established and novel anticonvulsant drugs on the basic mechanisms of epilepsy
    • Meldrum B. Action of established and novel anticonvulsant drugs on the basic mechanisms of epilepsy. Epilepsy Res. Suppl. 11 (1996) 67-77
    • (1996) Epilepsy Res. Suppl. , vol.11 , pp. 67-77
    • Meldrum, B.1
  • 72
    • 0032473367 scopus 로고    scopus 로고
    • Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging
    • Michaelis E.K. Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging. Prog. Neurobiol. 54 (1998) 369-415
    • (1998) Prog. Neurobiol. , vol.54 , pp. 369-415
    • Michaelis, E.K.1
  • 73
    • 33746217426 scopus 로고    scopus 로고
    • Pregabalin reduces the release of synaptic vesicles from cultured hippocampal neurons
    • Micheva K.D., Taylor C.P., and Smith S.J. Pregabalin reduces the release of synaptic vesicles from cultured hippocampal neurons. Mol. Pharmacol. 70 (2006) 467-476
    • (2006) Mol. Pharmacol. , vol.70 , pp. 467-476
    • Micheva, K.D.1    Taylor, C.P.2    Smith, S.J.3
  • 75
    • 0025405649 scopus 로고
    • Interaction of zonisamide with benzodiazepine and GABA receptors in rat brain
    • Mimaki T., Suzuki Y., Tagawa T., Karasawa T., and Yabuuchi H. Interaction of zonisamide with benzodiazepine and GABA receptors in rat brain. Med. J. Osaka Univ. 39 (1990) 13-17
    • (1990) Med. J. Osaka Univ. , vol.39 , pp. 13-17
    • Mimaki, T.1    Suzuki, Y.2    Tagawa, T.3    Karasawa, T.4    Yabuuchi, H.5
  • 76
    • 0035164999 scopus 로고    scopus 로고
    • Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action
    • Ng G.Y., Bertrand S., Sullivan R., Ethier N., Wang J., Yergey J., Belley M., Trimble L., Bateman K., Alder L., Smith A., McKernan R., et al. Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action. Mol. Pharmacol. 59 (2001) 144-152
    • (2001) Mol. Pharmacol. , vol.59 , pp. 144-152
    • Ng, G.Y.1    Bertrand, S.2    Sullivan, R.3    Ethier, N.4    Wang, J.5    Yergey, J.6    Belley, M.7    Trimble, L.8    Bateman, K.9    Alder, L.10    Smith, A.11    McKernan, R.12
  • 77
    • 0035933671 scopus 로고    scopus 로고
    • Levetiracetam inhibits the high-voltage-activated Ca(2+) current in pyramidal neurones of rat hippocampal slices
    • Niespodziany I., Klitgaard H., and Margineanu D.G. Levetiracetam inhibits the high-voltage-activated Ca(2+) current in pyramidal neurones of rat hippocampal slices. Neurosci. Lett. 306 (2001) 5-8
    • (2001) Neurosci. Lett. , vol.306 , pp. 5-8
    • Niespodziany, I.1    Klitgaard, H.2    Margineanu, D.G.3
  • 78
    • 0036763717 scopus 로고    scopus 로고
    • Characteristics and indications of topiramate
    • Nieto-Barrera M. Characteristics and indications of topiramate. Rev. Neurol. 35 Suppl. 1 (2002) S88-S95
    • (2002) Rev. Neurol. , vol.35 , Issue.SUPPL. 1
    • Nieto-Barrera, M.1
  • 79
    • 0028825031 scopus 로고
    • The novel antiepileptic drug levetiracetam (ucb L059) appears to act via a specific binding site in CNS membranes
    • Noyer M., Gillard M., Matagne A., Henichart J.P., and Wulfert E. The novel antiepileptic drug levetiracetam (ucb L059) appears to act via a specific binding site in CNS membranes. Eur. J. Pharmacol. 286 (1995) 137-146
    • (1995) Eur. J. Pharmacol. , vol.286 , pp. 137-146
    • Noyer, M.1    Gillard, M.2    Matagne, A.3    Henichart, J.P.4    Wulfert, E.5
  • 80
    • 8344264314 scopus 로고    scopus 로고
    • Phenobarbital and other barbiturates: Mechanisms of action
    • Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds), Lippincott Williams & Wilkins, Philadelphia
    • Olsen R.W. Phenobarbital and other barbiturates: Mechanisms of action. In: Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds). "Antiepileptic Drugs". 5th ed. (2002), Lippincott Williams & Wilkins, Philadelphia 489-495
    • (2002) "Antiepileptic Drugs". 5th ed. , pp. 489-495
    • Olsen, R.W.1
  • 81
    • 3042841014 scopus 로고    scopus 로고
    • Gabapentin activates presynaptic GABAB heteroreceptors in rat cortical slices
    • Parker D.A., Ong J., Marino V., and Kerr D.I. Gabapentin activates presynaptic GABAB heteroreceptors in rat cortical slices. Eur. J. Pharmacol. 495 (2004) 137-143
    • (2004) Eur. J. Pharmacol. , vol.495 , pp. 137-143
    • Parker, D.A.1    Ong, J.2    Marino, V.3    Kerr, D.I.4
  • 82
    • 0031467511 scopus 로고    scopus 로고
    • Felbamate: 1997 update
    • Pellock J.M., and Brodie M.J. Felbamate: 1997 update. Epilepsia 38 (1997) 1261-1264
    • (1997) Epilepsia , vol.38 , pp. 1261-1264
    • Pellock, J.M.1    Brodie, M.J.2
  • 83
    • 0038821615 scopus 로고    scopus 로고
    • Felbamate
    • Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds), Lippincott Williams & Wilkins, Philadelphia
    • Pellock J.M., Perhach J.L., and Sofia R.D. Felbamate. In: Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds). "Antiepileptic Drugs". 5th ed. (2002), Lippincott Williams & Wilkins, Philadelphia 301-318
    • (2002) "Antiepileptic Drugs". 5th ed. , pp. 301-318
    • Pellock, J.M.1    Perhach, J.L.2    Sofia, R.D.3
  • 84
    • 0342759370 scopus 로고
    • Gabapentin increases brain gama-aminobutyric acid levels in patients with epilepsy [abstract]
    • Abstract M46
    • Petroff O.A.C., Rothman D.L., Behar K.L., Lamoureax D., and Mattson R.H. Gabapentin increases brain gama-aminobutyric acid levels in patients with epilepsy [abstract]. Ann. Neurol. 38 (1995) 295-296 Abstract M46
    • (1995) Ann. Neurol. , vol.38 , pp. 295-296
    • Petroff, O.A.C.1    Rothman, D.L.2    Behar, K.L.3    Lamoureax, D.4    Mattson, R.H.5
  • 86
    • 0021996795 scopus 로고
    • Effect of stimulus intensity on the profile of anticonvulsant activity of phenytoin, ethosuximide and valproate
    • Piredda S.G., Woodhead J.H., and Swinyard E.A. Effect of stimulus intensity on the profile of anticonvulsant activity of phenytoin, ethosuximide and valproate. J. Pharmacol. Exp. Ther. 232 (1985) 741-745
    • (1985) J. Pharmacol. Exp. Ther. , vol.232 , pp. 741-745
    • Piredda, S.G.1    Woodhead, J.H.2    Swinyard, E.A.3
  • 88
    • 37049223719 scopus 로고
    • Experimental determination of the anticonvulsant properties of some phenyl derivatives
    • Putnam T.J., and Merritt H.H. Experimental determination of the anticonvulsant properties of some phenyl derivatives. Science 85 (1937) 525-526
    • (1937) Science , vol.85 , pp. 525-526
    • Putnam, T.J.1    Merritt, H.H.2
  • 89
    • 0021036376 scopus 로고
    • Inhibition by GABA, baclofen and gabapentin of dopamine release from rabbit caudate nucleus: Are there common or different sites of action?
    • Reimann W. Inhibition by GABA, baclofen and gabapentin of dopamine release from rabbit caudate nucleus: Are there common or different sites of action?. Eur. J. Pharmacol. 94 (1983) 341-344
    • (1983) Eur. J. Pharmacol. , vol.94 , pp. 341-344
    • Reimann, W.1
  • 91
    • 0025060943 scopus 로고
    • The effect of two lipophilic gamma-aminobutyric acid uptake blockers in CA1 of the rat hippocampal slice
    • Rekling J.C., Jahnsen H., and Mosfeldt Laursen A. The effect of two lipophilic gamma-aminobutyric acid uptake blockers in CA1 of the rat hippocampal slice. Br. J. Pharmacol. 99 (1990) 103-106
    • (1990) Br. J. Pharmacol. , vol.99 , pp. 103-106
    • Rekling, J.C.1    Jahnsen, H.2    Mosfeldt Laursen, A.3
  • 92
    • 0013981376 scopus 로고
    • Anticonvulsant therapy, folic acid and vitamin B12 metabolism and mental symptoms
    • Reynolds E.H., Chanarin I., Milner G., and Matthews D.M. Anticonvulsant therapy, folic acid and vitamin B12 metabolism and mental symptoms. Epilepsia 7 (1966) 261-270
    • (1966) Epilepsia , vol.7 , pp. 261-270
    • Reynolds, E.H.1    Chanarin, I.2    Milner, G.3    Matthews, D.M.4
  • 93
    • 0032730181 scopus 로고    scopus 로고
    • The pharmacologic basis of antiepileptic drug action
    • Rho J.M., and Sankar R. The pharmacologic basis of antiepileptic drug action. Epilepsia 40 (1999) 1471-1483
    • (1999) Epilepsia , vol.40 , pp. 1471-1483
    • Rho, J.M.1    Sankar, R.2
  • 94
    • 0028008995 scopus 로고
    • Mechanism of action of the anticonvulsant felbamate: Opposing effects on N-methyl-D-aspartate and gamma-aminobutyric acidA receptors
    • Rho J.M., Donevan S.D., and Rogawski M.A. Mechanism of action of the anticonvulsant felbamate: Opposing effects on N-methyl-D-aspartate and gamma-aminobutyric acidA receptors. Ann. Neurol. 35 (1994) 229-234
    • (1994) Ann. Neurol. , vol.35 , pp. 229-234
    • Rho, J.M.1    Donevan, S.D.2    Rogawski, M.A.3
  • 95
    • 34047237123 scopus 로고
    • Correlation of inhibition of veratrine evoked [14C] guanidine uptake with inhibition of veratrine evoked release of glutamate by lamotrigine and its analogues [abstract]
    • Abstract 6-11-17
    • Riddall D.R., Clackers M., and Leach M.J. Correlation of inhibition of veratrine evoked [14C] guanidine uptake with inhibition of veratrine evoked release of glutamate by lamotrigine and its analogues [abstract]. Can. J. Neurol. Sci. 20 Suppl. 4 (1993) S181 Abstract 6-11-17
    • (1993) Can. J. Neurol. Sci. , vol.20 , Issue.SUPPL. 4
    • Riddall, D.R.1    Clackers, M.2    Leach, M.J.3
  • 97
    • 0024593140 scopus 로고
    • Blockade of sustained repetitive action potentials in cultured spinal cord neurons by zonisamide (AD 810, CI 912), a novel anticonvulsant
    • Rock D.M., Macdonald R.L., and Taylor C.P. Blockade of sustained repetitive action potentials in cultured spinal cord neurons by zonisamide (AD 810, CI 912), a novel anticonvulsant. Epilepsy Res. 3 (1989) 138-143
    • (1989) Epilepsy Res. , vol.3 , pp. 138-143
    • Rock, D.M.1    Macdonald, R.L.2    Taylor, C.P.3
  • 98
    • 0026447816 scopus 로고
    • Comparison of the effect of the GABA uptake blockers, tiagabine and nipecotic acid, on inhibitory synaptic efficacy in hippocampal CA1 neurones
    • Roepstorff A., and Lambert J.D. Comparison of the effect of the GABA uptake blockers, tiagabine and nipecotic acid, on inhibitory synaptic efficacy in hippocampal CA1 neurones. Neurosci. Lett. 146 (1992) 131-134
    • (1992) Neurosci. Lett. , vol.146 , pp. 131-134
    • Roepstorff, A.1    Lambert, J.D.2
  • 99
    • 30144443464 scopus 로고    scopus 로고
    • Molecular targets versus models for new antiepileptic drug discovery
    • Rogawski M.A. Molecular targets versus models for new antiepileptic drug discovery. Epilepsy Res. 68 (2006) 22-28
    • (2006) Epilepsy Res. , vol.68 , pp. 22-28
    • Rogawski, M.A.1
  • 100
    • 0025050694 scopus 로고
    • Antiepileptic drugs: Pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds
    • Rogawski M.A., and Porter R.J. Antiepileptic drugs: Pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds. Pharmacol. Rev. 42 (1990) 223-286
    • (1990) Pharmacol. Rev. , vol.42 , pp. 223-286
    • Rogawski, M.A.1    Porter, R.J.2
  • 101
    • 0028181698 scopus 로고
    • Benzodiazepine and beta-carboline regulation of single GABAA receptor channels of mouse spinal neurones in culture
    • Rogers C.J., Twyman R.E., and Macdonald R.L. Benzodiazepine and beta-carboline regulation of single GABAA receptor channels of mouse spinal neurones in culture. J. Physiol. 475 (1994) 69-82
    • (1994) J. Physiol. , vol.475 , pp. 69-82
    • Rogers, C.J.1    Twyman, R.E.2    Macdonald, R.L.3
  • 102
    • 0026788484 scopus 로고
    • An assessment of serum and red blood cell folate concentrations in patients with epilepsy on lamotrigine therapy
    • Sander J.W., and Patsalos P.N. An assessment of serum and red blood cell folate concentrations in patients with epilepsy on lamotrigine therapy. Epilepsy Res. 13 (1992) 89-92
    • (1992) Epilepsy Res. , vol.13 , pp. 89-92
    • Sander, J.W.1    Patsalos, P.N.2
  • 103
    • 0023186374 scopus 로고
    • Zonisamide enhances slow sodium inactivation in Myxicola
    • Schauf C.L. Zonisamide enhances slow sodium inactivation in Myxicola. Brain Res. 413 (1987) 185-188
    • (1987) Brain Res. , vol.413 , pp. 185-188
    • Schauf, C.L.1
  • 104
    • 0002368059 scopus 로고
    • Potential antiepileptic drugs: Gabapentin
    • Levy R., Mattson R., Meldrum B., Penry J.K., and Dreifuss F.E. (Eds), Raven Press, New York
    • Schmidt B. Potential antiepileptic drugs: Gabapentin. In: Levy R., Mattson R., Meldrum B., Penry J.K., and Dreifuss F.E. (Eds). "Antiepileptic Drugs". 3rd ed. (1989), Raven Press, New York 925-935
    • (1989) "Antiepileptic Drugs". 3rd ed. , pp. 925-935
    • Schmidt, B.1
  • 105
    • 0000946466 scopus 로고
    • GP 47779, the main human metabolite of oxcarbazepine (Trileptal), and both enantiomers have equal anticonvulsant activity [abstract]
    • Schmutz M., Ferrat T., Heckendorn R., Jeker A., Portet C., and Olpe H.R. GP 47779, the main human metabolite of oxcarbazepine (Trileptal), and both enantiomers have equal anticonvulsant activity [abstract]. Epilepsia 34 Suppl. 2 (1993) 122
    • (1993) Epilepsia , vol.34 , Issue.SUPPL. 2 , pp. 122
    • Schmutz, M.1    Ferrat, T.2    Heckendorn, R.3    Jeker, A.4    Portet, C.5    Olpe, H.R.6
  • 106
    • 0024372376 scopus 로고
    • Phenytoin and carbamazepine: Potential- and frequency-dependent block of Na currents in mammalian myelinated nerve fibers
    • Schwarz J.R., and Grigat G. Phenytoin and carbamazepine: Potential- and frequency-dependent block of Na currents in mammalian myelinated nerve fibers. Epilepsia 30 (1989) 286-294
    • (1989) Epilepsia , vol.30 , pp. 286-294
    • Schwarz, J.R.1    Grigat, G.2
  • 107
    • 0002007589 scopus 로고
    • Other antiepileptic drugs. Zonisamide
    • Levy R.H., Mattson R.H., and Meldrum B.S. (Eds), Raven Press Ltd., New York
    • Seino M., Naruto S., Ito T., and Miyazaki H. Other antiepileptic drugs. Zonisamide. In: Levy R.H., Mattson R.H., and Meldrum B.S. (Eds). "Antiepileptic Drugs". 4th ed. (1995), Raven Press Ltd., New York 1011-1023
    • (1995) "Antiepileptic Drugs". 4th ed. , pp. 1011-1023
    • Seino, M.1    Naruto, S.2    Ito, T.3    Miyazaki, H.4
  • 108
    • 0002836371 scopus 로고
    • Topiramate selectively blocks kainate currents in cultured hippocampal neurons [abstract]
    • Abstract 2.16
    • Severt L., Coulter D.A., Sombati S., and DeLorenzo R.J. Topiramate selectively blocks kainate currents in cultured hippocampal neurons [abstract]. Epilepsia 36 Suppl. 4 (1995) 38 Abstract 2.16
    • (1995) Epilepsia , vol.36 , Issue.SUPPL. 4 , pp. 38
    • Severt, L.1    Coulter, D.A.2    Sombati, S.3    DeLorenzo, R.J.4
  • 110
    • 0034034180 scopus 로고    scopus 로고
    • An overview of the preclinical aspects of topiramate: Pharmacology, pharmacokinetics, and mechanism of action
    • Shank R.P., Gardocki J.F., Streeter A.J., and Maryanoff B.E. An overview of the preclinical aspects of topiramate: Pharmacology, pharmacokinetics, and mechanism of action. Epilepsia 41 Suppl. 1 (2000) S3-S9
    • (2000) Epilepsia , vol.41 , Issue.SUPPL. 1
    • Shank, R.P.1    Gardocki, J.F.2    Streeter, A.J.3    Maryanoff, B.E.4
  • 111
    • 17244370036 scopus 로고    scopus 로고
    • Direct activation of the recombinant α4β3γ2S GABAA receptor by the novel anticonvulsant topiramate
    • Simeone T.A., McClellan A.M.L., Twyman R.E., and White H.S. Direct activation of the recombinant α4β3γ2S GABAA receptor by the novel anticonvulsant topiramate. Soc. Neurosci. Abstr. 26 (2000) 631
    • (2000) Soc. Neurosci. Abstr. , vol.26 , pp. 631
    • Simeone, T.A.1    McClellan, A.M.L.2    Twyman, R.E.3    White, H.S.4
  • 112
    • 33646693680 scopus 로고    scopus 로고
    • Subunit selectivity of topiramate modulation of heteromeric GABA(A) receptors
    • Simeone T.A., Wilcox K.S., and White H.S. Subunit selectivity of topiramate modulation of heteromeric GABA(A) receptors. Neuropharmacology 50 (2006) 845-857
    • (2006) Neuropharmacology , vol.50 , pp. 845-857
    • Simeone, T.A.1    Wilcox, K.S.2    White, H.S.3
  • 113
    • 0034115767 scopus 로고    scopus 로고
    • Topiramate blocks kainate-evoked cobalt influx into cultured neurons
    • Skradski S., and White H.S. Topiramate blocks kainate-evoked cobalt influx into cultured neurons. Epilepsia 41 Suppl. 1 (2000) S45-S47
    • (2000) Epilepsia , vol.41 , Issue.SUPPL. 1
    • Skradski, S.1    White, H.S.2
  • 114
    • 0002650306 scopus 로고
    • Felbamate. Mechanisms of action
    • Levy R.H., Mattson R.H., and Meldrum B.S. (Eds), Raven Press Ltd., New York
    • Sofia R.D. Felbamate. Mechanisms of action. In: Levy R.H., Mattson R.H., and Meldrum B.S. (Eds). "Antiepileptic Drugs". 4th ed. (1995), Raven Press Ltd., New York 791-797
    • (1995) "Antiepileptic Drugs". 4th ed. , pp. 791-797
    • Sofia, R.D.1
  • 115
    • 0029082313 scopus 로고
    • Action of GP 47779, the active metabolite of oxcarbazepine, on the corticostriatal system. II. Modulation of high-voltage-activated calcium currents
    • Stefani A., Pisani A., De Murtas M., Mercuri N.B., Marciani M.G., and Calabresi P. Action of GP 47779, the active metabolite of oxcarbazepine, on the corticostriatal system. II. Modulation of high-voltage-activated calcium currents. Epilepsia 36 (1995) 997-1002
    • (1995) Epilepsia , vol.36 , pp. 997-1002
    • Stefani, A.1    Pisani, A.2    De Murtas, M.3    Mercuri, N.B.4    Marciani, M.G.5    Calabresi, P.6
  • 116
    • 0030594562 scopus 로고    scopus 로고
    • Lamotrigine inhibits Ca2+ currents in cortical neurons: Functional implications
    • Stefani A., Spadoni F., Siniscalchi A., and Bernardi G. Lamotrigine inhibits Ca2+ currents in cortical neurons: Functional implications. Eur. J. Pharmacol. 307 (1996) 113-116
    • (1996) Eur. J. Pharmacol. , vol.307 , pp. 113-116
    • Stefani, A.1    Spadoni, F.2    Siniscalchi, A.3    Bernardi, G.4
  • 117
    • 0030848858 scopus 로고    scopus 로고
    • Voltage-activated calcium channels: Targets of antiepileptic drug therapy?
    • Stefani A., Spadoni F., and Bernardi G. Voltage-activated calcium channels: Targets of antiepileptic drug therapy?. Epilepsia 38 (1997) 959-965
    • (1997) Epilepsia , vol.38 , pp. 959-965
    • Stefani, A.1    Spadoni, F.2    Bernardi, G.3
  • 118
    • 0031809165 scopus 로고    scopus 로고
    • Gabapentin inhibits calcium currents in isolated rat brain neurons
    • Stefani A., Spadoni F., and Bernardi G. Gabapentin inhibits calcium currents in isolated rat brain neurons. Neuropharmacology 37 (1998) 83-91
    • (1998) Neuropharmacology , vol.37 , pp. 83-91
    • Stefani, A.1    Spadoni, F.2    Bernardi, G.3
  • 119
    • 0033003368 scopus 로고    scopus 로고
    • The reduction in paired-pulse inhibition in the rat hippocampus by gabapentin is independent of GABA(B) receptor activation
    • Stringer J.L., and Lorenzo N. The reduction in paired-pulse inhibition in the rat hippocampus by gabapentin is independent of GABA(B) receptor activation. Epilepsy Res. 33 (1999) 169-176
    • (1999) Epilepsy Res. , vol.33 , pp. 169-176
    • Stringer, J.L.1    Lorenzo, N.2
  • 120
    • 0019638379 scopus 로고
    • Diazepam and (-)-pentobarbital: Fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neurons
    • Study R.E., and Barker J.L. Diazepam and (-)-pentobarbital: Fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neurons. Proc. Natl. Acad. Sci. USA 78 (1981) 7180-7184
    • (1981) Proc. Natl. Acad. Sci. USA , vol.78 , pp. 7180-7184
    • Study, R.E.1    Barker, J.L.2
  • 122
    • 0027916864 scopus 로고
    • Characterisation of [3H]gabapentin binding to a novel site in rat brain: Homogenate binding studies
    • Suman-Chauhan N., Webdale L., Hill D.R., and Woodruff G.N. Characterisation of [3H]gabapentin binding to a novel site in rat brain: Homogenate binding studies. Eur. J. Pharmacol. 244 (1993) 293-301
    • (1993) Eur. J. Pharmacol. , vol.244 , pp. 293-301
    • Suman-Chauhan, N.1    Webdale, L.2    Hill, D.R.3    Woodruff, G.N.4
  • 123
    • 0028999957 scopus 로고
    • A review of the preclinical pharmacology of tiagabine: A potent and selective anticonvulsant GABA uptake inhibitor
    • Suzdak P.D., and Jansen J.A. A review of the preclinical pharmacology of tiagabine: A potent and selective anticonvulsant GABA uptake inhibitor. Epilepsia 36 (1995) 612-626
    • (1995) Epilepsia , vol.36 , pp. 612-626
    • Suzdak, P.D.1    Jansen, J.A.2
  • 125
    • 0022627469 scopus 로고
    • Comparative anticonvulsant activity and neurotoxicity of felbamate and four prototype antiepileptic drugs in mice and rats
    • Swinyard E.A., Sofia R.D., and Kupferberg H.J. Comparative anticonvulsant activity and neurotoxicity of felbamate and four prototype antiepileptic drugs in mice and rats. Epilepsia 27 (1986) 27-34
    • (1986) Epilepsia , vol.27 , pp. 27-34
    • Swinyard, E.A.1    Sofia, R.D.2    Kupferberg, H.J.3
  • 128
    • 0038144920 scopus 로고    scopus 로고
    • Gabapentin: Mechanisms of action
    • Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds), Lippincott Williams & Wilkins, Philadelphia
    • Taylor C.P. Gabapentin: Mechanisms of action. In: Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds). "Antiepileptic Drugs". 5th ed. (2002), Lippincott Williams & Wilkins, Philadelphia 321-334
    • (2002) "Antiepileptic Drugs". 5th ed. , pp. 321-334
    • Taylor, C.P.1
  • 130
    • 0026771403 scopus 로고
    • Effects of the GABA uptake inhibitor tiagabine on inhibitory synaptic potentials in rat hippocampal slice cultures
    • Thompson S.M., and Gahwiler B.H. Effects of the GABA uptake inhibitor tiagabine on inhibitory synaptic potentials in rat hippocampal slice cultures. J. Neurophysiol. 67 (1992) 1698-1701
    • (1992) J. Neurophysiol. , vol.67 , pp. 1698-1701
    • Thompson, S.M.1    Gahwiler, B.H.2
  • 131
    • 0027332638 scopus 로고
    • [3H]gabapentin may label a system-L-like neutral amino acid carrier in brain
    • Thurlow R.J., Brown J.P., Gee N.S., Hill D.R., and Woodruff G.N. [3H]gabapentin may label a system-L-like neutral amino acid carrier in brain. Eur. J. Pharmacol. 247 (1993) 341-345
    • (1993) Eur. J. Pharmacol. , vol.247 , pp. 341-345
    • Thurlow, R.J.1    Brown, J.P.2    Gee, N.S.3    Hill, D.R.4    Woodruff, G.N.5
  • 132
    • 0025913690 scopus 로고
    • Effect of anticonvulsant felbamate on GABAA receptor system
    • Ticku M.K., Kamatchi G.L., and Sofia R.D. Effect of anticonvulsant felbamate on GABAA receptor system. Epilepsia 32 (1991) 389-391
    • (1991) Epilepsia , vol.32 , pp. 389-391
    • Ticku, M.K.1    Kamatchi, G.L.2    Sofia, R.D.3
  • 133
    • 0026739945 scopus 로고
    • Modulatory role of GABA receptor subtypes and glutamate receptors in the anticonvulsant effect of barbiturates
    • Ticku M.K., Kulkarni S.K., and Mehta A.K. Modulatory role of GABA receptor subtypes and glutamate receptors in the anticonvulsant effect of barbiturates. Epilepsy Res. Suppl. 8 (1992) 57-62
    • (1992) Epilepsy Res. Suppl. , vol.8 , pp. 57-62
    • Ticku, M.K.1    Kulkarni, S.K.2    Mehta, A.K.3
  • 134
    • 0024522273 scopus 로고
    • Sodium channels from human brain RNA expressed in Xenopus oocytes. Basic electrophysiologic characteristics and their modification by diphenylhydantoin
    • Tomaselli G.F., Marban E., and Yellen G. Sodium channels from human brain RNA expressed in Xenopus oocytes. Basic electrophysiologic characteristics and their modification by diphenylhydantoin. J. Clin. Invest. 83 (1989) 1724-1732
    • (1989) J. Clin. Invest. , vol.83 , pp. 1724-1732
    • Tomaselli, G.F.1    Marban, E.2    Yellen, G.3
  • 135
    • 0024549518 scopus 로고
    • Differential regulation of gamma-aminobutyric acid receptor channels by diazepam and phenobarbital
    • Twyman R.E., Rogers C.J., and Macdonald R.L. Differential regulation of gamma-aminobutyric acid receptor channels by diazepam and phenobarbital. Ann. Neurol. 25 (1989) 213-220
    • (1989) Ann. Neurol. , vol.25 , pp. 213-220
    • Twyman, R.E.1    Rogers, C.J.2    Macdonald, R.L.3
  • 136
    • 0027223365 scopus 로고
    • Valproate and sodium currents in cultured hippocampal neurons
    • Van den Berg R.J., Kok P., and Voskuyl R.A. Valproate and sodium currents in cultured hippocampal neurons. Exp. Brain Res. 93 (1993) 279-287
    • (1993) Exp. Brain Res. , vol.93 , pp. 279-287
    • Van den Berg, R.J.1    Kok, P.2    Voskuyl, R.A.3
  • 137
    • 0022530225 scopus 로고
    • Valproate reduces excitability by blockage of sodium and potassium conductance
    • VanDongen A.M., VanErp M.G., and Voskuyl R.A. Valproate reduces excitability by blockage of sodium and potassium conductance. Epilepsia 27 (1986) 177-182
    • (1986) Epilepsia , vol.27 , pp. 177-182
    • VanDongen, A.M.1    VanErp, M.G.2    Voskuyl, R.A.3
  • 139
    • 0023600780 scopus 로고
    • - channels recorded from membrane patches of neonatal rat cortical neurons in culture
    • - channels recorded from membrane patches of neonatal rat cortical neurons in culture. J. Pharmacol. Exp. Ther. 243 (1987) 1195-1201
    • (1987) J. Pharmacol. Exp. Ther. , vol.243 , pp. 1195-1201
    • Vicini, S.1    Mienville, J.M.2    Costa, E.3
  • 140
    • 0024368757 scopus 로고
    • Effects of chlordiazepoxide, chlorpromazine, diazepam, diphenylhydantoin, flunitrazepam and haloperidol on the voltage-dependent sodium current of isolated mammalian brain neurons
    • Wakamori M., Kaneda M., Oyama Y., and Akaike N. Effects of chlordiazepoxide, chlorpromazine, diazepam, diphenylhydantoin, flunitrazepam and haloperidol on the voltage-dependent sodium current of isolated mammalian brain neurons. Brain Res. 494 (1989) 374-378
    • (1989) Brain Res. , vol.494 , pp. 374-378
    • Wakamori, M.1    Kaneda, M.2    Oyama, Y.3    Akaike, N.4
  • 141
    • 0027200131 scopus 로고
    • Glycine reversal of felbamate hypoxic protection
    • Wallis R.A., and Panizzon K.L. Glycine reversal of felbamate hypoxic protection. Neuroreport 4 (1993) 951-954
    • (1993) Neuroreport , vol.4 , pp. 951-954
    • Wallis, R.A.1    Panizzon, K.L.2
  • 142
    • 0029591971 scopus 로고
    • Felbamate neuroprotection against CA1 traumatic neuronal injury
    • Wallis R.A., and Panizzon K.L. Felbamate neuroprotection against CA1 traumatic neuronal injury. Eur. J. Pharmacol. 294 (1995) 475-482
    • (1995) Eur. J. Pharmacol. , vol.294 , pp. 475-482
    • Wallis, R.A.1    Panizzon, K.L.2
  • 143
    • 0001812259 scopus 로고
    • Oxcarbazepine and its monohydroxy metabolite limit action potential firing by mouse central neurons in cell culture [abstract]
    • Wamil A.W. Oxcarbazepine and its monohydroxy metabolite limit action potential firing by mouse central neurons in cell culture [abstract]. Epilepsia 32 Suppl. 3 (1991) 65
    • (1991) Epilepsia , vol.32 , Issue.SUPPL. 3 , pp. 65
    • Wamil, A.W.1
  • 144
    • 0027977004 scopus 로고
    • Limitation by gabapentin of high frequency action potential firing by mouse central neurons in cell culture
    • Wamil A.W., and McLean M.J. Limitation by gabapentin of high frequency action potential firing by mouse central neurons in cell culture. Epilepsy Res. 17 (1994) 1-11
    • (1994) Epilepsy Res. , vol.17 , pp. 1-11
    • Wamil, A.W.1    McLean, M.J.2
  • 145
    • 0028171975 scopus 로고
    • Interaction of felbamate with [3H]DCKA-labeled strychnine-insensitive glycine receptors in human postmortem brain
    • Wamsley J.K., Sofia R.D., Faull R.L., Narang N., Ary T., and McCabe R.T. Interaction of felbamate with [3H]DCKA-labeled strychnine-insensitive glycine receptors in human postmortem brain. Exp. Neurol. 129 (1994) 244-250
    • (1994) Exp. Neurol. , vol.129 , pp. 244-250
    • Wamsley, J.K.1    Sofia, R.D.2    Faull, R.L.3    Narang, N.4    Ary, T.5    McCabe, R.T.6
  • 146
    • 0027723017 scopus 로고
    • Gabapentin anticonvulsant action in rats: Disequilibrium with peak drug concentrations in plasma and brain microdialysate
    • Welty D.F., Schielke G.P., Vartanian M.G., and Taylor C.P. Gabapentin anticonvulsant action in rats: Disequilibrium with peak drug concentrations in plasma and brain microdialysate. Epilepsy Res. 16 (1993) 175-181
    • (1993) Epilepsy Res. , vol.16 , pp. 175-181
    • Welty, D.F.1    Schielke, G.P.2    Vartanian, M.G.3    Taylor, C.P.4
  • 147
    • 0002017661 scopus 로고    scopus 로고
    • Mechanisms of antiepileptic drugs
    • Porter R., and Chadwick D. (Eds), Butterworth-Heinemann, Boston
    • White H.S. Mechanisms of antiepileptic drugs. In: Porter R., and Chadwick D. (Eds). "Epilepsies II" (1997), Butterworth-Heinemann, Boston 1-30
    • (1997) "Epilepsies II" , pp. 1-30
    • White, H.S.1
  • 148
    • 0032848061 scopus 로고    scopus 로고
    • Comparative anticonvulsant and mechanistic profile of the established and newer antiepileptic drugs
    • White H.S. Comparative anticonvulsant and mechanistic profile of the established and newer antiepileptic drugs. Epilepsia 40 Suppl. 5 (1999) S2-S10
    • (1999) Epilepsia , vol.40 , Issue.SUPPL. 5
    • White, H.S.1
  • 149
    • 0041451398 scopus 로고    scopus 로고
    • Topiramate: Mechanisms of action
    • Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds), Lippincott Williams & Wilkins, Philadelphia
    • White H.S. Topiramate: Mechanisms of action. In: Levy R.H., Mattson R.H., Meldrum B.S., and Perucca E. (Eds). "Antiepileptic Drugs". 5th ed. (2002), Lippincott Williams & Wilkins, Philadelphia 719-726
    • (2002) "Antiepileptic Drugs". 5th ed. , pp. 719-726
    • White, H.S.1
  • 150
    • 0026742204 scopus 로고
    • A neuropharmacological evaluation of felbamate as a novel anticonvulsant
    • White H.S., Wolf H.H., Swinyard E.A., Skeen G.A., and Sofia R.D. A neuropharmacological evaluation of felbamate as a novel anticonvulsant. Epilepsia 33 (1992) 564-572
    • (1992) Epilepsia , vol.33 , pp. 564-572
    • White, H.S.1    Wolf, H.H.2    Swinyard, E.A.3    Skeen, G.A.4    Sofia, R.D.5
  • 151
    • 0002394897 scopus 로고
    • The anticonvulsant topiramate displays a unique ability to potentiate GABA-evoked chloride currents
    • White H.S., Brown D., Skeen G.A., Wolf H.H., and Twyman R.E. The anticonvulsant topiramate displays a unique ability to potentiate GABA-evoked chloride currents. Epilepsia 36 Suppl. 3 (1995) S39-S40
    • (1995) Epilepsia , vol.36 , Issue.SUPPL. 3
    • White, H.S.1    Brown, D.2    Skeen, G.A.3    Wolf, H.H.4    Twyman, R.E.5
  • 152
    • 0028796695 scopus 로고
    • Felbamate modulates the strychnine-insensitive glycine receptor
    • White H.S., Harmsworth W.L., Sofia R.D., and Wolf H.H. Felbamate modulates the strychnine-insensitive glycine receptor. Epilepsy Res. 20 (1995) 41-48
    • (1995) Epilepsy Res. , vol.20 , pp. 41-48
    • White, H.S.1    Harmsworth, W.L.2    Sofia, R.D.3    Wolf, H.H.4
  • 153
    • 0002021428 scopus 로고
    • General principles: Experimental selection, quantification, and evaluation of antiepileptic drugs
    • Levy R.H., Mattson R.H., and Meldrum B.S. (Eds), Raven Press, New York
    • White H.S., Woodhead J.H., Franklin M.R., Swinyard E.A., and Wolf H.H. General principles: Experimental selection, quantification, and evaluation of antiepileptic drugs. In: Levy R.H., Mattson R.H., and Meldrum B.S. (Eds). "Antiepileptic Drugs". 4th ed. (1995), Raven Press, New York 99-110
    • (1995) "Antiepileptic Drugs". 4th ed. , pp. 99-110
    • White, H.S.1    Woodhead, J.H.2    Franklin, M.R.3    Swinyard, E.A.4    Wolf, H.H.5
  • 154
    • 0030758984 scopus 로고    scopus 로고
    • Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold
    • White H.S., Brown S.D., Woodhead J.H., Skeen G.A., and Wolf H.H. Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold. Epilepsy Res. 28 (1997) 167-179
    • (1997) Epilepsy Res. , vol.28 , pp. 167-179
    • White, H.S.1    Brown, S.D.2    Woodhead, J.H.3    Skeen, G.A.4    Wolf, H.H.5
  • 155
    • 0020334077 scopus 로고
    • Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine
    • Willow M., and Catterall W.A. Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Mol. Pharmacol. 22 (1982) 627-635
    • (1982) Mol. Pharmacol. , vol.22 , pp. 627-635
    • Willow, M.1    Catterall, W.A.2
  • 156
    • 0021347623 scopus 로고
    • Inhibition of voltage-sensitive sodium channels in neuroblastoma cells and synaptosomes by the anticonvulsant drugs diphenylhydantoin and carbamazepine
    • Willow M., Kuenzel E.A., and Catterall W.A. Inhibition of voltage-sensitive sodium channels in neuroblastoma cells and synaptosomes by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Mol. Pharmacol. 25 (1984) 228-234
    • (1984) Mol. Pharmacol. , vol.25 , pp. 228-234
    • Willow, M.1    Kuenzel, E.A.2    Catterall, W.A.3
  • 157
    • 0021913947 scopus 로고
    • Voltage clamp analysis of the inhibitory actions of diphenylhydantoin and carbamazepine on voltage-sensitive sodium channels in neuroblastoma cells
    • Willow M., Gonoi T., and Catterall W.A. Voltage clamp analysis of the inhibitory actions of diphenylhydantoin and carbamazepine on voltage-sensitive sodium channels in neuroblastoma cells. Mol. Pharmacol. 27 (1985) 549-558
    • (1985) Mol. Pharmacol. , vol.27 , pp. 549-558
    • Willow, M.1    Gonoi, T.2    Catterall, W.A.3
  • 158
    • 0028858375 scopus 로고
    • The sensitivity of AMPA-selective glutamate receptor channels to pentobarbital is determined by a single amino acid residue of the alpha 2 subunit
    • Yamakura T., Sakimura K., Mishina M., and Shimoji K. The sensitivity of AMPA-selective glutamate receptor channels to pentobarbital is determined by a single amino acid residue of the alpha 2 subunit. FEBS Lett. 374 (1995) 412-414
    • (1995) FEBS Lett. , vol.374 , pp. 412-414
    • Yamakura, T.1    Sakimura, K.2    Mishina, M.3    Shimoji, K.4
  • 159
    • 0345583240 scopus 로고    scopus 로고
    • Topiramate reduces high-voltage activated Ca2+ currents in CA1 pyramidal neurons in vitro [abstract]
    • Zhang X., Velumian A.A., Jones O.T., and Carlen P.L. Topiramate reduces high-voltage activated Ca2+ currents in CA1 pyramidal neurons in vitro [abstract]. Epilepsia 39 Suppl. 6 (1998) 44
    • (1998) Epilepsia , vol.39 , Issue.SUPPL. 6 , pp. 44
    • Zhang, X.1    Velumian, A.A.2    Jones, O.T.3    Carlen, P.L.4
  • 160
    • 0034076789 scopus 로고    scopus 로고
    • Modulation of high-voltage-activated calcium channels in dentate granule cells by topiramate
    • Zhang X., Velumian A.A., Jones O.T., and Carlen P.L. Modulation of high-voltage-activated calcium channels in dentate granule cells by topiramate. Epilepsia 41 Suppl. 1 (2000) S52-S60
    • (2000) Epilepsia , vol.41 , Issue.SUPPL. 1
    • Zhang, X.1    Velumian, A.A.2    Jones, O.T.3    Carlen, P.L.4
  • 161
    • 0025348895 scopus 로고
    • Effects induced by the antiepileptic drug valproic acid upon the ionic currents recorded in rat neocortical neurons in cell culture
    • Zona C., and Avoli M. Effects induced by the antiepileptic drug valproic acid upon the ionic currents recorded in rat neocortical neurons in cell culture. Exp. Brain Res. 81 (1990) 313-317
    • (1990) Exp. Brain Res. , vol.81 , pp. 313-317
    • Zona, C.1    Avoli, M.2
  • 162
    • 0030867764 scopus 로고    scopus 로고
    • Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells
    • Zona C., Ciotti M.T., and Avoli M. Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells. Neurosci. Lett. 231 (1997) 123-126
    • (1997) Neurosci. Lett. , vol.231 , pp. 123-126
    • Zona, C.1    Ciotti, M.T.2    Avoli, M.3


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