The large-conductance Ca2+-activated K+ channel is essential for innate immunity

Nature

Volumn 427, Issue 6977, 2004, Pages 853-858

  Ahluwalia, Jatinder ^a   Tinker, Andrew ^a   Clapp, Lucie H ^a   Buchen, Michael R ^a   Abramov, Andrey Y ^a   Pope, Simon ^a   Nobles, Muriel ^a   Segal, Anthony W ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIODIVERSITY; BIOLOGICAL MEMBRANES; ELECTRIC CONDUCTANCE; PH EFFECTS;

IMMUNODEFICIENCY; REACTIVE OXYGEN SPECIES (ROP);

IMMUNOLOGY;

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; CALCIUM ACTIVATED POTASSIUM CHANNEL; HALOGEN; IBERIOTOXIN; PAXILLINE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RUBIDIUM 86; CALCIUM; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT; PHORBOL 13 ACETATE 12 MYRISTATE; POTASSIUM; RUBIDIUM;

MEDICINE;

ALKALINIZATION; ARTICLE; BACTERICIDAL ACTIVITY; CALCIUM CELL LEVEL; CELL VACUOLE; CONTROLLED STUDY; ENZYME ACTIVITY; EOSINOPHIL; HUMAN; HUMAN CELL; IMMUNITY; MEMBRANE DEPOLARIZATION; NEUTROPHIL; NUCLEOTIDE SEQUENCE; PHAGOCYTOSIS; POTASSIUM CURRENT; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN EXPRESSION; REACTION ANALYSIS; STAPHYLOCOCCUS AUREUS; WESTERN BLOTTING; CELL MEMBRANE POTENTIAL; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ELECTRIC CONDUCTIVITY; IMMUNOLOGY; INNATE IMMUNITY; ION TRANSPORT; METABOLISM; OXYGEN CONSUMPTION; PH;

NEGIBACTERIA; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

CALCIUM; ELECTRIC CONDUCTIVITY; EOSINOPHILS; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNITY, NATURAL; ION TRANSPORT; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MEMBRANE POTENTIALS; NEUTROPHILS; OXYGEN CONSUMPTION; PHAGOCYTOSIS; POTASSIUM; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; RUBIDIUM RADIOISOTOPES; STAPHYLOCOCCUS AUREUS; TETRADECANOYLPHORBOL ACETATE; VACUOLES;

EID: 1542318099     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02356     Document Type: Article

References (30)

1. Klebanoff, S. J. Antimicrobial mechanisms in neutrophilic polymorphonuclear leukocytes, Semin. Hematol. 12, 117-142 (1975).
2. Babior, B. M. Phagocytes and oxidative stress. Am. J. Med. 109, 33-44 (2000).
3. + flux. Nature 416, 291-297 (2002).
4. Thrasher, A. J., Keep, N. H., Wientjes, F. & Segal, A. W. Chronic granulomatous disease. Biochim. Biophys. Acta 1227, 1-24 (1994).
5. + channel. Biochem. J. 246, 325-329 (1987).
6. Henderson, L. M., Chappell, J. B. & Jones, O. T. Superoxide generation by the electrogenic NADPH oxidase of human neutrophils is limited by the movement of a compensating charge. Biochem. J. 255, 285-290 (1988).
7. Segal, A. W., Geisow, M., Garcia, R., Harper, A. & Miller, R. The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH. Nature 290, 406-409 (1981).
8. Galvez, A. et al. Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus. J. Biol. Chem. 265, 11083-11090 (1990).
9. Sanchez, M. & McManus, O. B. Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel. Neuropharmacology 35, 963-968 (1996).
10. Clapp, L. H. & Tinker, A. Potassium channels in the vasculature. Curr. Opin. Nephrol. Hypertens 7, 91-98 (1998).
11. Garcia, M. L. et al. Use of toxins to study potassium channels. J. Bioenerg. Biomembr. 23, 615-646 (1991).
12. Santos-Silva, J. E., Santos-Silva, M. C., Cunha, F. D. Q. & Assreuy, J. The role of ATP-sensitive potassium channels in neutrophil migration and plasma exudation. J. Pharmac. Exp. Ther. 300, 946-951 (2002).
13. + channel TASK-1. EMBO J. 20, 47-54 (2001).
14. Lawson, K. Potassium channel openers as potential therapeutic weapons in ion channel disease. Kidney Int. 57, 838-845 (2000).
15. + channel mediates regulatory volume decrease response in a human bronchial epithelial cell line. Am. J. Physiol. Cell Physiol. 283, C1705-C1714 (2002).
16. DeCoursey, T. E., Morgan, D. & Cherny, V. V. The voltage dependence of NADPH oxidase reveals why phagocytes need proton channels. Nature 422, 531-534 (2003).
17. Schrenzel, J. et al. Electron currents generated by the human phagocyte NADPH oxidase. Nature 392, 734-737 (1998).
18. Petreccia, D. C., Nauseef, W. M. & Clark, R. A. Respiratory burst of normal human eosinophils. J. Leukoc. Biol 41, 283-288 (1987).
19. + conducting channel. Biochem. J. 251, 563-567 (1988).
20. Cherny, V. V., Henderson, L. M., Xu, W., Thomas, L. L. & DeCoursey, T. E. Activation of NADPH oxidase-related proton and electron currents in human eosinophils by arachidonic acid. J. Physiol. (Lond.) 535, 783-794 (2001).
21. Kaczorowski, G. J. et al. High-conductance calcium activated potassium channel; structure, pharmacology, and function. J. Bioenerg. Biomembr. 28, 255-267 (1996).
22. Mahomed, G. A. & Anderson, R. Activation of human neutrophils with chemotactic peptide, opsonised zymosan and the calcium ionophore A23187, but not with a phorbol ester, is accompanied by efflux and store-operated influx of calcium. Inflammation 24, 559-569 (2000).
23. Jankowski, A. & Grinstein, S. A noninvasive fluorimetric procedure for measurement of membrane potential. Quantification of the NADPH oxidase-induced depolarization in activated neutrophils. J. Biol. Chem. 274, 26098-26104 (1999).
24. Tsien, R. Y. Fluorescent indicators of ion concentrations. Methods Cell Biol. 30, 127-156 (1989).
25. Vergun, O. et al. Exploration of the role of reactive oxygen species in glutamate neurotoxicity in rat hippocampal neurones in culture. J. Physiol. (Lond.) 531, 147-163 (2001).
26. 2+ influx in human neutrophils. Biochem. J. 297, 595-601 (1994).
27. Grinstein, S. & Furuya, W. Cytoplasmic pH regulation in phorbol ester-activated human neutrophils. Am. J. Physiol. 231, C555-C65 (1986).
28. Willoughby, D., Thomas, R. & Schwiening, C. The effects of intracellular pH changes on resting cytosolic calcium in voltage-clamped snail neurones. J. Physiol. (Lond.) 530, 405-416 (2001).
29. Salvemini, D., Riley, D. P. & Cuzzocrea, S. SOD mimetics are coming of age. Nature Rev. Drug Discov. 1, 367-374 (2002).
30. Pick, E. & Keisari, Y. A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture. J. Immunol. Methods 38, 161-170 (1980).