Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiae

Molecular and Cellular Biology

Volumn 17, Issue 10, 1997, Pages 6105-6113

  Huang, Mingxia ^a   Elledge, Stephen J ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; RIBONUCLEOTIDE REDUCTASE; RNA;

ARTICLE; CONTROLLED STUDY; DELETION MUTANT; DNA DAMAGE; ENZYME ANALYSIS; ENZYME INDUCTION; ENZYME LOCALIZATION; ENZYME SUBUNIT; FLOW CYTOMETRY; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MITOSIS; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

SACCHAROMYCES CEREVISIAE;

EID: 0030813561     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.10.6105     Document Type: Article

References (42)

1. Allen, J. B., Z. Zhou, W. Siede, E. C. Friedberg, and S. J. Elledge. 1994. The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. Genes Dev. 8:2401-2424.
2. Barlow, T. R. Eliasson, A. Platz, P. Reichard, and B. M. Sjoberg. 1983. Enzymic modification of a tyrosine residue to a stable free radical in ribonucleotide reductase. Proc. Natl. Acad. Sci. USA 80:1492-1495.
3. Bjorklund, S., S. Skog, B. Tribukait, and L. Thelander. 1990. S-phase-specific expression of mammalian ribonucleotide reductase R1 and R2 subunit mRNAs. Biochemistry 29:5452-5458.
4. Conner, J., J. Murray, A. Cross, J. B. Clements, and J. S. Marsden. 1995. Intracellular localization of herpes simplex virus type 1 ribonucleotide reductase subunits during infection of cultured cell. Virology 213:615-623.
5. Desany, B., and S. J. Elledge. Unpublished data.
6. Elledge, S. J., and R. W. Davis. 1987. Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: a DNA damage-inducible gene required for mitotic viability. Mol. Cell. Biol. 7:2783-2793.
7. Elledge, S. J., and R. W. Davis. 1989. DNA damage induction of ribonucleotide reductase. Mol. Cell. Biol. 9:4932-4940.
8. Elledge, S. J., and R. W. Davis. 1989. Identification of a damage-regulatory element of RNR2 and evidence that four distinct proteins bind to it. Mol. Cell. Bio. 9:5373-5386.
9. Elledge, S. J., and R. W. Davis. 1990. Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternate regulatory subunits of ribonucleotide reductase. Genes Dev. 4:740-751.
10. Elledge, S. J., Z. Zhou, J. B. Allen, and T. A. Navas. 1993. DNA damage and cell cycle regulation of ribonucleotide reductase. Bioessays 15:333-339.
11. Engstrom, Y., S. Eriksson, I. Jildevik, S. Skog, L. Thelander, and B. Tribukait. 1985. Cell cycle-dependent expression of mammalian ribonucleotide reductase. J. Biol. Chem. 260:9114-9116.
12. Engstrom, Y., and B. Rozell. 1988. Immunocytochemical evidence for the cytoplasmic localization and differential expression during the cell cycle of the M1 and M2 subunits of mammalian ribonucleotide reductase. EMBO J. 7:1615-1620.
13. Eriksson, S., A. Graslund, S. Skog, L. Thelander, and B. Tribukait. 1984. Cell cycle-dependent regulation of mammalian ribonucleotide reductase. J. Biol. Chem. 259:11695-11700.
14. + of the fission yeast Schizosaccharomyces pombe encode the large and small subunits of ribonucleotide reductase. Mol. Gen. Genet. 238:241-251.
15. + expression in fission yeast. Mol. Gen. Genet. 252:284-291.
16. Hofmann, K., and P. Bucher. 1995. The FHA domain: a putative nuclear signaling domain found in protein kinases and transcription factors. Trends. Biochem. Sci. 20:347-349.
17. Huang, M. Unpublished data.
18. Jones, W., and S. J. Elledge. Unpublished data.
19. Kohrer, K., and H. Domdey. 1991. Preparation of high molecular weight RNA. Methods Enzymol. 194:398-405.
20. Leem, S.-H., and H. Ogawa. 1991. The MRE4 gene encodes a novel protein kinase homologue required for meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res. 20:449-457.
21. Lycksell, P. O., R. Ingemarson, R. Davis, A. Graslund, and L. Thelander. 1994. 1H NMR studies of mouse ribonucleotide reductase: the R2 protein carboxyl-terminal tail, essential for subunit interaction, is highly flexible but becomes rigid in the presence of protein R1. Biochemistry 33:2838-2842.
22. Lydall, D., and T. Weinert. 1995. Yeast checkpoint genes in DNA damage processing: implications for repair and arrest. Science 270:1488-1491.
23. Mathews, C. K., B. M. Sjoberg, and P. Reichard. 1987. Ribonucleotide reductase of Escherichia coli. Cross-linking agents as probes of quaternary and quinary structure. Eur. J. Biochem. 166:279-285.
24. Navas, T. A., Z. Zhou, and S. J. Elledge. 1995. DNA polymerase ε links the DNA replication machinery to the S phase checkpoint. Cell 80:29-39.
25. Petersson, L., A. Graslund, A. Ehrenberg, B. Sjoberg, and P. Reichard. 1980. The iron center in ribonucleotide reductase from Escherichia coli. J. Biol. Chem. 255:6706-6712.
26. Reichard, P. 1993. From RNA to DNA, why so many ribonucleotide reductases? Science 260:1773-1777.
27. Rockmill, B., and G. S. Roeder. 1991. A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination. Genes Dev. 5:2392-2404.
28. Rothstein, R. 1983. One-step gene disruption in yeast. Methods Enzymol. 101:202-211.
29. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
30. Sanchez, Y., B. A. Desany, W. J. Jones, Q. Liu, B. Wang, and S. J. Elledge. 1996. Regulation of RAD53 by the ATM-like kinase MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 271:357-360.
31. Sikorska, M., L. M. Brewer, T. Youdale, R. Richards, J. F. Whitfield, R. A. Houghten, and P. R. Walker. 1990. Evidence that mammalian ribonucleotide reductase is a nuclear membrane associated glycoprotein. Biochem. Cell Biol. 68:880-888.
32. Sikorski, R. S., and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Sacchromyces cerevisiae. Genetics 122:19-27.
33. Stern, D., P. Zheng, D. R. Berdler, and C. Zerillo. 1991. Spk1, a new kinase from Sacchromyces cerevisiae, phosphorylates proteins on serine, threonine, and tyrosine. Mol. Cell Biol. 11:987-1001.
34. Stubbe, J. 1990. Ribonucleotide reductases: amazing and confusing. J. Biol. Chem. 265:5329-5332.
35. Sugimoto, K., T. Shimomura, K. Hashimoto, H. Araki, A. Sugino, and K. Matsumoto. 1996. Rfc5, a small subunit of replication factor C complex, couples DNA replication and mitosis in budding yeast. Proc. Natl. Acad. Sci. USA 93:7048-7052.
36. Sun, L., and J. A. Fuchs. 1992. Escherichia coli ribonucleotide reductase expression is cell cycle regulated. Mol. Biol. Cell 3:1095-1105.
37. Sun, Z., D. S. Fay, F. Marini, M. Foiani, and D. F. Stern. 1996. Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. Genes Dev. 10:395-406.
38. Wang, P. J., A. Chabes, R. Casagrande, X. C. Tian, L. Thelander, and T. C. Huffaker. 1997. RNR4, a novel ribonucleotide reductase small-subunit protein. Mol. Cell. Biol. 17:6114-6121.
39. Weinert, T. A., G. L. Kiser, and L. H. Hartwell. 1994. Mitotic checkpoint genes in budding yeast and dependence of mitosis on DNA replication and repair. Genes. Dev. 8:652-665.
40. Wheeler, L. J., N. B. Ray, C. Ungermann, S. P. Hendricks, M. A. Bernard, E. S. Hanson, and C. K. Mathews. 1996. T4 phage gene 32 protein as a candidate organizing factor for the deoxyribonucleotide triphosphate synthetase complex. J. Biol. Chem. 271:11156-11162.
41. Zhou, Z., and S. J. Elledge. 1992. Isolation of crt mutants constitutive for transcription of the DNA damage inducible gene RNR3 in Saccharomyces cerevisiae. Genetics 131:851-866.
42. Zhou, Z., and S. J. Elledge. 1993. DUN1 encodes a protein kinase that controls the DNA damage response in yeast. Cell 75:1119-1127.