Alternative and efficient extraction methods for marine-derived compounds

Marine Drugs

Volumn 13, Issue 5, 2015, Pages 3182-3230

  Grosso, Clara ^a   Valentão, Patrícia ^a   Ferreres, Federico ^b   Andrade, Paula B ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b RESEARCH GROUP ON QUALITY   (Spain)

Author keywords

Enzyme assisted extraction; Ionic liquids; Marine compounds; Microwave assisted extraction; Pressurized solvent extraction; Pulsed electric field assisted extraction; Supercritical fluid extraction; Switchable solvents; Ultrasound assisted extraction

Indexed keywords

ALKALOID; ALPHA CAROTENE; ANTHERAXANTHIN; ASTAXANTHIN; BETA CAROTENE; BETA CRIPTOXANTHIN; CAROTENOID; CHEMICAL COMPOUND; CHLOROPHYLL A; CHLOROPHYLL B; CHONDROITIN SULFATE; DITERPENE; FATTY ACID; FUCOXANTHIN; IONIC LIQUID; NEOXANTHIN; PYRROLOACRIDINE ALKALOID; SESQUITERPENE; SOLVENT; STEROL; SWITCHABLE HYDROPHILICITY SOLVENT; SWITCHABLE POLARITY SOLVENT; TAURINE; TERPENE; TERPENOID; UNCLASSIFIED DRUG; VAUCHERIAXANTHIN; VIOLAXANTHIN; XANTHOPHYLL; ZEAXANTHIN; BIOLOGICAL PRODUCT;

CALLINECTES SAPIDUS; CHLOROCOCCUM LITTORALE; CRUSTACEA; CYLINDROTHECA CLOSTERIUM; DUNALIELLA SALINA; DUNALIELLA TERTIOLECTA; EISENIA BICYCLIS; ENZYME ASSISTED EXTRACTION; EUPHAUSIA; EUPHAUSIA PACIFICA; EUPHAUSIA SUPERBA; EXTRACTION; FARFANTEPENAEUS PAULENSIS; INTERMETHOD COMPARISON; LAMINARIA JAPONICA; LITOPENAEUS VANNAMEI; MACERATION; MACROALGA; MARINE SPECIES; MICROALGA; MICROWAVE ASSISTED EXTRACTION; NANNOCHLOROPSIS GADITANA; NONHUMAN; PARACOCCUS; PARACOCCUS ZEAXANTHINIFACIENS; PENAEUS; PENAEUS BRASILIENSIS; PENAEUS MONODON; PENAEUS PAULENSIS; PHAEODACTYLUM TRICORNUTUM; PRESSURIZED SOLVENT EXTRACTION; PULSED ELECTRIC FIELD ASSISTED EXTRACTION; REVIEW; SARGASSUM; SARGASSUM FUSIFORME; SOLID LIQUID EXTRACTION; SOLVENT EXTRACTION; SOXHLET EXTRACTION; SUPERCRITICAL FLUID EXTRACTION; SYNECHOCOCCUS; ULTRASOUND ASSISTED EXTRACTION; UNDARIA PINNATIFIDA; ANIMAL; AQUATIC SPECIES; CHEMISTRY; HUMAN; MARINE BIOLOGY; MICROWAVE RADIATION; PROCEDURES; SUPERCRITICAL FLUID CHROMATOGRAPHY;

ANIMALS; AQUATIC ORGANISMS; BIOLOGICAL PRODUCTS; CHROMATOGRAPHY, SUPERCRITICAL FLUID; HUMANS; MARINE BIOLOGY; MICROWAVES; SOLVENTS;

EID: 84930685209     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md13053182     Document Type: Review

References (205)

1. Hu, G.-P.; Yuan, J.; Sun, L.; She, Z.-G.; Wu, J.-H.; Lan, X.-J.; Zhu, X.; Lin, Y.-C.; Chen, S.-P. Statistical research on marine natural products based on data obtained between 1985 and 2008. Mar. Drugs 2011, 9, 514-525.
2. Faulkner, D.J. Marine natural products: Metabolites of marine algae and herbivorous marine molluscs. Nat. Prod. Rep. 1984, 1, 251-280.
3. Faulkner, D.J. Marine natural products: Metabolites of marine invertebrates. Nat. Prod. Rep. 1984, 1, 551-598.
4. Faulkner, D.J. Marine natural products. Nat. Prod. Rep. 1986, 3, 1-33.
5. Faulkner, D.J. Marine natural products. Nat. Prod. Rep. 1987, 4, 539-576.
6. Faulkner, D.J. Marine natural products. Nat. Prod. Rep. 1988, 5, 613-663.
7. Faulkner, D.J. Marine natural products. Nat. Prod. Rep. 1990, 7, 269-309.
8. Faulkner, D.J. Marine natural products. Nat. Prod. Rep. 1991, 8, 97-147.
9. Faulkner, D.J. Marine natural products. Nat. Prod. Rep. 1992, 9, 323-364.
10. Faulkner, D.J. Marine natural products. Nat. Prod. Rep. 1993, 10, 497-539.
11. Faulkner, D.J. Marine natural products. Nat. Prod. Rep. 1994, 11, 355-394.
12. Faulkner, D.J. Marine natural products. Nat. Prod. Rep. 1995, 12, 223-269.
13. Faulkner, D.J. Marine natural products. Nat. Prod. Rep. 1996, 13, 75-125.
14. Faulkner, D.J. Marine natural products. Nat. Prod. Rep. 1997, 14, 259-302.
15. Faulkner, D.J. Marine natural products. Nat. Prod. Rep. 1998, 15, 113-158.
16. Faulkner, D.J. Marine natural products. Nat. Prod. Rep. 1999, 16, 155-198.
17. Faulkner, D.J. Marine natural products. Nat. Prod. Rep. 2000, 17, 7-55.
18. Faulkner, D.J. Marine natural products. Nat. Prod. Rep. 2001, 18, 1R-49R.
19. Faulkner, D.J. Marine natural products. Nat. Prod. Rep. 2002, 19, 1-49.
20. Blunt, J.W.; Copp, B.R.; Munro, M.H.G.; Northcote, P.T.; Prinsep, M.R. Marine natural products. Nat. Prod. Rep. 2003, 20, 1-48.
21. Blunt, J.W.; Copp, B.R.; Munro, M.H.G.; Northcote, P.T.; Prinsep, M.R. Marine natural products. Nat. Prod. Rep. 2004, 21, 1-49.
22. Blunt, J.W.; Copp, B.R.; Munro, M.H.G.; Northcote, P.T.; Prinsep, M.R. Marine natural products. Nat. Prod. Rep. 2005, 22, 15-61.
23. Blunt, J.W.; Copp, B.R.; Munro, M.H.G.; Northcote, P.T.; Prinsep, M.R. Marine natural products. Nat. Prod. Rep. 2006, 23, 26-78.
24. Blunt, J.W.; Copp, B.R.; Hu, W.-P.; Munro, M.H.G.; Northcote, P.T.; Prinsep, M.R. Marine natural products. Nat. Prod. Rep. 2007, 24, 31-86.
25. Blunt, J.W.; Copp, B.R.; Hu, W.-P.; Munro, M.H.G.; Northcote, P.T.; Prinsep, M.R.; Marine natural products. Nat. Prod. Rep. 2008, 25, 35-94.
26. Blunt, J.W.; Copp, B.R.; Hu, W.-P.; Munro, M.H.G.; Northcote, P.T.; Prinsep, M.R. Marine natural products. Nat. Prod. Rep. 2009, 26, 170-244.
27. Blunt, J.W.; Copp, B.R.; Munro, M.H.G.; Northcote, P.T.; Prinsep, M.R. Marine natural products. Nat. Prod. Rep. 2010, 27, 165-237.
28. Blunt, J.W.; Copp, B.R.; Munro, M.H.G.; Northcote, P.T.; Prinsep, M.R. Marine natural products. Nat. Prod. Rep. 2011, 28, 196-268.
29. Blunt, J.W.; Copp, B.R.; Keyzers, R.A.; Munro, M.H.G.; Prinsep, M.R. Marine natural products. Nat. Prod. Rep. 2012, 29, 144-222.
30. Blunt, J.W.; Copp, B.R.; Keyzers, R.A.; Munro, M.H.G.; Prinsep, M.R. Marine natural products. Nat. Prod. Rep. 2013, 30, 237-323.
31. Blunt, J.W.; Copp, B.R.; Keyzers, R.A.; Munro, M.H.G.; Prinsep, M.R. Marine natural products. Nat. Prod. Rep. 2014, 31, 160-258.
32. Rostagno, M.A.; Villares, A.; Guillamón, E.; García-Lafuente, A.; Martínez, J.A. Sample preparation for the analysis of isoflavones from soybeans and soy foods. J. Chromatogr. A 2009, 1216, 2-29.
33. Luthria, D.L. Significance of sample preparation in developing analytical methodologies for accurate estimation of bioactive compounds in functional foods. J. Sci. Food Agric. 2006, 86, 2266-2272.
34. Romanik, G.; Gilgenast, E.; Przyjazny, A.; Kamiński, M. Techniques of preparing plant material for chromatographic separation and analysis. J. Biochem. Biophys. Methods 2007, 70, 253-261.
35. nd ed.; CRC Press; Taylor and Francis Group: London, UK, 2009; pp. 87-91.
36. Heng, M.Y.; Tan, S.N.; Yong, J.W.H.; Ong, E.S. Emerging green technologies for the chemical standardization of botanicals and herbal preparations. Trends Anal. Chem. 2013, 50, 1-10.
37. Veggi, P.C.; Martinez, J.; Meireles, M.A.A. Fundamentals of microwave extraction. In Microwave-Assisted Extraction for Bioactive Compounds: Theory and Practice, Food Engineering Series 4, Chemat, F., Cravotto, G., Eds.; Springer: New York, NY, USA, 2013; pp. 15-52.
38. Sticher, O. Natural product isolation. Nat. Prod. Rep. 2008, 25, 517-554.
39. Bucar, F.; Wube, A.; Schmid, M. Natural product isolation - How to get from biological material to pure compounds. Nat. Prod. Rep. 2013, 30, 525-545.
40. Chemat, F.; Vian, M.A.; Cravotto, G. Green extraction of natural products: Concept and principles. Int. J. Mol. Sci. 2012, 13, 8615-8627.
41. Zhao, L.; Chen, G.; Zhao, G.; Hu, X. Optimization of microwave-assisted extraction of astaxanthin from Haematococcus pluvialis by response surface methodology and antioxidant activities of the extracts. Sep. Sci. Technol. 2009, 44, 243-262.
42. Kaufmann, B.; Christen, P. Recent extraction techniques for natural products: Microwave-assisted extraction and pressurised solvent extraction. Phytochem. Anal. 2002, 13, 105-113.
43. Xiao, X.; Si, X.; Yuan, Z.; Xu, X.; Li, G. Isolation of fucoxanthin from edible brown algae by microwave-assisted extraction coupled with high-speed countercurrent chromatography. J. Sep. Sci. 2012, 35, 2313-2317.
44. Balasubramanian, S.; Allen, J.D.; Kanitkar, A.; Boldor, D. Oil extraction from Scenedesmus obliquus using a continuous microwave system-Design, optimization, and quality characterization. Bioresour. Technol. 2011, 102, 3396-3403.
45. Choi, I.L.; Choi, S.J.; Chun, J.K.; Moon, T.W. Extraction yield of soluble protein and microstructure of soybean affected by microwave heating. J. Food Process. Preserv. 2006, 30, 407-419.
46. Wang, L. Advances in extraction of plant products in nutraceutical processing. In Handbook of Nutraceuticals Volume II Scale-Up, Processing and Automation; Pathak, Y., Ed.; CRC Press: Boca Raton, FL, USA, 2011; pp. 15-52.
47. Popper, Z.A.; Michel, G.; Hervé, C.; Domozych, D.S.; Willats, W.G.T.; Tuohy, M.G.; Kloareg, B.; Stengel, D.B. Evolution and diversity of plant cell walls: From algae to flowering plants. Ann. Rev. Plant Biol. 2011, 62, 567-590.
48. th ed.; Jones & Battlett: Sudbury, MA, USA, 2012.
49. Zou, T.-B.; Jia, Q.; Li, H.-W.; Wang, C.-X.; Wu, H.-F. Response surface methodology for ultrasound-assisted extraction of astaxanthin from Haematococcus pluvialis. Mar. Drugs 2013, 11, 1644-1655.
50. Vardanega, R.; Santos, D.T.; Meireles, M.A.A. Intensification of bioactive compounds extraction from medicinal plants using ultrasonic irradiation. Pharmacogn. Rev. 2014, 8, 88-95.
51. Picó, Y. Ultrasound-assisted extraction for food and environmental samples. Trends Anal. Chem. 2013, 43, 84-99.
52. Kong, W.; Liu, N.; Zhang, J.; Yang, Q.; Hua, S.; Song, H.; Xia, C. Optimization of ultrasound-assisted extraction parameters of chlorophyll from Chlorella vulgaris residue after lipid separation using response surface methodology. J. Food Sci. Technol. 2014, 51, 2006-2013.
53. Macías-Sánchez, M.D.; Mantell, C.; Rodríguez, M.; Martínez de la Ossa, E.; Lubián, L.M.; Montero, O. Comparison of supercritical fluid and ultrasound-assisted extraction of carotenoids and chlorophyll a from Dunaliella salina. Talanta 2009, 77, 948-952.
54. Natarajan, R.; Ang, W.M.R.; Chen, X.; Voigtmann, M.; Lau, R. Lipid releasing characteristics of microalgae species through continuous ultrasonication. Bioresour. Technol. 2014, 158, 7-11.
55. Plaza, M.; Santoyo, S.; Jaime, L.; Avalo, B.; Cifuentes, A.; Reglero, G.; García-Blairsy Reina, G.; Señoráns, F.J.; Ibáñez, E. Comprehensive characterization of the functional activities of pressurized liquid and ultrasound-assisted extracts from Chlorella vulgaris. LWT Food Sci. Technol. 2012, 46, 245-253.
56. Quitain, A.T.; Kai, T.; Sasaki, M.; Goto, M. Supercritical carbon dioxide extraction of fucoxanthin from Undaria pinnatifida. J. Agric. Food Chem. 2013, 61, 5792-5797.
57. Ali-Nehari, A.; Kim, S.-B.; Lee, Y.-B.; Lee, H.-Y.; Chun, B.-S. Characterization of oil including astaxanthin extracted from krill (Euphausia superba) using supercritical carbon dioxide and organic solvent as comparative method. Korean J. Chem. Eng. 2012, 29, 329-336.
58. Careri, M.; Furlattini, L.; Mangia, A.; Musci, M.; Anklam, E.; Theobald, A.; von Holst, C. Supercritical fluid extraction for liquid chromatographic determination of carotenoids in Spirulina pacifica algae: A chemometric approach. J. Chromatogr. A 2001, 912, 61-71.
59. Mendes, R.L.; Nobre, B.P.; Cardoso, M.T.; Pereira, A.P.; Palavra, A.F. Supercritical carbon dioxide extraction of compounds with pharmaceutical importance from microalgae. Inorg. Chim. Acta 2003, 356, 328-334.
60. Macías-Sánchez, M.D.; Mantell, C.; Rodríguez, M.; Martínez de la Ossa, E.; Lubián, L.M.; Montero, O. Supercritical fluid extraction of carotenoids and chlorophyll a from Nannochloropsis gaditana. J. Food Eng. 2005, 66, 245-251.
61. Macías-Sánchez, M.D.; Mantell Serrano, C.; Rodríguez Rodríguez, M.; Martínez de la Ossa, E.; Lubián, L.M.; Montero, O. Extraction of carotenoids and chlorophyll from microalgae with supercritical carbon dioxide and ethanol as cosolvent. J. Sep. Sci. 2008, 31, 1352-1362.
62. Jaime, L.; Mendiola, J.A.; Ibáñez, E.; Martin-Álvarez, P.J.; Cifuentes, A.; Reglero, G.; Señoráns, F.J. β-Carotene isomer composition of sub- and supercritical carbon dioxide extracts. Antioxidant activity measurement. J. Agric. Food Chem. 2007, 55, 10585-10590.
63. th ed.; Perry, R.H., Green, D.W., Maloney, J.O., Eds.; McGrawHill: New York, NY, USA, 1999; Section 2.
64. Kadam, S.U.; Tiwari, B.K.; O'Donnell, C.P. Application of novel extraction technologies for bioactives from marine algae. J. Agric. Food Chem. 2013, 61, 4667-4675.
65. Lu, J.; Feng, X.; Han, Y.; Xue, C. Optimization of subcritical fluid extraction of carotenoids and chlorophyll a from Laminaria japonica Aresch by response surface methodology. J. Sci. Food Agric. 2014, 94, 139-145.
66. Herrero, M.; Castro-Puyana, M.; Mendiola, J.A.; Ibañez, E. Compressed fluids for the extraction of bioactive compounds. Trends Anal. Chem. 2013, 43, 67-83.
67. Li, P.; Makino, H. Liquefied dimethyl ether: An energy-saving, green extraction solvent. In Alternative Solvents for Natural Products Extraction; Chemat, F., Abert, V.M., Eds.; Springer: Berlin Heidelberg, Germany, 2014; pp. 91-106.
68. Kanda, H.; Li, P. Simple extraction method of green crude from natural blue-green microalgae by dimethyl ether. Fuel 2011, 90, 1264-1266.
69. Kanda, H.; Kamo, Y.; Machmudah, S.; Wahyudiono, E.Y.; Goto, M. Extraction of fucoxanthin from raw macroalgae excluding drying and cell wall disruption by liquefied dimethyl ether. Mar. Drugs 2014, 12, 2383-2396.
70. 2 and subcritical dimethyl ether. J. Supercrit. Fluids 2015, 96, 245-251.
71. Kandušer, M.; Miklavčič, D. Electroporation in biological cell and tissue: An overview. In Electrotechnologies for Extraction from Food Plants and Biomaterials; Vorobiev, E., Lebovka, N., Eds.; Springer Science + Business Media, LLC: New York, NY, USA, 2008; pp. 1-37.
72. Siemer, C.; Toepfl, S.; Heinz, V. Mass transport improvement by PEF - Applications in the area of extraction and distillation. In Distillation - Advances from Modeling to Applications; Zereshki, S., Ed.; InTech: Rijeka, Croatia, 2012; pp. 211-232.
73. Zbinden, M.D.A.; Sturm, B.S.M.; Nord, R.D.; Carey, W.J.; Moore, D.; Shinogle, H.; Stagg-Williams, S.M. Pulsed electric field (PEF) as an intensification pretreatment for greener solvent lipid extraction from microalgae. Biotechnol. Bioeng. 2013, 110, 1605-1615.
74. Wijesinghe, W.A.J.P.; Jeon, Y.-J. Enzyme-assistant extraction (EAE) of bioactive components: A useful approach for recovery of industrially important metabolites from seaweeds: A review. Fitoterapia 2012, 83, 6-12.
75. Ko, S.-C.; Lee, S.-H.; Ahn, G.; Kim, K.-N.; Cha, S.-H.; Kim, S.-K.; Jeon, B.-T.; Park, P.-J.; Lee, K.-W.; Jeon, Y.-J. Effect of enzyme-assisted extract of Sargassum coreanum on induction of apoptosis in HL-60 tumor cells. J. Appl. Phycol. 2012, 24, 675-684.
76. Fleurence, J.; Massiani, L.; Guyader, O.; Mabeau, S. Use of enzymatic cell wall degradation for improvement of protein extraction from Chondrus crispus, Gracilaria verrucosa and Palmaria palmata. J. Appl. Phycol. 1995, 7, 393-397.
77. Heo, S.-J.; Park, E.-J.; Lee, K.-W.; Jeon, Y.-J. Antioxidant activities of enzymatic extracts from brown seaweeds. Bioresour. Technol. 2005, 96, 1613-1623.
78. Kim, K.-N.; Heo, S.-J.; Song, C.B.; Lee, J.; Heo, M.-S.; Yeo, I.-K.; Kang, K.A.; Hyun, J.W.; Jeon, Y.-J. Protective effect of Ecklonia cava enzymatic extracts on hydrogen peroxide-induced cell damage. Process Biochem. 2006, 41, 2393-2401.
79. Wang, T.; Jónsdóttir, R.; Kristinsson, H.G.; Hreggvidsson, G.O.; Jónsson, J.Ó.; Thorkelsson, G.; Ólafsdóttir, G. Enzyme-enhanced extraction of antioxidant ingredients from red algae Palmaria palmata. LWT - Food Sci. Technol. 2010, 43, 1387-1393.
80. Zhu, B.-W.; Qin, L.; Zhou, D.-Y.; Wu, H.-T.; Wu, J.; Yang, J.-F.; Li, D.-M.; Dong, X.-P.; Murata, Y. Extraction of lipid from sea urchin (Strongylocentrotus nudus) gonad by enzyme-assisted aqueous and supercritical carbon dioxide methods. Eur. Food Res. Technol. 2010, 230, 737-743.
81. Liang, K.; Zhang, Q.; Cong, W. Enzyme-assisted aqueous extraction of lipid from microalgae. J. Agric. Food Chem. 2012, 60, 11771-11776.
82. Jessop, P.G.; Heldebrant, D.J.; Li, X.; Eckert, C.A.; Liotta, C.L. Green chemistry: Reversible nonpolar-to-polar solvent. Nature 2005, 436, 1102-1102.
83. Samorì, C.; Torri, C.; Samorì, G.; Fabbri, D.; Galletti, P.; Guerrini, F.; Pistocchi, R.; Tagliavini, E. Extraction of hydrocarbons from microalga Botryococcus braunii with switchable solvents. Bioresour. Technol. 2010, 101, 3274-3279.
84. 2-triggered switchable solvents, surfactants, and other materials. Energy Environ. Sci. 2012, 5, 7240-7253.
85. Boyd, A.R.; Champagne, P.; McGinn, P.J.; MacDougall, K.M.; Melanson, J.E.; Jessop, P.G. Switchable hydrophilicity solvents for lipid extraction from microalgae for biofuel production. Bioresour. Technol. 2012, 118, 628-632.
86. Han, D.; Row, K.H. Recent applications of ionic liquids in separation technology. Molecules 2010, 15, 2405-2426.
87. Dai, Y.; van Spronsen, J.; Witkamp, G.-J.; Verpoorte, R.; Choi, Y.H. Ionic liquids and deep eutectic solvents in natural products research: Mixtures of solids as extraction solvents. J. Nat. Prod. 2013, 76, 2162-2173.
88. Deetlefs, M.; Seddon, K.R. Assessing the greenness of some typical laboratory ionic liquid preparations. Green Chem. 2010, 12, 17-30.
89. Donia, M.; Hamann, M.T. Marine natural products and their potential applications as anti-infective agents. Lancet Infect. Dis. 2003, 3, 338-348.
90. Fattorusso, E.; Taglialatela-Scafati, O. Marine antimalarials. Mar. Drugs 2009, 7, 130-152.
91. El Sayed, K.A.; Bartyzel, P.; Shen, X.; Perry, T.L.; Zjawiony, J.K.; Hamann, M.T. Marine natural products as antituberculosis agents. Tetrahedron 2000, 56, 949-953.
92. Gochfeld, D.J.; El Sayed, K.A.; Yousaf, M.; Hu, J.F.; Bartyzel, P.; Dunbar, D.C.; Wilkins, S.P.; Zjawiony, J.K.; Schinazi, R.F.; Wirtz, S.S. Marine natural products as lead anti-HIV agents. Mini Rev. Med. Chem. 2003, 3, 401-424.
93. Li, Y.-X.; Himaya, S.; Kim, S.-K. Triterpenoids of marine origin as anti-cancer agents. Molecules 2013, 18, 7886-7909.
94. Sima, P.; Vetvicka, V. Bioactive substances with anti-neoplastic efficacy from marine invertebrates: Porifera and Coelenterata. World J. Clin. Oncol. 2011, 2, 355-361.
95. Vílchez, C.; Forján, E.; Cuaresma, M.; Bédmar, F.; Garbayo, I.; Vega, J.M. Marine carotenoids: Biological functions and commercial applications. Mar. Drugs 2011, 9, 319-333.
96. Jang, S.H.; Lim, J.W.; Kim, H. Mechanism of β-carotene-induced apoptosis of gastric cancer cells: Involvement of ataxia-telangiectasia-mutated. Ann. N.Y. Acad. Sci. 2009, 1171, 156-162.
97. Chew, B.P.; Park, J.S.; Wong, M.W.; Wong, T.S. A comparison of the anticancer activities of dietary beta-carotene, canthaxanthin and astaxanthin in mice in vivo. Cancer Res. 1999, 19, 1849-1853.
98. Anderson, M.L. A Preliminary investigation of the enzymatic inhibition of 5α-reductase and growth of prostatic carcinoma cell line LNCap-FGC by natural astaxanthin and saw palmetto lipid extract in vitro. J. Herb. Pharmacother. 2005, 5, 17-26.
99. D'Orazio, N.; Gammone, M.A.; Gemello, E.; de Girolamo, M.; Cusenza, S.; Riccioni, G. Marine bioactives: Pharmacological properties and potential applications against inflammatory diseases. Mar. Drugs 2012, 10, 812-833.
100. Sajilata, M.G.; Bule, M.V.; Chavan, P.; Singhal, R.S.; Kamat, M.Y. Development of efficient supercritical carbon dioxide extraction methodology for zeaxanthin from dried biomass of Paracoccus zeaxanthinifaciens. Sep. Purif. Technol. 2010, 71, 173-177.
101. Nobre, B.; Marcelo, F.; Passos, R.; Beirão, L.; Palavra, A.; Gouveia, L.; Mendes, R. Supercritical carbon dioxide extraction of astaxanthin and other carotenoids from the microalga Haematococcus pluvialis. Eur. Food Res. Technol. 2006, 223, 787-790.
102. Wu, Z.; Wu, S.; Shi, X. Supercritical fluid extraction and determination of lutein in heterotrophically cultivated Chlorella pyrenoidosa. J. Food Process Eng. 2007, 30, 174-185.
103. Tang, G. Bioconversion of dietary provitamin A carotenoids to vitamin A in humans. Am. J. Clin. Nutr. 2010, 91, 1468S-1473S.
104. Guerin, M.; Huntley, M.E.; Olaizola, M. Haematococcus astaxanthin: Applications for human health and nutrition. Trends Biotechnol. 2003, 21, 210-216.
105. Palozza, P. Prooxidant actions of carotenoids in biologic systems. Nutr. Rev. 1998, 56, 257-265.
106. Gao, D.; Okuda, R.; Lopez-Avila, V. Supercritical fluid extraction of halogenated monoterpenes from the red alga Plocamium cartilagineum. J. AOAC Int. 2001, 84, 1313-1331.
107. Zheng, J.; Chen, Y.; Yao, F.; Chen, W.; Shi, G. Chemical composition and antioxidant/antimicrobial activities in supercritical carbon dioxide fluid extract of Gloiopeltis tenax. Mar. Drugs 2012, 10, 2634-2647.
108. Johnson, T.A.; Amagata, T.; Sashidhara, K.V.; Oliver, A.G.; Tenney, K.; Matainaho, T.; Ang, K.K.-H.; McKerrow, J.H.; Crews, P. The aignopsanes, a new class of sesquiterpenes from selected chemotypes of the sponge Cacospongia mycofijiensis. Org. Lett. 2009, 11, 1975-1978.
109. Johnson, T.A.; Sohn, J.; Inman, W.D.; Estee, S.A.; Loveridge, S.T.; Vervoort, H.C.; Tenney, K.; Liu, J.; Ang, K.K.-H.; Ratnam, J.; et al. Natural product libraries to accelerate the high-throughput discovery of therapeutic leads. J. Nat. Prod. 2011, 74, 2545-2555.
110. Johnson, T.A.; Tenney, K.; Cichewicz, R.H.; Morinaka, B.I.; White, K.N.; Amagata, T.; Subramanian, B.; Media, J.; Mooberry, S.L.; Valeriote, F.A.; et al. The sponge-derived fijianolide polyketide class: Further evaluation of their structural and cytotoxicity properties. J. Med. Chem. 2007, 50, 3795-3803.
111. Coué, M.; Brenner, S.L.; Spector, I.; Korn, E.D. Inhibition of actin polymerization by latrunculin A. FEBS Lett. 1987, 213, 316-318.
112. Hattab, M.E.; Culioli, G.; Piovetti, L.; Chitour, S.E.; Valls, R. Comparison of various extraction methods for identification and determination of volatile metabolites from the brown alga Dictyopteris membranacea. J. Chromatogr. A 2007, 1143, 1-7.
113. Rubio, B.K.; van Soest, R.W.M.; Crews, P. Extending the record of meroditerpenes from Cacospongia marine sponges. J. Nat. Prod. 2007, 70, 628-631.
114. Pasquet, V.; Chérouvrier, J.-R.; Farhat, F.; Thiéry, V.; Piot, J.-M.; Bérard, J.-B.; Kaas, R.; Serive, B.; Patrice, T.; Cadoret, J.-P.; et al. Study on the microalgal pigments extraction process: Performance of microwave assisted extraction. Process Biochem. 2011, 46, 59-67.
115. Kim, S.; Jung, Y.-J.; Kwon, O.-N.; Cha, K.; Um, B.-H.; Chung, D.; Pan, C.-H. A Potential commercial source of fucoxanthin extracted from the microalga Phaeodactylum tricornutum. Appl. Biochem. Biotechnol. 2012, 166, 1843-1855.
116. Macías-Sánchez, M.D.; Mantell, C.; Rodríguez, M.; Martínez de la Ossa, E.; Lubián, L.M.; Montero, O. Supercritical fluid extraction of carotenoids and chlorophyll a from Synechococcus sp. J. Supercrit. Fluids 2007, 39, 323-329.
117. Mezzomo, N.; Maestri, B.; dos Santos, R.L.; Maraschin, M.; Ferreira, S.R.S. Pink shrimp (P. brasiliensis and P. paulensis) residue: Influence of extraction method on carotenoid concentration. Talanta 2011, 85, 1383-1391.
118. Ota, M.; Watanabe, H.; Kato, Y.; Watanabe, M.; Sato, Y.; Smith, R.L.; Inomata, H. Carotenoid production from Chlorococcum littorale in photoautotrophic cultures with downstream supercritical fluid processing. J. Sep. Sci. 2009, 32, 2327-2335.
119. 2 and ethanol as cosolvent. Chem. Eng. J. 2009, 150, 104-113.
120. Nobre, B.P.; Villalobos, F.; Barragán, B.E.; Oliveira, A.C.; Batista, A.P.; Marques, P.A.S.S.; Mendes, R.L.; Sovová, H.; Palavra, A.F.; Gouveia, L. A biorefinery from Nannochloropsis sp. microalga - Extraction of oils and pigments. Production of biohydrogen from the leftover biomass. Bioresour. Technol. 2013, 135, 128-136.
121. Liau, B.-C.; Hong, S.-E.; Chang, L.-P.; Shen, C.-T.; Li, Y.-C.; Wu, Y.-P.; Jong, T.-T.; Shieh, C.-J.; Hsu, S.-L.; Chang, C.-M.J. Separation of sight-protecting zeaxanthin from Nannochloropsis oculata by using supercritical fluids extraction coupled with elution chromatography. Sep. Purif. Technol. 2011, 78, 1-8.
122. 2 extraction of β-carotene from a marine strain of the cyanobacterium Synechococcus species. J. Agric. Food Chem. 2005, 53, 9701-9707.
123. Roh, M.-K.; Uddin, M.S.; Chun, B.-S. Extraction of fucoxanthin and polyphenol from Undaria pinnatifida using supercritical carbon dioxide with co-solvent. Biotechnol. Bioprocess Eng. 2008, 13, 724-729.
124. 2/ethanol extraction of astaxanthin from blue crab (Callinectes sapidus) shell waste. J. Food Process Eng. 2001, 24, 101-112.
125. Sánchez-Camargo, A.P.; Almeida Meireles, M.A.; Lopes, B.L.F.; Cabral, F.A. Proximate composition and extraction of carotenoids and lipids from Brazilian redspotted shrimp waste (Farfantepenaeus paulensis). J. Food Eng. 2011, 102, 87-93.
126. 2 extraction of lipids and astaxanthin from Brazilian redspotted shrimp waste (Farfantepenaeus paulensis). J. Supercrit. Fluids 2011, 56, 164-173.
127. 2 J. Supercrit. Fluids 2012, 66, 176-180.
128. Radzali, S.A.; Baharin, B.S.; Othman, R.; Markom, M.; Rahman, R.A. Co-solvent selection for supercritical fluid extraction of astaxanthin and other carotenoids from Penaeus monodon waste. J. Oleo Sci. 2014, 63, 769-777.
129. Herrero, M.; Jaime, L.; Martín-Álvarez, P.J.; Cifuentes, A.; Ibáñez, E. Optimization of the extraction of antioxidants from Dunaliella salina microalga by pressurized liquids. J. Agric. Food Chem. 2006, 54, 5597-5603.
130. Shang, Y.F.; Kim, S.M.; Lee, W.J.; Um, B.-H. Pressurized liquid method for fucoxanthin extraction from Eisenia bicyclis (Kjellman) Setchell. J. Biosci. Bioeng. 2011, 111, 237-241.
131. Han, Y.; Ma, Q.; Wang, L.; Xue, C. Extraction of astaxanthin from Euphausia pacific using subcritical 1,1,1,2-tetrafluoroethane. J. Ocean Univ. China 2012, 11, 562-568.
132. th International Symposium on Supercritical Fluids; King, J., Ed.; CASSS: Emeryville, CA, USA, 2012.
133. Wong, T.Y.; Preston, L.A.; Schiller, N.L. Alginate lyase: Review of major sources and enzyme characteristics, structure-function analysis, biological roles, and applications. Ann. Rev. Microbiol. 2000, 54, 289-340.
134. Bi, W.; Tian, M.; Zhou, J.; Row, K.H. Task-specific ionic liquid-assisted extraction and separation of astaxanthin from shrimp waste. J. Chromatogr. B 2010, 878, 2243-2248.
135. Gillingham, L.; Harris-Janz, S.; Jones, P.H. Dietary monounsaturated fatty acids are protective against metabolic syndrome and cardiovascular disease risk factors. Lipids 2011, 46, 209-228.
136. Sahena, F.; Zaidul, I.S.M.; Jinap, S.; Saari, N.; Jahurul, H.A.; Abbas, K.A.; Norulaini, N.A. PUFAs in fish: Extraction, fractionation, importance in health. Compr. Rev. Food Sci. Food Saf. 2009, 8, 59-74.
137. Rubio-Rodríguez, N.; de Diego, S.M.; Beltrán, S.; Jaime, I.; Sanz, M.T.; Rovira, J. Supercritical fluid extraction of fish oil from fish by-products: A comparison with other extraction methods. J. Food Eng. 2012, 109, 238-248.
138. Kris-Etherton, P.M. Monounsaturated fatty acids and risk of cardiovascular disease. Circulation 1999, 100, 1253-1258.
139. Kris-Etherton, P.M.; Pearson, T.A.; Wan, Y.; Hargrove, R.L.; Moriarty, K.; Fishell, V.; Etherton, T.D. High-monounsaturated fatty acid diets lower both plasma cholesterol and triacylglycerol concentrations. Am. J. Clin. Nutr. 1999, 70, 1009-1015.
140. Solana, M.; Rizza, C.S.; Bertucco, A. Exploiting microalgae as a source of essential fatty acids by supercritical fluid extraction of lipids: Comparison between Scenedesmus obliquus, Chlorella protothecoides and Nannochloropsis salina. J. Supercrit. Fluids 2014, 92, 311-318.
141. Kennedy, M.J.; Reader, S.L.; Davies, R.J. Fatty acid production characteristics of fungi with particular emphasis on gamma linolenic acid production. Biotechnol. Bioeng. 1993, 42, 625-634.
142. Couto, R.M.; Simões, P.C.; Reis, A.; da Silva, T.L.; Martins, V.H.; Sánchez-Vicente, Y. Supercritical fluid extraction of lipids from the heterotrophic microalga Crypthecodinium cohnii. Eng. Life Sci. 2010, 10, 158-164.
143. Church, M.W.; Jen, K.L.C.; Dowhan, L.M.; Adams, B.R.; Hotra, J.W. Excess and deficient omega-3 fatty acid during pregnancy and lactation cause impaired neural transmission in rat pups. Neurotoxicol. Teratol. 2008, 30, 107-117.
144. Miles, E.A.; Calder, P.C. Influence of marine n-3 polyunsaturated fatty acids on immune function and a systematic review of their effects on clinical outcomes in rheumatoid arthritis. Br. J. Nutr. 2012, 107, S171-S184.
145. Whitehouse, M.W.; Macrides, T.A.; Kalafatis, N.; Betts, W.H.; Haynes, D.R.; Broadbent, J. Anti-inflammatory activity of a lipid fraction (lyprinol) from the NZ green-lipped mussel. Inflammopharmacolology 1997, 5, 237-246.
146. Li, G.; Fu, Y.; Zheng, J.; Li, D. Anti-Inflammatory activity and mechanism of a lipid extract from hard-shelled mussel (Mytilus coruscus) on chronic arthritis in rats. Mar. Drugs 2014, 12, 568-588.
147. 2 to obtain extracts with antimicrobial activity from Chaetoceros muelleri microalga. A correlation with their lipidic content. Eur. Food Res. Technol. 2007, 224, 505-510.
148. Sun, C.Q.; O'Connor, C.J.; Roberton, A.M. Antibacterial actions of fatty acids and monoglycerides against Helicobacter pylori. FEMS Immunol. Med. Microbiol. 2003, 36, 9-17.
149. Zheng, C.J.; Yoo, J.-S.; Lee, T.-G.; Cho, H.-Y.; Kim, Y.-H.; Kim, W.-G. Fatty acid synthesis is a target for antibacterial activity of unsaturated fatty acids. FEBS Lett. 2005, 579, 5157-5162.
150. Desbois, A.; Lawlor, K. Antibacterial activity of long-chain polyunsaturated fatty acids against Propionibacterium acnes and Staphylococcus aureus. Mar. Drugs 2013, 11, 4544-4557.
151. Park, N.-H.; Choi, J.-S.; Hwang, S.-Y.; Kim, Y.-C.; Hong, Y.-K.; Cho, K.; Choi, I. Antimicrobial activities of stearidonic and gamma-linolenic acids from the green seaweed Enteromorpha linza against several oral pathogenic bacteria. Bot. Stud. 2013, 54, 1-9.
152. Mubarak, M.; Shaija, A.; Suchithra, T.V. A review on the extraction of lipid from microalgae for biodiesel production. Algal Res. 2015, 7, 117-123.
153. Qv, X.-Y.; Zhou, Q.-F.; Jiang, J.-G. Ultrasound-enhanced and microwave-assisted extraction of lipid from Dunaliella tertiolecta and fatty acid profile analysis. J. Sep. Sci. 2014, 37, 2991-2999.
154. Iqbal, J.; Theegala, C. Microwave assisted lipid extraction from microalgae using biodiesel as co-solvent. Algal Res. 2013, 2, 34-42.
155. Teo, C.L.; Idris, A. Enhancing the various solvent extraction method via microwave irradiation for extraction of lipids from marine microalgae in biodiesel production. Bioresour. Technol. 2014, 171, 477-481.
156. Adam, F.; Abert-Vian, M.; Peltier, G.; Chemat, F. "Solvent-free" ultrasound-assisted extraction of lipids from fresh microalgae cells: A green, clean and scalable process. Bioresour. Technol. 2012, 114, 457-465.
157. Halim, R.; Gladman, B.; Danquah, M.K.; Webley, P.A. Oil extraction from microalgae for biodiesel production. Bioresour. Technol. 2011, 102, 178-185.
158. Andrich, G.; Nesti, U.; Venturi, F.; Zinnai, A.; Fiorentini, R. Supercritical fluid extraction of bioactive lipids from the microalga Nannochloropsis sp. Eur. J. Lipid Sci. Technol. 2005, 107, 381-386.
159. 2 extraction of neutral lipids from microalgae: Experiments and modelling. J. Supercrit. Fluids 2013, 77, 7-16.
160. 2 extraction from Nannochloropsis oculata. J. Supercrit. Fluids 2013, 79, 337-344.
161. Bjornsson, W.J.; MacDougall, K.M.; Melanson, J.E.; O'Leary, S.J.B.; McGinn, P.J. Pilot-scale supercritical carbon dioxide extractions for the recovery of triacylglycerols from microalgae: A practical tool for algal biofuels research. J. Appl. Phycol. 2012, 24, 547-555.
162. Tang, S.; Qin, C.; Wang, H.; Li, S.; Tian, S. Study on supercritical extraction of lipids and enrichment of DHA from oil-rich microalgae. J. Supercrit. Fluids 2011, 57, 44-49.
163. Zhou, D.-Y.; Zhu, B.-W.; Tong, L.; Wu, H.-T.; Qin, L.; Tan, H.; Chi, Y.-L.; Qu, J.-Y.; Murata, Y. Extraction of lipid from scallop (Patinopecten yessoensis) viscera by enzyme-assisted solvent and supercritical carbon dioxide methods. Int. J. Food Sci. Technol. 2010, 45, 1787-1793.
164. Pieber, S.; Schober, S.; Mittelbach, M. Pressurized fluid extraction of polyunsaturated fatty acids from the microalga Nannochloropsis oculata. Biomass Bioenergy 2012, 47, 474-482.
165. Reddy, H.K.; Muppaneni, T.; Sun, Y.; Li, Y.; Ponnusamy, S.; Patil, P.D.; Dailey, P.; Schaub, T.; Holguin, F.O.; Dungan, B.; et al. Subcritical water extraction of lipids from wet algae for biodiesel production. Fuel 2014, 133, 73-81.
166. Golmakani, M.T.; Mendiola, J.A.; Rezaei, K.; Ibáñez, E. Pressurized limonene as an alternative bio-solvent for the extraction of lipids from marine microorganisms. J. Supercrit. Fluids 2014, 92, 1-7.
167. Rodríguez-Meizoso, I.; Jaime, L.; Santoyo, S.; Cifuentes, A.; García-Blairsy Reina, G.; Señoráns, F.; Ibáñez, E. Pressurized fluid extraction of bioactive compounds from Phormidium species. J. Agric. Food Chem. 2008, 56, 3517-3523.
168. Liaset, B.; Julshamn, K.; Espe, M. Chemical composition and theoretical nutritional evaluation of the produced fractions from enzymic hydrolysis of salmon frames with ProtamexTM. Process Biochem. 2003, 38, 1747-1759.
169. Linder, M.; Fanni, J.; Parmentier, M. Proteolytic extraction of salmon oil and PUFA concentration by lipases. Mar. Biotechnol. 2005, 15, 70-76.
170. Converti, A.; Casazza, A.A.; Ortiz, E.Y.; Perego, P.; del Borghi, M. Effect of temperature and nitrogen concentration on the growth and lipid content of Nannochloropsis oculata and Chlorella vulgaris for biodiesel production. Chem. Eng. Process. Process Intensif. 2009, 48, 1146-1151.
171. Samori, C.; Lopez Barreiro, D.; Vet, R.; Pezzolesi, L.; Brilman, D.W.F.; Galletti, P.; Tagliavini, E. Effective lipid extraction from algae cultures using switchable solvents. Green Chem. 2013, 15, 353-356.
172. Hao, S.; Wei, Y.; Li, L.; Yang, X.; Cen, J.; Huang, H.; Lin, W.; Yuan, X. The effects of different extraction methods on composition and storage stability of sturgeon oil. Food Chem. 2015, 173, 274-282.
173. Xiao, X.-H.; Yuan, Z.-Q.; Li, G.-K. Preparation of phytosterols and phytol from edible marine algae by microwave-assisted extraction and high-speed counter-current chromatography. Sep. Purif. Technol. 2013, 104, 284-289.
174. Gupta, S.; Abu-Ghannam, N. Bioactive potential and possible health effects of edible brown seaweeds. Trends Food Sci. Technol. 2011, 22, 315-326.
175. Lee, Y.; Shin, K.; Kim, B.-K.; Lee, S. Anti-diabetic activities of fucosterol from Pelvetia siliquosa. Arch. Pharm. Res. 2004, 27, 1120-1122.
176. Lee, S.; Lee, Y.; Jung, S.; Kang, S.; Shin, K. Anti-oxidant activities of fucosterol from the marine algae Pelvetia siliquosa. Arch. Pharm. Res.2003, 26, 719-722.
177. Becerra, M.; Boutefnouchet, S.; Córdoba, O.; Vitorina, G.P.; Brehu, L.; Lamour, I.; Laimay, F.; Efstathiou, A.; Smirlis, D.; Michel, S.; et al. Antileishmanial activity of fucosterol recovered from Lessonia vadosa Searles (Lessoniaceae) by SFE, PSE and CPC. Phytochem. Lett. 2015, 11, 418-423.
178. Ralifo, P.; Sanchez, L.; Gassner, N.C.; Tenney, K.; Lokey, R.S.; Holman, T.R.; Valeriote, F.A.; Crews, P. Pyrroloacridine alkaloids from Plakortis quasiamphiaster: Structures and bioactivity. J. Nat. Prod. 2007, 70, 95-99.
179. Johnson, T.A.; Morgan, M.V.C.; Aratow, N.A.; Estee, S.A.; Sashidhara, K.V.; Loveridge, S.T.; Segraves, N.L.; Crews, P. Assessing pressurized liquid extraction for the high-throughput extraction of marine-sponge derived natural products. J. Nat. Prod. 2010, 73, 359-364.
180. Anaëlle, T.; Leon, E.S.; Laurent, V.; Elena, I.; Mendiola, J.A.; Stéphane, C.; Nelly, K.; Stéphane, L.B.; Luc, M.; Valérie, S.-P. Green improved processes to extract bioactive phenolic compounds from brown macroalgae using Sargassum muticum as model. Talanta 2013, 104, 44-52.
181. Ahn, G.; Hwang, I.; Park, E.; Kim, J.; Jeon, Y.-J.; Lee, J.; Park, J.W.; Jee, Y. Immunomodulatory effects of an enzymatic extract from Ecklonia cava on murine splenocytes. Mar. Biotechnol. 2008, 10, 278-289.
182. Ahn, G.; Park, E.; Lee, W.-W.; Hyun, J.-W.; Lee, K.-W.; Shin, T.; Jeon, Y.-J.; Jee, Y. Enzymatic extract from Ecklonia cava induces the activation of lymphocytes by IL-2 production through the classical NF-κB pathway. Mar. Biotechnol. 2011, 13, 66-73.
183. Kang, S.M.; Kim, K.N.; Lee, S.H.; Ahn, G.; Chan, S.H.; Kim, A.D.; Yang, X.-D.; Kang, M.-C.; Jeon, Y.-J. Antiinflammatory activity of polysaccharide purified from AMG-assistant extract of Ecklonia cava in LPS-stimulated RAW 264.7 macrophages. Carbohydr. Polym. 2011, 85, 80-85.
184. Siriwardhana, N.; Kim, K.N.; Lee, K.W.; Kim, S.H.; Ha, J.H.; Song, C.B.; Lee, J.B.; Jeon, Y.-J. Optimization of hydrophilic antioxidant extraction from Hiziki fusiformis by integrating treatments of enzymes, heat and pH control. Int. J. Food Sci. Technol. 2008, 43, 587-596.
185. Grimi, N.; Dubois, A.; Marchal, L.; Jubeau, S.; Lebovka, N.I.; Vorobiev, E. Selective extraction from microalgae Nannochloropsis sp. using different methods of cell disruption. Bioresour. Technol. 2014, 153, 254-259.
186. Wang, F.; Guo, X.-Y.; Zhang, D.-N.; Wu, Y.; Wu, T.; Chen, Z.-G. Ultrasound-assisted extraction and purification of taurine from the red algae Porphyra yezoensis. Ultrason. Sonochem. 2015, 24, 36-42.
187. 2 extraction of bioactive Tyrian purple precursors from hypobranchial gland of marine gastropod. J. Supercrit. Fluids 2014, 94, 1-7.
188. Tripoteau, L.; Bedoux, G.; Gagnon, J.; Bourgougnon, N. In vitro antiviral activities of enzymatic hydrolysates extracted from byproducts of the Atlantic holothurian Cucumaria frondosa. Process Biochem. 2015, 50, 867-875.
189. Hardouin, K.; Burlot, A.-S.; Umami, A.; Tanniou, A.; Stiger-Pouvreau, V.; Wildowati, I.; Bedoux, G.; Bourgougnon, N. Biochemical and antiviral activities of enzymatic hydrolysates from different invasive French seaweeds. J. Appl. Phycol. 2014, 26, 1029-1042.
190. He, G.; Yin, Y.; Yan, X.; Yu, Q. Optimisation extraction of chondroitin sulfate from fish bone by high intensity pulsed electric fields. Food Chem. 2014, 164, 205-210.
191. Prado, J.M.; Prado, G.H.C.; Meireles, M.A.A. Scale-up study of supercritical fluid extraction process for clove and sugarcane residue. J. Supercrit. Fluids 2011, 56, 231-237.
192. Barba, J.F.; Grimi, N.; Vorobiev, E. New Approaches for the Use of Non-conventional cell disruption technologies to extract potential food additives and nutraceuticals from microalgae. Food Eng. Rev. 2015, 7, 45-62.
193. European Parliament; Council of the European Union. Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC; LASTMODIN 32013R0517; European Union: Brussels, Belgium, 2014.
194. European Union. Directive 2008/1/EC of the European Parliament and of the Council of 15 January 2008 concerning integrated pollution prevention and control. Off. J. Eur. Union 2008, L24, 8-29
195. Justino, C.I.L.; Duarte, K.; Freitas, A.C.; Duarte, A.C.; Rocha-Santos, T. Classical Methodologies for Preparation of Extracts and Fraction. In Analysis of Marine Samples in Search of Bioactive Compounds; Rocha-Santos, T., Duarte, A.C., Eds.; Elsevier: Amsterdam, The Netherland, 2014; pp. 35-57.
196. Grosso, C.; Valentão, P.; Ferreres, F.; Andrade, P.B. Bioactive marine drugs and marine biomaterials for brain diseases. Mar. Drugs 2014, 12, 2539-2589.
197. Anastas, P.T.; Warner, J.C. Green Chemistry: Theory and Practice; Oxford University Press: New York, NY, USA, 1998; p. 30.
198. Andraos, J.; Dicks, A.P. Green chemistry teaching in higher education: A review of effective practices. Chem. Educ. Res. Pract. 2012, 13, 69-79.
199. Ibañez, E.; Herrero, M.; Jose, A.; Mendiola, J.A.; Castro-Puyana, M. Extraction and Characterization of Bioactive Compounds with Health Benefits from Marine Resources: Macro and Micro Algae, Cyanobacteria, and Invertebrates. In Marine Bioactive Compounds: Sources, Characterization and Applications; Hayes, M., Ed.; Springer Science + Business Media: New York, NY, USA, 2012; pp. 55-98.
200. Lagadec, A.J.M.; Miller, D.J.; Lilke, A.L.; Hawthorne, S.B. Pilot-scale subcritical water remediation of polycyclic aromatic hydrocarbon-and pesticide contaminated soil. Environ. Sci. Technol. 2000, 34, 1542-1548.
201. 2 extraction of essential oil from orange peel; effect of the height of the bed. J. Supercrit. Fluids 2002, 18, 227-237.
202. Meireles, M.A.A. Supercritical extraction from solid: Process design data (2001-2003). Curr. Opin. Solid State Mater. Sci. 2003, 7, 321-330.
203. Pronyk, C.; Mazza, G. Design and scale-up of pressurized fluid extractors for food and bioproducts. J. Food Eng. 2009, 95, 215-226.
204. Terigar B.G.; Balasubramanian S.; Sabliov, C.M.; Lima, M.; Boldor, D. Soybean and rice bran oil extraction in a continuous microwave system: From laboratory- to pilot-scale. J. Food Eng. 2011, 104, 208-217.
205. Boonkird, S.; Phisalaphong, C.; Phisalaphong, M. Ultrasound-assisted extraction of capsaicinoids from Capsicum frutescens on a lab- and pilot-plant scale. Ultrason. Sonochem. 2008, 15, 1075-1079.