Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

Nature Genetics

Volumn 47, Issue 3, 2015, Pages 257-262

  Shlien, Adam ^a,b   Campbell, Brittany B ^a,b   De Borja, Richard ^a   Alexandrov, Ludmil B ^c   Merico, Daniele ^a,d   Wedge, David ^c   Van Loo, Peter ^c,e   Tarpey, Patrick S ^c   Coupland, Paul ^f   Behjati, Sam ^c   Pollett, Aaron ^g   Lipman, Tatiana ^a   Heidari, Abolfazl ^a   Deshmukh, Shriya ^a   Avitzur, Na'ama ^a   Meier, Bettina ^h   Gerstung, Moritz ^c   Hong, Ye ^h   Merino, Diana M ^a   Ramakrishna, Manasa ^c   Remke, Marc ^a   Arnold, Roland ^a   Panigrahi, Gagan B ^a   Thakkar, Neha P ^a,b   Hodel, Karl P ⁱ   Henninger, Erin E ⁱ   Göksenin, A Yasemin ⁱ   Bakry, Doua ^a,j   Charames, George S ^b,g   Druker, Harriet ^a,b   Lerner Ellis, Jordan ^b,g,k   Mistry, Matthew ^a,b   Dvir, Rina ^l   Grant, Ronald ^a,j   Elhasid, Ronit ^l   Farah, Roula ^m   Taylor, Glenn P ^a   Nathan, Paul C ^a,j   Alexander, Sarah ^a,j   Ben Shachar, Shay ^l   Ling, Simon C ^a,j   Gallinger, Steven ^g   Constantini, Shlomi ^l   Dirks, Peter ^a   Huang, Annie ^a,j   Scherer, Stephen W ^a,b,d,j   Grundy, Richard G ⁿ   Durno, Carol ^a,g   Aronson, Melyssa ^g   Gartner, Anton ^h   Meyn, M Stephen ^a,b,j   Taylor, Michael D ^a   Pursell, Zachary F ⁱ   Pearson, Christopher E ^a,b   Malkin, David ^a,j   Futreal, P Andrew ^c   Stratton, Michael R ^c   Bouffet, Eric ^a,j   Hawkins, Cynthia ^a,b   Campbell, Peter J ^c,o   Tabori, Uri ^a,j   more..

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

^e UNIVERSITY OF LEUVEN   (Belgium)

^f WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^g MOUNT SINAI HOSPITAL   (Canada)

^h UNIVERSITY OF DUNDEE   (United Kingdom)

ⁱ TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^j UNIVERSITY OF TORONTO   (Canada)

^k ONTARIO INSTITUTE FOR CANCER RESEARCH   (Canada)

^l TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^m SAINT GEORGE HOSPITAL UNIVERSITY MEDICAL CENTER   (Lebanon)

ⁿ UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^o UNIVERSITY OF CAMBRIDGE   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DNA DIRECTED DNA POLYMERASE DELTA; DNA DIRECTED DNA POLYMERASE EPSILON; DNA DIRECTED DNA POLYMERASE;

ARTICLE; BIALLELIC MISMATCH REPAIR DEFICIENCY; BRAIN TUMOR; CANCER GENETICS; CANCER SURVIVAL; CELL DIVISION; CHILD; GENE REPLICATION; GENE SEQUENCE; GENETIC DISORDER; GERM LINE; HUMAN; MISMATCH REPAIR; PRIORITY JOURNAL; SOMATIC HYPERMUTATION; TUMOR BIOPSY; BASE MISPAIRING; DNA REPAIR; DNA REPLICATION; EXON; GENETICS; GERMLINE MUTATION; MICROSATELLITE INSTABILITY;

BASE PAIR MISMATCH; BRAIN NEOPLASMS; DNA MISMATCH REPAIR; DNA REPAIR; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; EXONS; GERM-LINE MUTATION; HUMANS; MICROSATELLITE INSTABILITY;

EID: 84923989372     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3202     Document Type: Article

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