DNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 19, 2015, Pages E2457-E2466

  Williams, Lindsey N ^a   Marjavaara, Lisette ^b   Knowels, Gary M ^a   Schultz, Eric M ^a   Fox, Edward J ^a   Chabes, Andrei ^b   Herr, Alan J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UMEÅ UNIVERSITY   (Sweden)

Author keywords

Cancer; Dna replication and repair; Lethal mutagenesis; Polymerase fidelity

Indexed keywords

CHECKPOINT KINASE 2; DNA DIRECTED DNA POLYMERASE EPSILON; MEDIATOR OF THE REPLICATION CHECKPOINT 1; NUCLEOSIDE DIPHOSPHATE KINASE; PROTEIN; PROTEIN RAD9; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DNA DIRECTED DNA POLYMERASE; DNA DIRECTED DNA POLYMERASE ETA; NUCLEOTIDE; PHOSPHATE;

ARTICLE; CELL CYCLE PROGRESSION; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; ENZYME PHOSPHORYLATION; GENE DELETION; GENE MUTATION; GENE REPLICATION; GENETIC VARIABILITY; LETHALITY; MUTATION RATE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; S PHASE CELL CYCLE CHECKPOINT; UPREGULATION; ALLELE; CELL CYCLE; CELL CYCLE S PHASE; CHEMISTRY; DNA REPLICATION; GENETICS; HUMAN; METABOLISM; MUTAGENESIS; MUTATION; NEOPLASMS; NUCLEOTIDE SEQUENCE; PLASMID; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCETALES;

ALLELES; ANTINEOPLASTIC AGENTS; CELL CYCLE; DNA MUTATIONAL ANALYSIS; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; GENETIC VARIATION; HUMANS; MUTAGENESIS; MUTATION; NEOPLASMS; NUCLEOTIDES; PHENOTYPE; PHOSPHATES; PLASMIDS; S PHASE; SACCHAROMYCES CEREVISIAE;

EID: 84929224147     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1422948112     Document Type: Article

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