Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication

Genome Research

Volumn 24, Issue 11, 2014, Pages 1740-1750

  Shinbrot, Eve ^a   Henninger, Erin E ^b   Weinhold, Nils ^c   Covington, Kyle R ^a   Göksenin, A Yasemin ^b   Schultz, Nikolaus ^c   Chao, Hsu ^a   Doddapaneni, Harsha Vardhan ^a   Muzny, Donna M ^a   Gibbs, Richard A ^a   Sander, Chris ^c   Pursell, Zachary F ^b   Wheeler, David A ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; DNA DIRECTED DNA POLYMERASE EPSILON; EXONUCLEASE; PIK3R1 PROTEIN; PROTEIN P53; TUMOR PROTEIN; UNCLASSIFIED DRUG; ATM PROTEIN, HUMAN; DNA DIRECTED DNA POLYMERASE ALPHA; DNA DIRECTED DNA POLYMERASE GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PIK3R1 PROTEIN, HUMAN; POLD1 PROTEIN, HUMAN; STOP CODON;

AMINO ACID SUBSTITUTION; ARTICLE; BLADDER CARCINOMA; BREAST CARCINOMA; COLORECTAL TUMOR; ENDOMETRIUM TUMOR; GENE MUTATION; GENE REPLICATION; GLIOBLASTOMA; GLIOMA; HEAD AND NECK CANCER; HUMAN; KIDNEY CARCINOMA; LUNG ADENOCARCINOMA; MAJOR CLINICAL STUDY; MUTATION RATE; NONSENSE MUTATION; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; SOMATIC MUTATION; STOMACH CANCER; TUMOR SUPPRESSOR GENE; CHEMICAL STRUCTURE; CHEMISTRY; DNA REPLICATION; DNA REPLICATION ORIGIN; ENZYMOLOGY; GENETIC ASSOCIATION; GENETIC DATABASE; GENETICS; METABOLISM; MICROSATELLITE INSTABILITY; MISSENSE MUTATION; NEOPLASM; NUCLEOTIDE SEQUENCE; PROTEIN TERTIARY STRUCTURE; STOP CODON;

EUKARYOTA;

ATAXIA TELANGIECTASIA MUTATED PROTEINS; CODON, NONSENSE; DATABASES, GENETIC; DNA MUTATIONAL ANALYSIS; DNA POLYMERASE II; DNA POLYMERASE III; DNA REPLICATION; EXONUCLEASES; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MICROSATELLITE INSTABILITY; MODELS, MOLECULAR; MUTATION, MISSENSE; NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN STRUCTURE, TERTIARY; REPLICATION ORIGIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84919743846     PISSN: 10889051     EISSN: 15495469     Source Type: Journal    
DOI: 10.1101/gr.174789.114     Document Type: Article

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