Prooxidant actions of carotenoids in biologic systems

Nutrition Reviews

Volumn 56, Issue 9, 1998, Pages 257-265

  Palozza, Paola ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CAROTENE; CAROTENOID;

ANTIOXIDANT ACTIVITY; CHRONIC DISEASE; HUMAN; OXIDATION REDUCTION POTENTIAL; REVIEW; RISK ASSESSMENT; VITAMIN INTAKE;

EID: 0031669520     PISSN: 00296643     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1753-4887.1998.tb01762.x     Document Type: Review

References (74)

1. Mayne ST. Beta-carotene, carotenoids, and disease prevention in humans. FASEB J 1996; 10:690-701
2. Hennekens CH, Buring JE, Manson JE, et al. Lack of effect of long-term supplementation with β-carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med 1996:334:1145-9
3. Greenberg ER, Baron JA, Karagas MR, et al. Mortality associated with low plasma concentration ofβ -carotene and the effect of oral supplementation. JAMA 1996;275:699-703
4. Alpha-tocopherol, Beta-Carotene Cancer Prevention Study Group: the effect of vitamin E and β-carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994;330:1029-35
5. Omenn GS, Goodman GE, Thornquist MD, et al. Effects of a combination of β-carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 1996;334:1150-5
6. Zhang, LX., Cooney KW, Bertram JS. Carotenoids upregulate connexin 43 gene expression independent of their provitamin A or antioxidant properties. Cancer Res 1992;52:5707-12
7. Bendich A, Shapiro SS. Effect of β-carotene and canthaxanthin on the immune response of the rat. J Nutr 1986;116:2254-62
8. Foote CS, Denny RW. Chemistry of singlet oxygen. VIII. Quenching by β-carotene. J Am Chem Soc 1968;90:6233-5
9. Palozza P, Krinsky NI. Antioxidant effects of carotenoids in vivo and in vitro: an overview. Methods Enzymol 1992;213:403-20
10. Krinsky NI. Actions of carotenoids in biological systems. Annu Rev Nutr 1993;13:561-87
11. Sies H, Stahl W. Vitamins E and C, β-carotene, and other carotenoids as antioxidants. Am J Clin Nutr 1995;62(suppl):1315S-21S
12. Burton GW, Ingold KU. β-carotene: an unusual type of lipid antioxidant. Science 1984;224:569-73
13. Stocker R, Yamamoto Y, McDonagh AF, et al. Bilirubin is an antioxidant of possible physiological importance. Science 1987;235:1043-6
14. Palozza P, Krinsky NI. The inhibition of radical-initiated peroxidation of microsomal lipids by both α-tocopherol and β-carotene. Free Radic Biol Med 1991;11:407-14
15. Kennedy TA, Liebler DC. Peroxyl radical scavenging of β-carotene in lipid bilayers: effect of oxygen partial pressure. J Biol Chem 1992;267:4658-63
16. Vile GF, Winterbourn CC. Inhibition of adriamycin-promoted microsomal lipid peroxidation by β-carotene, α-tocopherol, and retinal at high and low oxygen partial pressure. FEBS Lett 1988;238:353-6
17. Palozza P, Calviello G, Bartoli GM. Prooxidant activity of β-carotene under 100% oxygen pressure in rat liver microsomes. Free Radic Biol Med 1995;19:887-92
18. Palozza P, Luberto C, Calviello G, et al. Antioxidant and prooxidant role of β-carotene in murine normal and tumor thymocytes: effects of oxygen partial pressure. Free Radic Biol Med 1997;22:1065-73
19. Kennedy TA, Liebler DC. Peroxyl radical oxidation of β-carotene: formation of β-carotene epoxides. Chem Res Toxicol 1991;4:290-5
20. Handelman GJ, van Kuijk FJGM, Chatterjee A, Krinsky NI. Characterization of products formed during the autooxidation of β-carotene. Free Radic Biol Med 1991;10:427-37
21. Liebler DC, McClure TD. Antioxidant reactions of β-carotene: identification of carotenoid-radical adducts. Chem Res Toxicol 1996;9:8-11
22. 2 radical. J Am Chem Soc 1993;117:8322-6
23. Truscott TG. β-Carotene and disease: a suggested prooxidant and antioxidant mechanism and speculations concerning its role in cigarette smoking. J Photochem Photobiol B 1996;35:233-5
24. Niki E, Noguchi N, Tsuchihashi H, Gotoh N. Interaction among vitamin C, vitamin E, and β-carotene. Am J Clin Nutr 1995;62(suppl):1322S-6S
25. Liebler DC, Stratton SP, Kaysen KL. Antioxidant actions of β-carotene in liposomal and microsomal membranes: role of carotenoid-membrane incorporation and α-tocopherol. Arch Biochem Biophys 1997;338:244-50
26. Cruickshank GS, Rampling R. Peri-tumoral hypoxia in human brain: perioperative measurement of the tissue oxygen tension around malignant brain tumours. Acta Neurochir Suppl (Wien) 1994;60:575-7
27. Andersen HR, Andersen O. Effects of dietary α-tocopherol and β-carotene on lipid peroxidation induced by methyl mercuric chloride in mice. Pharmacol Toxicol 1993;73:192-201
28. Lomnitsky L, Bergman M, Schon I, Grossman S. The effect of dietary vitamin E and β-carotene on oxidation processes in rat testis. Biochim Biophys Acta 1991;1082:101-7
29. Lomnitsky S, Grossman S, Bergman M, et al. In vitro and in vivo effects of β-carotene on rat epidermal lipoxygenase. Int J Vitam Nutr Res 1997;67:407-14
30. Alam SQ, Alam BS. Lipid peroxide, α-tocopherol, and retinoid levels in plasma and liver of rats fed diets containing β-carotene and 13-cis-retinoic acid. J Nutr 1983;113:2608-14
31. Terao J, Yamauchi R, Murakami H, Matsushita S. Inhibitory effects of tocopherols and β-carotene on singlet oxygen-initiated photooxidation of methyl linoleate and soybean oil. J Food Proc Preserv 1980;4:79-93
32. Haila K, Heinonen, M. Action of β-carotene on purified rapeseed oil during light storage. Lebensm Wiss U Technol 1994;27:573-7
33. Haila KM, Lievonen SM, Heinonen MI. Effects of lutein, lycopene, annatto, and γ-tocopherol on autoxidation of triglycerides. J Agric Food Chem 1996;44:2096-2100
34. Palozza P, Krinsky NI. β-Carotene and α-tocopherol are synergistic antioxidants. Arch Biochem Biophys 1992;297:184-7
35. Mayne ST, Parker RS. Antioxidant activity of dietary canthaxanthin. Nutr Cancer 1989;12:225-36
36. Blakely SR, Mitchell GV, Jenkins MY, et al. Canthaxanthin and excess vitamin A alter α-tocopherol, carotenoid, and iron status in adult rats. J Nutr 1991;121:1649-55
37. Lim BP, Nagao A, Terao J, et al. Antioxidant activity of xanthophylls on peroxyl radical-mediated phospholipid peroxidation. Biochim Biophys Acta 1992;1126:178-84
38. Xu MJ, Plezia PM, Alberts DS, et al. Reduction in plasma or skin α-tocopherol concentration with long-term oral administration of β-carotene in humans and mice. J Natl Cancer Inst 1992;84:1559-65
39. Lambert LA, Warner WG, Wei RR, et al. The protective but nonsynergistic effect of dietary β-carotene and vitamin E on skin tumorigenesis in Skh mice. Nutr Cancer 1994;21:1-12
40. Tang G, Blanco MC, Fox JG, Russell RM. Supplementing ferrets with canthaxanthin affects the tissue distributions of canthaxanthin, other carotenoids, vitamin A and vitamin E. J Nutr 1995;125:1945-51
41. Woodall AA, Britton G, Jackson MJ. Dietary supplementation with carotenoids: effects on α-tocopherol levels and susceptibility of tissues to oxidative stress. Br J Nutr 1996;76:307-17
42. Palozza P, Calviello G, Serini S, et al. Supplementation with canthaxanthin affects plasma and tissue distribution of α- and γ-tocopherols in mice. J Nutr 1998 (in press)
43. Mobarhan S, Shiau A, Grande A, et al. β-Carotene supplementation results in an increased serum and colonic mucosal concentration of β-carotene and a decrease in α-tocopherol concentration in patients with colonic neoplasia. Cancer Epidemiol Biomarkers Prev 1994;3:501-3
44. Nierenberg DW, Stukel TA, Mott LA, Greenber ER. Steady-state serum concentration of α-tocopherol not altered by supplementation with oral -carotene. J Natl Cancer Inst 1994;86:117-20
45. Goodman GE, Metch BJ, Omenn GS. The effect of long-term β-carotene and vitamin A administration on serum concentrations of α-tocopherol. Cancer Epidemiol Biomarkers Prev 1994;3:429-32
46. Willet WC, Stampfer MJ, Underwood BA, et al. Vitamins A, E, and carotene: effects of supplementation on their plasma levels. Am J Clin Nutr 1983;38:559-66
47. Van Poppel G, Hospers J, Buytenhek R, Princen HMG. No effect of β-carotene supplementation on plasma lipoproteins in healthy smokers. Am J Clin Nutr 1994;60:730-4
48. Schwarte JL, Tanaka J, Khandekar V, et al. The effectiveness of a mixture of β-carotene, α-tocopherol, glutathione, and ascorbic acid for cancer prevention. Nutr Cancer 1993;20:145-51
49. Suda D, Schwartz JL, Shklar G. GGT reduction in β-carotene inhibition of hamster buccal pouch carcinogenesis. Eur J Cancer Clin Oncol 1987;23:43-6
50. Packer L. Antioxidant action of carotenoids in vitro and in vivo and protection against oxidation of human low-density lipoproteins. Ann N Y Acad Sci 1993;691:48-60
51. Jialal J, Grundy SM. Preservation of the endogenous antioxidants in low-density lipoprotein by ascorbate but not probucol during oxidative modification. J Clin Invest 1991;87:597-601
52. Reaven PD, Ferguson E, Navab M, Powell FL. Susceptibility of human LDL to oxidative modifications: effects of variations in β-carotene concentration and oxygen tension. Arterioscler Thromb Vasc Biol 1994;14:1162-9
53. Blakely SR, Slaughter L, Adkins J, Knight EV. Effects of β-carotene and retinyl palmitate on corn oil-induced Superoxide dismutase and catalase in rats. J Nutr 1988;118:152-8
54. 10 and selenium protect tissues against lipid peroxidation in rat tissue slices. J Nutr 1990;120:97-104
55. 10, β-carotene, canthaxanthin, and (+)-catechin against oxidative damage to rat blood and tissues in vivo. Free Radic Biol Med 1995;5:949-53
56. White WS, Peck KM, Bierer TL, et al. Interactions of oral β-carotene and canthaxanthin in ferrets. J Nutr 1993;123:1405-13
57. White WS, Stacewicz-Sapuntzakis M, Erdman JW Jr, Bowen PE. Pharmacokinetics of β-carotene and canthaxanthin after ingestion of individual and combined doses by human subjects. J Am Coll Nutr 1994;13:665-71
58. Kostic D, White WS, Olson JA. Intestinal absorption, serum clearance and interactions between lutein and β-carotene when administered to human adults in separate or combined oral doses. Am J Clin Nutr 1995;62:604-10
59. Wahlqvist ML, Wattanapenpaiboon N, Macrae FA, et al. Changes in serum carotenoids in subjects with colorectal adenomas after 24 months of β-carotene supplementation. Am J Clin Nutr 1994;60:936-43
60. Jacques PF, Halpner AD, Blumberg JB. Influence of combined antioxidant nutrient intakes on their plasma concentrations in an elderly population. Am J Clin Nutr 1995;62:1228-33
61. Shklar G, Schwartz J, Trickier D, Cheverie SR. The effectiveness of a mixture of β-carotene, α-tocopherol, glutathione, and ascorbic acid for cancer prevention. Nutr Cancer 1993;20:145-51
62. Van Poppel G. Carotenoids and cancer: an update with emphasis on human intervention studies. Eur J Cancer 1993;9:1335-44
63. Toyokuni S, Okamoto K, Yodoi J, Hiai H. Persistent oxidative stress in cancer. FEBS Lett 1995;358:1-3
64. Schwartz JL, Singh RP, Teicher B, et al. Induction of a 70 kD protein associated with the selective cytotoxicity of β-carotene in human epidermal carcinoma. Biochem Biophys Res Commun 1990,169:941-6
65. Abdel-Fatth G, Watzl B, Huang D, Watson RR. β-Carotene in vitro stimulates tumor necrosis factor-α and interleukin-1 α secretion by human peripheral blood mononuclear cells. Nutr Res 1993;13:863-71
66. Schwartz JL. The dual roles of nutrients as antioxidants and prooxidants: their effects on tumor cell growth. J Nutr 1996;126:1221S-7S
67. Hazuka MB, Edwards-Prasad J, Newman F, et al. β-Carotene induces morphological differentiation and decreases adenylate cyclase activity in melanoma cell culture. J Am Coll Nutr 1990;9:143-9
68. Levy J, Bosin E, Feldman B, et al. Lycopene is a more potent inhibitor of human cancer cell proliferation than either α-carotene or β-carotene. Nutr Cancer 1995;24:257-66
69. Escribano J, Alonso GL, Coca-Prados M, Fernandez JA. Crocin, safranal, and picrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Lett 1996;100:23-30
70. Okuzumi J, Nishino H, Murakoshi M, et al. Inhibitory effects of fucoxanthin, a natural carotenoid, on N-myc expression and cell cycle progression in human malignant tumor cells. Cancer Lett 1990;55:75-81
71. Muto Y, Fujii J, Shidoji Y, et al. Growth retardation in human cervical dysplasia-derived cell lines by β-carotene through down-regulation of epidermal growth factor receptor. Am J Clin Nutr 1995;62:1535S-40S
72. Palozza P, Maggiano N, Calviello G, et al. Canthaxanthin induces apoptosis in human cancer cell lines. Carcinogenesis. 1998;19:373-6
73. Palozza P, Calviello C, Serini S, et al. Antitumor effect of an oral administration of canthaxanthin in BALB/c mice bearing thymoma cells. Nutr Cancer 1997;28:199-205
74. Gerster H. β-Carotene, vitamin E, and vitamin C in different stages of experimental carcinogenesis. Eur J Clin Nutr 1995;49:155-68