BK channel activity determines the extent of cell degeneration after oxygen and glucose deprivation: A study in organotypical hippocampal slice cultures

Neuroscience

Volumn 112, Issue 2, 2002, Pages 277-288

  Runden Pran E ^a   Haug, F M ^a   Storm, J F ^a   Ottersen, O P ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

Iberiotoxin; Ischemia; Neuroprotection; NS1619; Paxilline; Propidium iodide

Indexed keywords

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; CALCIUM; FLUORESCENT DYE; GLUCOSE; GLUTAMIC ACID; IBERIOTOXIN; OXYGEN; PAXILLINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL STIMULATING AGENT; PROPIDIUM IODIDE;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN SLICE; CONTROLLED STUDY; DENTATE GYRUS; DRUG EFFECT; ELECTROPHYSIOLOGY; GRANULE CELL; HIPPOCAMPUS; MALE; NERVE CELL DEGENERATION; NERVE CELL EXCITABILITY; NERVE CELL LESION; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NEUROTRANSMITTER RELEASE; NONHUMAN; PRESYNAPTIC POTENTIAL; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; REGULATORY MECHANISM; REPOLARIZATION; STROKE;

ANIMALS; BENZIMIDAZOLES; CELL DEATH; CELL HYPOXIA; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENT DYES; GLUCOSE; HIPPOCAMPUS; HYPOXIA, BRAIN; INDOLES; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MALE; NEUROGLIA; NEURONS; PEPTIDES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; RATS; RATS, WISTAR;

EID: 0037129943     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(02)00092-1     Document Type: Article

References (49)

1. Intracellular Ca2+ activates a fast voltage-sensitive K+ current in vertebrate sympathetic neurones
2. HKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family
3. Identification of two toxins from scorpion (Leiurus quinquestriatus) venom which block distinct classes of calcium-activated potassium channel
4. Potassium channel openers and vascular smooth muscle relaxation
5. Regulation of the cerebral circulation: Role of endothelium and potassium channels
6. Interaction of anthelmintic benzimidazoles and benzimidazole derivatives with bovine brain tubulin
7. Potassium channel opener reduces extracellular glutamate concentration in rat focal cerebral ischemia
8. Organotypic cultures of neural tissue
9. Differential changes of synaptic transmission in spiny neurons of rat neostriatum following transient forebrain ischemia
10. Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus
11. Changes in membrane properties of CA1 pyramidal neurons after transient forebrain ischemia in vivo
12. Use of toxins to study potassium channels
13. Regulation of neuronal birth, migration and death in the rat dentate gyrus
14. Effects of channel modulators on cloned large-conductance calcium-activated potassium channels
15. The pharmacology and molecular biology of large-conductance calcium-activated (BK) potassium channels
16. Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels
17. Effects of the BKCa channel activator, NS1619, on rat cerebral artery smooth muscle
18. Presynaptic Ca2+-activated K+ channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter release
19. Differential BK channels contribute to action potential repolarization in granule cells of the rat dentate gyrus
20. Role of potassium channels in cerebral blood vessels
21. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels
22. Distribution of high-conductance Ca(2+)-activated K+ channels in rat brain: Targeting to axons and nerve terminals
23. A simple in vitro model of ischemia based on hippocampal slice cultures and propidium iodide fluorescence
24. Varieties of calcium-activated potassium channels
25. Is there a therapeutic future for 'potassium channel openers'?, [editorial]
26. Potassium channel activation: A potential therapeutic approach?
27. The physiological role of calcium-dependent channels
28. A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin
29. Markers for neuronal degeneration in organotypic slice cultures
30. Selective activation of Ca(2+)-dependent K+ channels by novel benzimidazolone
31. A family of calcium-dependent potassium channels from rat brain
32. Presynaptic calcium signals and transmitter release are modulated by calcium-activated potassium channels
33. Glutamate release in severe brain ischaemia is mainly by reversed uptake
34. Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: Evidence for a MAP kinase-dependent mechanism
35. Binding of [3H]benzimidazole carbamates to mammalian brain tubulin and the mechanism of selective toxicity of the benzimidazole anthelmintics
36. Ca(2+)-activated K+ currents in neurones: Types, physiological roles and modulation
37. Calcium-activated potassium currents in mammalian neurons
38. Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel
39. In vitro effects of tremorgenic mycotoxins
40. The role of BK-type Ca2+-dependent K+ channels in spike broadening during repetitive firing in rat hippocampal pyramidal cells
41. Iberiotoxin (IbTX) and charybdotoxin (ChTX) slows the somatic spike repolarization but fails to enhance excitatory synaptic transmission in hippocampal pyramidal cells
42. Inhibition of guinea pig detrusor contraction by NS-1619 is associated with activation of BKCa and inhibition of calcium currents
43. Action potential repolarization and a fast after-hyperpolarization in rat hippocampal pyramidal cells
44. Potassium currents in hippocampal pyramidal cells
45. Calcium-activated potassium channels
46. High-conductance calcium-activated potassium channels in rat brain: Pharmacology, distribution, and subunit composition
47. Effects of benzimidazole analogs on cultures of differentiating rodent embryonic cells
48. BK channel activation by NS-1619 is partially mediated by intracellular Ca2+ release in smooth muscle cells of porcine coronary artery