Acute administration of docosahexaenoic acid increases resistance to pentylenetetrazol-induced seizures in rats

Epilepsy and Behavior

Volumn 17, Issue 3, 2010, Pages 336-343

  Taha, Ameer Y ^a   Jeffrey, Melanie A ^a   Taha, Nadeen M Y ^a   Bala, Saimir ^a   Burnham, W M ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Anticonvulsant; Docosahexaenoic acid; Epilepsy; n 3 polyunsaturated fatty acids; Omega 3 polyunsaturated fatty acids; Pentylenetetrazol; Seizures

Indexed keywords

DOCOSAHEXAENOIC ACID; FATTY ACID; LIPID; OLEIC ACID; PENTETRAZOLE; PHOSPHOLIPID; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; LATENT PERIOD; LIPID BLOOD LEVEL; MALE; NONHUMAN; RAT; SEDATION; SEIZURE; TOXICITY TESTING;

ANALYSIS OF VARIANCE; ANIMALS; ANTICONVULSANTS; DISEASE MODELS, ANIMAL; DOCOSAHEXAENOIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACIDS; INJECTIONS, SUBCUTANEOUS; LIPIDS; MALE; OLEIC ACID; PENTYLENETETRAZOLE; PHOSPHOLIPIDS; RATS; RATS, WISTAR; REACTION TIME; SEIZURES; SEVERITY OF ILLNESS INDEX; TIME FACTORS;

EID: 77649314172     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2010.01.001     Document Type: Article

References (52)

1. Burnham W.M. Antiseizure drugs. In: Kalant H., Grant D.M., and Mitchell J. (Eds). Principles of medical pharmacology (2007), Saunders Elsevier, Toronto 223-235
2. Abdelmalik P.A., Burnham W.M., and Carlen P.L. Increased seizure susceptibility of the hippocampus compared with the neocortex of the immature mouse brain in vitro. Epilepsia 46 (2005) 356-366
3. Ng M.S., Hwang P., and Burnham W.M. Afterdischarge threshold reduction in the kindling model of epilepsy. Epilepsy Res 72 (2006) 97-101
4. Shorvon S.D. The epidemiology and treatment of chronic and refractory epilepsy. Epilepsia 37 Suppl. 2 (1996) S1-S3
5. Prasad A.N., Stafstrom C.F., and Holmes G.L. Alternative epilepsy therapies: the ketogenic diet, immunoglobulins, and steroids. Epilepsia 37 Suppl. 1 (1996) S81-S95
6. Swink T.D., Vining E.P., and Freeman J.M. The ketogenic diet: 1997. Adv Pediatr 44 (1997) 297-329
7. Vining E.P. Clinical efficacy of the ketogenic diet. Epilepsy Res 37 (1999) 181-190
8. Yehuda S., Carasso R.L., and Mostofsky D.I. Essential fatty acid preparation (SR-3) raises the seizure threshold in rats. Eur J Pharmacol 254 (1994) 193-198
9. Yehuda S., Brandys Y., Blumenfeld A., and Mostofsky D.I. Essential fatty acid preparation reduces cholesterol and fatty acids in rat cortex. Int J Neurosci 86 (1996) 249-256
10. Sprecher H. Metabolism of highly unsaturated n-3 and n-6 fatty acids. Biochim Biophys Acta 1486 (2000) 219-231
11. Taha A.Y., Baghiu B.M., Lui R., Nylen K., Ma D.W., and Burnham W.M. Lack of benefit of linoleic and alpha-linolenic polyunsaturated fatty acids on seizure latency, duration, severity or incidence in rats. Epilepsy Res 71 (2006) 40-46
12. Taha A.Y., Filo E., Ma D.W., and McIntyre Burnham W. Dose-dependent anticonvulsant effects of linoleic and alpha-linolenic polyunsaturated fatty acids on pentylenetetrazol induced seizures in rats. Epilepsia 50 (2009) 72-82
13. Porta N., Bourgois B., Galabert C., et al. Anticonvulsant effects of linolenic acid are unrelated to brain phospholipid cell membrane compositions. Epilepsia 50 (2009) 65-71
14. Gilby K.L., Jans J., and McIntyre D.C. Chronic omega-3 supplementation in seizure-prone versus seizure-resistant rat strains: a cautionary tale. Neuroscience 163 (2009) 750-758
15. Willis S., Samala R., Rosenberger T.A., and Borges K. Eicosapentaenoic and docosahexaenoic acids are not anticonvulsant or neuroprotective in acute mouse seizure models. Epilepsia 50 (2009) 138-142
16. Voskuyl R.A., Vreugdenhil M., Kang J.X., and Leaf A. Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model. Eur J Pharmacol 341 (1998) 145-152
17. Schlanger S., Shinitzky M., and Yam D. Diet enriched with omega-3 fatty acids alleviates convulsion symptoms in epilepsy patients. Epilepsia 43 (2002) 103-104
18. Bromfield E., Dworetzky B., Hurwitz S., et al. A randomized trial of polyunsaturated fatty acids for refractory epilepsy. Epilepsy Behav 12 (2008) 187-190
19. DeGiorgio C.M., Miller P., Meymandi S., and Gornbein J.A. n-3 fatty acids (fish oil) for epilepsy, cardiac risk factors, and risk of SUDEP: clues from a pilot, double-blind, exploratory study. Epilepsy Behav 13 (2008) 681-684
20. Yuen A.W., Sander J.W., Fluegel D., et al. Omega-3 fatty acid supplementation in patients with chronic epilepsy: a randomized trial. Epilepsy Behav 7 (2005) 253-258
21. Taha A.Y., Ciobanu F.A., Saxena A., and McIntyre Burnham W. Assessing the link between omega-3 fatty acids, cardiac arrest, and sudden unexpected death in epilepsy. Epilepsy Behav 14 (2009) 27-31
22. Fisher R.S. Animal models of the epilepsies. Brain Res Brain Res Rev 14 (1989) 245-278
23. Krall R.L., Penry J.K., White B.G., Kupferberg H.J., and Swinyard E.A. Antiepileptic drug development. II. Anticonvulsant drug screening. Epilepsia 19 (1978) 409-428
24. Loscher W., Honack D., and Hashem A. Anticonvulsant efficacy of clonazepam and the beta-carboline ZK 93423 during chronic treatment in amygdala-kindled rats. Eur J Pharmacol 143 (1987) 403-414
25. Okada K., Sugihara H., Minami S., and Wakabayashi I. Effect of parenteral administration of selected nutrients and central injection of gamma-globulin from antiserum to neuropeptide Y on growth hormone secretory pattern in food-deprived rats. Neuroendocrinology 57 (1993) 678-686
26. Morris M.J., Gannan E., Stroud L.M., Beck-Sickinger A.G., and O'Brien T.J. Neuropeptide Y suppresses absence seizures in a genetic rat model primarily through effects on Y receptors. Eur J Neurosci 25 (2007) 1136-1143
27. Noe F., Pool A.H., Nissinen J., et al. Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy. Brain 131 (2008) 1506-1515
28. Obay B.D., Tasdemir E., Tumer C., Bilgin H.M., and Sermet A. Antiepileptic effects of ghrelin on pentylenetetrazole-induced seizures in rats. Peptides 28 (2007) 1214-1219
29. Woldbye D.P. Antiepileptic effects of NPY on pentylenetetrazole seizures. Regul Pept 75 /76 (1998) 279-282
30. Bazan Jr. N.G. Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain. Biochim Biophys Acta 218 (1970) 1-10
31. Bazan Jr. N.G. Changes in free fatty acids of brain by drug-induced convulsions, electroshock and anaesthesia. J Neurochem 18 (1971) 1379-1385
32. Rodriguez de Turco E.B., and Bazan N.G. Changes in free fatty acids and diglycerides in mouse brain at birth and during anoxia. J Neurochem 41 (1983) 794-800
33. Young C., Gean P.W., Chiou L.C., and Shen Y.Z. Docosahexaenoic acid inhibits synaptic transmission and epileptiform activity in the rat hippocampus. Synapse 37 (2000) 90-94
34. Lauritzen I., Blondeau N., Heurteaux C., Widmann C., Romey G., and Lazdunski M. Polyunsaturated fatty acids are potent neuroprotectors. EMBO J 19 (2000) 1784-1793
35. Xiao Y., and Li X. Polyunsaturated fatty acids modify mouse hippocampal neuronal excitability during excitotoxic or convulsant stimulation. Brain Res 846 (1999) 112-121
36. Vreugdenhil M., Bruehl C., Voskuyl R.A., Kang J.X., Leaf A., and Wadman W.J. Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons. Proc Natl Acad Sci USA 93 (1996) 12559-12563
37. Bazan N.G. Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection. Curr Opin Clin Nutr Metab Care 10 (2007) 136-141
38. Akarsu E.S., Ozdayi S., Algan E., and Ulupinar F. The neuronal excitability time-dependently changes after lipopolysaccharide administration in mice: possible role of cyclooxygenase-2 induction. Epilepsy Res 71 (2006) 181-187
39. Auvin S., Porta N., Nehlig A., Lecointe C., Vallee L., and Bordet R. Inflammation in rat pups subjected to short hyperthermic seizures enhances brain long-term excitability. Epilepsy Res 86 (2009) 124-130
40. Tandon M., Anuradha K., and Pandhi P. Evaluation of antiepileptic activity of aspirin in combination with newer antiepileptic lamotrigine in mice. Methods Find Exp Clin Pharmacol 25 (2003) 607-610
41. Tu B., and Bazan N.G. Hippocampal kindling epileptogenesis upregulates neuronal cyclooxygenase-2 expression in neocortex. Exp Neurol 179 (2003) 167-175
42. Dhir A., Naidu P.S., and Kulkarni S.K. Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: possible mechanism of action. Prog Neuropsychopharmacol Biol Psychiatry 30 (2006) 1478-1485
43. Oliveira M.S., Furian A.F., Royes L.F., et al. Cyclooxygenase-2/PGE2 pathway facilitates pentylenetetrazol-induced seizures. Epilepsy Res 79 (2008) 14-21
44. 3H-oleic acid tracers. J Mol Neurosci 33 (2007) 56-66
45. Robinson P.J., Noronha J., DeGeorge J.J., Freed L.M., Nariai T., and Rapoport S.I. A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: review and critical analysis. Brain Res Brain Res Rev 17 (1992) 187-214
46. Albright P.S. Effects of carbamazepine, clonazepam, and phenytoin on seizure threshold in amygdala and cortex. Exp Neurol 79 (1983) 11-17
47. Polozova A., Gionfriddo E., and Salem Jr. N. Effect of docosahexaenoic acid on tissue targeting and metabolism of plasma lipoproteins. Prostaglandins Leukot Essent Fatty Acids 75 (2006) 183-190
48. Chen C.T., Green J.T., Orr S.K., and Bazinet R.P. Regulation of brain polyunsaturated fatty acid uptake and turnover. Prostaglandins Leukot Essent Fatty Acids 79 (2008) 85-91
49. Ouellet M., Emond V., Chen C.T., et al. Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: an in situ cerebral perfusion study. Neurochem Int 55 (2009) 476-482
50. Chen C.T., Ma D.W., Kim J.H., Mount H.T., and Bazinet R.P. The low density lipoprotein receptor is not necessary for maintaining mouse brain polyunsaturated fatty acid concentrations. J Lipid Res 49 (2008) 147-152
51. Taha A.Y., Ryan M.A., and Cunnane S.C. Despite transient ketosis, the classic high-fat ketogenic diet induces marked changes in fatty acid metabolism in rats. Metabolism 54 (2005) 1127-1132
52. Cunnane S.C., Musa K., Ryan M.A., Whiting S., and Fraser D.D. Potential role of polyunsaturates in seizure protection achieved with the ketogenic diet. Prostaglandins Leukot Essent Fatty Acids 67 (2002) 131-135