Presynaptic Ca2+-activated K+channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter release

Journal of Neuroscience

Volumn 21, Issue 24, 2001, Pages 9585-9597

  Hu, H ^a   Shao, Li Rong ^a   Chavoshy, Sorush ^a   Gu, Ning ^a   Trieb, Maria ^b   Behrens, Ralf ^c   Laake, Petter ^a   Pongs, Olaf ^c   Knaus, Hans Günther ^b   Ottersen, Ole Petter ^a   Storm, Johan F ^a,d  

^a UNIVERSITY OF OSLO   (Norway)

^b Institute of Biochemical Pharmacology   (Austria)

^c UNIVERSITY OF HAMBURG   (Germany)

^d Institute of Physiology   (Norway)

Author keywords

Action potential repolarization; BK channels; BK 4; CA1; CA3; Calcium activated potassium channels; Glutamatergic synapses; Hippocampus; Immunogold cytochemistry; KCNMB4; Maxi K; Presynaptic mechanisms; Slo

Indexed keywords

POTASSIUM CHANNEL; 4 AMINOPYRIDINE; AMINO ACID RECEPTOR BLOCKING AGENT; GLUTAMIC ACID; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROTRANSMITTER; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNELS, CALCIUM ACTIVATED; RECEPTORS, N METHYL D ASPARTATE;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELLULAR DISTRIBUTION; HIPPOCAMPUS; MALE; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT; REPOLARIZATION; ANIMAL; CALCIUM ACTIVATED POTASSIUM CHANNEL; DRUG EFFECT; ELECTROSTIMULATION; EXCITATORY POSTSYNAPTIC POTENTIAL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; METABOLISM; METHODOLOGY; PATCH CLAMP; PHYSIOLOGY; POTASSIUM CHANNEL; PYRAMIDAL NERVE CELL; RAT STRAIN; SYNAPTIC TRANSMISSION; SYNAPTOSOME; ULTRASTRUCTURE;

4-AMINOPYRIDINE; ACTION POTENTIALS; ANIMAL; ELECTRIC STIMULATION; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; GLUTAMIC ACID; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IN VITRO; MALE; NEUROTRANSMITTERS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; PRESYNAPTIC TERMINALS; PYRAMIDAL CELLS; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; SUPPORT, NON-U.S. GOV'T; SYNAPTIC TRANSMISSION;

EID: 0035892242     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-24-09585.2001     Document Type: Article

References (72)

1. Intracellular Ca2+ activates a fast voltage-sensitive K+ current in vertebrate sympathetic neurones
2. Functional characteristics of unmyelinated fibers in the hippocampal cortex
3. hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family
4. Three potassium channels in rat posterior pituitary nerve terminals
5. Presynaptic calcium-activated potassium channels and calcium channels at a crayfish neuromuscular junction
6. Intraterminal recordings from the rat neurohypophysis in vitro
7. Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4
8. Presynaptic localization of Kv1.4-containing A-type potassium channels near excitatory synapses in the hippocampus
9. Ionic basis of membrane potential changes induced by anoxia in rat dorsal vagal motoneurones
10. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome
11. + channels
12. Electrophysiological characteristics of hippocampal complex-spike cells and theta cells
13. Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K(+) channels in hippocampal mossy fiber boutons
14. Analysis of repolarization of presynaptic motor terminals in Drosophila larvae using potassium-channel-blocking drugs and mutations
15. The pharmacology and molecular biology of large-conductance calcium-activated (BK) potassium channels
16. Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels
17. Mobilization of calcium from intracellular stores, potentiation of neurotransmitter-induced calcium transients, and capacitative calcium entry by 4-aminopyridine
18. 4-Aminopyridine and fiber potentials in rat and human hippocampal slices
19. Anoxia increases potassium conductance in hippocampal nerve cells
20. K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons
21. Regulation of back-propagating action potentials in hippocampal neurons
22. Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits
23. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels
24. + channels in rat brain: Targeting to axons and nerve terminals
25. Coupling of neuronal metabolism and electrical activity
26. Hippocampal long-term potentiation is not accompanied by presynaptic spike broadening, unlike synaptic potentiation by K+ channel blockers
27. Properties of two calcium-activated hyperpolarizations in rat hippocampal neurones
28. Modulation of a single ion channel by several different protein kinases
29. Calcium-activated potassium channels in adrenal chromaffin cells
30. Long-term potentiation - A decade of progress?
31. Selective activation of Ca2+-activated K+ channels by co-localized Ca2+ channels in hippocampal neurons
32. The early events of oxygen and glucose deprivation: Setting the scene for neuronal death?
33. Organization of AMPA receptor subunits at a glutamate synapse: A quantitative immunogold analysis of hair cell synapses in the rat organ of Corti
34. A neuronal beta subunit (KC-NMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin
35. Ion channels in presynaptic nerve terminals and control of transmitter release
36. The inconstancy of the human heart
37. Metabolic compartmentation of glutamate and glutamine: Morphological evidence obtained by quantitative immunocytochemistry in rat cerebellum
38. Calcium-activated potassium channels and their role in secretion
39. Light and electron microscope distribution of the NMDA receptor subunit NMDAR1 in the rat nervous system using a selective anti-peptide antibody
40. The NMDA receptor subunits NR2A and NR2B show histological and ultrastructural localization patterns similar to those of NR1
41. Calcium-activated potassium conductances contribute to action potential repolarization at the soma but not the dendrites of hippocampal CA1 pyramidal neurons
42. Modulation of transmitter release by action potential duration at the hippocampal CA3-CA1 synapse
43. + channel complexes
44. Presynaptic calcium signals and transmitter release are modulated by calcium-activated potassium channels
45. Functional colocalization of calcium and calcium-gated potassium channels in control of transmitter release
46. Presynaptic potassium channels
47. 2+/calmodulin-dependent protein kinase
48. Depolarizing effects of anoxia on pyramidal cells of rat neocortex
49. Glutamate release in severe brain ischaemia is mainly by reversed uptake
50. Ca(2+)-activated K+ currents in neurones: Types, physiological roles and modulation
51. Iberiotoxin (IbTX) and charybdotoxin (ChTX) slow the somatic spike repolarization but fail to enhance the excitatory synaptic transmission in hippocampal pyramidal cells
52. The role of BK-type Ca2+-dependent K+ channels in spike broadening during repetitive firing in rat hippocampal pyramidal cells
53. Contributions of four ionic currents (BK, SK, M and H) to the medium afterhyperpolarization (mAHP) and early spike frequency adaptation, and M- and H-current to the resting potential, in CA1 hippocampal neurons
54. Mode switching characterizes the activity of large conductance potassium channels recorded from rat cortical fused nerve terminals
55. Intracellular injection of a Ca2+ chelator inhibits spike repolarization in hippocampal neurons
56. Action potential repolarization and a fast after-hyperpolarization in rat hippocampal pyramidal cells
57. Potassium currents in hippocampal pyramidal cells
58. Presynaptic BK channels in glutamatergic hippocampal terminals: Their role in spike repolarization and regulation of transmitter release
59. Single-channel properties of BK-type calcium-activated potassium channels at a cholinergic presynaptic nerve terminal
60. Membrane currents in visually identified motoneurones of neonatal rat spinal cord
61. Different modes of expression of AMPA and NMDA receptors in hippocampal synapses
62. 2+] changes induced by 2-deoxy-D-glucose in rat hippocampal slices
63. Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit
64. Calcium-activated potassium channels
65. High-conductance calcium-activated potassium channels in rat brain: Pharmacology, distribution, and subunit composition
66. A novel nervous system β subunit that downregulates human large-conductance calcium-dependent potassium channels
67. Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission
68. Presynaptic calcium is increased during normal synaptic transmission and paired-pulse facilitation, but not in long-term potentiation in area CA1 of hippocampus
69. Tracking presynaptic Ca2+ dynamics during neurotransmitter release with Ca2+-activated K+ channels
70. Short-term synaptic plasticity